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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Iron-catalyzed allylic substitution reactions of allylic ethers with Grignard reagents
Fulltext Access 7 Pages 2016
Tetrodecamycin: An unusual and interesting tetronate antibiotic
Fulltext Access 7 Pages 2016
Translational pharmacologyPerspectives in regulatory science: translational and clinical pharmacology
Fulltext Access 7 Pages 2016
Computational Models of Neurological DisorderMultiscale models of pharmacological, immunological and neurostimulation treatments in Alzheimer's disease
Fulltext Access 7 Pages 2016
Computational Models of Neurological DisorderComputer modeling of ischemic stroke
Fulltext Access 7 Pages 2016
Computational Models of Neurological DisorderThe use of dynamic computational models of neural circuitry to streamline new drug development
Fulltext Access 7 Pages 2016
Computational Models of Neurological DisorderComputer modeling for pharmacological treatments for dystonia
Fulltext Access 7 Pages 2016
Computational Models of Neurological DisorderComputational modeling to improve treatments for essential tremor
Fulltext Access 7 Pages 2016
Computational Models of Neurological DisorderComputational Drug Networks: a computational approach to elucidate drug mode of action and to facilitate drug repositioning for neurodegenerative diseases
Fulltext Access 7 Pages 2016
Assessing the potential of surface-immobilized molecular logic machines for integration with solid state technology
Fulltext Access 7 Pages 2016
Predicting gene expression level by the transcription factor binding signals in human embryonic stem cells
Fulltext Access 7 Pages 2016
Microwave assisted synthesis and cytotoxic activity evaluations of new benzimidazole derivatives
Fulltext Access 7 Pages 2016
Phosphine- and copper-free palladium catalyzed one-pot four-component carbonylation reaction for the synthesis of isoxazoles and pyrazoles
Fulltext Access 7 Pages 2016
Synthesis and pharmacological evaluation of conformationally constrained glutamic acid higher homologues
Fulltext Access 7 Pages 2016
Copper-catalyzed [3+2] annulation of propargylic acetates with anilines in the presence of trimethylsilyl chloride leading to 2,3-disubstituted indoles via an aza-Claisen rearrangement
Fulltext Access 7 Pages 2016
Phase-vanishing method with gas evolution and its application to organic synthesis
Fulltext Access 7 Pages 2016
Boron trifluoride-methanol complex. Mild and powerful reagent for deprotection of acetylated amines. Scope and selectivity
Fulltext Access 7 Pages 2016
A turn-on fluorescent chemosensor selectively detects cyanide in pure water and food sample
Fulltext Access 7 Pages 2016
A colorimetric and fluorescent turn-on probe for carbon monoxide and imaging in living cells
Fulltext Access 7 Pages 2016
A highly efficient catalytic α-alkylation of unactivated amides using primary alcohols
Fulltext Access 7 Pages 2016
Microwave-assisted synthesis of functionalized spirohydantoins as 3-D privileged fragments for scouting the chemical space
Fulltext Access 7 Pages 2016
A new synthetic strategy to 2,3-diallyl-1,4-quinones via one-pot double Claisen rearrangement and retro Diels-Alder reaction
Fulltext Access 7 Pages 2016
Synthesis of a novel archaeal tetraether-type lipid containing a diorthoester group as a helper lipid for gene delivery
Fulltext Access 7 Pages 2016
Selective synthesis of imidazolidine-2-thiones via ring expansion of aziridine-2-carboxylates with isothiocyanates
Fulltext Access 7 Pages 2016
A remarkably simple and convergent partial synthesis of pomolic acid
Fulltext Access 7 Pages 2016
Cholesterol derived cationic lipids as potential non-viral gene delivery vectors and their serum compatibility
Fulltext Access 7 Pages 2016
Bridging the translational gap: collaborative drug development and dispelling the stigma of commercialization
Fulltext Access 7 Pages 2016
Curcumin as a therapeutic agent in the chemoprevention of inflammatory bowel disease
Fulltext Access 7 Pages 2016
Improving the drug development process by reducing the impact of adverse events: the case of cataracts considered
Fulltext Access 7 Pages 2016
The impact of early human data on clinical development: there is time to win
Fulltext Access 7 Pages 2016
Expanding roles of superoxide dismutases in cell regulation and cancer
Fulltext Access 7 Pages 2016
Patent term extension systems differentiate Japanese and US drug lifecycle management
Fulltext Access 7 Pages 2016
Potential pancreatic lipase inhibitory activity of phenolic constituents from the root bark of Morus alba L.
Fulltext Access 7 Pages 2016
Copper-catalyzed three-component synthesis of aminonaphthoquinone-sulfonylamidine conjugates and in vitro evaluation of their antiproliferative activity
Fulltext Access 7 Pages 2016
New pentasubstituted pyrrole hybrid atorvastatin-quinoline derivatives with antiplasmodial activity
Fulltext Access 7 Pages 2016
Regulatory effect of hydroquinone-tetraethylene glycol conjugates on zebrafish pigmentation
Fulltext Access 7 Pages 2016
Synthesis, antibacterial and cytotoxic activities of new biflorin-based hydrazones and oximes
Fulltext Access 7 Pages 2016
Design, synthesis and biological evaluation of 5-fluorouracil-derived benzimidazoles as novel type of potential antimicrobial agents
Fulltext Access 7 Pages 2016
Petasis three-component reaction accelerated by trifluoroacetic acid: synthesis of indoline-derived glycines
Fulltext Access 7 Pages 2016
Proteasome inhibition by new dual warhead containing peptido vinyl sulfonyl fluorides
Fulltext Access 7 Pages 2016
Biofilm vivacity and destruction on antimicrobial nanosurfaces assayed within a microbial fuel cell
Fulltext Access 7 Pages 2016
Preclinical models of childhood cancer for the development of targeted therapies
Fulltext Access 7 Pages 2016
Reverse engineering the inflammatory “clock”: from computational modeling to rational resetting
Fulltext Access 7 Pages 2016
Population-reaction model and microbial experimental ecosystems for understanding hierarchical dynamics of ecosystems
Fulltext Access 7 Pages 2016
On hybridising lettuce seedlings with nanoparticles and the resultant effects on the organisms' electrical characteristics
Fulltext Access 7 Pages 2016
Reducing complexity in an agent based reaction model-Benefits and limitations of simplifications in relation to run time and system level output
Fulltext Access 7 Pages 2016
Synthesis and evaluation of colletoic acid core derivatives
Fulltext Access 7 Pages 2016
Do cinnamylideneacetophenones have antioxidant properties and a protective effect toward the oxidation of phosphatidylcholines?
Fulltext Access 7 Pages 2016
Focused screening to identify new adenosine kinase inhibitors
Fulltext Access 7 Pages 2016
Direct protein-protein conjugation by genetically introducing bioorthogonal functional groups into proteins
Fulltext Access 7 Pages 2016
Inhibition of plasma lipid oxidation induced by peroxyl radicals, peroxynitrite, hypochlorite, 15-lipoxygenase, and singlet oxygen by clinical drugs
Fulltext Access 7 Pages 2016
Anion receptors based on 4-nitrophenylhydrazone
Fulltext Access 7 Pages 2016
Pyrrole, imidazole, and triazole derivatives as ion-pair recognition receptors
Fulltext Access 7 Pages 2016
Straightforward synthesis and antioxidant studies of chalcogenoaziridines
Fulltext Access 7 Pages 2016
One-pot synthesis of glycyrrhetic acid polyglycosides based on grafting-from method using cyclic sulfite
Fulltext Access 7 Pages 2016
Direct and facile synthesis of 9-aminoacridine and acridin-9-yl-ureas
Fulltext Access 7 Pages 2016
A tight 1:1 complex between an allosteric receptor and an organic effector with hydrogen and coordination bonds
Fulltext Access 7 Pages 2016
Sulfated tungstate catalyzed activation of nitriles: addition of amines to nitriles for synthesis of amidines
Fulltext Access 7 Pages 2016
Palladium-catalyzed carbonylative annulation toward new [1,2,5]thiadiazole-fused heteroacenes for solution-processed field-effect transistors
Fulltext Access 7 Pages 2016
Design, development of new synthetic methodology, and biological evaluation of substituted quinolines as new anti-tubercular leads
Fulltext Access 7 Pages 2016
Synthesis and fungicidal activity of 1,1-diaryl tertiary alcohols
Fulltext Access 7 Pages 2016
2-Benzylidene-1-indanone derivatives as inhibitors of monoamine oxidase
Fulltext Access 7 Pages 2016
Reduced immune response to polymeric micelles coating sialic acids
Fulltext Access 7 Pages 2016
Direct halogenation of alcohols with halosilanes under catalyst- and organic solvent-free reaction conditions
Fulltext Access 7 Pages 2016
Human microbial metabolites as a source of new drugs
Fulltext Access 7 Pages 2016
Drug combination therapy increases successful drug repositioning
Fulltext Access 7 Pages 2016
Treatment of insulin resistance: straight from the gut
Fulltext Access 7 Pages 2016
Development of cell therapy medicinal products by academic institutes
Fulltext Access 7 Pages 2016
A model of dopamine regulation of glutamatergic synapse on medium size spiny neurons
Fulltext Access 7 Pages 2016
Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid
Fulltext Access 7 Pages 2016
Novel squaramides with in vitro liver stage antiplasmodial activity
Fulltext Access 7 Pages 2016
The effective direct resolution procedure for the chiral drug bevantolol hydrochloride
Fulltext Access 7 Pages 2016
Synthesis of 4-hydroxy-2-methylproline derivatives via pyrrolidine ring assembly: chromatographic resolution and diastereoselective synthesis approaches
Fulltext Access 7 Pages 2016
Polymerization of l-proline functionalized styrene and its catalytic performance as a supported organocatalyst for direct enantioselective aldol reaction
Fulltext Access 7 Pages 2016
Novel efficient bifunctional calixarene thiourea organocatalysts: synthesis and application in the direct enantioselective aldol reactions
Fulltext Access 7 Pages 2016
Addition of cyanomethyl anion to the cyano group of 2-cyano-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazol-3-oxide-1-oxyl, a nitronyl nitroxide
Fulltext Access 7 Pages 2016
Amino acid derived ionic liquid supported iron Schiff base catalyzed greener approach for the aerobic oxidation of amines to nitriles
Fulltext Access 7 Pages 2016
Efficient synthesis of rottlerin and its two subunits
Fulltext Access 7 Pages 2016
Sodium chlorate as a viable substoichiometric oxidant for cobalt-catalyzed oxidative annulation of aryl sulfonamides with alkynes
Fulltext Access 7 Pages 2016
Visible light mediated chemo-selective oxidation of benzylic alcohols
Fulltext Access 7 Pages 2016
Iodine-catalyzed [3+2] cyclization of 2-pyridylesters and chalcones: metal-free approach for the synthesis of substituted indolizines
Fulltext Access 7 Pages 2016
Efficient and highly stereoselective assembly of rosuvastatin
Fulltext Access 7 Pages 2016
Mild and efficient synthesis of iodylarenes using Oxone as oxidant
Fulltext Access 7 Pages 2016
Synthesis of 5-hydroxy hydantoins via a tandem process
Fulltext Access 7 Pages 2016
Efficient chemoselective hydrogenation of organic azides catalyzed by palladium nanoparticles with alkyne-derived homogeneous supports
Fulltext Access 7 Pages 2016
Transition-metal-free cross-coupling reaction of benzylic halides with arylboronic acids leading to diarylmethanes
Fulltext Access 7 Pages 2016
Microwave-assisted one-pot three-component synthesis of imine 1,2,3-triazoles
Fulltext Access 7 Pages 2016
Synthesis of colchifulvin, a colchicine-griseofulvin hybrid
Fulltext Access 7 Pages 2016
Systemic amyloidoses and proteomics: The state of the art
Fulltext Access 7 Pages 2016
Domino Wittig-Diels Alder reaction: synthesis of carbazole lignans
Fulltext Access 7 Pages 2016
Microwave assisted benzylation of naphthols and 4-hydroxycoumarin under catalyst & solvent free conditions
Fulltext Access 7 Pages 2016
Superacid-promoted synthesis of polychlorinated dibenzofurans
Fulltext Access 7 Pages 2016
Synthesis, characterization, and application of palladium-dithizone immobilized on magnetic nanoparticles as an efficient and recoverable catalyst for Suzuki type coupling reactions
Fulltext Access 7 Pages 2016
An efficient synthesis of moronic and heterobetulonic acids from allobetulin
Fulltext Access 7 Pages 2016
Reversible addition and elimination of alcohols by vicinal tetracarbonyl compound
Fulltext Access 7 Pages 2016
A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides
Fulltext Access 7 Pages 2016
Graphene oxide: a reusable and metal-free carbocatalyst for the one-pot synthesis of 2-amino-3-cyanopyridines in water
Fulltext Access 7 Pages 2016
Manganese-catalyzed Sonogashira coupling of aryl iodides
Fulltext Access 7 Pages 2016
Preparation of vinyl ethers using a Wittig approach, and their subsequent hydrogenation employing continuous-flow processing
Fulltext Access 7 Pages 2016
Computational and mechanistic studies of the acylation of cyclopropanes
Fulltext Access 7 Pages 2016
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