Co-administration with simvastatin or lovastatin alters the pharmacokinetic profile of sinomenine in rats through cytochrome P450-mediated pathways Fulltext Access 8 Pages 2018
Liver nitrosation and inflammation in septic rats were suppressed by propofol via downregulating TLR4/NF-κB-mediated iNOS and IL-6 gene expressions Fulltext Access 8 Pages 2018
Cathepsin B inhibition attenuates cardiovascular pathology in mucopolysaccharidosis I mice Fulltext Access 8 Pages 2018
LncRNA FAL1 promotes cell proliferation and migration by acting as a CeRNA of miR-1236 in hepatocellular carcinoma cells Fulltext Access 8 Pages 2018
Assessment of the TRPM8 inhibitor AMTB in breast cancer cells and its identification as an inhibitor of voltage gated sodium channels Fulltext Access 8 Pages 2018
The possible neuroprotective effect of ellagic acid on sodium arsenate-induced neurotoxicity in rats Fulltext Access 8 Pages 2018
N-Acetyl-l-Cysteine treatment efficiently prevented pre-diabetes and inflamed-dysmetabolic liver development in hypothalamic obese rats Fulltext Access 8 Pages 2018
Long term treadmill exercise performed to chronic social isolated rats regulate anxiety behavior without improving learning Fulltext Access 8 Pages 2018
The antidepressant effects of rosiglitazone on rats with depression induced by neuropathic pain Fulltext Access 8 Pages 2018
O-linked N-acetyl-glucosamine deposition in placental proteins varies according to maternal glycemic levels Fulltext Access 8 Pages 2018
Perilla aldehyde attenuates CUMS-induced depressive-like behaviors via regulating TXNIP/TRX/NLRP3 pathway in rats Fulltext Access 8 Pages 2018
α-Lipoic acid inhibits the migration and invasion of breast cancer cells through inhibition of TGFβ signaling Fulltext Access 8 Pages 2018
Luteolin induces caspase-dependent apoptosis via inhibiting the AKT/osteopontin pathway in human hepatocellular carcinoma SK-Hep-1 cells Fulltext Access 8 Pages 2018
Decreased CD122 on CD56dim NK associated with its impairment in asymptomatic chronic HBV carriers with high levels of HBV DNA, HBsAg and HBeAg Fulltext Access 8 Pages 2018
Tumor necrosis factor-alpha suppresses the invasion of HTR-8/SVneo trophoblast cells through microRNA-145-5p-mediated downregulation of Cyr61 Fulltext Access 8 Pages 2018
Taxifolin suppresses rat and human testicular androgen biosynthetic enzymes Fulltext Access 8 Pages 2018
Prepubertal chrysin exposure upregulates either AR in male ventral prostate or AR and ERα in Skene's paraurethral gland of pubertal and adult gerbils Fulltext Access 8 Pages 2018
Miscellaneous lanostane triterpenoids with cytotoxicities from fruiting bodies of the basidiomycete Stereum sp. Fulltext Access 8 Pages 2018
Improving anti-trypanosomal activity of alkamides isolated from Achillea fragrantissima Fulltext Access 8 Pages 2018
Isolation and identification of a tribenzylisoquinoline alkaloid from Nelumbo nucifera Gaertn, a novel potential smooth muscle relaxant Fulltext Access 8 Pages 2018
Two new bis-iridoids isolated from Scabiosa stellata and their antibacterial, antioxidant, anti-tyrosinase and cytotoxic activities Fulltext Access 8 Pages 2018
New diterpenes from Salvia pseudorosmarinus and their activity as inhibitors of monoacylglycerol lipase (MAGL) Fulltext Access 8 Pages 2018
Potential therapeutic role of Co-Q10 in alleviating intervertebral disc degeneration and suppressing IL-1β-mediated inflammatory reaction in NP cells Fulltext Access 8 Pages 2018
miR-181a regulates Th17 cells distribution via up-regulated BCL-2 in primary biliary cholangitis Fulltext Access 8 Pages 2018
21âBenzylidene digoxin, a novel digoxin hemi-synthetic derivative, presents an anti-inflammatory activity through inhibition of edema, tumour necrosis factor alpha production, inducible nitric oxide synthase expression and leucocyte migration Fulltext Access 8 Pages 2018
Naringin protects against perfluorooctane sulfonate-induced liver injury by modulating NRF2 and NF-κB in mice Fulltext Access 8 Pages 2018
(E)âphenethyl 3â(3,5âdihydroxyâ4âisopropylphenyl) acrylate gel improves DNFB-induced allergic contact hypersensitivity via regulating the balance of Th1/Th2/Th17/Treg cell subsets Fulltext Access 8 Pages 2018
ONO-5046 suppresses reactive oxidative species-associated formation of neutrophil extracellular traps Fulltext Access 8 Pages 2018
Agomelatine-induced modulation of brain-derived neurotrophic factor (BDNF) in the rat hippocampus Fulltext Access 8 Pages 2018
Oral administration of vitamin D and importance in prevention of cerebral malaria Fulltext Access 8 Pages 2018
Isofraxidin inhibits interleukin-1β induced inflammatory response in human osteoarthritis chondrocytes Fulltext Access 8 Pages 2018
Baicalin exerts neuroprotective effects via inhibiting activation of GSK3β/NF-κB/NLRP3 signal pathway in a rat model of depression Fulltext Access 8 Pages 2018
Synthesis and characterization of zinc oxide nanoparticles using tuber extract of anchote (Coccinia abyssinica (Lam.) Cong.) for antimicrobial and antioxidant activity assessment Fulltext Access 8 Pages 2018
Neo-clerodane and abietane diterpenoids with neurotrophic activities from the aerial parts of Salvia leucantha Cav. Fulltext Access 8 Pages 2018
Polyketide derivatives from the sponge associated fungus Aspergillus europaeus with antioxidant and NO inhibitory activities Fulltext Access 8 Pages 2018
Effects of Antarctic krill docosahexaenoic acid on MCF-7 cell migration and invasion induced by the interaction of CD95 with caveolin-1 Fulltext Access 8 Pages 2018
Lycium barbarum polysaccharides improve CCl4-induced liver fibrosis, inflammatory response and TLRs/NF-kB signaling pathway expression in wistar rats Fulltext Access 8 Pages 2018
Effect of the FE2Â + chelation by 2,2â²-dipyridyl in the doxorubicin-induced lethality in breast tumor cell lines Fulltext Access 8 Pages 2018
Splenectomy after partial hepatectomy accelerates liver regeneration in mice by promoting tight junction formation via polarity protein Par 3-aPKC Fulltext Access 8 Pages 2018
Mechanisms of l-alpha-lysophosphatidylinositol-induced relaxation in human pulmonary arteries Fulltext Access 8 Pages 2018
CRISPR-mediated deletion of the PECAM-1 cytoplasmic domain increases receptor lateral mobility and strengthens endothelial cell junctional integrity Fulltext Access 8 Pages 2018
Activation of the capsaicin-receptor TRPV1 by the acetaminophen metabolite N-arachidonoylaminophenol results in cytotoxicity Fulltext Access 8 Pages 2018
Characterization of the binding site for d-deprenyl in human inflamed synovial membrane Fulltext Access 8 Pages 2018
Independent roles of CGRP in cardioprotection and hemodynamic regulation in ischemic postconditioning Fulltext Access 8 Pages 2018
Ameliorative effect of panaxynol on the reduction in high-molecular-weight adiponectin secretion from 3T3-L1 adipocytes treated with palmitic acids Fulltext Access 8 Pages 2018
Statins reduce the expressions of Tim-3 on NK cells and NKT cells in atherosclerosis Fulltext Access 8 Pages 2018
Direct modification of the 5-HT3 receptor current by some anticancer drugs Fulltext Access 8 Pages 2018
Pirfenidone prevents radiation-induced intestinal fibrosis in rats by inhibiting fibroblast proliferation and differentiation and suppressing the TGF-β1/Smad/CTGF signaling pathway Fulltext Access 8 Pages 2018
Dual inhibition of HY023016 based on binding properties of platelet membrane receptor subunit glycoprotein Ibα and thrombin exosites Fulltext Access 8 Pages 2018
Involvement of the N/OFQ-NOP system in rat morphine antinociceptive tolerance: Are astrocytes the crossroad? Fulltext Access 8 Pages 2018
Metabotropic glutamate 7 receptor agonist AMN082 inhibits glutamate release in rat cerebral cortex nerve terminal Fulltext Access 8 Pages 2018
Berberine attenuates podocytes injury caused by exosomes derived from high glucose-induced mesangial cells through TGFβ1-PI3K/AKT pathway Fulltext Access 8 Pages 2018
SP600125 blocks the proteolysis of cytoskeletal proteins in apoptosis induced by gas signaling molecule (NO) via decreasing the activation of caspase-3 in rabbit chondrocytes Fulltext Access 8 Pages 2018
The HDAC1/c-JUN complex is essential in the promotion of nerve injury-induced neuropathic pain through JNK signaling Fulltext Access 8 Pages 2018
Selectivity profiling of NOP, MOP, DOP and KOP receptor antagonists in the rat spinal nerve ligation model of mononeuropathic pain Fulltext Access 8 Pages 2018
Differential contribution of calcium channels to α1-adrenoceptor-mediated contraction is responsible for diverse responses to cooling between rat tail and iliac arteries Fulltext Access 8 Pages 2018
Pharmacological evidence that metformin blocks the vasopressor responses mediated by stimulation of α1- and α2-adrenoceptors in pithed rats Fulltext Access 8 Pages 2018
Treatment with D-β-hydroxybutyrate protects heart from ischemia/reperfusion injury in mice Fulltext Access 8 Pages 2018
Vascular and molecular pharmacology of the metabolically stable CGRP analogue, SAX Fulltext Access 8 Pages 2018
Prevention of progression of diabetic nephropathy by the SGLT2 inhibitor ipragliflozin in uninephrectomized type 2 diabetic mice Fulltext Access 8 Pages 2018
miR-182 enhances acute kidney injury by promoting apoptosis involving the targeting and regulation of TCF7L2/Wnt/β-catenins pathway Fulltext Access 8 Pages 2018
Investigation of association of chemical profiles with the tracheobronchial relaxant activity of Chinese medicinal herb Beimu derived from various Fritillaria species Fulltext Access 8 Pages 2018
Chemopreventive and remediation effect of Adansonia digitata L. Baobab (Bombacaceae) stem bark extracts in mouse model malaria Fulltext Access 8 Pages 2018
Anti-inflammatory effect of stem bark of Paulownia tomentosa Steud. in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and LPS-induced murine model of acute lung injury Fulltext Access 8 Pages 2018
Anti-sepsis protection of Xuebijing injection is mediated by differential regulation of pro- and anti-inflammatory Th17 and T regulatory cells in a murine model of polymicrobial sepsis Fulltext Access 8 Pages 2018
Anti-scorpion venom activity of Thapsia garganica methanolic extract: Histopathological and biochemical evidences Fulltext Access 8 Pages 2018
Leishmania mexicana cell death achieved by Cleoserrata serrata (Jacq.) Iltis: Learning from Maya healers Fulltext Access 8 Pages 2018
Evaluation of genotoxicity and subchronic toxicity of the standardized leaves infusion extract of Copaifera malmei Harms in experimental models Fulltext Access 8 Pages 2018
Antiprotozoan sesterterpenes and triterpenes isolated from two Ghanaian mushrooms Fulltext Access 8 Pages 2018
Antibacterial compounds from the Australian native plant Eremophila glabra Fulltext Access 8 Pages 2018
Anti-Helicobacter pylori metabolites from Heterotheca inuloides (Mexican arnica) Fulltext Access 8 Pages 2018
New cycloartane-type ester triterpenes from Euphorbia pterococca and biological evaluation Fulltext Access 8 Pages 2018
Antiadhesive hydroalcoholic extract from Apium graveolens fruits prevents bladder and kidney infection against uropathogenic E. coli Fulltext Access 8 Pages 2018
The influence of natural deep eutectic solvents on bioactive natural products: studying interactions between a hydrogel model and Schisandra chinensis metabolites Fulltext Access 8 Pages 2018
Jatrophanes as promising multidrug resistance modulators: Advances of structure-activity relationships Fulltext Access 8 Pages 2018
The influence of procyanidins isolated from small-leaved lime flowers (Tilia cordata Mill.) on human neutrophils Fulltext Access 8 Pages 2018
Dothiorelone derivatives from an endophyte Diaporthe pseudomangiferaea inhibit the activation of human lung fibroblasts MRC-5 cells Fulltext Access 8 Pages 2018
Antioxidant, anti-rheumatic and anti-inflammatory investigation of extract and dicentrinone from Duguetia furfuracea (A. St.-Hil.) Benth. & Hook. f. Fulltext Access 8 Pages 2018
Poly p-hydroxybenzyl substituted bibenzyls and phenanthrenes from Bletilla ochracea Schltr with anti-inflammatory and cytotoxic activity Fulltext Access 8 Pages 2018
Supplementation with resveratrol as Polygonum cuspidatum Sieb. et Zucc. extract induces changes in the excretion of urinary markers associated to aging in rats Fulltext Access 8 Pages 2018
Castalagin and vescalagin purified from leaves of Syzygium samarangense (Blume) Merrill & L.M. Perry: Dual inhibitory activity against PARP1 and DNA topoisomerase II Fulltext Access 8 Pages 2018
Alkaloids from Scindapsus officinalis (Roxb.) Schott. and their biological activities Fulltext Access 8 Pages 2018
Pro-apoptotic activity of new triterpenoid saponins from the roots of Albizia adianthifolia (Schumach.) W.Wight Fulltext Access 8 Pages 2018
Mechanism of sodium hydrosulfide modulation of L-type calcium channels in rat colonic smooth muscle cells Fulltext Access 8 Pages 2018
The cardioprotective effects of (-)-Epicatechin are mediated through arginase activity inhibition in a murine model of ischemia/reperfusion Fulltext Access 8 Pages 2018
Anti-aggregation effect of aroxyalkyl derivatives of 2-methoxyphenylpiperazine is due to their 5-HT2A and α2-adrenoceptor antagonistic properties. A comparison with ketanserin, sarpogrelate, prazosin, yohimbine and ARC239 Fulltext Access 8 Pages 2018
Non-adrenergic vasoconstriction and vasodilatation of guinea-pig aorta by β-phenylethylamine and amphetamine - Role of nitric oxide determined with L-NAME and NO scavengers Fulltext Access 8 Pages 2018
Role of β2- and β3-adrenoceptors in arterial stiffness in a state of hypertension Fulltext Access 8 Pages 2018
DT-13 synergistically potentiates the sensitivity of gastric cancer cells to topotecan via cell cycle arrest in vitro and in vivo Fulltext Access 8 Pages 2018