Prediction of human drug clearance from animal data: Application of the rule of exponents and 'fu corrected intercept method' (FCIM) Fulltext Access 12 Pages 2006
Identification, Preparation, and Characterization of Several Polymorphs and Solvates of Terazosin Hydrochloride Fulltext Access 12 Pages 2006
Determination of solubility profiles of eflucimibe polymorphs: Experimental and modeling Fulltext Access 12 Pages 2006
Comparison between dehydration and desolvation kinetics of fluconazole monohydrate and fluconazole ethylacetate solvate using three different methods Fulltext Access 12 Pages 2006
Thermodynamic modeling of activity coefficient and prediction of solubility: Part 2. Semipredictive or semiempirical models Fulltext Access 12 Pages 2006
Catanionic mixtures involving a drug: A rather general concept that can be utilized for prolonged drug release from gels Fulltext Access 12 Pages 2006
Disassembly and reassembly of yeastâderived recombinant human papillomavirus virusâlike particles (HPV VLPs) Fulltext Access 12 Pages 2006
Towards an understanding of the molecular mechanism of solvation of drug molecules: A thermodynamic approach by crystal lattice energy, sublimation, and solubility exemplified by paracetamol, acetanilide, and phenacetin Fulltext Access 12 Pages 2006
Multiscale Modelling Methodology for Virtual Prototyping of Effervescent Tablets Fulltext Access 12 Pages 2006
Stability profiles of drug products extended beyond labeled expiration dates Fulltext Access 12 Pages 2006
Towards an Understanding of the Structurally Based Potential for Mechanically Activated Disordering of Small Molecule Organic Crystals Fulltext Access 12 Pages 2006
Novel Colon-Specific Microspheres With Highly Dispersed Hydroxycamptothecin Cores: Their Preparation, ReleaseBehavior, and Therapeutic Efficiency Against Colonic Cancer Fulltext Access 12 Pages 2006
Aluminum hydroxide adjuvant produced under constant reactant concentration Fulltext Access 12 Pages 2006
The Influence of Actuation Parameters on in Vitro Testing of Nasal Spray Products Fulltext Access 12 Pages 2006
Enhanced bioavailability of a new thiazolidine derivative FPFS-410, an antidiabetic and lipid-lowering drug, after oral administration of its hydroxypropyl-β-cyclodextrin complex to bile duct-cannulated rats Fulltext Access 12 Pages 2006
Sertaconazole/hydroxypropyl-β-cyclodextrin complexation: Isothermal titration calorimetry and solubility approaches Fulltext Access 12 Pages 2006
Grid-Based Molecular Modeling for Pharmaceutical Salt Screening: Case Example of 3,4,6,7,8,9-Hexahydro-2H-pyrimido (1,2-a) Pyrimidinium Acetate Fulltext Access 12 Pages 2006
Intraluminal drug and formulation behavior and integration in in vitro permeability estimation: A case study with amprenavir Fulltext Access 12 Pages 2006
Carrier-mediated hepatic uptake of a novel nonrenal excretion type uric acid generation inhibitor, Y-700 Fulltext Access 12 Pages 2006
Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin Fulltext Access 12 Pages 2006
Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants Fulltext Access 12 Pages 2006
Development, validation and utility of an in vitro technique for assessment of potential clinical drug–drug interactions involving P-glycoprotein Fulltext Access 12 Pages 2006
Can 29 kDa rhGM-CSF expressed by Silkworm pupae bioreactor bring into effect as active cytokine through orally administration? Fulltext Access 12 Pages 2006
Insulin encapsulation in reinforced alginate microspheres prepared by internal gelation Fulltext Access 12 Pages 2006
Towards a molecular characterization of pharmaceutical excipients: Mass spectrometric studies of ethoxylated surfactants Fulltext Access 12 Pages 2006
Rheological, adhesive and release characterisation of semisolid Carbopol/tetraglycol systems Fulltext Access 12 Pages 2006
Calorimetric investigation of protein/amino acid interactions in the solid state Fulltext Access 12 Pages 2006
Incorporation of a model protein into chitosan–bile salt microparticles Fulltext Access 12 Pages 2006
Influence of rheological behaviour of particulate/polymer dispersions on liquid-filling characteristics for hard gelatin capsules Fulltext Access 12 Pages 2006
Plasmid DNA and siRNA transfection of intestinal epithelial monolayers by electroporation Fulltext Access 12 Pages 2006
Controlled release of a self-emulsifying formulation from a tablet dosage form: Stability assessment and optimization of some processing parameters Fulltext Access 12 Pages 2006
Drug–polymer interactions and their effect on thermoresponsive poly(N-isopropylacrylamide) drug delivery systems Fulltext Access 12 Pages 2006
Dehydration of trehalose dihydrate at low relative humidity and ambient temperature Fulltext Access 12 Pages 2006
The potential inhibitory effect of antiparasitic drugs and natural products on P-glycoprotein mediated efflux Fulltext Access 12 Pages 2006
Characterising the size and shape of polyamidoamines in solution as a function of pH using neutron scattering and pulsed-gradient spin-echo NMR Fulltext Access 12 Pages 2006
A critical study of novel physically structured lipid matrices composed of a homolipid from Capra hircus and theobroma oil Fulltext Access 12 Pages 2006
An experimental/computational approach for examining unconfined cohesive powder flow Fulltext Access 12 Pages 2006
In situ coating—An approach for particle modification and encapsulation of proteins during spray-drying Fulltext Access 12 Pages 2006
Histopathology and histomorphometry of the urogenital tract in 15-month old male and female rats treated neonatally with SERMs and estrogens Fulltext Access 12 Pages 2006
A review of background findings in cynomolgus monkeys (Macaca fascicularis) from three different geographical origins Fulltext Access 12 Pages 2006
Anti-diabetic properties of the Canadian lowbush blueberry Vaccinium angustifolium Ait. Fulltext Access 12 Pages 2006
Inhibitory effects of aloe carboxypeptidase fraction on streptozotocin-induced enhancement of vascular permeability in the pancreatic islets Fulltext Access 12 Pages 2006
Evaluation of Ingredient Concentration in Powders Using Two-Speed Photon Migration Theory and Measurements Fulltext Access 12 Pages 2006
Solid state interactions between the proton pump inhibitor omeprazole and various enteric coating polymers Fulltext Access 12 Pages 2006
Stereoselective allyl transfer to chiral α-methoxycarbaldehydes: A model study related to the C-9/C-15 fragment of geldanamycin Fulltext Access 12 Pages 2006
Direct observation (NMR) of the efficacy of glucagon receptor antagonists in murine liver expressing the human glucagon receptor Fulltext Access 12 Pages 2006
Understanding the structure–activity and structure–selectivity correlation of cyclic guanine derivatives as phosphodiesterase-5 inhibitors by molecular docking, CoMFA and CoMSIA analyses Fulltext Access 12 Pages 2006
Synthesis and biological evaluation of new non-imidazole H3-receptor antagonists of the 2-aminobenzimidazole series Fulltext Access 12 Pages 2006
Structure–intrinsic activity relationship studies in the group of 1-imido/amido substituted 4-(4-arylpiperazin-1-yl)cyclohexane derivatives; new, potent 5-HT1A receptor agents with anxiolytic- like activity Fulltext Access 12 Pages 2006
Analogs of 1α,25-dihydroxyvitamin D3 with high potency in induction of osteoclastogenesis and prevention of dendritic cell differentiation: Synthesis and biological evaluation of 2-substituted 19-norvitamin D analogs Fulltext Access 12 Pages 2006
4,5-Diaryl-1H-pyrrole-2-carboxylates as combretastatin A-4/lamellarin T hybrids: Synthesis and evaluation as anti-mitotic and cytotoxic agents Fulltext Access 12 Pages 2006
Synthesis of 7-amino-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole derivatives displaying combined α2-adrenoceptor antagonistic and 5-HT reuptake inhibiting activities Fulltext Access 12 Pages 2006
Anti-inflammatory profile of some synthesized heterocyclic pyridone and pyridine derivatives fused with steroidal structure Fulltext Access 12 Pages 2006
Efficient approach to acyloxymethyl esters of nalidixic acid and in vitro evaluation as intra-ocular prodrugs Fulltext Access 12 Pages 2006
QSAR studies about cytotoxicity of benzophenazines with dual inhibition toward both topoisomerases I and II: 3D-MoRSE descriptors and statistical considerations about variable selection Fulltext Access 12 Pages 2006
Solid phase synthesis and antiprotozoal evaluation of di- and trisubstituted 5′-carboxamidoadenosine analogues Fulltext Access 12 Pages 2006
Targeting integrins: Insights into structure and activity of cyclic RGD pentapeptide mimics containing azabicycloalkane amino acids Fulltext Access 12 Pages 2006
Novel boronated derivatives of 5,10,15,20-tetraphenylporphyrin: Synthesis and toxicity for drug-resistant tumor cells Fulltext Access 12 Pages 2006
Synthesis and activity of a new class of pathway-selective estrogen receptor ligands: Hydroxybenzoyl-3,4-dihydroquinoxalin-2(1H)-ones Fulltext Access 12 Pages 2006
Synthesis and anticonvulsant activity of a class of 2-amino 3-hydroxypropanamide and 2-aminoacetamide derivatives Fulltext Access 12 Pages 2006
Drug Guru: A computer software program for drug design using medicinal chemistry rules Fulltext Access 12 Pages 2006
Development of new CoMFA and CoMSIA 3D-QSAR models for anti-inflammatory phthalimide-containing TNFα modulators Fulltext Access 12 Pages 2006
Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110α inhibitors Fulltext Access 12 Pages 2006
Design and synthesis of 3,4-methylenedioxy-6-nitrophenoxyacetylhydrazone derivatives obtained from natural safrole: New lead-agents with analgesic and antipyretic properties Fulltext Access 12 Pages 2006
Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs) Fulltext Access 12 Pages 2006
Synthesis, antimycobacterial and antitumor activities of new (1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)methyl N,N-disubstituted dithiocarbamate/O-alkyldithiocarbonate derivatives Fulltext Access 12 Pages 2006
Design, synthesis and molecular modeling study of iminodiacetyl monohydroxamic acid derivatives as MMP inhibitors Fulltext Access 12 Pages 2006
Contribution of solid-state properties to the aqueous solubility of drugs Fulltext Access 12 Pages 2006
Pharmacokinetics of DA-6034, an agent for inflammatory bowel disease, in rats and dogs: Contribution of intestinal first-pass effect to low bioavailability in rats Fulltext Access 12 Pages 2006
Solid-state chemistry and particle engineering with supercritical fluids in pharmaceutics Fulltext Access 12 Pages 2006
Design and evaluation of a water-soluble bioadhesive patch formulation for cutaneous delivery of 5-aminolevulinic acid to superficial neoplastic lesions Fulltext Access 12 Pages 2006
Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides Fulltext Access 12 Pages 2006
Discovery of heteroaryl sulfonamides as new EP1 receptor selective antagonists Fulltext Access 12 Pages 2006
Synthesis and biological activities of 7-aza rebeccamycin analogues bearing the sugar moiety on the nitrogen of the pyridine ring Fulltext Access 12 Pages 2006
Design, synthesis, and biological evaluation of (E)-3-(4-methanesulfonylphenyl)-2-(aryl)acrylic acids as dual inhibitors of cyclooxygenases and lipoxygenases Fulltext Access 12 Pages 2006
Synthesis of 15,20-triamide analogue with polar substituent on the phenyl ring of arenastatin A, an extremely potent cytotoxic spongean depsipeptide Fulltext Access 12 Pages 2006
Dicationic DNA-targeted antiprotozoal agents: Naphthalene replacement of benzimidazole Fulltext Access 12 Pages 2006
Synthesis of bicyclic molecular scaffolds (BTAa): An investigation towards new selective MMP-12 inhibitors Fulltext Access 12 Pages 2006
Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1H-indol-1-yl)-3-arylpropan-1-amines Fulltext Access 12 Pages 2006
Binding interaction of quercetin-3-β-galactoside and its synthetic derivatives with SARS-CoV 3CLpro: Structure–activity relationship studies reveal salient pharmacophore features Fulltext Access 12 Pages 2006
Two- and three-dimensional quantitative structure–activity relationships for a series of purine nucleoside phosphorylase inhibitors Fulltext Access 12 Pages 2006
Anti-tumor and proapoptotic effect of novel synthetic benzophenone analogues in Ehrlich ascites tumor cells Fulltext Access 12 Pages 2006
Synthesis and antiandrogenic activity of some new 3-substituted androstano[17,16-c]-5′-aryl-pyrazoline and their derivatives Fulltext Access 12 Pages 2006
Design, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives Fulltext Access 12 Pages 2006
Structure–activity relationship study of homoallylamines and related derivatives acting as antifungal agents Fulltext Access 12 Pages 2006