Strategy for identification of leachables in packaged pharmaceutical liquid formulations Fulltext Access 8 Pages 2008
The importance of CH/π hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase Fulltext Access 8 Pages 2008
Convergent synthesis and cruzain inhibitory activity of novel 2-(N′-benzylidenehydrazino)-4-trifluoromethyl-pyrimidines Fulltext Access 8 Pages 2008
Identification of pharmacophore model, synthesis and biological evaluation of N-phenyl-1-arylamide and N-phenylbenzenesulfonamide derivatives as BACE 1 inhibitors Fulltext Access 8 Pages 2008
New lycorine-type alkaloid from Lycoris traubii and evaluation of antitrypanosomal and antimalarial activities of lycorine derivatives Fulltext Access 8 Pages 2008
Simultaneous determination of citalopram, fluoxetine and their main metabolites in human urine samples by solid-phase microextraction coupled with high-performance liquid chromatography Fulltext Access 8 Pages 2008
Probing the binding of morin to human serum albumin by optical spectroscopy Fulltext Access 8 Pages 2008
Non-covalent inclusion of ferulic acid with α-cyclodextrin improves photo-stability and delivery: NMR and modeling studies Fulltext Access 8 Pages 2008
Assessment of MEKC suitability for residue drug monitoring on pharmaceutical manufacturing equipment Fulltext Access 8 Pages 2008
Acylamido analogs of endocannabinoids selectively inhibit cancer cell proliferation Fulltext Access 8 Pages 2008
HPLC–DAD–ESI–MS analysis of the constituents of aqueous preparations of verbena and lemon verbena and evaluation of the antioxidant activity Fulltext Access 8 Pages 2008
Determination of chlorophylls and their derivatives in Gynostemma pentaphyllum Makino by liquid chromatography–mass spectrometry Fulltext Access 8 Pages 2008
An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC–MS/MS end-point Fulltext Access 8 Pages 2008
HPLC analysis, isolation and identification of a new degradation product in carvedilol tablets Fulltext Access 8 Pages 2008
Tablet identification using near-infrared spectroscopy (NIRS) for pharmaceutical quality control Fulltext Access 8 Pages 2008
Characterization of drug–protein binding process by employing equilibrium sampling through hollow-fiber supported liquid membrane and Bjerrum and Scatchard plots Fulltext Access 8 Pages 2008
Determination of plasma and urine levels of Δ9-tetrahydrocannabinol and its main metabolite by liquid chromatography after solid-phase extraction Fulltext Access 8 Pages 2008
pH adjustment of human blood plasma prior to bioanalytical sample preparation Fulltext Access 8 Pages 2008
A detailed analysis of biodegradable nanospheres by different techniques—A combined approach to detect particle sizes and size distributions Fulltext Access 8 Pages 2008
Simultaneous analysis of coumarins and secoiridoids in Cortex Fraxini by high-performance liquid chromatography–diode array detection–electrospray ionization tandem mass spectrometry Fulltext Access 8 Pages 2008
Simultaneous estimation of phenolic acids in sea buckthorn (Hippophaë rhamnoides) using RP-HPLC with DAD Fulltext Access 8 Pages 2008
Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: Inhibition of inosine monophosphate dehydrogenase Fulltext Access 8 Pages 2008
QSAR studies on CCR2 antagonists with chiral sensitive hologram descriptors Fulltext Access 8 Pages 2008
Incorporation of positively charged ribonucleic guanidine linkages into oligodeoxyribonucleotides: Development of potent antisense agents Fulltext Access 8 Pages 2008
Synthesis and biological evaluation of thiobenzanilides as anticancer agents Fulltext Access 8 Pages 2008
Rationally designed PKA inhibitors for positron emission tomography: Synthesis and cerebral biodistribution of N-(2-(4-bromocinnamylamino)ethyl)-N-[11C]methyl-isoquinoline-5-sulfonamide Fulltext Access 8 Pages 2008
Novel antioxidant agents deriving from molecular combination of Vitamin C and NO-donor moieties Fulltext Access 8 Pages 2008
Facile synthesis of novel mutual derivatives of nucleosides and pyrimidines by regioselectively chemo-enzymatic protocol Fulltext Access 8 Pages 2008
Hymenoic acid, a novel specific inhibitor of human DNA polymerase λ from a fungus of Hymenochaetaceae sp. Fulltext Access 8 Pages 2008
Petrosamine, a potent anticholinesterase pyridoacridine alkaloid from a Thai marine sponge Petrosia n. sp Fulltext Access 8 Pages 2008
Synthesis and antitumor activity evaluations of albumin-binding prodrugs of CC-1065 analog Fulltext Access 8 Pages 2008
Synthesis and characterization of water-soluble free-base, zinc and copper porphyrin–oligonucleotide conjugates Fulltext Access 8 Pages 2008
An expeditious one-pot synthesis of 1,6-dideoxy-N-alkylated nojirimycin derivatives and their inhibitory effects on the secretion of IFN-γ and IL-4 Fulltext Access 8 Pages 2008
Identification and quantification of degradations in the Asp–Asp motifs of a recombinant monoclonal antibody Fulltext Access 8 Pages 2008
Syntheses of phosphatidyl-β-d-glucoside analogues to probe antigen selectivity of monoclonal antibody ‘DIM21’ Fulltext Access 8 Pages 2008
Synthesis, inhibitory activities, and QSAR study of xanthone derivatives as α-glucosidase inhibitors Fulltext Access 8 Pages 2008
Synthesis of scyllo-inositol derivatives and their effects on amyloid beta peptide aggregation Fulltext Access 8 Pages 2008
Peptidyl epoxides extended in the P′ direction as cysteine protease inhibitors: Effect on affinity and mechanism of inhibition Fulltext Access 8 Pages 2008
Synthesis and anticonvulsant activities of N-benzyl (2R)-2-acetamido-3-oxysubstituted propionamide derivatives Fulltext Access 8 Pages 2008
Molecularly imprinted polymer of 5-methyluridine for solid-phase extraction of pyrimidine nucleoside cancer markers in urine Fulltext Access 8 Pages 2008
Screening helix-threading peptides for RNA binding using a thiazole orange displacement assay Fulltext Access 8 Pages 2008
3D-QSAR studies of heterocyclic quinones with inhibitory activity on vascular smooth muscle cell proliferation using pharmacophore-based alignment Fulltext Access 8 Pages 2008
Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs Fulltext Access 8 Pages 2008
Synthesis and antitumoral activity of novel 3-(2-substituted-1,3,4-oxadiazol-5-yl) and 3-(5-substituted-1,2,4-triazol-3-yl) β-carboline derivatives Fulltext Access 8 Pages 2008
Time-dependent intracellular trafficking of FITC-conjugated epigallocatechin-3-O-gallate in L-929 cells Fulltext Access 8 Pages 2008
Evaluation of the composition of the binder bridges in matrix granules prepared with a small-scale high-shear granulator Fulltext Access 8 Pages 2008
LC and LC–MS methods for the investigation of polypills for the treatment of cardiovascular diseases: Part 1. Separation of active components and classification of their interaction/degradation products Fulltext Access 8 Pages 2008
High performance liquid chromatography–tandem mass spectrometric determination of rupatadine in human plasma and its pharmacokinetics Fulltext Access 8 Pages 2008
Chromatographic fingerprint analysis and characterization of furocoumarins in the roots of Angelica dahurica by HPLC/DAD/ESI-MSn technique Fulltext Access 8 Pages 2008
Determination of ionophore coccidiostats in feedingstuffs by liquid chromatography–tandem mass spectrometry: Part I. Application to targeted feed Fulltext Access 8 Pages 2008
Process characterization of powder blending by near-infrared spectroscopy: Blend end-points and beyond Fulltext Access 8 Pages 2008
The practical application of implementing the equimolar response principle of chemiluminescent nitrogen detection in pharmaceutical analysis Fulltext Access 8 Pages 2008
Interaction of anthracycline disaccharide with human serum albumin: Investigation by fluorescence spectroscopic technique and modeling studies Fulltext Access 8 Pages 2008
Quantitative determination of diclofenac sodium in solid dosage forms by FT-Raman spectroscopy Fulltext Access 8 Pages 2008
LC–UV–PDA and LC–MS studies to characterize degradation products of glimepiride Fulltext Access 8 Pages 2008
Optimization of capillary liquid chromatography with electrochemical detection for determining femtogram levels of baicalin and baicalein on the basis of the FUMI theory Fulltext Access 8 Pages 2008
Raman spectroscopy as a process analytical technology (PAT) tool for the in-line monitoring and understanding of a powder blending process Fulltext Access 8 Pages 2008
Identification, synthesis, isolation and spectral characterization of potential impurities of montelukast sodium Fulltext Access 8 Pages 2008
Simultaneous determination of Ciprofloxacin and the active metabolite of Prulifloxacin in aqueous human humor by high-performance liquid chromatography Fulltext Access 8 Pages 2008
Stability studies of anticancer agent bis(4-fluorobenzyl)trisulfide and synthesis of related substances Fulltext Access 8 Pages 2008
Application of hydrophilic interaction chromatography for simultaneous separation of six impurities of mildronate substance Fulltext Access 8 Pages 2008
High-performance liquid chromatography–diode array and electrospray-mass spectrometry analysis of non-allowed substances in cosmetic products for preventing hair loss and other hormone-dependent skin diseases Fulltext Access 8 Pages 2008
Rapid and reliable quantification of reovirus type 3 by high performance liquid chromatography during manufacturing of Reolysin® Fulltext Access 8 Pages 2008
Determination of phenolic compounds and their antioxidant activity in Erigeron acris L. extracts and pharmaceutical formulation by flow injection analysis with inhibited chemiluminescent detection Fulltext Access 8 Pages 2008
Near-infrared chemical imaging (NIR-CI) on pharmaceutical solid dosage forms—Comparing common calibration approaches Fulltext Access 8 Pages 2008
Identification, isolation and characterization of impurities of clindamycin palmitate hydrochloride Fulltext Access 8 Pages 2008
Insertion mode of a novel anionic antimicrobial peptide MDpep5 (Val-Glu-Ser-Trp-Val) from Chinese traditional edible larvae of housefly and its effect on surface potential of bacterial membrane Fulltext Access 8 Pages 2008
Metabolic urinary profiling of alcohol hepatotoxicity and intervention effects of Yin Chen Hao Tang in rats using ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry Fulltext Access 8 Pages 2008
HPLC study on the stability of bendamustine hydrochloride immobilized onto polyphosphoesters Fulltext Access 8 Pages 2008
Characterization and drug release investigation of amorphous drug–hydroxypropyl methylcellulose composites made via supercritical carbon dioxide assisted impregnation Fulltext Access 8 Pages 2008
Purification method development for chiral separation in supercritical fluid chromatography with the solubilities in supercritical fluid chromatographic mobile phases Fulltext Access 8 Pages 2008
Impact of sample preparation in peptide/protein profiling in human serum by MALDI-TOF mass spectrometry Fulltext Access 8 Pages 2008
Study of forced degradation behavior of enalapril maleate by LC and LC–MS and development of a validated stability-indicating assay method Fulltext Access 8 Pages 2008
Myrmecia pilosula (Jack Jumper) ant venom: Validation of a procedure to standardise an allergy vaccine Fulltext Access 8 Pages 2008
Control and analysis of alkyl esters of alkyl and aryl sulfonic acids in novel active pharmaceutical ingredients (APIs) Fulltext Access 8 Pages 2008
Quantitative determination of zidovudine diaryl phosphate triester pro-drugs in rat plasma by high-performance liquid chromatography–electrospray ionization tandem mass spectrometry Fulltext Access 8 Pages 2008
Insights in the application of research-grade diagnostic kits for biomarker assessments in support of clinical drug development: Bioanalysis of circulating concentrations of soluble receptor activator of nuclear factor κB ligand Fulltext Access 8 Pages 2008
Development and validation of a rapid RP-HPLC method for the determination of cetirizine or fexofenadine with pseudoephedrine in binary pharmaceutical dosage forms Fulltext Access 8 Pages 2008
Application of Raman microscopy and band-target entropy minimization to identify minor components in model pharmaceutical tablets Fulltext Access 8 Pages 2008
Isolation and structure elucidation of photodegradation products of fexofenadine Fulltext Access 8 Pages 2008
Stereoselective analysis of thioridazine-2-sulfoxide and thioridazine-5-sulfoxide: An investigation of rac-thioridazine biotransformation by some endophytic fungi Fulltext Access 8 Pages 2008
A method for determination of the plasma levels of modafinil enantiomers, (±)-modafinic acid and modafinil sulphone by direct human plasma injection and bidimensional achiral–chiral chromatography Fulltext Access 8 Pages 2008
Liquid-phase microextraction combined with high-performance liquid chromatography for the enantioselective analysis of mefloquine in plasma samples Fulltext Access 8 Pages 2008
Development, validation and transfer into a factory environment of a liquid chromatography tandem mass spectrometry assay for the highly neurotoxic impurity FMTP (4-(4-fluorophenyl)-1-methyl-1,2,3,6-tetrahydropyridine) in paroxetine active pharmaceutical Fulltext Access 8 Pages 2008
Quantitative determination of underivatized polyamines by using isotope dilution RP-LC–ESI-MS/MS Fulltext Access 8 Pages 2008
Quantitative multi-agent models for simulating protein release from PLGA bioerodible nano- and microspheres Fulltext Access 8 Pages 2008
HPLC-DAD and MS/MS analysis of novel drug candidates from the group of aromatic hydrazones revealing the presence of geometric isomers Fulltext Access 8 Pages 2008
Chemical comparison and classification of Radix Astragali by determination of isoflavonoids and astragalosides Fulltext Access 8 Pages 2008
Study on the effect of eicosapentaenoic acid on phospholipids composition in membrane microdomains of tight junctions of epithelial cells by liquid chromatography/electrospray mass spectrometry Fulltext Access 8 Pages 2008
Liquid chromatography–atmospheric pressure ionization electrospray mass spectrometry determination of “hallucinogenic designer drugs” in urine of consumers Fulltext Access 8 Pages 2008
Near-infrared reflectance spectroscopy as a process analytical technology tool in Ginkgo biloba extract qualification Fulltext Access 8 Pages 2008
A high-temperature liquid chromatographic reactor approach for investigating the solvolytic stability of a pharmaceutical compound and an investigation of its retention behavior on a C18-modified zirconia stationary phase Fulltext Access 8 Pages 2008
Study of the interaction between hydroxymethylnitrofurazone and 2-hydroxypropyl-β-cyclodextrin Fulltext Access 8 Pages 2008
Mechanism of interaction between human serum albumin and N-alkyl phenothiazines studied using spectroscopic methods Fulltext Access 8 Pages 2008
Simultaneous separation and determination of coenzyme Q10 and its process related impurities by NARP-HPLC and atmospheric pressure chemical ionization-mass spectrometry (APCI-MS) Fulltext Access 8 Pages 2008