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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Review of carbazole based conjugated molecules for highly efficient organic solar cell application
Fulltext Access 13 Pages 2016
Development of near-infrared photoactivable phthalocyanine-loaded nanoparticles to kill tumor cells: An improved tool for photodynamic therapy of solid cancers
Fulltext Access 13 Pages 2016
Multi-omics “upstream analysis” of regulatory genomic regions helps identifying targets against methotrexate resistance of colon cancer
Fulltext Access 13 Pages 2016
Contents (graphical abstracts and research highlights)
Fulltext Access 13 Pages 2016
A comparative study of the electronic spectra, fluorescence quantum yields, cyclic voltammograms and theoretical calculations of phenanthrene-type benzodifurans
Fulltext Access 13 Pages 2016
Arabino mycolates from synthetic mycolic acids
Fulltext Access 13 Pages 2016
Approaches to 3,4,5-substituted piperidines via 1,2,5,6-tetrahydropyridines prepared by ring-closing metathesis
Fulltext Access 13 Pages 2016
Metal-organic hybrid architectures built from functionalized fullerenes and metal ions or clusters
Fulltext Access 13 Pages 2016
Synthesis of 6-amino-2,3-dihydropyridine-4-thiones via novel efficient thioenolate-carbodiimide rearrangement
Fulltext Access 13 Pages 2016
From phosphine-promoted to phosphine-catalyzed reactions by in situ phosphine oxide reduction
Fulltext Access 13 Pages 2016
A simple turn-on Schiff base fluorescence sensor for aluminum ion
Fulltext Access 13 Pages 2016
An overview of the recent synthetic studies toward penifulvins and other fenestranes
Fulltext Access 13 Pages 2016
Recent progress in transition metal-catalyzed stereoselective synthesis of acyclic all-carbon tetrasubstituted alkenes
Fulltext Access 13 Pages 2016
Cyclisation of aryl acetylides with isothiocyanates: new insight into an old reaction
Fulltext Access 13 Pages 2016
Solid-phase synthesis of 6,7-cycloalkane-fused 1,4-diazepane-2,5-diones via a cyclization/release strategy
Fulltext Access 13 Pages 2016
Synthesis of terpene derivatives of ethanolamine using telomerization reaction
Fulltext Access 13 Pages 2016
A new method for the synthesis of pyrazolidines
Fulltext Access 13 Pages 2016
Hybrid agent-based model for quantitative in-silico cell-free protein synthesis
Fulltext Access 13 Pages 2016
Multiple sequence alignment using multi-objective based bacterial foraging optimization algorithm
Fulltext Access 13 Pages 2016
Structural features and inhibitors of bromodomains
Fulltext Access 13 Pages 2016
Design, synthesis and biological evaluation of novel hamamelitannin analogues as potentiators for vancomycin in the treatment of biofilm related Staphylococcus aureus infections
Fulltext Access 13 Pages 2016
Analogue based drug design, synthesis, molecular docking and anticancer evaluation of novel chromene sulfonamide hybrids as aromatase inhibitors and apoptosis enhancers
Fulltext Access 13 Pages 2016
Multi-target screening mines hesperidin as a multi-potent inhibitor: Implication in Alzheimer's disease therapeutics
Fulltext Access 13 Pages 2016
Part-1: Design, synthesis and biological evaluation of novel bromo-pyrimidine analogs as tyrosine kinase inhibitors
Fulltext Access 13 Pages 2016
Toward Understanding Drug Release From Biodegradable Polymer Microspheres of Different Erosion Kinetics Modes
Fulltext Access 13 Pages 2016
Gold nanorods inhibit respiratory syncytial virus by stimulating the innate immune response
Fulltext Access 13 Pages 2016
Synthesis and biological evaluation of 2-arylimino-3-pyridin-thiazolineone derivatives as antibacterial agents
Fulltext Access 13 Pages 2016
Dendrimer technologies for brain tumor
Fulltext Access 13 Pages 2016
Numeric promoter description – A comparative view on concepts and general application
Fulltext Access 13 Pages 2016
Discovery of novel diaryl urea derivatives bearing a triazole moiety as potential antitumor agents
Fulltext Access 13 Pages 2016
Synthesis of triazoloquinazolinone based compounds as tubulin polymerization inhibitors and vascular disrupting agents
Fulltext Access 13 Pages 2016
Design and synthesis of novel androgen receptor antagonists via molecular modeling
Fulltext Access 13 Pages 2016
Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors
Fulltext Access 13 Pages 2016
Cationic lipid-conjugated hydrocortisone as selective antitumor agent
Fulltext Access 13 Pages 2016
Synthesis and biological evaluation of isomeric methoxy substitutions on anti-cancer indolyl-pyridinyl-propenones: Effects on potency and mode of activity
Fulltext Access 13 Pages 2016
Selective killing of cancer cells with triterpenoic acid amides - The substantial role of an aromatic moiety alignment
Fulltext Access 13 Pages 2016
Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents
Fulltext Access 13 Pages 2016
The importance of triazole scaffold in the development of anticonvulsant agents
Fulltext Access 13 Pages 2016
Non-symmetrical furan-amidines as novel leads for the treatment of cancer and malaria
Fulltext Access 13 Pages 2016
New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-diones
Fulltext Access 13 Pages 2016
Transcriptional response networks for elucidating mechanisms of action of multitargeted agents
Fulltext Access 13 Pages 2016
Triazole-curcuminoids: A new class of derivatives for ‘tuning’ curcumin bioactivities?
Fulltext Access 13 Pages 2016
Interactions between carbon nanotubes and bioactives: a drug delivery perspective
Fulltext Access 13 Pages 2016
Synthesis and structure–activity relationships of novel hybrid ferrocenyl compounds based on a bicyclic core skeleton for breast cancer therapy
Fulltext Access 13 Pages 2016
Development of hydroxy-based sphingosine kinase inhibitors and anti-inflammation in dextran sodium sulfate induced colitis in mice
Fulltext Access 13 Pages 2016
A self-assembly peptide nanofibrous scaffold reduces inflammatory response and promotes functional recovery in a mouse model of intracerebral hemorrhage
Fulltext Access 13 Pages 2016
Design, synthesis, molecular docking and biological evaluation of thiophen-2-iminothiazolidine derivatives for use against Trypanosoma cruzi
Fulltext Access 13 Pages 2016
Ring-closing metathesis in peptides
Fulltext Access 14 Pages 2016
Synthesis, antiamoebic and molecular docking studies of furan-thiazolidinone hybrids
Fulltext Access 14 Pages 2016
Design and synthesis of natural product derivatives with selective and improved cytotoxicity based on a sesquiterpene scaffold
Fulltext Access 14 Pages 2016
Data-driven optimizations for model checking of multi-valued regulatory networks
Fulltext Access 14 Pages 2016
Synthesis and evaluation of antitubercular activity of fluorinated 5-aryl-4-(hetero)aryl substituted pyrimidines
Fulltext Access 14 Pages 2016
Effect of hydrogen bond formation/replacement on solubility characteristics, gastric permeation and pharmacokinetics of curcumin by application of powder solution technology
Fulltext Access 14 Pages 2016
Is lithium essential for epididymal sperm maturation?
Fulltext Access 14 Pages 2016
Structure activity relationship studies on chemically non-reactive glycine sulfonamide inhibitors of diacylglycerol lipase
Fulltext Access 14 Pages 2016
Migraine: A disorder of metabolism?
Fulltext Access 14 Pages 2016
A novel hybrid drug between two potent anti-tubulin agents as a potential prolonged anticancer approach
Fulltext Access 14 Pages 2016
Pharmacokinetic models of morphine and its metabolites in neonates:: Systematic comparisons of models from the literature, and development of a new meta-model
Fulltext Access 14 Pages 2016
Pathogenesis of Rushton bodies: A novel hypothesis
Fulltext Access 14 Pages 2016
Impact of Ice Morphology on Design Space of Pharmaceutical Freeze-Drying
Fulltext Access 14 Pages 2016
Self-Assembly of Cyclodextrins and Their Complexes in Aqueous Solutions
Fulltext Access 14 Pages 2016
On the importance of modelling the internal spatial dynamics of biological cells
Fulltext Access 14 Pages 2016
Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer
Fulltext Access 14 Pages 2016
Depletion of nucleus accumbens dopamine leads to impaired reward and aversion processing in mice: Relevance to motivation pathologies
Fulltext Access 14 Pages 2016
A clickable neurosteroid photolabel reveals selective Golgi compartmentalization with preferential impact on proximal inhibition
Fulltext Access 14 Pages 2016
In-silico screening for anti-Zika virus phytochemicals
Fulltext Access 14 Pages 2016
Synthesis and biological evaluation of santacruzamate A analogues for anti-proliferative and immunomodulatory activity
Fulltext Access 14 Pages 2016
Discovery of a sulfamate-based steroid sulfatase inhibitor with intrinsic selective estrogen receptor modulator properties
Fulltext Access 14 Pages 2016
Evaluation of the anti-malarial activity and cytotoxicity of 2,4-diamino-pyrimidine-based kinase inhibitors
Fulltext Access 14 Pages 2016
Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications
Fulltext Access 14 Pages 2016
Gary H. Posner: Professor, Scientist, Colleague, Role Model, and Friend
Fulltext Access 14 Pages 2016
Advanced formulations for improving therapies with anti-inflammatory or anaesthetic drugs: A review
Fulltext Access 14 Pages 2016
Immunogenicity of Therapeutic Protein Aggregates
Fulltext Access 14 Pages 2016
Integrated Application of Quality-by-Design Principles to Drug Product Development: A Case Study of Brivanib Alaninate Film-Coated Tablets
Fulltext Access 14 Pages 2016
Maternal postpartum corticosterone and fluoxetine differentially affect adult male and female offspring on anxiety-like behavior, stress reactivity, and hippocampal neurogenesis
Fulltext Access 14 Pages 2016
Cross-talk between metabotropic glutamate receptor 7 and beta adrenergic receptor signaling at cerebrocortical nerve terminals
Fulltext Access 14 Pages 2016
Contrasting gene expression patterns induced by levodopa and pramipexole treatments in the rat model of Parkinson's disease
Fulltext Access 14 Pages 2016
Bioactive compounds isolated from apple, tea, and ginger protect against dicarbonyl induced stress in cultured human retinal epithelial cells
Fulltext Access 14 Pages 2016
Combining bioinformatics, chemoinformatics and experimental approaches to design chemical probes: Applications in the field of blood coagulation
Fulltext Access 14 Pages 2016
Factors to consider in developing individual pharmaceutical product quality risk profiles useful to government procurement agencies
Fulltext Access 14 Pages 2016
Contents (graphical abstracts and research highlights)
Fulltext Access 14 Pages 2016
Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase
Fulltext Access 14 Pages 2016
Diversity-oriented one-pot multicomponent synthesis of spirooxindole derivatives and their biological evaluation for anticancer activities
Fulltext Access 14 Pages 2016
Combined nitroxide mediated radical polymerization techniques for block copolymer synthesis
Fulltext Access 14 Pages 2016
Synthesis of thiolactone building blocks as potential precursors for sustainable functional materials
Fulltext Access 14 Pages 2016
Total syntheses and structure-activity relationship study of parthenolide analogues
Fulltext Access 14 Pages 2016
Observations concerning the synthesis of tryptamine homologues and branched tryptamine derivatives via the borrowing hydrogen process: synthesis of psilocin, bufotenin, and serotonin
Fulltext Access 14 Pages 2016
Synthesis of 1,1-diarylethylenes
Fulltext Access 14 Pages 2016
Synthesis of amino-substituted pyridylglyoxylamides via palladium-catalysed aminocarbonylation
Fulltext Access 14 Pages 2016
Base-promoted ring expansion of 3-aminopyrimidine-2-thiones into 1,2,4-triazepine-3-thiones
Fulltext Access 14 Pages 2016
Simulation of coupled folding and binding of an intrinsically disordered protein in explicit solvent with metadynamics
Fulltext Access 14 Pages 2016
Advantages and challenges offered by biofunctional core–shell fiber systems for tissue engineering and drug delivery
Fulltext Access 14 Pages 2016
Recent developments in asymmetric alkynylations
Fulltext Access 14 Pages 2016
Synthesis, enantiomeric resolution and optical properties of 8-cyanohexahelicene
Fulltext Access 14 Pages 2016
Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents
Fulltext Access 14 Pages 2016
Regioselective transition metal-free acylation of coumarins via cross-dehydrogenative coupling reaction of coumarins and aldehydes
Fulltext Access 14 Pages 2016
Design, synthesis, and biological evaluation of novel quinazolinyl-diaryl urea derivatives as potential anticancer agents
Fulltext Access 14 Pages 2016
Design, synthesis and biological evaluation of chalconyl blended triazole allied organosilatranes as giardicidal and trichomonacidal agents
Fulltext Access 14 Pages 2016
Laminated sponges as challenging solid hydrophilic matrices for the buccal delivery of carvedilol microemulsion systems: Development and proof of concept via mucoadhesion and pharmacokinetic assessments in healthy human volunteers
Fulltext Access 14 Pages 2016
The emergence of sulfoxide and iodonio-based redox arylation as a synthetic tool
Fulltext Access 14 Pages 2016
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