Synthesis of caged 2,3,3a,7a-tetrahydro-3,6-methanobenzofuran-7(6H)-ones: Evaluating the minimum structure for apoptosis induction by gambogic acid Fulltext Access 9 Pages 2008
Characterization of thyroid hormone receptor α (TRα)-specific analogs with varying inner- and outer-ring substituents Fulltext Access 9 Pages 2008
Synthesis, nicotinic acetylcholine receptor binding, and pharmacological properties of 3′-(substituted phenyl)deschloroepibatidine analogs Fulltext Access 9 Pages 2008
Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines Fulltext Access 9 Pages 2008
Identification of novel ligands for the RNA pseudoknot that regulate −1 ribosomal frameshifting Fulltext Access 9 Pages 2008
The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands Fulltext Access 9 Pages 2008
Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease Fulltext Access 9 Pages 2008
Synthesis, cytotoxic activities and structure–activity relationships of topoisomerase I inhibitors: Indolizinoquinoline-5,12-dione derivatives Fulltext Access 9 Pages 2008
Design and synthesis of nitrate esters of aromatic heterocyclic compounds as pharmacological preconditioning agents Fulltext Access 9 Pages 2008
Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation Fulltext Access 9 Pages 2008
Labeling, characterization, and in vivo localization of a new 90Y-based phosphonate chelate 2,3-dicarboxypropane-1,1-diphosphonic acid for the treatment of bone metastases: Comparison with 99mTc–DPD complex Fulltext Access 9 Pages 2008
Regioselective synthesis and antitumor screening of some novel N-phenylpyrazole derivatives Fulltext Access 9 Pages 2008
Synthesis and antiproliferative activity of benzyl and phenethyl analogs of makaluvamines Fulltext Access 9 Pages 2008
Three-dimensional quantitative structure–activity relationship studies on novel series of benzotriazine based compounds acting as Src inhibitors using CoMFA and CoMSIA Fulltext Access 9 Pages 2008
Synthesis and structure–immunosuppressive activity relationships of bakuchiol and its derivatives Fulltext Access 9 Pages 2008
Imidazolidines as new anti-Trypanosoma cruzi agents: Biological evaluation and structure–activity relationships Fulltext Access 9 Pages 2008
Progesterone receptor antagonists with a 3-phenylquinazoline-2,4-dione/2-phenylisoquinoline-1,3-dione skeleton Fulltext Access 9 Pages 2008
Selective angiotensin II AT2 receptor agonists: Benzamide structure–activity relationships Fulltext Access 9 Pages 2008
Study by HPLC-MS of the interaction of platinum antitumor complexes with potato carboxypeptidase inhibitor (PCI) Fulltext Access 9 Pages 2008
Deoxygenated phosphorothioate inositol phosphate analogs: Synthesis, phosphatase stability, and binding affinity Fulltext Access 9 Pages 2008
Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts Fulltext Access 9 Pages 2008
Synthesis of naphtho[2,3-a]phenoxazinium chlorides: Structure–activity relationships of these heterocycles and benzo[a]phenoxazinium chlorides as new antimicrobials Fulltext Access 9 Pages 2008
Heteroallyl-containing 5-nitrofuranes as new anti-Trypanosoma cruzi agents with a dual mechanism of action Fulltext Access 9 Pages 2008
Synthesis, antifungal activity and CoMFA analysis of novel 1,2,4-triazolo[1,5-a]pyrimidine derivatives Fulltext Access 9 Pages 2008
QSAR study of heparanase inhibitors activity using artificial neural networks and Levenberg–Marquardt algorithm Fulltext Access 9 Pages 2008
A novel quantitative structure–activity relationship method to predict the affinities of MT3 melatonin binding site Fulltext Access 9 Pages 2008
2/4-Substituted-9-fluorenones and their O-glucosides as potential immunomodulators and anti-herpes simplex virus-2 agents. Part 5 Fulltext Access 9 Pages 2008
1,2,3-Triazol-carboxanilides and 1,2,3-triazol-(N-benzyl)-carboxamides as BK-potassium channel activators. XII Fulltext Access 9 Pages 2008
Synthesis and antimicrobial activities of silver(I) 3-(substituted phenyl)sulfanylpropenoates Fulltext Access 9 Pages 2008
Synthesis, characterization and pharmacological evaluation of amide prodrugs of ketorolac Fulltext Access 9 Pages 2008
Synthesis, anti-tubercular activity and 3D-QSAR study of coumarin-4-acetic acid benzylidene hydrazides Fulltext Access 9 Pages 2008
Synthesis and induction of G0–G1 phase arrest with apoptosis of 3,5-dimethyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazepin-4(3H)-one Fulltext Access 9 Pages 2008
Synthesis and antitumor studies on novel Co(II), Ni(II) and Cu(II) metal complexes of bis(3-acetylcoumarin)thiocarbohydrazone Fulltext Access 9 Pages 2008
Ligand binding to nucleic acids and proteins: Does selectivity increase with strength? Fulltext Access 9 Pages 2008
Design and synthesis of bisubstrate inhibitors of type 1 17β-hydroxysteroid dehydrogenase: Overview and perspectives Fulltext Access 9 Pages 2008
Synthesis and biological evaluation of novel dimiracetam derivatives useful for the treatment of neuropathic pain Fulltext Access 9 Pages 2008
N-Phenyl and N-phenylalkyl-maleimides acting against Candida spp.: Time-to-kill, stability, interaction with maleamic acids Fulltext Access 9 Pages 2008
Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides Fulltext Access 9 Pages 2008
Design and synthesis of diketopiperazine and acyclic analogs related to the caprazamycins and liposidomycins as potential antibacterial agents Fulltext Access 9 Pages 2008
Studies toward the structural optimization of new brazilizone-related trypanocidal 1,3,4-thiadiazole-2-arylhydrazone derivatives Fulltext Access 9 Pages 2008
SAR of a series of anti-HSV-1 acridone derivatives, and a rational acridone-based design of a new anti-HSV-1 3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridine series Fulltext Access 9 Pages 2008
Discovery of novel α-glucosidase inhibitors based on the virtual screening with the homology-modeled protein structure Fulltext Access 9 Pages 2008
Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition Fulltext Access 9 Pages 2008
New, stronger nucleophiles for nucleic acid-templated chemistry: Synthesis and application in fluorescence detection of cellular RNA Fulltext Access 9 Pages 2008
Sequence-specific Methyltransferase-Induced Labelling (SMILing) of plasmid DNA for studying cell transfection Fulltext Access 9 Pages 2008
Synthesis, DNA binding, and cytotoxicity of 1,4-bis(2-amino-ethylamino)anthraquinone–amino acid conjugates Fulltext Access 9 Pages 2008
Novel amino linkers enabling efficient labeling and convenient purification of amino-modified oligonucleotides Fulltext Access 9 Pages 2008
Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant Fulltext Access 9 Pages 2008
Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues Fulltext Access 9 Pages 2008
Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators Fulltext Access 9 Pages 2008
SAR and QSAR study on 2-aminothiazole derivatives, modulators of transcriptional repression in Huntington’s disease Fulltext Access 9 Pages 2008
Peptomeric analogues of trypsin inhibitor SFTI-1 isolated from sunflower seeds Fulltext Access 9 Pages 2008
Synthetic methods for the preparation of ARQ 501 (β-Lapachone) human blood metabolites Fulltext Access 9 Pages 2008
Design, synthesis, and QSAR studies of novel lysine derives as amino-peptidase N/CD13 inhibitors Fulltext Access 9 Pages 2008
Development of novel water-soluble photocleavable protective group and its application for design of photoresponsive paclitaxel prodrugs Fulltext Access 9 Pages 2008
Original preparation of conjugates for antibody production against Amicoumacin-related anti-microbial agents Fulltext Access 9 Pages 2008
Proteochemometrics analysis of substrate interactions with dengue virus NS3 proteases Fulltext Access 9 Pages 2008
Perylene side chains modulate G-quadruplex conformation in biologically relevant DNA sequences Fulltext Access 9 Pages 2008
Synthesis and recovery of high bioactive phenolics from table-olive brine process wastewater Fulltext Access 9 Pages 2008
Sequence specific and high affinity recognition of 5â²-ACGCGT-3â² by rationally designed pyrrole-imidazole H-pin polyamides: Thermodynamic and structural studies Fulltext Access 9 Pages 2008
The design, synthesis, and anti-tumor mechanism study of N-phosphoryl amino acid modified resveratrol analogues Fulltext Access 9 Pages 2008
Synthesis and anticonvulsant activity of aromatic tetramethylcyclopropanecarboxamide derivatives Fulltext Access 9 Pages 2008
Support vector machines classification of hERG liabilities based on atom types Fulltext Access 9 Pages 2008
Total synthesis of phenanthroindolizidine alkaloids (±)-antofine, (±)-deoxypergularinine, and their dehydro congeners and evaluation of their cytotoxic activity Fulltext Access 9 Pages 2008
Detection of triplet repeat sequences in the double-stranded DNA using pyrene-functionalized pyrrole–imidazole polyamides with rigid linkers Fulltext Access 9 Pages 2008
Design and synthesis of 7-alkoxy-4-heteroarylamino-3-quinolinecarbonitriles as dual inhibitors of c-Src kinase and nitric oxide synthase Fulltext Access 9 Pages 2008
Towards the first inhibitors of trihydroxynaphthalene reductase from Curvularia lunata: Synthesis of artificial substrate, homology modelling and initial screening Fulltext Access 9 Pages 2008
High-throughput evaluation of relative cell permeability between peptoids and peptides Fulltext Access 9 Pages 2008
Design, synthesis and spectroscopic studies of resveratrol aliphatic acid ligands of human serum albumin Fulltext Access 9 Pages 2008
Synthesis and analgesic/anti-inflammatory evaluation of fused heterocyclic ring systems incorporating phenylsulfonyl moiety Fulltext Access 9 Pages 2008
A new synthetic access to furo[3,2-f]chromene analogues of an antimycobacterial Fulltext Access 9 Pages 2008
Design, synthesis and in vitro antitumor activity of 4-aminoquinoline and 4-aminoquinazoline derivatives targeting EGFR tyrosine kinase Fulltext Access 9 Pages 2008
Disruption of Kv1.1 N-type inactivation by novel small molecule inhibitors (disinactivators) Fulltext Access 9 Pages 2008
New triterpenoid saponins with strong α-glucosidase inhibitory activity from the roots of Gypsophila oldhamiana Fulltext Access 9 Pages 2008
A genetic algorithm optimized fuzzy neural network analysis of the affinity of inhibitors for HIV-1 protease Fulltext Access 9 Pages 2008
Synthesis and exploration of novel curcumin analogues as anti-malarial agents Fulltext Access 9 Pages 2008
Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobin Fulltext Access 9 Pages 2008
Inhibitory effect of the alkyl side chain of caffeic acid analogues on lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages Fulltext Access 9 Pages 2008
Synthesis and preliminary pharmacological evaluation of novel derivatives of l-β-threo-benzylaspartate as inhibitors of the neuronal glutamate transporter EAAT3 Fulltext Access 9 Pages 2008
Synthesis and evaluation in vitro and in vivo of a 11C-labeled cyclooxygenase-2 (COX-2) inhibitor Fulltext Access 9 Pages 2008
Determination and characterization of new benzimidazoles with activity against Trypanosoma cruzi by UV spectroscopy and HPLC Fulltext Access 9 Pages 2008
Synthesis and cellular effects of cycloterpenals: Cyclohexadienal-based activators of neurite outgrowth Fulltext Access 9 Pages 2008
Structure–activity relationship studies on a novel class of antiproliferative agents derived from Lavendustin A. Part I: Ring A modifications Fulltext Access 9 Pages 2008
Antibacterial profile against drug-resistant Staphylococcus epidermidis clinical strain and structure–activity relationship studies of 1H-pyrazolo[3,4-b]pyridine and thieno[2,3-b]pyridine derivatives Fulltext Access 9 Pages 2008
Cytotoxic activity of proflavine diureas: Synthesis, antitumor, evaluation and DNA binding properties of 1′,1″-(acridin-3,6-diyl)-3′,3″-dialkyldiureas Fulltext Access 9 Pages 2008
Discovery of potent cholecystokinin-2 receptor antagonists: Elucidation of key pharmacophore elements by X-ray crystallographic and NMR conformational analysis Fulltext Access 9 Pages 2008
A spectroscopy approach for the study of the interactions of bioactive vanadium species with bovine serum albumin Fulltext Access 9 Pages 2008
Design, synthesis, inhibitory activity, and SAR studies of hydrophobic p-aminosalicylic acid derivatives as neuraminidase inhibitors Fulltext Access 9 Pages 2008
The synthesis of 5-substituted ring E analogs of methyllycaconitine via the Suzuki–Miyaura cross-coupling reaction Fulltext Access 9 Pages 2008
Design, synthesis, biological evaluation and docking studies of pterostilbene analogs inside PPARα Fulltext Access 9 Pages 2008
Ester derivatives of gallic acid with potential toxicity toward L1210 leukemia cells Fulltext Access 9 Pages 2008
Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation Fulltext Access 9 Pages 2008
Synthesis and antifungal activity of novel sulfoxide derivatives containing trimethoxyphenyl substituted 1,3,4-thiadiazole and 1,3,4-oxadiazole moiety Fulltext Access 9 Pages 2008
Design and synthesis of dual inhibitors of HIV reverse transcriptase and integrase: Introducing a diketoacid functionality into delavirdine Fulltext Access 9 Pages 2008
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators Fulltext Access 9 Pages 2008