A physiologically based pharmacokinetic model for Valproic acid in adults and children Fulltext Access 8 Pages 2014
Novel bronchodilatory quinazolines and quinoxalines: Synthesis and biological evaluation Fulltext Access 8 Pages 2014
Synthesis and biological evaluation of phosphorylated flavonoids as potent and selective inhibitors of cholesterol esterase Fulltext Access 8 Pages 2014
Design, synthesis, pharmacological evaluation and computational studies of 1-(biphenyl-4-yl)-2-[4-(substituted phenyl)-piperazin-1-yl]ethanones as potential antipsychotics Fulltext Access 8 Pages 2014
Antimycobacterial activity of chiral aminoalcohols with camphane scaffold Fulltext Access 8 Pages 2014
Beta and gamma carboline derivatives as potential anti-Alzheimer agents: A comparison Fulltext Access 8 Pages 2014
Novel benzopsoralen analogues: Synthesis, biological activity and molecular docking studies Fulltext Access 8 Pages 2014
In vitro and in silico antimalarial activity of 2-(2-hydrazinyl)thiazole derivatives Fulltext Access 8 Pages 2014
Formulation and in vivo human bioavailability of dissolving tablets containing a self-nanoemulsifying itraconazole solid dispersion without precipitation in simulated gastrointestinal fluid Fulltext Access 8 Pages 2014
The dynamics of shrinking and expanding drug-loaded microspheres: A semi-empirical approach Fulltext Access 8 Pages 2014
The construction, prediction and measurement of co-crystal ternary phase diagrams as a tool for solvent selection Fulltext Access 8 Pages 2014
Gene delivery to carcinoma cells via novel non-viral vectors: Nanoparticle tracking analysis and suicide gene therapy Fulltext Access 8 Pages 2014
Intranasal administration of carbamazepine to mice: A direct delivery pathway for brain targeting Fulltext Access 8 Pages 2014
Investigation of the retention behavior of structurally diverse drugs on alpha1 acid glycoprotein column: Insight on the molecular factors involved and correlation with protein binding data Fulltext Access 8 Pages 2014
Topological characterization of a bacterial cellulose–acrylic acid polymeric matrix Fulltext Access 8 Pages 2014
Exploring the potential of self-assembled mixed micelles in enhancing the stability and oral bioavailability of an acid-labile drug Fulltext Access 8 Pages 2014
Inhibition mechanism of hydroxypropyl methylcellulose acetate succinate on drug crystallization in gastrointestinal fluid and drug permeability from a supersaturated solution Fulltext Access 8 Pages 2014
A novel concentration dependent amino acid ion pair strategy to mediate drug permeation using indomethacin as a model insoluble drug Fulltext Access 8 Pages 2014
Preparation and characterization of co-amorphous Ritonavir–Indomethacin systems by solvent evaporation technique: Improved dissolution behavior and physical stability without evidence of intermolecular interactions Fulltext Access 8 Pages 2014
Synthesis, antinociceptive activity and pharmacokinetic profiles of nicorandil and its isomers Fulltext Access 8 Pages 2014
Synthesis and biological evaluation of 2-aminothiazole derivatives as antimycobacterial and antiplasmodial agents Fulltext Access 8 Pages 2014
Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure-activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part 1 Fulltext Access 8 Pages 2014
Synthesis and antitumor activities of novel dipeptide derivatives derived from dehydroabietic acid Fulltext Access 8 Pages 2014
Amino acidic scaffolds bearing unnatural side chains: An old idea generates new and versatile tools for the life sciences Fulltext Access 8 Pages 2014
Synthesis and biological evaluation of 2,5-di(7-indolyl)-1,3,4-oxadiazoles, and 2- and 7-indolyl 2-(1,3,4-thiadiazolyl)ketones as antimicrobials Fulltext Access 8 Pages 2014
Synthesis and biological evaluation of novel oxadiazole derivatives: A new class of thymidine phosphorylase inhibitors as potential anti-tumor agents Fulltext Access 8 Pages 2014
Preparation and evaluation of sustained-release solid dispersions co-loading gastrodin with borneol as an oral brain-targeting enhancer Fulltext Access 8 Pages 2014
Evaluation of sildenafil pressurized metered dose inhalers as a vasodilator in umbilical blood vessels of chicken egg embryos Fulltext Access 8 Pages 2014
Towards the bioequivalence of pressurised metered dose inhalers 2. Aerodynamically equivalent particles (with and without glycerol) exhibit different biopharmaceutical profiles in vitro Fulltext Access 8 Pages 2014
Developments and strategies for inhaled antibiotic drugs in tuberculosis therapy: A critical evaluation Fulltext Access 8 Pages 2014
The role of citric acid in oral peptide and protein formulations: Relationship between calcium chelation and proteolysis inhibition Fulltext Access 8 Pages 2014
Novel continuous flow technology for the development of a nanostructured Aprepitant formulation with improved pharmacokinetic properties Fulltext Access 8 Pages 2014
Controlled polymorphic transformation of continuously crystallized solid lipid nanoparticles in a microstructured device: A feasibility study Fulltext Access 8 Pages 2014
Innovative approaches to optimizing the delivery of vancomycin in individual patients Fulltext Access 8 Pages 2014
Synthesis of novel 1,2-benzothiazine 1,1-dioxide-3-ethanone oxime N-aryl acetamide ether derivatives as potent anti-inflammatory agents and inhibitors of monocyte-to-macrophage transformation Fulltext Access 8 Pages 2014
Nano-amorphous spray dried powder to improve oral bioavailability of itraconazole Fulltext Access 8 Pages 2014
Highly site-selective transvascular drug delivery by the use of nanosecond pulsed laser-induced photomechanical waves Fulltext Access 8 Pages 2014
Controlled release of free doxorubicin from peptide–drug conjugates by drug loading Fulltext Access 8 Pages 2014
Prolonged blood circulation and enhanced tumor accumulation of folate-targeted dendrimer-polymer hybrid nanoparticles Fulltext Access 8 Pages 2014
Synthesis and functional survey of new Tacrine analogs modified with nitroxides or their precursors Fulltext Access 8 Pages 2014
Rational design, synthesis and evaluation of chromone-indole and chromone-pyrazole based conjugates: Identification of a lead for anti-inflammatory drug Fulltext Access 8 Pages 2014
Syntheses and structure–activity relationships in cytotoxicities of 13-substituted quaternary coptisine derivatives Fulltext Access 8 Pages 2014
Design, synthesis and evaluation of Ospemifene analogs as anti-breast cancer agents Fulltext Access 8 Pages 2014
Synthesis of (3-hydroxy-pyrazolin-5-yl)glycine based ligands interacting with ionotropic glutamate receptors Fulltext Access 8 Pages 2014
Synthesis, characterization and anti-proliferative activity of heterocyclic hypervalent organoantimony compounds Fulltext Access 8 Pages 2014
In situ and in silico evaluation of amine- and folate-terminated dendrimers as nanocarriers of anesthetics Fulltext Access 8 Pages 2014
Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities Fulltext Access 8 Pages 2014
Interaction analysis of a ladder-shaped polycyclic ether and model transmembrane peptides in lipid bilayers by using Förster resonance energy transfer and polarized attenuated total reflection infrared spectroscopy Fulltext Access 8 Pages 2014
Development of caged non-hydrolyzable phosphoamino acids and application to photo-control of binding affinity of phosphopeptide mimetic to phosphopeptide-recognizing protein Fulltext Access 8 Pages 2014
Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation Fulltext Access 8 Pages 2014
Synthesis, antioxidant and cytoprotective evaluation of potential antiatherogenic phenolic hydrazones. A structure–activity relationship insight Fulltext Access 8 Pages 2014
Evaluation of thermosensitive poloxamer 407 gel systems for the sustained release of estradiol in a fish model Fulltext Access 8 Pages 2014
Fundamental aspects of solid dispersion technology for poorly soluble drugs Fulltext Access 8 Pages 2014
Novel coumarin–benzimidazole derivatives as antioxidants and safer anti-inflammatory agents Fulltext Access 8 Pages 2014
Inhibition of acetylcholinesterase by two genistein derivatives: kinetic analysis, molecular docking and molecular dynamics simulation Fulltext Access 8 Pages 2014
Research and development in drug innovation: reflections from the 2013 bioeconomy conference in China, lessons learned and future perspectives Fulltext Access 8 Pages 2014
Through-vial impedance spectroscopy of critical events during the freezing stage of the lyophilization cycle: The example of the impact of sucrose on the crystallization of mannitol Fulltext Access 8 Pages 2014
Co-extruded solid solutions as immediate release fixed-dose combinations Fulltext Access 8 Pages 2014
Elastin-like polypeptides: The influence of its molecular weight on local hyperthermia-induced tumor accumulation Fulltext Access 8 Pages 2014
Performance of magnetic chitosan–alginate core–shell beads for increasing the bioavailability of a low permeable drug Fulltext Access 8 Pages 2014
Efficacy of multi-functional liposomes containing daunorubicin and emetine for treatment of acute myeloid leukaemia Fulltext Access 8 Pages 2014
Impact of lipid dynamic behavior on physical stability, in vitro release and skin permeation of genistein-loaded lipid nanoparticles Fulltext Access 8 Pages 2014
A novel aerosol generator for homogenous distribution of powder over the lungs after pulmonary administration to small laboratory animals Fulltext Access 8 Pages 2014
Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography Fulltext Access 8 Pages 2014
In-line spatial filtering velocimetry for particle size and film thickness determination in fluidized-bed pellet coating processes Fulltext Access 8 Pages 2014
Development of chitosan oleate ionic micelles loaded with silver sulfadiazine to be associated with platelet lysate for application in wound healing Fulltext Access 8 Pages 2014
Controlled transdermal delivery of leuprorelin by pulsed iontophoresis and ion-exchange fiber Fulltext Access 8 Pages 2014
In vitro microbial culture models and their application in drug development Fulltext Access 8 Pages 2014
Oligomeric bile acid-mediated oral delivery of low molecular weight heparin Fulltext Access 8 Pages 2014
A robust and quantitative method for tracking liposome contents after intravenous administration Fulltext Access 8 Pages 2014
Quantification of nanoparticle uptake into hair follicles in pig ear and human forearm Fulltext Access 8 Pages 2014
Targeting and depletion of circulating leukocytes and cancer cells by lipophilic antibody-modified erythrocytes Fulltext Access 8 Pages 2014
Polymeric penetration enhancers promote humoral immune responses to mucosal vaccines Fulltext Access 8 Pages 2014
Oral drug delivery of therapeutic gases — Carbon monoxide release for gastrointestinal diseases Fulltext Access 8 Pages 2014
Transdermal iontophoretic delivery of a liquid lipophilic drug by complexation with an anionic cyclodextrin Fulltext Access 8 Pages 2014