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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Design, synthesis, anticancer, antimicrobial activities and molecular docking studies of theophylline containing acetylenes and theophylline containing 1,2,3-triazoles with variant nucleoside derivatives
Fulltext Access 18 Pages 2016
Original ArticleThe ligand (s) anchored lipobrid nanoconstruct mediated delivery of methotrexate: an effective approach in breast cancer therapeutics
Fulltext Access 18 Pages 2016
Synthesis of novel 25-hydroxyprotopanaxadiol derivatives by methylation and methoxycarbonylation using dimethyl carbonate as a environment-friendly reagent and their anti-tumor evaluation
Fulltext Access 18 Pages 2016
Asymmetric synthesis of dihydroartemisinic acid through intramolecular Stetter reaction
Fulltext Access 18 Pages 2016
Fine tuning the outcome of 1,3-dipolar cycloaddition reactions of benzimidazolium ylides to activated alkynes
Fulltext Access 18 Pages 2016
Nanotherapeutics for anti-inflammatory delivery
Fulltext Access 18 Pages 2016
Tetrahedron report 1100Chromatography with silver nitrate: part 2
Fulltext Access 18 Pages 2016
Vibrational analysis and formation mechanism of typical deep eutectic solvents: An experimental and theoretical study
Fulltext Access 18 Pages 2016
Analytical advances in pharmaceutical impurity profiling
Fulltext Access 18 Pages 2016
Structure of amyloid oligomers and their mechanisms of toxicities: Targeting amyloid oligomers using novel therapeutic approaches
Fulltext Access 18 Pages 2016
Invited reviewCherry-picked ligands at histamine receptor subtypes
Fulltext Access 18 Pages 2016
Differentiation of skeletal osteogenic progenitor cells to osteoblasts with 3,4-diarylbenzopyran based amide derivatives: Novel osteogenic agents
Fulltext Access 18 Pages 2016
New and Evolving Techniques for the Characterization of Peptide Therapeutics
Fulltext Access 18 Pages 2016
Polymeric Amorphous Solid Dispersions: A Review of Amorphization, Crystallization, Stabilization, Solid-State Characterization, and Aqueous Solubilization of Biopharmaceutical Classification System Class II Drugs
Fulltext Access 18 Pages 2016
Stereochemistry abstracts
Fulltext Access 18 Pages 2016
Stereochemistry abstracts
Fulltext Access 18 Pages 2016
Development of an accurate molecular mechanics model for buckling behavior of multi-walled carbon nanotubes under axial compression
Fulltext Access 18 Pages 2016
Overcoming chloroquine resistance in malaria: Design, synthesis and structure-activity relationships of novel chemoreversal agents
Fulltext Access 19 Pages 2016
Self-assemblies formed by isonicotinic acid analogues axially coordinating with zinc porphyrin via pyridyl unit: synthesis and application in dye sensitized solar cells
Fulltext Access 19 Pages 2016
Graphical contents list
Fulltext Access 19 Pages 2016
Synthesis and biological evaluation of novel structural hybrids of benzofuroxan derivatives and fluoroquinolones
Fulltext Access 19 Pages 2016
Ibuprofen or piroxicam protects nigral neurons and delays the development of l-dopa induced dyskinesia in rats with experimental Parkinsonism: Influence on angiogenesis
Fulltext Access 19 Pages 2016
Cyclodextrin-Mediated Hierarchical Self-Assembly and Its Potential in Drug Delivery Applications
Fulltext Access 19 Pages 2016
Biological interactions of carbon-based nanomaterials: From coronation to degradation
Fulltext Access 19 Pages 2016
Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine-benzenesulfonamides acting as carbonic anhydrase inhibitors
Fulltext Access 19 Pages 2016
Synthesis of novel anticancer ruthenium-arene pyridinylmethylene scaffolds via three-component reaction
Fulltext Access 19 Pages 2016
The synthesis of single enantiomers of trans-alkene containing mycolic acids and related sugar esters
Fulltext Access 19 Pages 2016
Progress and perspectives on targeting nanoparticles for brain drug delivery
Fulltext Access 19 Pages 2016
Secondary metabolites from cetrarioid lichens: Chemotaxonomy, biological activities and pharmaceutical potential
Fulltext Access 19 Pages 2016
Recent advances in polymeric micelles for anti-cancer drug delivery
Fulltext Access 19 Pages 2016
Pivotal role of glycogen synthase kinase-3: A therapeutic target for Alzheimer's disease
Fulltext Access 19 Pages 2016
Robust design of some selective matrix metalloproteinase-2 inhibitors over matrix metalloproteinase-9 through in silico/fragment-based lead identification and de novo lead modification: Syntheses and biological assays
Fulltext Access 19 Pages 2016
Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents
Fulltext Access 19 Pages 2016
Stereochemistry abstracts
Fulltext Access 20 Pages 2016
Hair follicle characteristics as early marker of Type 2 Diabetes
Fulltext Access 20 Pages 2016
Traditional Chinese medicine diagnosis and response to acupuncture for insomnia: An analysis of two randomized placebo-controlled trials
Fulltext Access 20 Pages 2016
Controlled release of anti-inflammatory peptides from reducible thermosensitive nanoparticles suppresses cartilage inflammation
Fulltext Access 20 Pages 2016
The impact of asymmetric organocatalysis in dearomatization and aromatization of carbocycles: increasing molecular complexity and diversity
Fulltext Access 20 Pages 2016
Synthesis, antimycobacterial screening and ligand-based molecular docking studies on novel pyrrole derivatives bearing pyrazoline, isoxazole and phenyl thiourea moieties
Fulltext Access 20 Pages 2016
Graphical contents list
Fulltext Access 20 Pages 2016
A highly selective dual channel hypochlorite probe based on fluorescein and 1,10-phenanthroline
Fulltext Access 20 Pages 2016
Solvatochromic property switching of a naphthoquinone pigment: 2-methyl-3-arylthio-1,4-naphthalenedione
Fulltext Access 20 Pages 2016
Novel bent-core mesogenic of 4-amino-triazole derivatives: synthesis, characterization and liquid crystalline study
Fulltext Access 20 Pages 2016
Neighboring amide participation in the Fenton oxidation of a sulfide to sulfoxide, vinyl sulfide and ketone relevant to oxidation of methionine thioether side chains in peptides
Fulltext Access 20 Pages 2016
Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones: Very strong correlation to pleurotin and thioredoxin reductase inhibition
Fulltext Access 20 Pages 2016
Role of glutamatergic neurotransmission in the enteric nervous system and brain-gut axis in health and disease
Fulltext Access 20 Pages 2016
Development of new Malt1 inhibitors and probes
Fulltext Access 20 Pages 2016
Non-canonical modulators of nuclear receptors
Fulltext Access 20 Pages 2016
Stereochemistry abstracts
Fulltext Access 21 Pages 2016
Pharmacological approaches to intervention in hypomyelinating and demyelinating white matter pathology
Fulltext Access 21 Pages 2016
Gold catalyzed double condensation reaction: Synthesis, antimicrobial and cytotoxicity of spirooxindole derivatives
Fulltext Access 21 Pages 2016
Phenotypic characterization of a pair of molecules in tissues confer to classical Mendelian or non Mendelian ratios
Fulltext Access 21 Pages 2016
Sulfatase inhibitors for recidivist breast cancer treatment: A chemical review
Fulltext Access 21 Pages 2016
Multifunctional diamine AGE/ALE inhibitors with potential therapeutical properties against Alzheimer's disease
Fulltext Access 21 Pages 2016
Quinazolines and quinazolinones as ubiquitous structural fragments in medicinal chemistry: An update on the development of synthetic methods and pharmacological diversification
Fulltext Access 21 Pages 2016
2-Benzoyl-6-benzylidenecyclohexanone analogs as potent dual inhibitors of acetylcholinesterase and butyrylcholinesterase
Fulltext Access 21 Pages 2016
Design and evaluation of novel glutaminase inhibitors
Fulltext Access 21 Pages 2016
China and the United States-Global partners, competitors and collaborators in nanotechnology development
Fulltext Access 21 Pages 2016
Crucial steps to life: From chemical reactions to code using agents
Fulltext Access 21 Pages 2016
Gentamicin release from chitosan and collagen composites
Fulltext Access 21 Pages 2016
Ethnobotanical study of herbal medicines for management of diabetes mellitus in Dangme West District of southern Ghana
Fulltext Access 21 Pages 2016
Recent application of oxa-Michael reaction in complex natural product synthesis
Fulltext Access 21 Pages 2016
Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline-thiazolidine-based hybrids
Fulltext Access 22 Pages 2016
Palladium-catalyzed construction of quaternary carbon centers with propargylic electrophiles
Fulltext Access 22 Pages 2016
A depsidone and six triterpenoids from the bark of Garcinia celebica
Fulltext Access 22 Pages 2016
Orthogonal protecting group strategies in carbohydrate chemistry
Fulltext Access 22 Pages 2016
Synthesis, aggregation-induced emission and electroluminescence properties of two new tetraphenylethene derivatives
Fulltext Access 22 Pages 2016
Twelve ways to confirm targets of activity-based probes in plants
Fulltext Access 22 Pages 2016
Myelin and oligodendrocyte lineage cells in white matter pathology and plasticity after traumatic brain injury
Fulltext Access 22 Pages 2016
Synthesis of 1,2,3-triazole 'click' analogues of thalidomide
Fulltext Access 23 Pages 2016
Controlled delivery systems for tissue repair and regeneration
Fulltext Access 23 Pages 2016
Stereochemistry abstracts
Fulltext Access 23 Pages 2016
Stereochemistry abstracts
Fulltext Access 23 Pages 2016
A practical synthesis of novel chiral sulfoxide-nitrogen ligands
Fulltext Access 23 Pages 2016
Synthesis and biological evaluation of some novel triazole hybrids of curcumin mimics and their selective anticancer activity against breast and prostate cancer cell lines
Fulltext Access 23 Pages 2016
Recent advances of synthesis of fluorenone and fluorene containing natural products
Fulltext Access 23 Pages 2016
Mechanisms and pharmaceutical consequences of processes of stereoisomerisation - A didactic excursion
Fulltext Access 23 Pages 2016
Preclinical evaluation of 99mTc labeled chondroitin sulfate for monitoring of cartilage degeneration in osteoarthritis
Fulltext Access 23 Pages 2016
Effects of mulberry leaf extract on blood glucose and serum lipid profiles in patients with type 2 diabetes mellitus: A systematic review
Fulltext Access 23 Pages 2016
Graphical contents list
Fulltext Access 23 Pages 2016
Synthesis of (benzimidazol-2-yl)aniline derivatives as glycogen phosphorylase inhibitors
Fulltext Access 23 Pages 2016
Neuron-microglia interaction by purinergic signaling in neuropathic pain following neurodegeneration
Fulltext Access 23 Pages 2016
Sulfonamide chalcones: Synthesis and in vitro exploration for therapeutic potential against Brugia malayi
Fulltext Access 24 Pages 2016
Predicting link directionality in gene regulation from gene expression profiles using volatility-constrained correlation
Fulltext Access 24 Pages 2016
The effect of protonation of cytosine and adenine on their interactions with carbon nanotubes
Fulltext Access 24 Pages 2016
Synthesis of new homoconduritols and homoaminoconduritols
Fulltext Access 24 Pages 2016
Hybrid benzothiazole analogs as antiurease agent: Synthesis and molecular docking studies
Fulltext Access 24 Pages 2016
Convenient synthesis of disubstituted tacrine derivatives via electrophilic and copper induced reactions
Fulltext Access 24 Pages 2016
A new convenient synthetic approach to diarylpyrimidines
Fulltext Access 24 Pages 2016
How to study the relationship between Tai Chi Chuan, Qigong and medicine - A review of research frameworks
Fulltext Access 24 Pages 2016
'On water' direct vinylogous Henry (nitroaldol) reactions of 3,5-dimethyl-4-nitroisoxazole with aldehydes and trifluoromethyl ketones
Fulltext Access 25 Pages 2016
Association of lung cancer with skin diseases: A nationwide cohort study based on the “lung governing skin and hair” theory
Fulltext Access 25 Pages 2016
Inhibition of Rac1 activity in the hippocampus impaired extinction of contextual fear
Fulltext Access 25 Pages 2016
Screening and target identification of bioactive compounds that modulate cell migration and autophagy
Fulltext Access 25 Pages 2016
Practical modification of peptides using ligand-free copper-catalyzed azide-alkyne cycloaddition
Fulltext Access 25 Pages 2016
Design, synthesis and biological evaluation of novel cholesteryl ester transfer protein inhibitors bearing a cycloalkene scaffold
Fulltext Access 25 Pages 2016
π-Stacked polymers in drug delivery applications
Fulltext Access 25 Pages 2016
Methoxycarbonyl migration in 3-methylene-1,4-cyclohexadienes. An extension of the von Auwers rearrangement
Fulltext Access 25 Pages 2016
A rapid and efficient solvent-free microwave-assisted synthesis of pyrazolone derivatives containing substituted isoxazole ring
Fulltext Access 25 Pages 2016
New Atglistatin closely related analogues: Synthesis and structure-activity relationship towards adipose triglyceride lipase inhibition
Fulltext Access 25 Pages 2016
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