Synthesis and transdermal permeation-enhancing activity of ketone, amide, and alkane analogs of Transkarbam 12 Fulltext Access 8 Pages 2006
A new synthetic protocol for labeled oligonucleotides, using a chemically cleavable universal linker Fulltext Access 8 Pages 2006
Correlation of the acid-sensitivity of polyethylene glycol daunorubicin conjugates with their in vitro antiproliferative activity Fulltext Access 8 Pages 2006
Spirocyclopropyl pyrrolidines as a new series of α-l-fucosidase inhibitors Fulltext Access 8 Pages 2006
New Taxol® (paclitaxel) prodrugs designed for ADEPT and PMT strategies in cancer chemotherapy Fulltext Access 8 Pages 2006
Synthesis, study of 3D structures, and pharmacological activities of lipophilic nitroimidazolyl-1,4-dihydropyridines as calcium channel antagonist Fulltext Access 8 Pages 2006
QSAR study of 1,4-dihydropyridine calcium channel antagonists based on gene expression programming Fulltext Access 8 Pages 2006
Synthesis and antibacterial activity of substituted flavones, 4-thioflavones and 4-iminoflavones Fulltext Access 8 Pages 2006
Antioxidant and anticancer activities of novel p-alkylaminophenols and p-acylaminophenols (aminophenol analogues) Fulltext Access 8 Pages 2006
Synthesis, receptor binding, and activation studies of N(1)-alkyl-l-histidine containing thyrotropin-releasing hormone (TRH) analogues Fulltext Access 8 Pages 2006
Unify QSAR approach to antimicrobials. Part 1: Predicting antifungal activity against different species Fulltext Access 8 Pages 2006
Interaction of arylpiperazine ligands with the hydrophobic part of the 5-HT1A receptor binding site Fulltext Access 8 Pages 2006
Synthesis and cellular studies of a carboranylchlorin for the PDT and BNCT of tumors Fulltext Access 8 Pages 2006
Safrole oxide induces apoptosis by up-regulating Fas and FasL instead of integrin β4 in A549 human lung cancer cells Fulltext Access 8 Pages 2006
2-Aminothiophene-3-carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers Fulltext Access 8 Pages 2006
Solvent free microwave synthesis and evaluation of antimicrobial activity of pyrimido[4,5-b]- and pyrazolo[3,4-b]quinolines Fulltext Access 8 Pages 2006
Preparation of yuanhuacine and relative daphne diterpene esters from Daphne genkwa and structure–activity relationship of potent inhibitory activity against DNA topoisomerase I Fulltext Access 8 Pages 2006
Novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella verrucosa Fulltext Access 8 Pages 2006
Synthesis and biological activity of N,N-dialkylaminoalkyl-substituted bisindolyl and diphenyl pyrazolone derivatives Fulltext Access 8 Pages 2006
Ferrocenyl-QUINAP: a planar chiral P,N-ligand for palladium-catalyzed allylic substitution reactions Fulltext Access 8 Pages 2006
Chiral monometallic lanthanide(III) salt complexes are arrayed acid-base networks for enantioselective catalysis: a direct, nitroaldol (Henry) reaction Fulltext Access 8 Pages 2006
Creation of quaternary stereocentres: synthesis of new polyhydroxylated indolizidines Fulltext Access 8 Pages 2006
α-Chymotrypsin-catalyzed peptide synthesis in frozen aqueous solution using N-protected amino acid carbamoylmethyl esters as acyl donors Fulltext Access 8 Pages 2006
Synthesis and pharmacological evaluation of second-generation phosphatidic acid derivatives as lysophosphatidic acid receptor ligands Fulltext Access 8 Pages 2006
Characterization of high molecular weight impurities in synthetic phosphorothioate oligonucleotides Fulltext Access 8 Pages 2006
Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum Fulltext Access 8 Pages 2006
Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides Fulltext Access 8 Pages 2006
Respiratory syncytial virus fusion inhibitors. Part 3: Water-soluble benzimidazol-2-one derivatives with antiviral activity in vivo Fulltext Access 8 Pages 2006
Cluster analysis and two-dimensional quantitative structure–activity relationship (2D-QSAR) of Pseudomonas aeruginosa deacetylase LpxC inhibitors Fulltext Access 8 Pages 2006
Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: Targeting the gatekeeper residue and beyond Fulltext Access 8 Pages 2006
Structural characterization of novel cobalt corrinoids synthesized by enzymes of the vitamin B12 anaerobic pathway Fulltext Access 8 Pages 2006
Synthesis, antiviral, and antitumor activity of 2-substituted purine methylenecyclopropane analogues of nucleosides Fulltext Access 8 Pages 2006
3′-N-Alkylamino-3′-deoxy-ara-uridines: A new class of potential inhibitors of ribonuclease A and angiogenin Fulltext Access 8 Pages 2006
A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of β3-adrenergic receptor agonists Fulltext Access 8 Pages 2006
QSAR analysis of phenolic antioxidants using MOLMAP descriptors of local properties Fulltext Access 8 Pages 2006
QSAR by LFER model of HIV protease inhibitor mannitol derivatives using FA-MLR, PCRA, and PLS techniques Fulltext Access 8 Pages 2006
QSPR models for polychlorinated biphenyls: n-Octanol/water partition coefficient Fulltext Access 8 Pages 2006
Enzymatically stable 5′ mRNA cap analogs: Synthesis and binding studies with human DcpS decapping enzyme Fulltext Access 8 Pages 2006
Binding analysis of glycyrrhetinic acid to human serum albumin: Fluorescence spectroscopy, FTIR, and molecular modeling Fulltext Access 8 Pages 2006
Synthesis and antiproliferative evaluation of certain 4-anilino-8-methoxy-2-phenylquinoline and 4-anilino-8-hydroxy-2-phenylquinoline derivatives Fulltext Access 8 Pages 2006
Quantitative structure–activity relationship of spirosuccinimide type aldose reductase inhibitors diminishing sorbitol accumulation in vivo Fulltext Access 8 Pages 2006
Diastereoselective synthesis of (2S,5S)- and (2S,5R)-N-benzyloxycarbonyl-5-hydroxypipecolic acids from trans-4-hydroxy-l-proline Fulltext Access 8 Pages 2006
Separability of diastereomer salt pairs of 1-phenylethylamine with enantiomeric 2-substituted phenylacetic acids by fractional crystallization, and its relation to physical and phase properties Fulltext Access 8 Pages 2006
SN2 reaction of 2-substituted 3-piperidinol mesylate with retention of configuration: application to the asymmetric synthesis of (2R,3S)-CP-99,994 Fulltext Access 8 Pages 2006
Enantioselective cyanosilylation of aldehydes catalysed by a diastereomeric mixture of atropisomeric thioureas Fulltext Access 8 Pages 2006
Synthesis and chiral recognition ability of O-phenyl ethylphosphonothioic acid with a conformationally flexible phenoxy group for CH/π interaction Fulltext Access 8 Pages 2006
Highly enantioselective synthesis of α-methylene-δ-valerolactones by an asymmetric Michael reaction Fulltext Access 8 Pages 2006
Novel nitrogen ligands based on imidazole derivatives and their application in asymmetric catalysis Fulltext Access 8 Pages 2006
Enantioselective synthesis of 2-alkylidenetetrahydrofurans based on a ‘cyclization/enzymatic resolution’ strategy Fulltext Access 8 Pages 2006
Synthesis of the enantiomeric forms of α- and γ-damascone starting from commercial racemic α-ionone Fulltext Access 8 Pages 2006
Synthesis of 4-diphenylphosphanylmethyl- and 4-phenylthiomethyl-1,4-methano-11,11-dimethyl-1,2,3,4-tetrahydroacridine: new N–P and N–S camphor-derived chiral ligands for asymmetric catalysis Fulltext Access 8 Pages 2006
Stereoselective synthesis of a new chiral synthon: a cyclic pseudodipeptide containing an aspartic acid derivative and l-valine Fulltext Access 8 Pages 2006
Enantioselective addition of diethylzinc to aldehydes using immobilized chiral BINOL–Ti complex on ordered mesoporous silicas Fulltext Access 8 Pages 2006
Using ionic liquid [EMIM][CH3COO] as an enzyme-‘friendly’ co-solvent for resolution of amino acids Fulltext Access 8 Pages 2006
Creation of quarternary stereocentres via [3,3]-sigmatropic rearrangement of allylic thiocyanates. A synthetic approach to (+)-myriocin Fulltext Access 8 Pages 2006
Sensitive fluorescent sensors for malate based on calix[4]arene bearing anthracene Fulltext Access 8 Pages 2006
Clustering of Pentacene and Functionalized Pentacene Ions in a Matrix-Assisted Laser Desorption/Ionization Orthogonal TOF Mass Spectrometer Fulltext Access 8 Pages 2006
Combining Low and High Mass Ion Accumulation for Enhancing Shotgun Proteome Analysis by Accurate Mass Measurement Fulltext Access 8 Pages 2006
Dominulin A and B: Two New Antibacterial Peptides Identified on the Cuticle and in the Venom of the Social Paper Wasp Polistes dominulus Using MALDI-TOF, MALDI-TOF/TOF, and ESI-Ion Trap Fulltext Access 8 Pages 2006
Noncovalent Interaction Between Amyloid-β-Peptide (1-40) and Oleuropein Studied by Electrospray Ionization Mass Spectrometry Fulltext Access 8 Pages 2006
Observation of Pronounced b•,y Cleavages in the Electron Capture Dissociation Mass Spectrometry of Polyamidoamine (PAMAM) Dendrimer Ions with Amide Functionalities Fulltext Access 8 Pages 2006
Nafion-Coated Bismuth Film and Nafion-Coated Mercury Film Electrodes for Anodic Stripping Voltammetry Combined On-Line with ICP-Mass Spectrometry Fulltext Access 8 Pages 2006
Structural Analysis of κ-Carrageenan Sulfated Oligosaccharides by Positive Mode Nano-ESI-FTICR-MS and MS/MS by SORI-CID Fulltext Access 8 Pages 2006
A Comparative Study of the Fragmentation of Neutral Lactooligosaccharides in Negative-Ion Mode by UV-MALDI-TOF and UV-MALDI Ion-Trap/TOF Mass Spectrometry Fulltext Access 8 Pages 2006
Synthesis and antitumor activity of CBI-bearing ester and carbamate prodrugs of CC-1065 analogue Fulltext Access 8 Pages 2006
Synthesis and receptor binding affinity of carboxylate analogues of the mannose 6-phosphate recognition marker Fulltext Access 8 Pages 2006
Design, synthesis, and evaluation of new type of l-amino acids containing pyridine moiety as nitric oxide synthase inhibitor Fulltext Access 8 Pages 2006
Synthesis and biological activity of tricyclic analogues of 9-{[cis-1′,2′-bis(hydroxymethyl)cycloprop-1′-yl]methyl}guanine Fulltext Access 8 Pages 2006
Ether derivatives of 3-piperidinopropan-1-ol as non-imidazole histamine H3 receptor antagonists Fulltext Access 8 Pages 2006
Design, synthesis, and bioactivity of simplified paclitaxel analogs based on the T-Taxol bioactive conformation Fulltext Access 8 Pages 2006
Novel ketoconazole analogues based on the replacement of 2,4-dichlorophenyl group with 1,4-benzothiazine moiety: Design, synthesis, and microbiological evaluation Fulltext Access 8 Pages 2006
The introduction of fluorine atoms or trifluoromethyl groups in short cationic peptides enhances their antimicrobial activity Fulltext Access 8 Pages 2006
Cytotoxic labdane alkaloids from an ascidian Lissoclinum sp.: Isolation, structure elucidation, and structure–activity relationship Fulltext Access 8 Pages 2006
Gas Phase H/D Exchange of Sodiated Amino Acids: Why Do We See Zwitterions? Fulltext Access 8 Pages 2006
Design, synthesis, and biological evaluation of substituted 2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamine related compounds as fructose-1,6-bisphosphatase inhibitors Fulltext Access 8 Pages 2006
Inhibition of protein kinase C by dequalinium analogues: Structure–activity studies on head group variations Fulltext Access 8 Pages 2006
On-bead combinatorial techniques for the identification of selective aldose reductase inhibitors Fulltext Access 8 Pages 2006
Protein-enhanced decarboxylation of the covalent intermediate in benzoylformate decarboxylase—Desolvation or acid catalysis? Fulltext Access 8 Pages 2006
Synthesis of enantiomerically pure hydroxylated pyrroline N-oxides from d-ribose Fulltext Access 8 Pages 2006
Synthesis of hindered chiral guanidine bases starting from (S)-(N,N-dialkyl-aminomethyl)pyrrolidines and BrCN Fulltext Access 8 Pages 2006
Chemoenzymatic access to all four enantiopure stereoisomers of 1-ferrocenyl-1,3-butanediol Fulltext Access 8 Pages 2006
Synthesis of novel norephedrine-based chiral ligands with multiple stereogenic centers and their application in enantioselective addition of diethylzinc to aldehyde and chalcone Fulltext Access 8 Pages 2006