A comparative density-functional study of the reaction mechanism of the O2-dependent coproporphyrinogen III oxidase Fulltext Access 8 Pages 2008
Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling Fulltext Access 8 Pages 2008
Anti-retroviral and cytostatic activity of 2′,3′-dideoxyribonucleoside 3′-disulfides Fulltext Access 8 Pages 2008
Antileishmanial activity screening of 5-nitro-2-heterocyclic benzylidene hydrazides Fulltext Access 8 Pages 2008
Structure and estrogenic activity of new lignans from Iryanthera lancifolia Fulltext Access 8 Pages 2008
Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase Fulltext Access 8 Pages 2008
Synthesis and antiviral activities of novel chiral cyanoacrylate derivatives with (E) configuration Fulltext Access 8 Pages 2008
Synthesis and in silico biological activity evaluation of new N-substituted pyrazolo-oxazin-2-one systems Fulltext Access 8 Pages 2008
Novel 1,3,4-thiadiazolium-2-phenylamine chlorides derived from natural piperine as trypanocidal agents: Chemical and biological studies Fulltext Access 8 Pages 2008
Biocatalytic and semisynthetic optimization of the anti-invasive tobacco (1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol Fulltext Access 8 Pages 2008
Development of polymeric drug delivery system for recognizing vascular endothelial dysfunction Fulltext Access 8 Pages 2008
Interactive effects of polymethoxy flavones from Citrus on cell growth inhibition in human neuroblastoma SH-SY5Y cells Fulltext Access 8 Pages 2008
β-Ketophosphonates as β-lactamase inhibitors: Intramolecular cooperativity between the hydrophobic subsites of a class D β-lactamase Fulltext Access 8 Pages 2008
Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31) Fulltext Access 8 Pages 2008
Synthesis and pharmacological evaluation of pentacyclic 6a,7-dihydrodiindole and 2,3-dihydrodiindole derivatives as novel melatoninergic ligands Fulltext Access 8 Pages 2008
2-Phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors: A study on the importance of modifications at the side chain on the activity Fulltext Access 8 Pages 2008
Inhibition of oxidative metabolism of tocopherols with ω-N-heterocyclic derivatives of vitamin E Fulltext Access 8 Pages 2008
Microwave-assisted solid phase synthesis, PEGylation, and biological activity studies of glucagon-like peptide-1(7–36) amide Fulltext Access 8 Pages 2008
In silico prediction of novel phosphodiesterase type-5 inhibitors derived from Sildenafil, Vardenafil and Tadalafil Fulltext Access 8 Pages 2008
1,3,4-Oxadiazole-3(2H)-carboxamide derivatives as potential novel class of monoamine oxidase (MAO) inhibitors: Synthesis, evaluation, and role of urea moiety Fulltext Access 8 Pages 2008
Discovery of betamethasone 17α-carbamates as dissociated glucocorticoid receptor modulators in the rat Fulltext Access 8 Pages 2008
Synthesis, structure and antibacterial activity of novel 1-(5-substituted-3-substituted-4,5-dihydropyrazol-1-yl)ethanone oxime ester derivatives Fulltext Access 8 Pages 2008
Carbonic anhydrase inhibitors: Inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides Fulltext Access 8 Pages 2008
Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors Fulltext Access 8 Pages 2008
NMR evaluation of adipocyte fatty acid binding protein (aP2) with R- and S-ibuprofen Fulltext Access 8 Pages 2008
Substituted oxazolidinones as novel NPC1L1 ligands for the inhibition of cholesterol absorption Fulltext Access 8 Pages 2008
Synthesis and biological evaluation of 2-trifluoromethyl/sulfonamido-5,6-diaryl substituted imidazo[2,1-b]-1,3,4-thiadiazoles: A novel class of cyclooxygenase-2 inhibitors Fulltext Access 8 Pages 2008
Design, synthesis, and in vitro evaluation of new naphthylnitrobutadienes with potential antiproliferative activity: Toward a structure/activity correlation Fulltext Access 8 Pages 2008
A new synthesis of the ORL-1 antagonist 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397) and activity in a calcium mobilization assay Fulltext Access 8 Pages 2008
Design, synthesis, and radiosensitizing activities of sugar-hybrid hypoxic cell radiosensitizers Fulltext Access 8 Pages 2008
Design and physicochemical properties of new fluorescent ligands of protein kinase C isozymes focused on CH/π interaction Fulltext Access 8 Pages 2008
Synthesis, in vitro pharmacology, and pharmacokinetic profiles of 2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-1-fluorocyclopropanecarboxylic acid and its 6-heptyl ester, a potent mGluR2 antagonist Fulltext Access 8 Pages 2008
Synthesis and GABAA receptor activity of oxygen-bridged neurosteroid analogs Fulltext Access 8 Pages 2008
Natural and non-natural prenylated chalcones: Synthesis, cytotoxicity and anti-oxidative activity Fulltext Access 8 Pages 2008
Synthesis, nitric oxide release, and anti-leukemic activity of glutathione-activated nitric oxide prodrugs: Structural analogues of PABA/NO, an anti-cancer lead compound Fulltext Access 8 Pages 2008
Alachalasins A–G, new cytochalasins from the fungus Stachybotrys charatum Fulltext Access 8 Pages 2008
Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents Fulltext Access 8 Pages 2008
Nδ-Methylated l-arginine derivatives and their effects on the nitric oxide generating system Fulltext Access 8 Pages 2008
Docking and hydropathic scoring of polysubstituted pyrrole compounds with antitubulin activity Fulltext Access 8 Pages 2008
Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine Fulltext Access 8 Pages 2008
Oxidative transformation of 2-acetylaminofluorene by a chemical model for cytochrome P450: A water-insoluble porphyrin and tert-butyl hydroperoxide Fulltext Access 8 Pages 2008
Acridone-tagged DNA as a new probe for DNA detection by fluorescence resonance energy transfer and for mismatch DNA recognition Fulltext Access 8 Pages 2008
Synthesis and evaluation of unsymmetrical polyamine derivatives as antitumor agents Fulltext Access 8 Pages 2008
Synthesis and pharmacological evaluation of bis-3-(3,4-dichlorophenyl)acrylamide derivatives as glycogen phosphorylase inhibitors Fulltext Access 8 Pages 2008
Novel Azabicyclo[3.2.2]nonane derivatives and their activities against Plasmodium falciparum K1 and Trypanosoma brucei rhodesiense Fulltext Access 8 Pages 2008
Novel synthesis and pharmacological evaluation as α2-adrenoceptor ligands of O-phenylisouronium salts Fulltext Access 8 Pages 2008
Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy Fulltext Access 8 Pages 2008
Allele-specific inhibition of divergent protein tyrosine phosphatases with a single small molecule Fulltext Access 8 Pages 2008
Spin trapping experiments with different carbamoyl-substituted EMPO derivatives Fulltext Access 8 Pages 2008
Design, synthesis, and antitumor activity of new bis-aminomethylnaphthalenes Fulltext Access 8 Pages 2008
Antiproliferative and apoptosis-inducing activities of alkyl gallate and gallamide derivatives related to (−)-epigallocatechin gallate Fulltext Access 8 Pages 2008
Furoxan-, alkylnitrate-derivatives and related compounds as anti-trypanosomatid agents: Mechanism of action studies Fulltext Access 8 Pages 2008
New lithocholic and chenodeoxycholic piperazinylcarboxamides with antiproliferative and pro-apoptotic effects on human cancer cell lines Fulltext Access 8 Pages 2008
Piperidine variations in search for non-imidazole histamine H3 receptor ligands Fulltext Access 8 Pages 2008
Novel anticancer agents, kayeassamins C−I from the flower of Kayea assamica of Myanmar Fulltext Access 8 Pages 2008
Molecular modeling studies toward the structural optimization of new cyclopeptide-based HDAC inhibitors modeled on the natural product FR235222 Fulltext Access 8 Pages 2008
Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain Fulltext Access 8 Pages 2008
Development and biological evaluation of C60 fulleropyrrolidine-thalidomide dyad as a new anti-inflammation agent Fulltext Access 8 Pages 2008
Synthesis and biological evaluation of 2-(3′,4′,5′-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization Fulltext Access 8 Pages 2008
Specific fluorescent detection of fibrillar α-synuclein using mono- and trimethine cyanine dyes Fulltext Access 8 Pages 2008
Studies on the chemical constituents and anticancer activity of Saxifraga stolonifera (L) Meeb Fulltext Access 8 Pages 2008
Standard protecting groups create potent and selective κ opioids: Salvinorin B alkoxymethyl ethers Fulltext Access 8 Pages 2008
Synthesis, cytotoxic evaluation, and DNA binding of novel thiazolo[5,4-b]quinoline derivatives Fulltext Access 8 Pages 2008
Indeno[1,2-c]isoquinolines as enhancing agents on all-trans retinoic acid-mediated differentiation of human myeloid leukemia cells Fulltext Access 8 Pages 2008
DNA cleavage by novel copper (II) complex and the role of β-cyclodextrin in promoting cleavage Fulltext Access 8 Pages 2008
A novel sesquiterpenoid dimer parviflorene F induces apoptosis by up-regulating the expression of TRAIL-R2 and a caspase-dependent mechanism Fulltext Access 8 Pages 2008
Synthesis and properties of 3′-amino-2′,4′-BNA, a bridged nucleic acid with a N3′→P5′ phosphoramidate linkage Fulltext Access 8 Pages 2008
Synthesis of curcumin mimics with multidrug resistance reversal activities Fulltext Access 8 Pages 2008
Stereochemical studies on the novel monoamine oxidase B substrates (1R,6S)- and (1S,6R)-3-methyl-6-phenyl-3-aza-bicyclo[4.1.0]heptane Fulltext Access 8 Pages 2008
Poly(ADP-ribose) polymerase-1 activity facilitates the dissociation of nuclear proteins from platinum-modified DNA Fulltext Access 8 Pages 2008
Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry Fulltext Access 8 Pages 2008
Antiobesity designed multiple ligands: Synthesis of pyrazole fatty acid amides and evaluation as hypophagic agents Fulltext Access 8 Pages 2008
Synthesis and activity of tetrapeptidic HTLV-I protease inhibitors possessing different P3-cap moieties Fulltext Access 8 Pages 2008
Sensitization to p-amino aromatic compounds: Study of the covalent binding of 2,5-dimethyl-p-benzoquinonediimine to a model peptide by electrospray ionization tandem mass spectrometry Fulltext Access 8 Pages 2008
Synthesis, in vitro antibacterial and carbonic anhydrase II inhibitory activities of N-acylsulfonamides using silica sulfuric acid as an efficient catalyst under both solvent-free and heterogeneous conditions Fulltext Access 8 Pages 2008
Synergistic interaction between p-glycoprotein modulators and epirubicine on resistant cancer cells Fulltext Access 8 Pages 2008
Novel anti-HIV cyclotriazadisulfonamide derivatives as modeled by ligand- and receptor-based approaches Fulltext Access 8 Pages 2008
Aldehydic components of Cinnamon bark extract suppresses RANKL-induced osteoclastogenesis through NFATc1 downregulation Fulltext Access 8 Pages 2008
Carbonic anhydrase inhibitors: Synthesis and inhibition studies against mammalian isoforms I–XV with a series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides Fulltext Access 8 Pages 2008
5-Alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives inhibit growth of lung cancer A549 cell by inducing apoptosis Fulltext Access 8 Pages 2008
Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp Fulltext Access 8 Pages 2008
Synthesis and antitubercular activity of ferrocenyl diaminoalcohols and diamines Fulltext Access 8 Pages 2008
Molecular dynamics simulations of the amyloid-beta binding alcohol dehydrogenase (ABAD) enzyme Fulltext Access 8 Pages 2008
E,E-2-Benzylidene-6-(nitrobenzylidene)cyclohexanones: Syntheses, cytotoxicity and an examination of some of their electronic, steric, and hydrophobic properties Fulltext Access 8 Pages 2008
High specific activity tritium-labeled N-(2-methoxybenzyl)-2,5-dimethoxy-4-iodophenethylamine (INBMeO): A high-affinity 5-HT2A receptor-selective agonist radioligand Fulltext Access 8 Pages 2008
Study of the base discrimination ability of DNA and 2′-O-methylated RNA oligomers containing 2-thiouracil bases towards complementary RNA or DNA strands and their application to single base mismatch detection Fulltext Access 8 Pages 2008
Benzanilides with spasmolytic activity: Chemistry, pharmacology, and SAR Fulltext Access 8 Pages 2008
Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling Fulltext Access 8 Pages 2008