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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Peptide-based inhibitors of protein–protein interactions
Fulltext Access 7 Pages 2016
Assemblies of ionic zinc chlorins assisted by water-soluble polypeptides
Fulltext Access 7 Pages 2016
Dual and antagonic therapeutic effects of sulfated glycans
Fulltext Access 7 Pages 2016
Discovery of a new type of scaffold for the creation of novel tyrosinase inhibitors
Fulltext Access 7 Pages 2016
Structure–activity relationship of lipid core peptide-based Group A Streptococcus vaccine candidates
Fulltext Access 7 Pages 2016
Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors
Fulltext Access 7 Pages 2016
Design, synthesis and biological evaluation of novel tetrahydroisoquinoline quaternary derivatives as peripheral κ-opioid receptor agonists
Fulltext Access 7 Pages 2016
Mitochondrial drug targets in neurodegenerative diseases
Fulltext Access 7 Pages 2016
Triterpene sapogenin–polyarginine conjugates exhibit promising antibacterial activity against Gram-positive strains
Fulltext Access 7 Pages 2016
Highly potent tyrosinase inhibitor, neorauflavane from Campylotropis hirtella and inhibitory mechanism with molecular docking
Fulltext Access 7 Pages 2016
Synthesis, biological evaluation and structural analysis of novel peripherally active morphiceptin analogs
Fulltext Access 7 Pages 2016
Protective effect of novel substituted nicotine hydrazide analogues against hypoxic brain injury in neonatal rats via inhibition of caspase
Fulltext Access 7 Pages 2016
Synthesis, structure–activity relationships, and biological evaluation of a series of benzamides as potential multireceptor antipsychotics
Fulltext Access 7 Pages 2016
Synthesis and in vitro evaluation of hydrazinyl phthalazines against malaria parasite, Plasmodium falciparum
Fulltext Access 7 Pages 2016
Synthesis and antibacterial evaluation of macrocyclic diarylheptanoid derivatives
Fulltext Access 7 Pages 2016
Identification of novel protein tyrosine phosphatase sigma inhibitors promoting neurite extension
Fulltext Access 7 Pages 2016
Nature-inspired design of tetraindoles: Optimization of the core structure and evaluation of structure–activity relationship
Fulltext Access 7 Pages 2016
Inhibition of cancer cell invasion by new ((3,4-dihydroxy benzylidene)hydrazinyl)pyridine-3-sulfonamide analogs
Fulltext Access 7 Pages 2016
Inhibitors of diacylglycerol lipases in neurodegenerative and metabolic disorders
Fulltext Access 7 Pages 2016
Design, synthesis and antimalarial evaluation of novel thiazole derivatives
Fulltext Access 7 Pages 2016
Cytoprotective small molecule modulators of endoplasmic reticulum stress
Fulltext Access 7 Pages 2016
Synthesis and evaluation of substituted 3-(pyridin-2-yl)benzenesulfonamide derivatives as potent herbicidal agents
Fulltext Access 7 Pages 2016
Identification of a novel boronic acid as a potent, selective, and orally active hormone sensitive lipase inhibitor
Fulltext Access 7 Pages 2016
Synthetic isoprenoid analogues for the study of prenylated proteins: Fluorescent imaging and proteomic applications
Fulltext Access 7 Pages 2016
Synthesis and in vitro evaluation of novel rhodanine derivatives as potential cholinesterase inhibitors
Fulltext Access 7 Pages 2016
Short cationic lipopeptides as effective antibacterial agents: Design, physicochemical properties and biological evaluation
Fulltext Access 7 Pages 2016
Bistacrine derivatives as new potent antimalarials
Fulltext Access 7 Pages 2016
Inhibitory effect of flavonoids on human glutaminyl cyclase
Fulltext Access 7 Pages 2016
Conformational studies of glycosylated cyclic oligomers of furanoid sugar amino acids
Fulltext Access 8 Pages 2016
Inflammatory response to implantation of transparent nanocrystalline yttria-stabilized zirconia using a dorsal window chamber model
Fulltext Access 8 Pages 2016
Synthesis and properties of gallate ionic liquids
Fulltext Access 8 Pages 2016
Novel D(A-Ar)2 type small molecules with oligothiophene, diketopyrrolopyrrole and benzo[4,5]thieno [2,3-b]indole units: investigation on relationship between structure and property for organic solar cells
Fulltext Access 8 Pages 2016
Substituent effects in aminocarbonylation of para-substituted iodobenzenes
Fulltext Access 8 Pages 2016
Three-component reaction and organocatalysis in one: synthesis of densely substituted 4-aminochromanes
Fulltext Access 8 Pages 2016
Metal-free allylation of electron-rich heteroaryl boronic acids with allylic alcohols
Fulltext Access 8 Pages 2016
Immunosuppressive chalcone-isoflavonoid dimers from Campylotropis hirtella
Fulltext Access 8 Pages 2016
Synthesis of multivalent glycopeptide conjugates that mimic an HIV epitope
Fulltext Access 8 Pages 2016
Synthetic approaches to pallimamine and analogues using direct imine acylation
Fulltext Access 8 Pages 2016
An efficient, eco-friendly and sustainable tandem oxidative amidation of alcohols with amines catalyzed by heteropolyanion-based ionic liquids via a bifunctional catalysis process
Fulltext Access 8 Pages 2016
Synthesis and characterization of two new tetrapyrazolic macrocycles for the selective extraction of cesium cation
Fulltext Access 8 Pages 2016
Biodihydroxylation of substituted quinolines and isoquinolines by recombinant whole-cell mediated biotransformations
Fulltext Access 8 Pages 2016
Nonlinear optical and energy-level modulation of organic alkynes by click chemistry
Fulltext Access 8 Pages 2016
Synthesis of sulfonyl-substituted furans via copper-mediated annulation of acetylenic sulfones and activated methylenes
Fulltext Access 8 Pages 2016
Accelerating the discovery of antibacterial compounds using pathway-directed whole cell screening
Fulltext Access 8 Pages 2016
Rational modification of the lead molecule: Enhancement in the anticancer and dihydrofolate reductase inhibitory activity
Fulltext Access 8 Pages 2016
Repurposing strategies for tropical disease drug discovery
Fulltext Access 8 Pages 2016
Chemical manipulation of plant water use
Fulltext Access 8 Pages 2016
Design, synthesis and insecticidal evaluation of aryloxy dihalopropene derivatives
Fulltext Access 8 Pages 2016
A new motif for inhibitors of geranylgeranyl diphosphate synthase
Fulltext Access 8 Pages 2016
Intrinsically disordered regions stabilize the helical form of the C-terminal domain of RfaH: A molecular dynamics study
Fulltext Access 8 Pages 2016
Ensemble-based docking: From hit discovery to metabolism and toxicity predictions
Fulltext Access 8 Pages 2016
Design, synthesis, crystal structure, biological evaluation and molecular docking studies of carbazole-arylpiperazine derivatives
Fulltext Access 8 Pages 2016
Synthesis of novel tetrazole derivatives and evaluation of their antifungal activity
Fulltext Access 8 Pages 2016
Metal-stabilized carbocations derived from monoterpenes: dicobalt hexacarbonyl complexes of alkynyl-verbenols
Fulltext Access 8 Pages 2016
A mononuclear non-heme-iron dioxygen-carrying protein?
Fulltext Access 8 Pages 2016
Synthesis, characterization and cytotoxicity of new piplartine dimers
Fulltext Access 8 Pages 2016
Synthesis of polyfunctionalized benzophenones via the reaction of 3-formylchromones with tertiary push-pull enamines
Fulltext Access 8 Pages 2016
Oxone-mediated facile access to substituted pyrazoles
Fulltext Access 8 Pages 2016
Synthetic routes to large tripodal organic receptors and the structural characterisation of intermediates
Fulltext Access 8 Pages 2016
Direct enantioseparation of diarylmethylamines with an ortho-hydroxy group via diastereomeric salt formation and their application to the enantioselective addition reaction of diethylzinc
Fulltext Access 8 Pages 2016
Substrate screening of amino transaminase for the synthesis of a sitagliptin intermediate
Fulltext Access 8 Pages 2016
From antimicrobial activity to mechanism of resistance: the multifaceted role of simple quaternary ammonium compounds in bacterial eradication
Fulltext Access 8 Pages 2016
One-step construction of saturated six-membered rings directly using calcium carbide as an acetylene source: synthesis of 1,3,5-triaroylcyclohexanes
Fulltext Access 8 Pages 2016
The generality of kinase-catalyzed biotinylation
Fulltext Access 8 Pages 2016
Antiproliferative activity and apoptosis inducing effects of nitric oxide donating derivatives of evodiamine
Fulltext Access 8 Pages 2016
The influence of halogen substituents on the biological properties of sulfur-containing flavonoids
Fulltext Access 8 Pages 2016
The discovery of novel and selective fatty acid binding protein 4 inhibitors by virtual screening and biological evaluation
Fulltext Access 8 Pages 2016
Efficacy of peptide nucleic acid and selected conjugates against specific cellular pathologies of amyotrophic lateral sclerosis
Fulltext Access 8 Pages 2016
New imidazoquinoxaline derivatives: Synthesis, biological evaluation on melanoma, effect on tubulin polymerization and structure–activity relationships
Fulltext Access 8 Pages 2016
Preparation of chain-end clickable recombinant protein and its bio-orthogonal modification
Fulltext Access 8 Pages 2016
6-Methylpurine derived sugar modified nucleosides: Synthesis and evaluation of their substrate activity with purine nucleoside phosphorylases
Fulltext Access 8 Pages 2016
Improvement of catalytic activity of Candida rugosa lipase in the presence of calix[4]arene bearing iminodicarboxylic/phosphonic acid complexes modified iron oxide nanoparticles
Fulltext Access 8 Pages 2016
Novel biphenyl bis-sulfonamides as acetyl and butyrylcholinesterase inhibitors: Synthesis, biological evaluation and molecular modeling studies
Fulltext Access 8 Pages 2016
Fluorinated matrix metalloproteinases inhibitors—Phosphonate based potential probes for positron emission tomography
Fulltext Access 8 Pages 2016
Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists
Fulltext Access 8 Pages 2016
Mixing and matching chiral cobalt- and manganese-based calix-salen catalysts for the asymmetric hydrolytic ring opening of epoxides
Fulltext Access 8 Pages 2016
Synthesis and reactions of terpenyl diselenides functionalized with phenyl and naphthyl groups
Fulltext Access 8 Pages 2016
Highly enantioselective catalytic methyl propiolate addition to both aromatic and aliphatic aldehydes
Fulltext Access 8 Pages 2016
Convenient approach to an advanced intermediate for salinosporamide A synthesis
Fulltext Access 8 Pages 2016
Synthesis of panaxytriol and its stereoisomers as potential antitumor drugs
Fulltext Access 8 Pages 2016
Stereoselective conjugate addition of carbonyl compounds to maleimides using a diaminomethyleneindenedione organocatalyst
Fulltext Access 8 Pages 2016
Absolute configuration of stegane lignans by vibrational circular dichroism
Fulltext Access 8 Pages 2016
Potential role of metabolomics in the improvement of research on traditional African medicine
Fulltext Access 8 Pages 2016
Using inherent radical stabilization energies to predict unknown enthalpies of formation and associated bond dissociation energies of complex molecules
Fulltext Access 8 Pages 2016
Control of stereochemistry in atom transfer radical addition and step-growth radical polymerization by chiral transition metal catalysts
Fulltext Access 8 Pages 2016
Synthesis and investigation of catalytic affinities of water-soluble amphiphilic calix[n]arene surfactants in the coupling reaction of some heteroaromatic compounds
Fulltext Access 8 Pages 2016
A general method for obtaining calix[4]arene derivatives in the 1,2-alternate conformation
Fulltext Access 8 Pages 2016
Ionic self-assembly reactions of a porphyrin octacation
Fulltext Access 8 Pages 2016
Mixed arsonium-iodonium and sulfonium-iodonium ylides: synthesis and characteristics
Fulltext Access 8 Pages 2016
Recoverable platinum bis(fluoro-ponytailed) bipyridine complex as catalyst for hydrosilylation of alkynes under thermomorphic condition
Fulltext Access 8 Pages 2016
Phytochemical investigation and antimicrobial assessment of Bellis sylvestris leaves
Fulltext Access 8 Pages 2016
Rotational isomerization of 3-substituents in synthetic chlorophyll derivatives
Fulltext Access 8 Pages 2016
Molecular docking studies and biological evaluation of 1,3,4-thiadiazole derivatives bearing Schiff base moieties as tyrosinase inhibitors
Fulltext Access 8 Pages 2016
Pyrrolidine derived thioureas as organocatalysts in the Michael reaction of vinyl sulfone. Structure-stereoselectivity study
Fulltext Access 8 Pages 2016
Comparative proteomic analysis of malignant pleural mesothelioma: Focusing on the biphasic subtype
Fulltext Access 8 Pages 2016
Synthesis, biological evaluation and molecular docking study of some novel indole and pyridine based 1,3,4-oxadiazole derivatives as potential antitubercular agents
Fulltext Access 8 Pages 2016
Synthesis and multiparametric evaluation of thiadiazoles and oxadiazoles as diacylglycerol acyltransferase type 1 inhibitors
Fulltext Access 8 Pages 2016
Synthesis, antitumor activity and mechanism of action of novel 1,3-thiazole derivatives containing hydrazide–hydrazone and carboxamide moiety
Fulltext Access 8 Pages 2016
Synthesis and molecular modeling of antimicrobial active fluoroquinolone-pyrazine conjugates with amino acid linkers
Fulltext Access 8 Pages 2016
Photodynamic effects of novel 5,15-diaryl-tetrapyrrole derivatives on human colon carcinoma cells
Fulltext Access 8 Pages 2016
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