Quinoline-resistance reversing agents for the malaria parasite Plasmodium falciparum Fulltext Access 16 Pages 2006
Current and future issues in the manufacturing and development of monoclonal antibodies Fulltext Access 16 Pages 2006
Clinical experience and applications of drug-eluting stents in the noncoronary vasculature, bile duct and esophagus Fulltext Access 16 Pages 2006
3-Bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives as new lead compounds for antibacterially active substances Fulltext Access 16 Pages 2006
QSAR study for a novel series of ortho disubstituted phenoxy analogues of α1-adrenoceptor antagonist WB4101 Fulltext Access 16 Pages 2006
New highly potent GABA uptake inhibitors selective for GAT-1 and GAT-3 derived from (R)- and (S)-proline and homologous pyrrolidine-2-alkanoic acids Fulltext Access 16 Pages 2006
Design, synthesis and activity against Toxoplasma gondii, Plasmodium spp., and Mycobacterium tuberculosis of new 6-fluoroquinolones Fulltext Access 16 Pages 2006
Design, synthesis and early structure–activity relationship of farnesyltransferase inhibitors which mimic both the peptidic and the prenylic substrate Fulltext Access 16 Pages 2006
Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for the opioid receptors Fulltext Access 16 Pages 2006
Physical stability of crystal hydrates and their anhydrates in the presence of excipients Fulltext Access 16 Pages 2006
Formulation considerations for proteins susceptible to asparagine deamidation and aspartate isomerization Fulltext Access 16 Pages 2006
Preclinical Drug Metabolism and Pharmacokinetic Evaluation of GW844520, A Novel Anti-Malarial Mitochondrial Electron Transport Inhibitor Fulltext Access 16 Pages 2006
Physicochemical and Biopharmaceutical Characterization of endo-2-(8-Methyl-8-azabicyclo[3.2.1]oct-3-yl)-2,3-dihydro-1H-benz[e]isoindol-1-one (CR3124) a Novel Potent 5-HT3 Receptor Antagonist Fulltext Access 16 Pages 2006
Penetration of Crystalline Powder Particles into Excised Human Skin Membranes and Model Gels from a Supersonic Powder Injector Fulltext Access 16 Pages 2006
Pharmacokinetics and Pharmacodynamics Analysis of Transdermal Iontophoresis of 5-OH-DPAT in Rats: In vitro-in vivo Correlation Fulltext Access 16 Pages 2006
Permeability assessment of poorly waterâsoluble compounds under solubilizing conditions: The reciprocal permeability approach Fulltext Access 16 Pages 2006
MDR1 haplotypes significantly minimize intracellular uptake and transcellular Pâgp substrate transport in recombinant LLCâPK1 cells Fulltext Access 16 Pages 2006
Pharmacokinetics of 5-fluorouracil in the hamster following inhalation delivery of lipid-coated nanoparticles Fulltext Access 16 Pages 2006
Dynamic Heat Capacity and Relaxation Time of Ultraviscous Melt and Glassy Acetaminophen Fulltext Access 16 Pages 2006
The active components and the pharmacological multi-target principle of STW 5 (Iberogast®) Fulltext Access 16 Pages 2006
Prediction of pharmacist intention to provide Medicare medication therapy management services using the theory of planned behavior Fulltext Access 16 Pages 2006
Consumption and costs of antihypertensive drugs in Mexico: Are diuretic agents a standing technological trajectory? Fulltext Access 16 Pages 2006
A platform for designing HIV integrase inhibitors. Part 1: 2-Hydroxy-3-heteroaryl acrylic acid derivatives as novel HIV integrase inhibitor and modeling of hydrophilic and hydrophobic pharmacophores Fulltext Access 16 Pages 2006
Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3 Fulltext Access 16 Pages 2006
Synthesis and antimicrobial evaluation of new 2-substituted 5,7-di-tert-butylbenzoxazoles Fulltext Access 16 Pages 2006
Preparation of fluorescent tocopherols for use in protein binding and localization with the α-tocopherol transfer protein Fulltext Access 16 Pages 2006
Affinity prediction on A1 adenosine receptor agonists: The chemometric approach Fulltext Access 16 Pages 2006
Discovering novel chemical inhibitors of human cyclophilin A: Virtual screening, synthesis, and bioassay Fulltext Access 16 Pages 2006
Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors Fulltext Access 16 Pages 2006
Design, synthesis, and evaluation of Leu∗Ala hydroxyethylene-based non-peptide β-secretase (BACE) inhibitors Fulltext Access 17 Pages 2006
Development of a Respirable, Sustained Release Microcarrier for 5-Fluorouracil II: In Vitro and In Vivo Optimization of Lipid Coated Nanoparticles Fulltext Access 17 Pages 2006
Pyranocoumarin, a novel anti-TB pharmacophore: Synthesis and biological evaluation against Mycobacterium tuberculosis Fulltext Access 17 Pages 2006
A global examination of allometric scaling for predicting human drug clearance and the prediction of large vertical allometry* Fulltext Access 17 Pages 2006
Synthesis and biological evaluation of (3,4,5-trimethoxyphenyl)indol-3-ylmethane derivatives as potential antivascular agents Fulltext Access 17 Pages 2006
Polymorphism and Pseudopolymorphism of Salicaine and Salicaine Hydrochloride Crystal Polymorphism of Local Anaesthetic Drugs, Part V Fulltext Access 17 Pages 2006
Discovery of potent, selective 4-fluoroproline-based thrombin inhibitors with improved metabolic stability Fulltext Access 17 Pages 2006
Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors Fulltext Access 17 Pages 2006
Synthesis and metabolism of naphthyl substituted phosphoramidate derivatives of stavudine Fulltext Access 17 Pages 2006
Further optimization of sulfonamide analogs as EP1 receptor antagonists: Synthesis and evaluation of bioisosteres for the carboxylic acid group Fulltext Access 17 Pages 2006
In situ studies of regional absorption of lobucavir and ganciclovir from rabbit intestine and predictions of doseâlimited absorption and associated variability in humans Fulltext Access 17 Pages 2006
Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides Fulltext Access 17 Pages 2006
Nonsteroidal progesterone receptor ligands (II); synthesis and SAR of new tetrahydrobenzindolone derivatives Fulltext Access 17 Pages 2006
Pyrrolo[2,3-h]quinolinones: A new ring system with potent photoantiproliferative activity Fulltext Access 17 Pages 2006
High-throughput screening of ecdysone agonists using a reporter gene assay followed by 3-D QSAR analysis of the molting hormonal activity Fulltext Access 17 Pages 2006
Discovery of thiochroman and chroman derivatives as pure antiestrogens and their structure–activity relationship Fulltext Access 17 Pages 2006
Design and synthesis of novel 7-heterocycle-6-trifluoromethyl-3-oxoquinoxaline-2-carboxylic acids bearing a substituted phenyl group as superior AMPA receptor antagonists with good physicochemical properties Fulltext Access 17 Pages 2006
Structure–activity relationships in platelet-activating factor. Part 13: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 or pure antiretroviral activity Fulltext Access 17 Pages 2006
Engineering of therapeutic antibodies to minimize immunogenicity and optimize function Fulltext Access 17 Pages 2006
Isothiazolidinone heterocycles as inhibitors of protein tyrosine phosphatases: Synthesis and structure–activity relationships of a peptide scaffold Fulltext Access 17 Pages 2006
Design, synthesis, and BK channel-opening activity of hexahydrodibenzazepinone derivatives Fulltext Access 18 Pages 2006
Examining gender salary disparities: an analysis of the 2003 multistate salary survey Fulltext Access 18 Pages 2006
Potent and selective TF/FVIIa inhibitors containing a neutral P1 ligand Fulltext Access 18 Pages 2006
Extractables/leachables from plastic tubing used in product manufacturing Fulltext Access 18 Pages 2006
Thermodynamic Stability and Crystal Structures for Polymorphs and Solvates of Formoterol Fumarate Fulltext Access 18 Pages 2006
A topological substructural approach for the prediction of P-glycoprotein substrates Fulltext Access 18 Pages 2006
Orthogonal extraction/chromatography and UPLC, two powerful new techniques for bioanalytical quantitation of desloratadine and 3-hydroxydesloratadine at 25 pg/mL Fulltext Access 18 Pages 2006
Synthesis and pharmacological characterization of novel inverse agonists acting on the viral-encoded chemokine receptor US28 Fulltext Access 18 Pages 2006
Synthesis and biological activities of new 1α,25-dihydroxy-19-norvitamin D3 analogs with modifications in both the A-ring and the side chain Fulltext Access 18 Pages 2006
Benzodiazepine receptor ligands. 8: Synthesis and pharmacological evaluation of new pyrazolo[5,1-c] [1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: High affinity ligands endowed with inverse-agonist pharmacological efficacy Fulltext Access 18 Pages 2006
New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity Fulltext Access 18 Pages 2006
Gastroretentive dosage forms: Overview and special case of Helicobacter pylori Fulltext Access 18 Pages 2006
Transscleral drug delivery to the posterior eye: Prospects of pharmacokinetic modeling Fulltext Access 18 Pages 2006
Virus-based nanoparticles (VNPs): Platform technologies for diagnostic imaging Fulltext Access 18 Pages 2006
Discovery of imidazolidine-2,4-dione-linked HIV protease inhibitors with activity against lopinavir-resistant mutant HIV Fulltext Access 18 Pages 2006
Tyrosine kinase inhibitors and gemcitabine: New treatment options in pancreatic cancer? Fulltext Access 18 Pages 2006
Mediastinal node and diaphragmatic targeting after intracavitary injection of avidin/99mTc-blue-biotin-liposome system Fulltext Access 18 Pages 2006
Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases Fulltext Access 18 Pages 2006
Effects of pH, Temperature, and Sucrose on Benzyl Alcohol-Induced Aggregation of Recombinant Human Granulocyte Colony Stimulating Factor Fulltext Access 18 Pages 2006
Novel ligands for the human histamine H1 receptor: Synthesis, pharmacology, and comparative molecular field analysis studies of 2-dimethylamino-5-(6)-phenyl-1,2,3,4-tetrahydronaphthalenes Fulltext Access 19 Pages 2006
Design, synthesis and evaluation of peptidomimetics based on substituted bicyclic 2-pyridones—Targeting virulence of uropathogenic E. coli Fulltext Access 19 Pages 2006