A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity Fulltext Access 14 Pages 2016
Modelling of compound combination effects and applications to efficacy and toxicity: state-of-the-art, challenges and perspectives Fulltext Access 14 Pages 2016
Multidrug co-crystals: towards the development of effective therapeutic hybrids Fulltext Access 14 Pages 2016
Metal-organic frameworks: mechanisms of antibacterial action and potential applications Fulltext Access 14 Pages 2016
Drug-repositioning opportunities for cancer therapy: novel molecular targets for known compounds Fulltext Access 14 Pages 2016
Intramolecular carbonyl-ene reactions in the synthesis of peri-oxygenated hydroaromatics Fulltext Access 15 Pages 2016
Synthesis and cytotoxic evaluation of novel indenoisoquinoline-propan-2-ol hybrids Fulltext Access 15 Pages 2016
Substituent effect on di-π-methane reactions of benzopyrazinobarrelenes and benzoquinoxalinobarrelenes Fulltext Access 15 Pages 2016
Differential dopaminergic regulation of inwardly rectifying potassium channel mediated subthreshold dynamics in striatal medium spiny neurons Fulltext Access 15 Pages 2016
Recent advances in the transition metal catalyzed etherification reactions Fulltext Access 15 Pages 2016
Reactions of organoboranes with carbanions bearing three potential leaving groups: unusual processes, products and mechanisms Fulltext Access 15 Pages 2016
Synthesis of new donepezil analogues and investigation of their effects on cholinesterase enzymes Fulltext Access 15 Pages 2016
Therapeutic progress in amyotrophic lateral sclerosis-beginning to learning Fulltext Access 15 Pages 2016
Novel pyrazolopyridine derivatives as potential angiogenesis inhibitors: Synthesis, biological evaluation and transcriptome-based mechanistic analysis Fulltext Access 15 Pages 2016
Cell type- and region-specific enhancement of adult hippocampal neurogenesis by daidzein in middle-aged female mice Fulltext Access 15 Pages 2016
Cyclophane-shaped ionic liquids with planar chirality: effects of bridge unit on thermal properties and chirality-recognition ability Fulltext Access 15 Pages 2016
A novel treatment for “morning sickness”: Nausea of pregnancy could be induced by excess sulfite which molybdenum can help alleviate Fulltext Access 15 Pages 2016
Recent advances in the field of nucleophilic aromatic substitution of hydrogen Fulltext Access 15 Pages 2016
A new carbazole-based helically chiral architecture: synthesis and physical properties Fulltext Access 15 Pages 2016
Synthesis of functionalized alkynes via palladium-catalyzed Sonogashira reactions Fulltext Access 15 Pages 2016
Single-cell level methods for studying the effect of antibiotics on bacteria during infection Fulltext Access 15 Pages 2016
Boolean network identification from perturbation time series data combining dynamics abstraction and logic programming Fulltext Access 15 Pages 2016
Developing clinical practice guidelines for the integration of Chinese medicine and biomedicine: A new process Fulltext Access 15 Pages 2016
A Review: Pharmaceutical and Pharmacokinetic Aspect of Nanocrystalline Suspensions Fulltext Access 15 Pages 2016
Cancer stem cells, cancer-initiating cells and methods for their detection Fulltext Access 15 Pages 2016
Synthesis and evaluation of thiophene-based guanylhydrazones (iminoguanidines) efficient against panel of voriconazole-resistant fungal isolates Fulltext Access 15 Pages 2016
Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer’s disease based on the fusion of donepezil and melatonin Fulltext Access 15 Pages 2016
Effect of food and acid-reducing agents on the absorption of oral targeted therapies in solid tumors Fulltext Access 15 Pages 2016
Recent developments in using mechanistic cardiac modelling for drug safety evaluation Fulltext Access 15 Pages 2016
Amyloid cascade in Alzheimer's disease: Recent advances in medicinal chemistry Fulltext Access 15 Pages 2016
Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy Fulltext Access 15 Pages 2016
Synthesis and pharmacological evaluation of mono-arylimidamides as antileishmanial agents Fulltext Access 15 Pages 2016
Synthesis of a series of novel dihydroartemisinin monomers and dimers containing chalcone as a linker and their anticancer activity Fulltext Access 15 Pages 2016
Molecular design, synthesis and anticoagulant activity evaluation of fluorinated dabigatran analogues Fulltext Access 15 Pages 2016
Understanding how replication processes can maintain systems away from equilibrium using Algorithmic Information Theory Fulltext Access 15 Pages 2016
Recent studies on the delivery of hydrophilic drugs in nanoparticulate systems Fulltext Access 15 Pages 2016
Development of a physiology-directed population pharmacokinetic and pharmacodynamic model for characterizing the impact of genetic and demographic factors on clopidogrel response in healthy adults Fulltext Access 15 Pages 2016
Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment Fulltext Access 15 Pages 2016
Exploring isoxazole and carboxamide derivatives as potential non-nucleoside reverse transcriptase inhibitors Fulltext Access 16 Pages 2016
Ovarian hormones, but not fluoxetine, impart resilience within a chronic unpredictable stress model in middle-aged female rats Fulltext Access 16 Pages 2016
X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors Fulltext Access 16 Pages 2016
In search of the mutual relationship between the structure, solid-state spectroscopy and molecular dynamics in selected calcium channel blockers Fulltext Access 16 Pages 2016
Synthesis and structure-activity relationships of 1-benzylindane derivatives as selective agonists for estrogen receptor beta Fulltext Access 16 Pages 2016
A new class of flavonol-based anti-prostate cancer agents: Design, synthesis, and evaluation in cell models Fulltext Access 16 Pages 2016
Synthesis and in vitro anticancer evaluation of some 4,6-diamino-1,3,5-triazine-2-carbohydrazides as Rad6 ubiquitin conjugating enzyme inhibitors Fulltext Access 16 Pages 2016
Distinctive effects of nicotinic receptor intracellular-loop mutations associated with nocturnal frontal lobe epilepsy Fulltext Access 16 Pages 2016
Hypothesis concerning embodied calendars: A case study of number form, color spreading, and taste-color synaesthesia Fulltext Access 16 Pages 2016
Novel 1,3,4-oxadiazole/oxime hybrids: Synthesis, docking studies and investigation of anti-inflammatory, ulcerogenic liability and analgesic activities Fulltext Access 16 Pages 2016
Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights Fulltext Access 16 Pages 2016
Discovery and development of natural product oridonin-inspired anticancer agents Fulltext Access 16 Pages 2016
Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities Fulltext Access 16 Pages 2016
Modulating antibiotic activity towards respiratory bacterial pathogens by co-medications: a multi-target approach Fulltext Access 16 Pages 2016
Role of disulfide linkage in action of bis(dialkylaminethiocarbonyl)disulfides as potent double-Edged microbicidal spermicide: Design, synthesis and biology Fulltext Access 16 Pages 2016
Seasonality and selective trends in viral acute respiratory tract infections Fulltext Access 16 Pages 2016
Design and synthesis of calindol derivatives as potent and selective calcium sensing receptor agonists Fulltext Access 16 Pages 2016
Similarities and differences in affinity and binding modes of tricyclic pyrimido- and pyrazinoxanthines at human and rat adenosine receptors Fulltext Access 16 Pages 2016
Multifunctional heterocyclic scaffolds for hybrid Lewis acid/Lewis base catalysis of carbon-carbon bond formation Fulltext Access 16 Pages 2016
Absolute configuration assignment of oxindole derivatives by vibrational circular dichroism exciton coupling Fulltext Access 16 Pages 2016
An efficient blue thermally activated delayed fluorescence material based on 4-fluorocyanobenzene derivative for organic light-emitting diodes Fulltext Access 16 Pages 2016
Mechanisms of histone lysine-modifying enzymes: A computational perspective on the role of the protein environment Fulltext Access 16 Pages 2016
Evaluating clustering methods within the Artificial Ecosystem Algorithm and their application to bike redistribution in London Fulltext Access 17 Pages 2016
Synthesis of pyrrolidones and quinolines from the known biomass feedstock levulinic acid and amines Fulltext Access 17 Pages 2016
Synthesis of novel diazaphosphinanes coumarin derivatives with promoted cytotoxic and anti-tyrosinase activities Fulltext Access 17 Pages 2016
Ameliorative effects of amide derivatives of 1,3,4-thiadiazoles on scopolamine induced cognitive dysfunction Fulltext Access 17 Pages 2016
Synthesis and anticancer activity of novel fluorinated asiatic acid derivatives Fulltext Access 17 Pages 2016
Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury Fulltext Access 17 Pages 2016
Combinatorial synthesis, in silico, molecular and biochemical studies of tetrazole-derived organic selenides with increased selectivity against hepatocellular carcinoma Fulltext Access 17 Pages 2016
A single polycystic kidney disease 2-like 1 channel opening acts as a spike generator in cerebrospinal fluid-contacting neurons of adult mouse brainstem Fulltext Access 17 Pages 2016
Structure-activity relationship of novel series of 1,5-disubstituted tetrazoles as cyclooxygenase-2 inhibitors: Design, synthesis, bioassay screening and molecular docking studies Fulltext Access 17 Pages 2016
Molecular complexity and diversity from aromatics. Intramolecular cycloaddition of cyclohexa-2,4-dienones and sigmatropic shift in excited state: a unified approach towards synthesis of polycyclic frameworks related to crotogoudin, conidiogenol, and crini Fulltext Access 17 Pages 2016
In silico identification of gene amplification targets based on analysis of production and growth coupling Fulltext Access 18 Pages 2016
Antibacterial activity of Mannich bases derived from 2-naphthols, aromatic aldehydes and secondary aliphatic amines Fulltext Access 18 Pages 2016
Synthesis of novel coumarin appended bis(formylpyrazole) derivatives: Studies on their antimicrobial and antioxidant activities Fulltext Access 18 Pages 2016
Identification of a novel class of quinoline-oxadiazole hybrids as anti-tuberculosis agents Fulltext Access 18 Pages 2016