Novel ofloxacin derivatives: Synthesis, antimycobacterial and toxicological evaluation Fulltext Access 8 Pages 2008
Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives Fulltext Access 8 Pages 2008
Chemoenzymatic synthesis and antiviral evaluation of conformationally constrained and 3′-methyl-branched carbanucleosides using both enantiomers of the same building block Fulltext Access 8 Pages 2008
Pyridazinone derivatives: Design, synthesis, and in vitro vasorelaxant activity Fulltext Access 8 Pages 2008
Facile preparation of new 4-phenylamino-3-quinolinecarbonitrile Src kinase inhibitors via 7-fluoro intermediates: Identification of potent 7-amino analogs Fulltext Access 8 Pages 2008
Design, synthesis, and preliminary evaluation of 4-(6-(3-nitroguanidino)hexanamido)pyrrolidine derivatives as potential iNOS inhibitors Fulltext Access 8 Pages 2008
The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor Fulltext Access 8 Pages 2008
A molecular modeling study of the interaction of 2â²-fluoro-substituted analogues of dUMP/FdUMP with thymidylate synthase Fulltext Access 8 Pages 2008
The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations Fulltext Access 8 Pages 2008
Structural modifications of N-arylamide oxadiazoles: Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2 Fulltext Access 8 Pages 2008
Non-acidic pyrazole EP1 receptor antagonists with in vivo analgesic efficacy Fulltext Access 8 Pages 2008
Design and synthesis of 3-arylpyrrolidine-2-carboxamide derivatives as melanocortin-4 receptor ligands Fulltext Access 8 Pages 2008
Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor Fulltext Access 8 Pages 2008
Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives Fulltext Access 8 Pages 2008
5-(4-Chlorophenyl)-5,6-dihydro-1,3-oxazepin-7(4H)-one derivatives as lipophilic cyclic analogues of baclofen: Design, synthesis, and neuropharmacological evaluation Fulltext Access 9 Pages 2008
Iromycins from Streptomyces sp. and from synthesis: New inhibitors of the mitochondrial electron transport chain Fulltext Access 9 Pages 2008
Oleanolic acid and its derivatives: New inhibitor of protein tyrosine phosphatase 1B with cellular activities Fulltext Access 9 Pages 2008
Dual inhibition of monoamine oxidase B and antagonism of the adenosine A2A receptor by (E,E)-8-(4-phenylbutadien-1-yl)caffeine analogues Fulltext Access 9 Pages 2008
Synthesis and biological activity of 1-methyl-tryptophan-tirapazamine hybrids as hypoxia-targeting indoleamine 2,3-dioxygenase inhibitors Fulltext Access 9 Pages 2008
11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine derivatives as novel topoisomerase I-targeting agents Fulltext Access 9 Pages 2008
Synthesis of new 1-phenyl-3-{4-[(2E)-3-phenylprop-2-enoyl]phenyl}-thiourea and urea derivatives with anti-nociceptive activity Fulltext Access 9 Pages 2008
Synthesis of highly selective fluorescent peptide probes for metal ions: Tuning selective metal monitoring with secondary structure Fulltext Access 9 Pages 2008
Synthesis of new indeno[1,2-e]pyrimido[4,5-b][1,4]diazepine-5,11-diones as potential antitumor agents Fulltext Access 9 Pages 2008
S-Euglobals: Biomimetic synthesis, antileishmanial, antimalarial, and antimicrobial activities Fulltext Access 9 Pages 2008
5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancers Fulltext Access 9 Pages 2008
Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect Fulltext Access 9 Pages 2008
Corrugoside, a new immunostimulatory α-galactoglycosphingolipid from the marine sponge Axinella corrugata Fulltext Access 9 Pages 2008
The effect of flavonoid derivatives on doxorubicin transport and metabolism Fulltext Access 9 Pages 2008
Synthesis, metal ion binding, and biological evaluation of new anticancer 2-(2′-hydroxyphenyl)benzoxazole analogs of UK-1 Fulltext Access 9 Pages 2008
Protein phosphatase inhibitory activity of tautomycin photoaffinity probes evaluated at femto-molar level Fulltext Access 9 Pages 2008
Chemical and biological investigation of N-hydroxy-valdecoxib: An active metabolite of valdecoxib Fulltext Access 9 Pages 2008
Rational design, synthesis, and in vivo evaluation of the antileukemic activity of six new alkylating steroidal esters Fulltext Access 9 Pages 2008
Synthesis and anti-Trypanosoma cruzi activity of derivatives from nor-lapachones and lapachones Fulltext Access 9 Pages 2008
Interaction between artemisinin and heme. A Density Functional Theory study of structures and interaction energies Fulltext Access 9 Pages 2008
Design and synthesis of benzofuranic derivatives as new ligands at the melatonin-binding site MT3 Fulltext Access 9 Pages 2008
Additive SMILES-based optimal descriptors in QSAR modelling bee toxicity: Using rare SMILES attributes to define the applicability domain Fulltext Access 9 Pages 2008
Synthetic and pharmacological studies on new simplified analogues of the potent actin-targeting Jaspamide Fulltext Access 9 Pages 2008
Characterization of the binding properties of SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone Fulltext Access 9 Pages 2008
Multidrug resistance reverting activity and antitumor profile of new phenothiazine derivatives Fulltext Access 9 Pages 2008
Oxazaborolidine derivatives inducing autoinducer-2 signal transduction in Vibrio harveyi Fulltext Access 9 Pages 2008
Thiazolidinone CFTR inhibitors with improved water solubility identified by structure–activity analysis Fulltext Access 9 Pages 2008
Design and SAR of new substituted purines bearing aryl groups at N9 position as HIV-1 Tat–TAR interaction inhibitors Fulltext Access 9 Pages 2008
Synthesis and structure–activity relationship studies of theophylline analogs on population responses in the rat hippocampus in vitro Fulltext Access 9 Pages 2008
Synthesis and elastase-inhibiting activity of 2-pyridinyl-isothiazol-3(2H)-one 1,1-dioxides Fulltext Access 9 Pages 2008
Stress-driven discovery of metabolites from the phytopathogenic fungus Leptosphaeria maculans: Structure and activity of leptomaculins A–E Fulltext Access 9 Pages 2008
Evaluation of saliva collection devices for the analysis of steroids, peptides and therapeutic drugs Fulltext Access 9 Pages 2008
Preparative enantiomeric separation of potent AMP-activated protein kinase activator by HPLC on amylose-based chiral stationary phase: Determination of enantiomeric purity and assignment of absolute configuration Fulltext Access 9 Pages 2008
Comparative study of immobilized α1 acid glycoprotein and ovomucoid protein stationary phases for the enantiomeric separation of pharmaceutical compounds Fulltext Access 9 Pages 2008
A screening study of ChirBase molecular database to explore the expanded chiral pool derived from the application of chiral chromatography Fulltext Access 9 Pages 2008
Development of a liquid chromatography method for the analysis of josamycin Fulltext Access 9 Pages 2008
Development and validation of a liquid chromatographic method for the determination of ascorbic acid, dehydroascorbic acid and acetaminophen in pharmaceuticals Fulltext Access 9 Pages 2008
Screening of tobacco smoke condensate for nicotinic acetylcholine receptor ligands using cellular membrane affinity chromatography columns and missing peak chromatography Fulltext Access 9 Pages 2008
A liquid chromatography tandem mass spectrometry method for the quantification of indocyanine green in dog plasma and bile Fulltext Access 9 Pages 2008
Non-invasive quantitative assessment of the content of pharmaceutical capsules using transmission Raman spectroscopy Fulltext Access 9 Pages 2008
Liquid chromatography tandem mass spectrometry assay for the simultaneous determination of venlafaxine and O-desmethylvenlafaxine in human plasma and its application to a bioequivalence study Fulltext Access 9 Pages 2008
SPME–GC determination of potential volatile organic leachables in aqueous-based pharmaceutical formulations packaged in overwrapped LDPE vials Fulltext Access 9 Pages 2008
The simultaneous determination of coumarins in Angelica gigas root by high performance liquid chromatography–diode array detector coupled with electrospray ionization/mass spectrometry Fulltext Access 9 Pages 2008
Development of a chromatographic fingerprint for the chloroform extracts of Ganoderma lucidum by HPLC and LC–MS Fulltext Access 9 Pages 2008
Quantitative RT-PCR as an alternative to late-stage bioassays for vascular endothelial growth factor Fulltext Access 9 Pages 2008
Development of a method for the determination of caffeine anhydrate in various designed intact tables by near-infrared spectroscopy: A comparison between reflectance and transmittance technique Fulltext Access 9 Pages 2008
Validated stability-indicating HPLC method for the determination of dimethyl-4,4â²-dimethoxy-5,6,5â²,6â²-dimethylene dioxybiphenyl-2,2â²-dicarboxylate (DDB) and its degradation products Fulltext Access 9 Pages 2008
Liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for simultaneous determination of tenofovir and emtricitabine in human plasma and its application to a bioequivalence study Fulltext Access 9 Pages 2008
Pharmacokinetics of gastrodin and its metabolite p-hydroxybenzyl alcohol in rat blood, brain and bile by microdialysis coupled to LC–MS/MS Fulltext Access 9 Pages 2008
The distribution pattern of intravenous [14C] artesunate in rat tissues by quantitative whole-body autoradiography and tissue dissection techniques Fulltext Access 9 Pages 2008
Immunoassays for the measurement of IGF-II, IGFBP-2 and -3, and ICTP as indirect biomarkers of recombinant human growth hormone misuse in sport: Values in selected population of athletes Fulltext Access 9 Pages 2008
An integrated system for dissolution studies and magnetic resonance imaging of controlled release, polymer-based dosage forms-A tool for quantitative assessment of hydrogel formation processes Fulltext Access 9 Pages 2008
Validation of a method for the determination of sterols and triterpenes in the aerial part of Justicia anselliana (Nees) T. Anders by capillary gas chromatography Fulltext Access 9 Pages 2008
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis Fulltext Access 9 Pages 2008
Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor Fulltext Access 9 Pages 2008
Structure–activity correlations for β-phenethylamines at human trace amine receptor 1 Fulltext Access 9 Pages 2008
Phenyl phosphotriester derivatives of AZT: Variations upon the SATE moiety Fulltext Access 9 Pages 2008
Synthesis, DNA binding, and cytotoxic evaluation of new analogs of diallyldisulfide, an active principle of garlic Fulltext Access 9 Pages 2008
Development of a second generation of inhibitors of microsomal prostaglandin E synthase 1 expression bearing the γ-hydroxybutenolide scaffold Fulltext Access 9 Pages 2008
Synthesis of pdCpAs and transfer RNAs activated with derivatives of aspartic acid and cysteine Fulltext Access 9 Pages 2008
Design, synthesis, and docking studies of novel benzopyrone derivatives as H1-antihistaminic agents Fulltext Access 9 Pages 2008
Bisphosphonate inhibitors of ATP-mediated HIV-1 reverse transcriptase catalyzed excision of chain-terminating 3′-azido, 3′-deoxythymidine: A QSAR investigation Fulltext Access 9 Pages 2008
Synthesis and antiviral activity of novel pyrazole derivatives containing oxime esters group Fulltext Access 9 Pages 2008
Characterization of doxorubicin binding site and drug induced alteration in the functionally important structural state of oxyhemoglobin Fulltext Access 9 Pages 2008
An improved and fully validated LC–MS/MS method for the simultaneous quantification of simvastatin and simvastatin acid in human plasma Fulltext Access 9 Pages 2008
Study on the pharmacokinetics and metabolism of paeonol in rats treated with pure paeonol and an herbal preparation containing paeonol by using HPLC–DAD-MS method Fulltext Access 9 Pages 2008
Simultaneous determination of GFA and its active metabolites in human plasma by liquid chromatography electrospray ionization mass spectrometry and its application to pharmacokinetic studies Fulltext Access 9 Pages 2008
New ionophores for vitamin B1 and vitamin B6 potentiometric sensors for multivitaminic control Fulltext Access 9 Pages 2008
Determination of sitagliptin in human urine and hemodialysate using turbulent flow online extraction and tandem mass spectrometry Fulltext Access 9 Pages 2008
HPLC/ESI-MS and NMR analysis of flavonoids and tannins in bioactive extract from leaves of Maytenus ilicifolia Fulltext Access 9 Pages 2008
Quantitative analysis of a bis-thiazolium antimalarial compound, SAR97276, in mouse plasma and red blood cell samples, using liquid chromatography mass spectrometry Fulltext Access 9 Pages 2008
Analytical method transfer: New descriptive approach for acceptance criteria definition Fulltext Access 9 Pages 2008
Comparative analysis of essential oil components in Pericarpium Citri Reticulatae Viride and Pericarpium Citri Reticulatae by GC–MS combined with chemometric resolution method Fulltext Access 9 Pages 2008
Density mapping and chemical component calibration development of four-component compacts via terahertz pulsed imaging Fulltext Access 9 Pages 2008
Recent advances in analytical determination of thalidomide and its metabolites Fulltext Access 9 Pages 2008