Cationic cage-like complexes formed by DC-cholesterol, Quil-A, and phospholipid Fulltext Access 14 Pages 2005
Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of βII tryptase Fulltext Access 14 Pages 2005
Synthesis and biological evaluation of new symmetrical derivatives as cytotoxic agents and apoptosis inducers Fulltext Access 14 Pages 2005
Pharmacodynamic interactions between recombinant mouse interleukinâ10 and prednisolone using a mouse endotoxemia model Fulltext Access 14 Pages 2005
Uniform Encapsulation of Stable Protein Nanoparticles Produced by Spray Freezing for the Reduction of Burst Release Fulltext Access 14 Pages 2005
Measurement of Process-Dependent Material Properties of Pharmaceutical Solids by Nanoindentation Fulltext Access 14 Pages 2005
Effect of the Covalent Modification with Poly(ethylene glycol) on α-Chymotrypsin Stability upon Encapsulation in Poly(lactic-co-glycolic) Microspheres Fulltext Access 14 Pages 2005
Multidisciplinary Investigation of Atypical Inclusion Complexes of β-Cyclodextrin and a Phospholipase-A2 Inhibitor Fulltext Access 14 Pages 2005
Structure/Function Relationships of Polyamidoamine/DNA Dendrimers as Gene Delivery Vehicles Fulltext Access 14 Pages 2005
Effects of Tween 20® and Tween 80® on the Stability of Albutropin During Agitation Fulltext Access 14 Pages 2005
Potent antitumor 9-anilinoacridines bearing an alkylating N-mustard residue on the anilino ring: synthesis and biological activity Fulltext Access 14 Pages 2005
Stabilization of human papillomavirus virus-like particles by non-ionic surfactants Fulltext Access 14 Pages 2005
Pharmaceutical Development of a Lyophilised Dosage Form for the Investigational Anticancer Agent Imexon Using Dimethyl Sulfoxide as Solubilising and Stabilising Agent Fulltext Access 14 Pages 2005
Immobilization of Ibuprofen and Copper-Ibuprofen Drugs on Layered Double Hydroxides Fulltext Access 14 Pages 2005
Prediction of Contact Angle for Pharmaceutical Solids from Their Molecular Structure Fulltext Access 14 Pages 2005
Influence of Asymmetric Donor-Receiver ion Concentration Upon Transscleral Iontophoretic Transport Fulltext Access 14 Pages 2005
Adaptogenic activity of glyco-peptido-lipid fraction from the alcoholic extract of Trichopus zeylanicus Gaerten (part II) Fulltext Access 14 Pages 2005
Simultaneous quantification of atomoxetine as well as its primary oxidative and O-glucuronide metabolites in human plasma and urine using liquid chromatography tandem mass spectrometry (LC/MS/MS) Fulltext Access 14 Pages 2005
Discovery of 1,7-cyclized indoles as a new class of potent and highly selective human β3-adrenergic receptor agonists with high cell permeability Fulltext Access 14 Pages 2005
Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues Fulltext Access 14 Pages 2005
Synthesis and pharmacological evaluation of side chain modified glutamic acid analogues of the neuroprotective agent glycyl-l-prolyl-l-glutamic acid (GPE) Fulltext Access 14 Pages 2005
Hantzsch 1,4-dihydropyridines containing a diazen-1-ium-1,2-diolate nitric oxide donor moiety to study calcium channel antagonist structure-activity relationships and nitric oxide release Fulltext Access 14 Pages 2005
Diphenylcyclohexylamine derivatives as new potent multidrug resistance (MDR) modulators Fulltext Access 14 Pages 2005
α-cycloalkyl-substituted Ï-keto-dicarboxylic acids as lipid regulating agents Fulltext Access 14 Pages 2005
Isocoumarins as estrogen receptor beta selective ligands: Isomers of isoflavone phytoestrogens and their metabolites Fulltext Access 14 Pages 2005
A new type of ketolides bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether synthesis and structure–activity relationships Fulltext Access 14 Pages 2005
Structure–affinity relationship studies of non-competitive NMDA receptor antagonists derived from dexoxadrol and etoxadrol Fulltext Access 14 Pages 2005
Mechanism and structure–activity relationships of norspermidine-based peptidic inhibitors of trypanothione reductase Fulltext Access 14 Pages 2005
Selective anti-tubercular purines: Synthesis and chemotherapeutic properties of 6-aryl- and 6-heteroaryl-9-benzylpurines Fulltext Access 14 Pages 2005
QSAR modeling of blood:air and tissue:air partition coefficients using theoretical descriptors Fulltext Access 14 Pages 2005
Terpene trilactones from Gingko biloba: From ancient times to the 21st century Fulltext Access 14 Pages 2005
Nuclear receptor antagonists designed based on the helix-folding inhibition hypothesis Fulltext Access 14 Pages 2005
Substrate specificity of the bovine serum amine oxidase and in situ characterisation of aminoaldehydes by NMR spectroscopy Fulltext Access 14 Pages 2005
1-Substituted pyrazolo[1,5-c]quinazolines as novel Gly/NMDA receptor antagonists: Synthesis, biological evaluation, and molecular modeling study Fulltext Access 14 Pages 2005
Insight into 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as peripheral benzodiazepine receptor ligands: Synthesis, biological evaluation and 3D-QSAR investigation Fulltext Access 14 Pages 2005
Synthesis and pharmacological evaluation of benzamide derivatives as selective 5-HT4 receptor agonists Fulltext Access 14 Pages 2005
Synthesis of potent and selective inhibitors of Candida albicans N-myristoyltransferase based on the benzothiazole structure Fulltext Access 14 Pages 2005
Synthesis and inhibitory activity of benzoic acid and pyridine derivatives on influenza neuraminidase Fulltext Access 14 Pages 2005
Lysine–spermine conjugates: hydrophobic polyamine amides as potent lipopolysaccharide sequestrants Fulltext Access 14 Pages 2005
Quil A-lipid powder formulations releasing ISCOMs and related colloidal stuctures upon hydration Fulltext Access 15 Pages 2005
Physico-chemical characterization of polysaccharide-coated nanoparticles Fulltext Access 15 Pages 2005
In vivo release of plasmid DNA from composites of oligo(poly(ethylene glycol)fumarate) and cationized gelatin microspheres Fulltext Access 15 Pages 2005
In vitro controlled release of vinpocetine-cyclodextrin-tartaric acid multicomponent complexes from HPMC swellable tablets Fulltext Access 15 Pages 2005
Protection of oligonucleotides against nucleases by pegylated and non-pegylated liposomes as studied by fluorescence correlation spectroscopy Fulltext Access 15 Pages 2005
The influence of protein solubilisation, conformation and size on the burst release from poly(lactide-co-glycolide) microspheres Fulltext Access 15 Pages 2005
Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides Fulltext Access 15 Pages 2005
Synthesis and pharmacological evaluation of 4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide and N-(2-cyanomethylsulfonylphenyl)acylamide derivatives as potential activators of ATP sensitive potassium channels Fulltext Access 15 Pages 2005
Anticancer therapeutics: “Addictive” targets, multi-targeted drugs, new drug combinations Fulltext Access 15 Pages 2005
Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridin-(5H)ones Fulltext Access 15 Pages 2005
Discovery of an N-(2-aminopyridin-4-ylmethyl)nicotinamide derivative: a potent and orally bioavailable NCX inhibitor Fulltext Access 15 Pages 2005
New approaches to reverse resistance to hormonal therapy in human breast cancer Fulltext Access 15 Pages 2005
Controlling release from the lipidic cubic phase. Amino acids, peptides, proteins and nucleic acids Fulltext Access 15 Pages 2005
Polyplex Nanogel formulations for drug delivery of cytotoxic nucleoside analogs Fulltext Access 15 Pages 2005
Galactosylated ternary DNA/polyphosphoramidate nanoparticles mediate high gene transfection efficiency in hepatocytes Fulltext Access 15 Pages 2005
Saturated phospholipids promote crystallization but slow down polymorphic transitions in triglyceride nanoparticles Fulltext Access 15 Pages 2005
Enhancement of T helper type 1 immune responses against hepatitis B virus core antigen by PLGA nanoparticle vaccine delivery Fulltext Access 15 Pages 2005
N-Acyl-N-alkyl-sulfonamide anchors derived from Kenner's safety-catch linker: powerful tools in bioorganic and medicinal chemistry Fulltext Access 15 Pages 2005
Copolymers of poly-l-lysine with serine and tryptophan form stable DNA vectors: implications for receptor-mediated gene transfer Fulltext Access 15 Pages 2005
Advanced microscopy solutions for monitoring the kinetics and dynamics of drug-DNA targeting in living cells Fulltext Access 15 Pages 2005
Gentamicin-loaded discs and microspheres and their modifications: characterization and in vitro release Fulltext Access 15 Pages 2005
Fluorescence microscopy to follow the targeting of liposomes and micelles to cells and their intracellular fate Fulltext Access 15 Pages 2005
Biodegradable microspheres alone do not stimulate murine macrophages in vitro, but prolong antigen presentation by macrophages in vitro and stimulate a solid immune response in mice Fulltext Access 15 Pages 2005
Two novel series of allocolchicinoids with modified seven membered B-rings: design, synthesis, inhibition of tubulin assembly and cytotoxicity Fulltext Access 15 Pages 2005
A physically interpretable quantum-theoretic QSAR for some carbonic anhydrase inhibitors with diverse aromatic rings, obtained by a new QSAR procedure Fulltext Access 15 Pages 2005
2,9-Disubstituted-N6-(arylcarbamoyl)-8-azaadenines as new selective A3 adenosine receptor antagonists: Synthesis, biochemical and molecular modelling studies Fulltext Access 15 Pages 2005
Novel 3-amino-2-hydroxy acids containing protease inhibitors. Part 1: Synthesis and kinetic characterization as aminopeptidase P inhibitors Fulltext Access 15 Pages 2005
A novel class of sodium/calcium exchanger inhibitor: design, synthesis, and structure–activity relationships of 3,4-dihydro-2(1H)-quinazolinone derivatives Fulltext Access 15 Pages 2005
Synthesis, solution structure, and bioactivity of six new simplified analogues of the natural cyclodepsipeptide jaspamide Fulltext Access 15 Pages 2005
C3′-cis-Substituted carboxycyclopropyl glycines as metabotropic glutamate 2/3 receptor agonists: Synthesis and SAR studies Fulltext Access 15 Pages 2005
An overview of the recent developments in analytical methodologies for determination of COX-2 inhibitors in bulk drugs, pharmaceuticals and biological matrices Fulltext Access 15 Pages 2005
Structure-activity relationships of novel P2-receptor antagonists structurally related to Reactive Blue 2 Fulltext Access 15 Pages 2005
Protease-mediated enzymatic hydrolysis and activation of aryl phosphoramidate derivatives of stavudine Fulltext Access 15 Pages 2005
Stereoselective synthesis of E-64 and related cysteine proteases inhibitors from 2,3-epoxyamides Fulltext Access 15 Pages 2005
Stability of bovine serum albumin complexed with PEG-poly(l-histidine) diblock copolymer in PLGA microspheres Fulltext Access 15 Pages 2005
Deoxycholic acid-conjugated chitosan oligosaccharide nanoparticles for efficient gene carrier Fulltext Access 15 Pages 2005
The design and evaluation of a novel targeted drug delivery system using cationic emulsion-antibody conjugates Fulltext Access 15 Pages 2005
Combined application of saponin and chimeric toxins drastically enhances the targeted cytotoxicity on tumor cells Fulltext Access 15 Pages 2005
Dual growth factor delivery from degradable oligo(poly(ethylene glycol) fumarate) hydrogel scaffolds for cartilage tissue engineering Fulltext Access 15 Pages 2005
Rituximab-mediated chemosensitization of AIDS and non-AIDS non-Hodgkin's Lymphoma Fulltext Access 15 Pages 2005
Molecular modeling, design, synthesis, and biological evaluation of novel 3′,4′-dicamphanoyl-(+)-cis-khellactone (DCK) analogs as potent anti-HIV agents Fulltext Access 15 Pages 2005
Structure–activity relationships and molecular modelling of 5-arylidene-2,4-thiazolidinediones active as aldose reductase inhibitors Fulltext Access 15 Pages 2005
Concise syntheses of arabinogalactans with β-(1â6)-linked galactopyranose backbones and α-(1â3)- and α-(1â2)-linked arabinofuranose side chains Fulltext Access 15 Pages 2005
Structure activity studies of the serine-AIB dipeptide domain in 2,3-dihydroisothiazole based growth hormone secretagogues Fulltext Access 15 Pages 2005