Rac signaling in tumorigenesis and as target for anticancer drug development Fulltext Access 14 Pages 2006
Composite membrane of bacterially-derived cellulose and molecularly imprinted polymer for use as a transdermal enantioselective controlled-release system of racemic propranolol Fulltext Access 14 Pages 2006
Modeling of farnesyltransferase inhibition by some thiol and non-thiol peptidomimetic inhibitors using genetic neural networks and RDF approaches Fulltext Access 14 Pages 2006
Three-dimensional quantitative structure–activity relationship studies on diverse structural classes of HIV-1 integrase inhibitors using CoMFA and CoMSIA Fulltext Access 14 Pages 2006
Literature Highlights: Recent research in infectious disease drup resistance Fulltext Access 14 Pages 2006
Mechanisms of experimental resistance of Leishmania to miltefosine: Implications for clinical use Fulltext Access 14 Pages 2006
Literature highlights - 9/6 Recent research in infectious disease drug resistance Fulltext Access 14 Pages 2006
Effect of alkyl groups on the cellular hydrolysis of stavudine phosphoramidates Fulltext Access 14 Pages 2006
A low molecular weight fraction of polyethylenimine (PEI) displays increased transfection efficiency of DNA and siRNA in fresh or lyophilized complexes Fulltext Access 14 Pages 2006
Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation Fulltext Access 14 Pages 2006
Biologics in development for rheumatoid arthritis: Relevance to osteoarthritis Fulltext Access 14 Pages 2006
Enhancement of periodontal tissue regeneration by locally controlled delivery of insulin-like growth factor-I from dextran–co-gelatin microspheres Fulltext Access 14 Pages 2006
Computational approaches for predicting CYP-related metabolism properties in the screening of new drugs Fulltext Access 14 Pages 2006
Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 2: Synthesis and inhibitory activity of aryl-3-trifluoromethylpyrazoles Fulltext Access 14 Pages 2006
Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies Fulltext Access 14 Pages 2006
Understanding the antitumor activity of novel tricyclicpiperazinyl derivatives as farnesyltransferase inhibitors using CoMFA and CoMSIA Fulltext Access 14 Pages 2006
Optimized design and synthesis of chemical dimerizer substrates for detection of glycosynthase activity via chemical complementation Fulltext Access 14 Pages 2006
Hydrophilically enhanced 3-carboranyl thymidine analogues (3CTAs) for boron neutron capture therapy (BNCT) of cancer Fulltext Access 14 Pages 2006
Synthesis, stereochemistry, and antimicrobial evaluation of substituted piperidin-4-one oxime ethers Fulltext Access 14 Pages 2006
Synthesis of phenanthridinium–bis-nucleobase conjugates, interactions with poly U, nucleotides and in vitro antitumour activity of mono- and bis-nucleobase conjugates Fulltext Access 14 Pages 2006
Analytical methods for trace levels of reactive carbonyl compounds formed in lipid peroxidation systems Fulltext Access 14 Pages 2006
Glycosides and amino acyl esters of carbohydrates as potent inhibitors of angiotensin converting enzyme Fulltext Access 14 Pages 2006
Polyionic hydrocolloids for the intestinal delivery of protein drugs: Alginate and chitosan — a review Fulltext Access 14 Pages 2006
Pharmacophotonics: Utilizing multi-photon microscopy to quantify drug delivery and intracellular trafficking in the kidney Fulltext Access 15 Pages 2006
In vitro phototoxicity of 5-aminolevulinic acid and its methyl ester and the influence of barrier properties on their release from a bioadhesive patch Fulltext Access 15 Pages 2006
Imaging of cortical astrocytes using 2-photon laser scanning microscopy in the intact mouse brain Fulltext Access 15 Pages 2006
Improved peptide vaccine strategies, creating synthetic artificial infections to maximize immune efficacy Fulltext Access 15 Pages 2006
Investigating the uptake and intracellular fate of pH-sensitive liposomes by flow cytometry and spectral bio-imaging Fulltext Access 15 Pages 2006
Current status of gene delivery and gene therapy in lacrimal gland using viral vectors Fulltext Access 15 Pages 2006
Characterization of the transdermal transport of flurbiprofen and indomethacin Fulltext Access 15 Pages 2006
A Process Analytical Technology approach to near-infrared process control of pharmaceutical powder blending: Part II: Qualitative near-infrared models for prediction of blend homogeneity Fulltext Access 15 Pages 2006
Use of compressed gas precipitation to enhance the dissolution behavior of a poorly water-soluble drug: Generation of drug microparticles and drug–polymer solid dispersions Fulltext Access 15 Pages 2006
Rapid determination of dry layer mass transfer resistance for various pharmaceutical formulations during primary drying using product temperature profiles Fulltext Access 15 Pages 2006
Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges Fulltext Access 15 Pages 2006
Safety assessment of high fructose corn syrup (HFCS) as an ingredient added to cigarette tobacco Fulltext Access 15 Pages 2006
Manipulation of Beclomethasone-Hydrofluoroalkane Interactions using Biocompatible Macromolecules Fulltext Access 15 Pages 2006
Effect of buffer species on the thermally induced aggregation of interferon-tau Fulltext Access 15 Pages 2006
Corticosteroid Microparticles Produced by Supercritical-Assisted Atomization: Process Optimization, Product Characterization, and “in Vitro” Performance Fulltext Access 15 Pages 2006
Stealth PEG-PHDCA niosomes: Effects of Chain Length of PEG and Particle Size on Niosomes Surface Properties, In Vitro Drug Release, Phagocytic Uptake, In Vivo Pharmacokinetics and Antitumor Activity Fulltext Access 15 Pages 2006
The influence of drug kinetics in blood on the calculation of oral bioavailability in linear pharmacokinetics: The traditional equation may considerably overestimate the true value Fulltext Access 15 Pages 2006
Sustained delivery of plasmid DNA from polymeric scaffolds for tissue engineering Fulltext Access 15 Pages 2006
A Process Analytical Technology approach to near-infrared process control of pharmaceutical powder blending. Part I: D-optimal design for characterization of powder mixing and preliminary spectral data evaluation Fulltext Access 15 Pages 2006
Nanoscale analysis of protein and peptide absorption: Insulin absorption using complexation and pH-sensitive hydrogels as delivery vehicles Fulltext Access 15 Pages 2006
Investigation and modelling approach of the mechanical properties of compacts made with binary mixtures of pharmaceutical excipients Fulltext Access 15 Pages 2006
Novel potent and selective αvβ3/αvβ5 integrin dual antagonists with reduced binding affinity for human serum albumin Fulltext Access 15 Pages 2006
Antisense strategies in degenerative joint diseases: Sense or nonsense? Fulltext Access 15 Pages 2006
The role of gene therapy for craniofacial and dental tissue engineering Fulltext Access 15 Pages 2006
Design of potent inhibitors for Schistosoma japonica glutathione S-transferase Fulltext Access 15 Pages 2006
Chemical and biological characterisation of nutraceutical compounds of broccoli Fulltext Access 15 Pages 2006
Advances in the analysis of phenolic compounds in products derived from bees Fulltext Access 15 Pages 2006
Structure–activity relationships in platelet-activating factor. Part 14: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 activity Fulltext Access 15 Pages 2006
Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors Fulltext Access 15 Pages 2006
Synthesis and antimalarial activity of chain substituted pivaloyloxymethyl ester analogues of Fosmidomycin and FR900098 Fulltext Access 15 Pages 2006
Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists Fulltext Access 15 Pages 2006
Modeling of activity of cyclic urea HIV-1 protease inhibitors using regularized-artificial neural networks Fulltext Access 15 Pages 2006
Synthesis of functionalized biphenyl-C-nucleosides and their incorporation into oligodeoxynucleotides Fulltext Access 15 Pages 2006
Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes Fulltext Access 15 Pages 2006
Structural basis for androgen receptor agonists and antagonists: Interaction of SPEED 98-listed chemicals and related compounds with the androgen receptor based on an in vitro reporter gene assay and 3D-QSAR Fulltext Access 15 Pages 2006
Novel 1,3-dicarbonyl compounds having 2(3H)-benzazolonic heterocycles as PPARγ agonists Fulltext Access 15 Pages 2006
Flavonoids and cinnamic acid esters as inhibitors of fungal 17β-hydroxysteroid dehydrogenase: A synthesis, QSAR and modelling study Fulltext Access 15 Pages 2006
Design and synthesis of novel imidazoline derivatives with potent antihyperglycemic activity in a rat model of type 2 diabetes Fulltext Access 15 Pages 2006
Regiocontrolled synthesis and HIV inhibitory activity of unsymmetrical binaphthoquinone and trimeric naphthoquinone derivatives of conocurvone Fulltext Access 15 Pages 2006
CoMFA and CoMSIA investigations of dopamine D3 receptor ligands leading to the prediction, synthesis, and evaluation of rigidized FAUC 365 analogues Fulltext Access 15 Pages 2006
Effect of creatinine and specific gravity normalization techniques on xenobiotic biomarkers in smokers’ spot and 24-h urines Fulltext Access 15 Pages 2006
Synthesis, photochemical synthesis, DNA binding and antitumor evaluation of novel cyano- and amidino-substituted derivatives of naphtho-furans, naphtho-thiophenes, thieno-benzofurans, benzo-dithiophenes and their acyclic precursors Fulltext Access 15 Pages 2006
A new type of ketolide bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether: Synthesis and structure–activity relationships (2) Fulltext Access 15 Pages 2006
C19-Steroids as androgen receptor modulators: Design, discovery, and structure-activity relationship of new steroidal androgen receptor antagonists Fulltext Access 15 Pages 2006
The binding of DNA intercalating and non-intercalating compounds to A-form and protonated form of poly(rC)·poly(rG): Spectroscopic and viscometric study Fulltext Access 15 Pages 2006
Prodrugs of 3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (MGS0039): A potent and orally active group II mGluR antagonist with antidepressant-like potential Fulltext Access 15 Pages 2006
Potent inhibitors of the hepatitis C virus NS3 protease: Use of a novel P2 cyclopentane-derived template Fulltext Access 16 Pages 2006
Glycosyl bis-porphyrin conjugates: Synthesis and potential application in PDT Fulltext Access 16 Pages 2006
Optimization of sulfonamide derivatives as highly selective EP1 receptor antagonists Fulltext Access 16 Pages 2006
In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity at CYP-450 Fulltext Access 16 Pages 2006
Design, synthesis, and biological evaluation of chicoric acid analogs as inhibitors of HIV-1 integrase Fulltext Access 16 Pages 2006
A Staphylococcus aureus lipoteichoic acid (LTA) derived structural variant with two diacylglycerol residues Fulltext Access 16 Pages 2006
Synthesis, in vitro pharmacology, and structure–activity relationships of 2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as mGluR2 antagonists Fulltext Access 16 Pages 2006
Enantioselective synthesis of 1-methoxy- and 1-deoxy-2′-methyl-Δ8-tetrahydrocannabinols: New selective ligands for the CB2 receptor Fulltext Access 16 Pages 2006
Hydrophilic photolabelling of glycopeptides from the murine liver–intestine (LI) cadherin recognition domain Fulltext Access 16 Pages 2006