Antisense oligonucleotides: Efficient synthesis of 2′-O-methoxyethyl phosphorothioate oligonucleotides using 4,5-dicyanoimidazole. Are these oligonucleotides comparable to those synthesized using 1H-tetrazole as coupling activator? Fulltext Access 12 Pages 2006
Synthesis and in vivo biodistribution of F-18 labeled 3-cis-, 3-trans-, 4-cis-, and 4-trans-fluorocyclohexane derivatives of WAY 100635 Fulltext Access 12 Pages 2006
Phosphoramidate and phosphate prodrugs of (−)-β-d-(2R,4R)-dioxolane-thymine: Synthesis, anti-HIV activity and stability studies Fulltext Access 12 Pages 2006
Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IV Fulltext Access 12 Pages 2006
Synthesis and pharmacology of 11-nor-1-methoxy-9-hydroxyhexahydrocannabinols and 11-nor-1-deoxy-9-hydroxyhexahydrocannabinols: New selective ligands for the cannabinoid CB2 receptor Fulltext Access 12 Pages 2006
Side-chain and backbone amide bond requirements for glycopeptide stimulation of T-cells obtained in a mouse model for rheumatoid arthritis Fulltext Access 12 Pages 2006
γ-(Monophenyl)phosphono glutamate analogues as mechanism-based inhibitors of γ-glutamyl transpeptidase Fulltext Access 12 Pages 2006
Nonsteroidal progesterone receptor ligands (I): Synthesis and SAR of new tetrahydronaphthofuranone derivatives Fulltext Access 12 Pages 2006
Separation and detection of compounds in Honeysuckle by integration of ion-exchange chromatography fractionation with reversed-phase liquid chromatography-atmospheric pressure chemical ionization mass spectrometer and matrix-assisted laser desorption/ioni Fulltext Access 12 Pages 2006
Quantitative 31P NMR detection of oxygen-centered and carbon-centered radical species Fulltext Access 12 Pages 2006
Synthesis, antiviral activity, and pharmacokinetic evaluation of P3 pyridylmethyl analogs of oximinoarylsulfonyl HIV-1 protease inhibitors Fulltext Access 12 Pages 2006
Synthesis, labeling, and biological evaluation of halogenated 2-quinolinecarboxamides as potential radioligands for the visualization of peripheral benzodiazepine receptors Fulltext Access 12 Pages 2006
Binding of actinomycin C1 (D) and actinomin to base-modified oligonucleotide duplexes with parallel chain orientation Fulltext Access 12 Pages 2006
In silico ADME modelling 2: Computational models to predict human serum albumin binding affinity using ant colony systems Fulltext Access 12 Pages 2006
Discovery of a new chemical lead for a matrix metalloproteinase inhibitor Fulltext Access 12 Pages 2006
Synthesis and evaluation of antitubercular activity of imidazo[2,1-b][1,3,4]thiadiazole derivatives Fulltext Access 12 Pages 2006
Synthesis of (4R,15R,16R,21S)- and (4R,15S,16S,21S)-rollicosin, squamostolide, and their inhibitory action with bovine heart mitochondrial complex I Fulltext Access 12 Pages 2006
Online hyphenated liquid chromatography–nuclear magnetic resonance spectroscopy–mass spectrometry for drug metabolite and nature product analysis Fulltext Access 12 Pages 2006
Development of immunoaffinity solid phase microextraction probes for analysis of sub ng/mL concentrations of 7-aminoflunitrazepam in urine Fulltext Access 12 Pages 2006
Development of the chromatographic fingerprint of herbal preparations Shuang–Huang–Lian oral liquid Fulltext Access 12 Pages 2006
Photosensitized degradation of losartan potassium in an extemporaneous suspension formulation Fulltext Access 12 Pages 2006
Construction of universal quantitative models for determination of roxithromycin and erythromycin ethylsuccinate in tablets from different manufacturers using near infrared reflectance spectroscopy Fulltext Access 12 Pages 2006
Separation and quantitative analysis of coumarin compounds from Angelica dahurica (Fisch. ex Hoffm) Benth. et Hook. f by pressurized capillary electrochromatography Fulltext Access 12 Pages 2006
Structural variation of cationic lipids: Minimum requirement for improved oligonucleotide delivery into cells Fulltext Access 13 Pages 2006
Clinical perspectives on pulmonary systemic and macromolecular delivery Fulltext Access 13 Pages 2006
Manipulation of hydrogel assembly and growth factor delivery via the use of peptide–polysaccharide interactions Fulltext Access 13 Pages 2006
A novel stealth liposomal topotecan with amlodipine: Apoptotic effect is associated with deletion of intracellular Ca2+ by amlodipine thus leading to an enhanced antitumor activity in leukemia Fulltext Access 13 Pages 2006
Imidazole groups on a linear, cyclodextrin-containing polycation produce enhanced gene delivery via multiple processes Fulltext Access 13 Pages 2006
Sustained release of nanosized complexes of polyethylenimine and anti-TGF-β2 oligonucleotide improves the outcome of glaucoma surgery Fulltext Access 13 Pages 2006
Synthesis and biological evaluation of modified acridines: the effect of N- and O- substituent in the nitrogenated ring on antitumor activity Fulltext Access 13 Pages 2006
Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives Fulltext Access 13 Pages 2006
Structure of daunomycin complexed to d-TGATCA by two-dimensional nuclear magnetic resonance spectroscopy Fulltext Access 13 Pages 2006
Arylmethyl substituted derivatives of Fosmidomycin: Synthesis and antimalarial activity Fulltext Access 13 Pages 2006
Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist Fulltext Access 13 Pages 2006
Willingness to pay for praziquantel treatment in a hyperendemic community of Ogun State, Nigeria Fulltext Access 13 Pages 2006
Evaluation of sodium alginate as drug release modifier in matrix tablets Fulltext Access 13 Pages 2006
Effects of the anti-neoplastic agent ET-18-OCH3 and some analogs on the biophysical properties of model membranes Fulltext Access 13 Pages 2006
Novel interpenetrating network chitosan-poly(ethylene oxide-g-acrylamide) hydrogel microspheres for the controlled release of capecitabine Fulltext Access 13 Pages 2006
Excipient hydrolysis and ester formation increase pH in a parenteral solution over aging Fulltext Access 13 Pages 2006
Performance comparison of neural network training algorithms in modeling of bimodal drug delivery Fulltext Access 13 Pages 2006
The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties Fulltext Access 13 Pages 2006
Antiplasmodial activity of ferrocenyl chalcones: Investigations into the role of ferrocene Fulltext Access 13 Pages 2006
6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: Reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity Fulltext Access 13 Pages 2006
Methods and biomarkers for the diagnosis and prognosis of cancer and other diseases: Towards personalized medicine Fulltext Access 13 Pages 2006
Patterns of tumor oxygenation and their influence on the cellular hypoxic response and hypoxia-directed therapies Fulltext Access 13 Pages 2006
Physical stability, centrifugation tests, and entrapment efficiency studies of carnauba wax–decyl oleate nanoparticles used for the dispersion of inorganic sunscreens in aqueous media Fulltext Access 13 Pages 2006
Quantitative measurements of localized density variations in cylindrical tablets using X-ray microtomography Fulltext Access 13 Pages 2006
Controlled release of cephalexin through gellan gum beads: Effect of formulation parameters on entrapment efficiency, size, and drug release Fulltext Access 13 Pages 2006
Further characterization of theobroma oil–beeswax admixtures as lipid matrices for improved drug delivery systems Fulltext Access 13 Pages 2006
Pulmonary administration of therapeutic proteins using an immunoglobulin transport pathway Fulltext Access 13 Pages 2006
Novel vitamin D3 antipsoriatic antedrugs: 16-En-22-oxa-1α,25-(OH)2D3 analogs Fulltext Access 13 Pages 2006
5-Alkylated thiazolidinones as follicle-stimulating hormone (FSH) receptor agonists Fulltext Access 13 Pages 2006
Glycosidation of lupane-type triterpenoids as potent in vitro cytotoxic agents Fulltext Access 13 Pages 2006
Synthesis and biological evaluation of benzopyran analogues bearing class III antiarrhythmic pharmacophores Fulltext Access 13 Pages 2006
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 6: Exploration of aromatic substituents Fulltext Access 13 Pages 2006
Discovery of diphenyl amine based sodium channel blockers, effective against hNav1.2 Fulltext Access 13 Pages 2006
Quantitative proteome analysis using D-labeled N-ethylmaleimide and 13C-labeled iodoacetanilide by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry Fulltext Access 13 Pages 2006
Novel platinum(II) and palladium(II) complexes with cyclin-dependent kinase inhibitors: Synthesis, characterization and antitumour activity Fulltext Access 13 Pages 2006
Synthesis and comparative molecular field analysis (CoMFA) of argentatin B derivatives as growth inhibitors of human cancer cell lines Fulltext Access 13 Pages 2006
Synthesis and cytotoxic activities of β-carboline amino acid ester conjugates Fulltext Access 13 Pages 2006
Identification of a buried pocket for potent and selective inhibition of Chk1: Prediction and verification Fulltext Access 13 Pages 2006
Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling Fulltext Access 13 Pages 2006
Synthesis and pharmacology of pyrido[2,3-d]pyrimidinediones bearing polar substituents as adenosine receptor antagonists Fulltext Access 13 Pages 2006
Synthesis and study of the cancer cell growth inhibitory properties of α-, γ-tocopheryl and γ-tocotrienyl 2-phenylselenyl succinates Fulltext Access 13 Pages 2006
3D-QSAR analysis of antimalarial farnesyltransferase inhibitors based on a 2,5-diaminobenzophenone scaffold Fulltext Access 13 Pages 2006
Glycosyldisulfides from dynamic combinatorial libraries as O-glycoside mimetics for plant and endogenous lectins: Their reactivities in solid-phase and cell assays and conformational analysis by molecular dynamics simulations Fulltext Access 13 Pages 2006
Identification of 4-amino-2-cyclohexylaminoquinazolines as metabolically stable melanin-concentrating hormone receptor 1 antagonists Fulltext Access 13 Pages 2006
Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity Fulltext Access 13 Pages 2006
Delivery of 2-5A cargo into living cells using the Tat cell penetrating peptide: 2-5A-tat Fulltext Access 13 Pages 2006
Activity-guided isolation of cytotoxic constituents from the bark of Aglaia crassinervia collected in Indonesia Fulltext Access 13 Pages 2006
Ligand design and synthesis of new imidazo[5,1-b]quinazoline derivatives as α1-adrenoceptor agonists and antagonists Fulltext Access 13 Pages 2006
A new structural theme in C2-symmetric HIV-1 protease inhibitors: ortho-Substituted P1/P1′ side chains Fulltext Access 13 Pages 2006
Synthesis and TNF-α inducing activities of mycoloyl-arabinan motif of mycobacterial cell wall components Fulltext Access 13 Pages 2006
Official USP Reference Standards: Metrology concepts, overview, and scientific issues and opportunities Fulltext Access 13 Pages 2006
Discovery of substituted 4-anilino-2-(2-pyridyl)pyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. Part 1: Structure–activity relationships of the 4-anilino group Fulltext Access 13 Pages 2006
Design, synthesis, and biological activity of N6-substituted-4′-thioadenosines at the human A3 adenosine receptor Fulltext Access 13 Pages 2006
Stochastic entropy QSAR for the in silico discovery of anticancer compounds: Prediction, synthesis, and in vitro assay of new purine carbanucleosides Fulltext Access 13 Pages 2006
Synthesis and evaluation of novel 8,5-fused bicyclic peptidomimetic compounds as interleukin-1β converting enzyme (ICE) inhibitors Fulltext Access 13 Pages 2006
Synthesis and evaluation of α-hydroxymethylated conjugated nitroalkenes for their anticancer activity: Inhibition of cell proliferation by targeting microtubules Fulltext Access 13 Pages 2006
Novel diphenyl ethers: Design, docking studies, synthesis and inhibition of enoyl ACP reductase of Plasmodium falciparum and Escherichia coli Fulltext Access 13 Pages 2006
Time-dependent inhibitors of trypanothione reductase: Analogues of the spermidine alkaloid lunarine and related natural products Fulltext Access 13 Pages 2006
Chemotactic peptides: fMLF-OMe analogues incorporating proline–methionine chimeras as N-terminal residue Fulltext Access 13 Pages 2006
Synthesis, X-ray crystal structural study, antiviral and cytostatic evaluations of the novel unsaturated acyclic and epoxide nucleoside analogues Fulltext Access 13 Pages 2006
Arylamine based cathepsin K inhibitors: Investigating P3 heterocyclic substituents Fulltext Access 13 Pages 2006
An unusual functional group interaction and its potential to reproduce steric and electrostatic features of the transition states of peptidolysis Fulltext Access 13 Pages 2006