Controlled-release matrix tablets of ibuprofen using cellulose ethers and carrageenans: effect of formulation factors on dissolution rates Fulltext Access 13 Pages 2005
Multicomponent complex formation between vinpocetine, cyclodextrins, tartaric acid and water-soluble polymers monitored by NMR and solubility studies Fulltext Access 13 Pages 2005
Tissue distribution, pharmacokinetics and identification of roscovitine metabolites in rat Fulltext Access 13 Pages 2005
Biodistribution of 68Ga-labelled phosphodiester, phosphorothioate, and 2â²-O-methyl phosphodiester oligonucleotides in normal rats Fulltext Access 13 Pages 2005
Properties of hot-melt extruded tablet formulations for the colonic delivery of 5-aminosalicylic acid Fulltext Access 13 Pages 2005
The difficulty in the assessment of the compression behaviour of powder mixtures: Double layer tablets versus arithmetic additivity rule Fulltext Access 13 Pages 2005
Human respiratory epithelial cell culture for drug delivery applications Fulltext Access 13 Pages 2005
Transdermal iontophoresis: combination strategies to improve transdermal iontophoretic drug delivery Fulltext Access 13 Pages 2005
Disposition study of a new potential antineoplastic agent dimefluron in rats using high-performance liquid chromatography with ultraviolet and mass spectrometric detection Fulltext Access 13 Pages 2005
Poly (lactide-co-glycolide) particles of different physicochemical properties and their uptake by peyer's patches in mice Fulltext Access 13 Pages 2005
The characterization of aprotic polar liquids and percolation phenomena in DMSO/water mixtures Fulltext Access 13 Pages 2005
The influence of measurement conditions on the Hammett acidity function of solid pharmaceutical excipients Fulltext Access 13 Pages 2005
Local, non-viral IL-12 gene therapy using a water soluble lipopolymer as carrier system combined with systemic paclitaxel for cancer treatment Fulltext Access 13 Pages 2005
The role of branched polyesters and their modifications in the development of modern drug delivery vehicles Fulltext Access 13 Pages 2005
Polymeric gene carrier for insulin secreting cells: Poly(l-lysine)-g-sulfonylurea for receptor mediated transfection Fulltext Access 13 Pages 2005
Galactosylated polyethylenimine-graft-poly(vinyl pyrrolidone) as a hepatocyte-targeting gene carrier Fulltext Access 13 Pages 2005
Evaluation of cell penetrating peptides fused to elastin-like polypeptide for drug delivery Fulltext Access 13 Pages 2005
Mesoporous silicon microparticles for oral drug delivery: Loading and release of five model drugs Fulltext Access 13 Pages 2005
Construction and characterization of a t-PA mutant for use in ATTEMPTS: A drug delivery system for achieving targeted thrombolysis Fulltext Access 13 Pages 2005
FRET-FCS as a tool to evaluate the stability of oligonucleotide drugs after intracellular delivery Fulltext Access 13 Pages 2005
Long-circulating DNA-complexed biodegradable multiblock copolymers for gene delivery: degradation profiles and evidence of dysopsonization Fulltext Access 13 Pages 2005
Oligonucleotide-protamine-albumin nanoparticles: preparation, physical properties, and intracellular distribution Fulltext Access 13 Pages 2005
Preparation of uniform-sized PLA microcapsules by combining Shirasu Porous Glass membrane emulsification technique and multiple emulsion-solvent evaporation method Fulltext Access 13 Pages 2005
In vivo anti-tumor effect of dual release of cisplatin and adriamycin from biodegradable gelatin hydrogel Fulltext Access 13 Pages 2005
Ketoprofen controlled release from composite microcapsules for cell encapsulation: Effect on post-transplant acute inflammation Fulltext Access 13 Pages 2005
Amphiphilic conetworks as regenerative controlled releasing antimicrobial coatings Fulltext Access 13 Pages 2005
Thermosensitive and biodegradable polymeric micelles for paclitaxel delivery Fulltext Access 13 Pages 2005
TP10, a delivery vector for decoy oligonucleotides targeting the Myc protein Fulltext Access 13 Pages 2005
Enhancement of skin permeation of ketotifen by supersaturation generated by amorphous form of the drug Fulltext Access 13 Pages 2005
Lipid nanoparticles for skin penetration enhancement-correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy Fulltext Access 13 Pages 2005
Antitumor activity of poly(ethylene glycol)-camptothecin conjugate: The inhibition of tumor growth in vivo Fulltext Access 13 Pages 2005
Synthesis and receptor assay of aromatic-ethynyl-aromatic derivatives with potent mGluR5 antagonist activity Fulltext Access 13 Pages 2005
Exploring the active site of phenylethanolamine N-methyltransferase: 3-alkyl-7-substituted-1,2,3,4-tetrahydroisoquinoline inhibitors Fulltext Access 13 Pages 2005
Part 3: Synthesis and biological evaluation of some analogs of the antitumor agents, 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid, and 2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy}propionic acid Fulltext Access 13 Pages 2005
Studies of non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: Synthesis and structure-activity relationships of 2-cyano and 2-hydroxy thiazolidenebenzenesulfonamide derivatives Fulltext Access 13 Pages 2005
Synthesis, structure-activity relationship, and p210bcr-abl protein tyrosine kinase activity of novel AG 957 analogs Fulltext Access 13 Pages 2005
Synthesis and biological evaluation of lipophilic Ca1a2L analogues as potential bisubstrate inhibitors of protein:geranylgeranyl transferase-1 Fulltext Access 13 Pages 2005
Synthesis and biological activity of sulphostin analogues, novel dipeptidyl peptidase IV inhibitors Fulltext Access 13 Pages 2005
Stereochemical determination and bioactivity assessment of (S)-(+)-curcuphenol dimers isolated from the marine sponge Didiscus aceratus and synthesized through laccase biocatalysis Fulltext Access 13 Pages 2005
Oxathiolene oxide synthesis via chelation-controlled addition of organometallic reagents to alkynols followed by addition of sulfur electrophiles and evaluation of oxathiolene oxides as anticarcinogenic enzyme inducers Fulltext Access 13 Pages 2005
5-Alkyl-2-alkylamino-6-(2,6-difluorophenylalkyl)-3,4-dihydropyrimidin-4(3H)-ones, a new series of potent, broad-spectrum non-nucleoside reverse transcriptase inhibitors belonging to the DABO family Fulltext Access 13 Pages 2005
Protein linear indices of the ‘macromolecular pseudograph α-carbon atom adjacency matrix’ in bioinformatics. Part 1: Prediction of protein stability effects of a complete set of alanine substitutions in Arc repressor Fulltext Access 13 Pages 2005
Systematic synthesis of galloyl-substituted procyanidin B1 and B2, and their ability of DPPH radical scavenging activity and inhibitory activity of DNA polymerases Fulltext Access 13 Pages 2005
Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase Fulltext Access 13 Pages 2005
QSAR study for a novel series of ortho monosubstituted phenoxy analogues of α1-adrenoceptor antagonist WB4101 Fulltext Access 13 Pages 2005
Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives Fulltext Access 13 Pages 2005
Indolizine 1-sulfonates as potent inhibitors of 15-lipoxygenase from soybeans Fulltext Access 13 Pages 2005
Connecting traditional QSAR and molecular simulations of papain hydrolysis—importance of charge transfer Fulltext Access 13 Pages 2005
Design and synthesis of subtype-selective cyclooxygenase (COX) inhibitors derived from thalidomide Fulltext Access 13 Pages 2005
Protonated structures of naturally occurring deoxyribonucleic acids and their interaction with berberine Fulltext Access 13 Pages 2005
Antimycobacterial activity of new 3-substituted 5-(pyridin-4-yl)-3H-1,3,4-oxadiazol-2-one and 2-thione derivatives. Preliminary molecular modeling investigations Fulltext Access 13 Pages 2005
Design and synthesis of complementing ligands for mutant thyroid hormone receptor TRβ(R320H): a tailor-made approach toward the treatment of resistance to thyroid hormone Fulltext Access 13 Pages 2005
4-Alkyliden-β-lactams conjugated to polyphenols: Synthesis and inhibitory activity Fulltext Access 13 Pages 2005
Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α,β-unsaturated esters Fulltext Access 13 Pages 2005
DFT-based ranking of zinc-binding groups in histone deacetylase inhibitors Fulltext Access 13 Pages 2005
Core-modified porphyrins. Part 5: Electronic effects on photophysical and biological properties in vitro Fulltext Access 13 Pages 2005
The synthesis and evaluation of 10- and 12-membered ring benzofused enediyne amino acids Fulltext Access 13 Pages 2005
Indolyl esters and amides related to indomethacin are selective COX-2 inhibitors Fulltext Access 13 Pages 2005
Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[i]phenanthridine-12-carboxylic acid: Potent cytotoxic and topoisomerase I-targeting agents Fulltext Access 13 Pages 2005
Nitroarylmethylcarbamate prodrugs of doxorubicin for use with nitroreductase gene-directed enzyme prodrug therapy Fulltext Access 13 Pages 2005
A-ring hydroxymethyl 19-nor analogs of the natural hormone 1α,25-dihydroxyvitamin D3: synthesis and preliminary biological evaluation Fulltext Access 13 Pages 2005
Epithelial and inflammatory responses in the airways of laboratory rats coexposed to ozone and biogenic substances: Enhancement of toxicant-induced airway injury Fulltext Access 13 Pages 2005
A versatile family of degradable non-viral gene carriers based on hyperbranched poly(ester amine)s Fulltext Access 13 Pages 2005
In vivo tumor transfection mediated by polyplexes based on biodegradable poly(DMAEA)-phosphazene Fulltext Access 13 Pages 2005
AIDS vaccine: Intranasal immunization using inactivated HIV-1-capturing core-corona type polymeric nanospheres Fulltext Access 13 Pages 2005
Comparison of novel delivery systems for antisense peptide nucleic acids Fulltext Access 13 Pages 2005
Synthesis, molecular structure, and in vitro antitumor activity of new 4-chloro-2-mercaptobenzenesulfonamide derivatives Fulltext Access 13 Pages 2005
Synthesis, dopamine D2 receptor binding studies and docking analysis of 5-[3-(4-arylpiperazin-1-yl)propyl]-1H-benzimidazole, 5-[2-(4-arylpiperazin-1-yl)ethoxy]-1H-benzimidazole and their analogs Fulltext Access 13 Pages 2005
Aromatic-aromatic and proline-aromatic interactions in endomorphin-1 and endomorphin-2 Fulltext Access 13 Pages 2005
Molecular design, synthesis, and hypoglycemic and hypolipidemic activities of novel pyrimidine derivatives having thiazolidinedione Fulltext Access 13 Pages 2005
Analysis of low level radioactive metabolites in biological fluids using high-performance liquid chromatography with microplate scintillation counting: Method validation and application Fulltext Access 13 Pages 2005
Classification of drugs in absorption classes using the classification and regression trees (CART) methodology Fulltext Access 13 Pages 2005
New 3- and 4-hydroxyfuranones as anti-oxidants and anti-inflammatory agents Fulltext Access 13 Pages 2005
Differential immunoexpressions of cytoskeletons in renal epithelial and interstitial cells in rat and canine fibrotic kidneys, and in kidney-related cell lines under fibrogenic stimuli Fulltext Access 13 Pages 2005
Standardized assessment of cell proliferation: The approach of the RITA-CEPA working group Fulltext Access 13 Pages 2005
Effects of sucrose and mannitol on asparagine deamidation rates of model peptides in solution and in the solid state Fulltext Access 13 Pages 2005
Kinetics and Mechanism of the Reaction of Cysteine and Hydrogen Peroxide in Aqueous Solution Fulltext Access 13 Pages 2005
Glass Transition-Related Changes in Molecular Mobility below Glass Transition Temperature of Freeze-Dried Formulations, as Measured by Dielectric Spectroscopy and Solid State Nuclear Magnetic Resonance Fulltext Access 13 Pages 2005
Biosensor Analysis of the Interaction between Drug Compounds and Liposomes of Different Properties; a Two-Dimensional Characterization Tool for Estimation of Membrane Absorption Fulltext Access 13 Pages 2005
L'assistance circulatoire : de l'attente de récupération ou de transplantation à l'implantation définitive Fulltext Access 13 Pages 2005