Identification of compounds with anti-human cytomegalovirus activity that inhibit production of IE2 proteins Fulltext Access 7 Pages 2017
An Open-label, Single-dose, Pharmacokinetic Study of Factor VIII Activity After Administration of Moroctocog Alfa (AF-CC) in Male Chinese Patients With Hemophilia A Fulltext Access 7 Pages 2017
Rivaroxaban in the Treatment of PICC-associated Upper Extremity Venous Thrombosis Fulltext Access 7 Pages 2017
From dioxin toxicity to putative physiologic functions of the human Ah receptor in homeostasis of stem/progenitor cells Fulltext Access 7 Pages 2017
Steroid receptor coactivators present a unique opportunity for drug development in hormone-dependent cancers Fulltext Access 7 Pages 2017
A high throughput assay to identify substrate-selective inhibitors of the ERK protein kinases Fulltext Access 7 Pages 2017
Porcine parvovirus capsid protein expressed in Escherichia coli self-assembles into virus-like particles with high immunogenicity in mice and guinea pigs Fulltext Access 7 Pages 2017
Profile of anti-herpetic action of ASP2151 (amenamevir) as a helicase-primase inhibitor Fulltext Access 7 Pages 2017
Extended substrate specificity and first potent irreversible inhibitor/activity-based probe design for Zika virus NS2B-NS3 protease Fulltext Access 7 Pages 2017
Tenofovir alafenamide demonstrates broad cross-genotype activity against wild-type HBV clinical isolates and maintains susceptibility to drug-resistant HBV isolates in vitro Fulltext Access 7 Pages 2017
A profiling study of a newly developed HCVcc strain PR63cc's sensitivity to direct-acting antivirals Fulltext Access 7 Pages 2017
Effects of ribavirin/sofosbuvir treatment and ITPA phenotype on endogenous purines Fulltext Access 7 Pages 2017
Bioequivalence Demonstration for Ω-3 Acid Ethyl Ester Formulations: Rationale for Modification of Current Guidance Fulltext Access 7 Pages 2017
Mcl-1 small-molecule inhibitors encapsulated into nanoparticles exhibit increased killing efficacy towards HCMV-infected monocytes Fulltext Access 7 Pages 2017
Antiviral response and resistance analysis of treatment-naïve HCV infected patients receiving multiple doses of the NS3 protease inhibitor GS-9256 Fulltext Access 7 Pages 2017
IFN-lambda preferably inhibits PEDV infection of porcine intestinal epithelial cells compared with IFN-alpha Fulltext Access 7 Pages 2017
Novel chimeric virus-like particles vaccine displaying MERS-CoV receptor-binding domain induce specific humoral and cellular immune response in mice Fulltext Access 7 Pages 2017
NK cell phenotypic and functional shifts coincide with specific clinical phases in the natural history of chronic HBV infection Fulltext Access 7 Pages 2017
Oxymatrine provides protection against Coxsackievirus B3-induced myocarditis in BALB/c mice Fulltext Access 7 Pages 2017
Phosphonoamidate prodrugs of C5-substituted pyrimidine acyclic nucleosides for antiviral therapy Fulltext Access 7 Pages 2017
Suramin inhibits Zika virus replication by interfering with virus attachment and release of infectious particles Fulltext Access 7 Pages 2017
Cryptoporic acid E from Cryptoporus volvatus inhibits influenza virus replication in vitro Fulltext Access 7 Pages 2017
Evolutionary trends of resistance mutational patterns of HBV reverse transcriptase over years (2002-2012) of different treatment regimens: The legacy of lamivudine/adefovir combination treatment Fulltext Access 7 Pages 2017
The MEK-inhibitor CI-1040 displays a broad anti-influenza virus activity in vitro and provides a prolonged treatment window compared to standard of care in vivo Fulltext Access 7 Pages 2017
The suppression of premature termination codons and the repair of splicing mutations in CFTR Fulltext Access 7 Pages 2017
The implications of CFTR structural studies for cystic fibrosis drug development Fulltext Access 7 Pages 2017
Bypassing CFTR dysfunction in cystic fibrosis with alternative pathways for anion transport Fulltext Access 7 Pages 2017
Use of Monte Carlo simulation and considerations for PK-PD targets to support antibacterial dose selection Fulltext Access 7 Pages 2017
Nutrition in the management of gastrointestinal diseases and disorders: the evidence for the low FODMAP diet Fulltext Access 7 Pages 2017
A new paradigm for GERD pathogenesis. Not acid injury, but cytokine-mediated inflammation driven by HIF-2α: a potential role for targeting HIF-2α to prevent and treat reflux esophagitis Fulltext Access 7 Pages 2017
Modulating bile acid pathways and TGR5 receptors for treating liver and GI diseases Fulltext Access 7 Pages 2017
Safety and Efficacy of Recombinant Human Parathyroid Hormone in Adults With Hypoparathyroidism Randomly Assigned to Receive Fixed 25-μg or 50-μg Daily Doses Fulltext Access 7 Pages 2017
A short cross-linker activates human P-glycoprotein missing a catalytic carboxylate Fulltext Access 7 Pages 2017
Immune responses in DAA treated chronic hepatitis C patients with and without prior RG-101 dosing Fulltext Access 7 Pages 2017
Higher levels of IL-6, CD4 turnover and Treg frequency are already present before cART in HIV-infected subjects with later low CD4 recovery Fulltext Access 7 Pages 2017
Palmatine inhibits TRIF-dependent NF-κB pathway against inflammation induced by LPS in goat endometrial epithelial cells Fulltext Access 7 Pages 2017
Characterization and structure-activity relationship of natural flavonoids as hERG K+ channel modulators Fulltext Access 7 Pages 2017
Tyrosine kinase inhibition is an important factor for gene expression of CRTH2 in human eosinophils and lymphocytes: A novel mechanism for explaining eosinophils recruitment by the neuro-immune axis in allergic rhinitis Fulltext Access 7 Pages 2017
Natural helper cells are associated with the exacerbated airway inflammation seen during RSV reinfection of neonatally primed mice Fulltext Access 7 Pages 2017
Neurobiological insights and novel therapeutic opportunities for CNS disorders from mGlu receptor allosteric and biased modulation Fulltext Access 7 Pages 2017
ACE and SGLT2 inhibitors: the future for non-diabetic and diabetic proteinuric renal disease Fulltext Access 7 Pages 2017
Buccal delivery of small molecules and biologics: of mucoadhesive polymers, films, and nanoparticles Fulltext Access 7 Pages 2017
Antibacterial drug development program successes and failures: a pharmacometric explanation Fulltext Access 7 Pages 2017
Treatment Outcomes in Infections Caused by “SPICE” (Serratia, Pseudomonas, Indole-positive Proteus, Citrobacter, and Enterobacter) Organisms: Carbapenem versus Noncarbapenem Regimens Fulltext Access 7 Pages 2017
Trypanosuppresive effects of ellagic acid and amelioration of the trypanosome-associated pathological features coupled with inhibitory effects on trypanosomal sialidase in vitro and in silico Fulltext Access 7 Pages 2017
Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson's disease: Involvement of PI3K/Akt and MEK/ERK signaling pathways Fulltext Access 7 Pages 2017
Salvianolic acid A inhibits calpain activation and eNOS uncoupling during focal cerebral ischemia in mice Fulltext Access 7 Pages 2017
Prophylactic topical paeoniflorin prevents mechanical allodynia caused by paclitaxel in mice through adenosine A1 receptors Fulltext Access 7 Pages 2017
Antibacterial activity of epigallocatechin-3-gallate (EGCG) and its synergism with β-lactam antibiotics sensitizing carbapenem-associated multidrug resistant clinical isolates of Acinetobacter baumannii Fulltext Access 7 Pages 2017
Erythro-austrobailignan-6 down-regulates HER2/EGFR/integrinβ3 expression via p38 activation in breast cancer Fulltext Access 7 Pages 2017
Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells Fulltext Access 7 Pages 2017
Antidiarrhoeal activity of eriosematin E isolated from the roots of Eriosema chinense Vogel Fulltext Access 7 Pages 2017
Effects of a standardised extract of Trifolium pratense (Promensil) at a dosage of 80 mg in the treatment of menopausal hot flushes: A systematic review and meta-analysis Fulltext Access 7 Pages 2017
Aphrodisiac activity of Phlegmariurus saururus in copulating and noncopulating male rats Fulltext Access 7 Pages 2017
Benzophenones and xanthone derivatives from Garcinia schomburgkiana-induced P-glycoprotein overexpression in human colorectal Caco-2 cells via oxidative stress-mediated mechanisms Fulltext Access 7 Pages 2017
Pharmacokinetic herb-drug interaction of Xuesaitong dispersible tablet and aspirin after oral administration in blood stasis model rats Fulltext Access 7 Pages 2017
Bioassay-guided fractionation of ethyl acetate extract from Armillaria mellea attenuates inflammatory response in lipopolysaccharide (LPS) stimulated BV-2 microglia Fulltext Access 7 Pages 2017
Berberine inhibits the proliferation and migration of breast cancer ZR-75-30 cells by targeting Ephrin-B2 Fulltext Access 7 Pages 2017
An alkaloid extract obtained from Phlegmariurus Saururus induces neuroprotection after status epilepticus Fulltext Access 7 Pages 2017
Cytotoxic activities of Telectadium dongnaiense and its constituents by inhibition of the Wnt/β-catenin signaling pathway Fulltext Access 7 Pages 2017
Neem (Azadirachta indica): An indian traditional panacea with modern molecular basis Fulltext Access 7 Pages 2017
Capillarisin attenuates exercise-induced muscle damage through MAPK and NF-κB signaling Fulltext Access 7 Pages 2017
Carica papaya ameliorates allergic asthma via down regulation of IL-4, IL-5, eotaxin, TNF-α, NF-ĸB, and iNOS levels Fulltext Access 7 Pages 2017
Hepatoprotective and hypoglycemic effects of a tannin rich extract from Ximenia americana var. caffra root Fulltext Access 7 Pages 2017
Hepatoprotective naphthalene diglucoside from Neanotis wightiana aerial parts Fulltext Access 7 Pages 2017
Anti-adipogenesis mechanism of pterostilbene through the activation of heme oxygenase-1 in 3T3-L1 cells Fulltext Access 7 Pages 2017
Cytotoxicity and mode of action of a naturally occurring naphthoquinone, 2-acetyl-7-methoxynaphtho[2,3-b]furan-4,9-quinone towards multi-factorial drug-resistant cancer cells Fulltext Access 7 Pages 2017
Angelica polysaccharides inhibit the growth and promote the apoptosis of U251 glioma cells in vitro and in vivo Fulltext Access 7 Pages 2017
Long-term feeding of red algae (Gelidium amansii) ameliorates glucose and lipid metabolism in a high fructose diet-impaired glucose tolerance rat model Fulltext Access 7 Pages 2017
Combined administration of synthetic RNA and a conventional vaccine improves immune responses and protection against foot-and-mouth disease virus in swine Fulltext Access 7 Pages 2017
1,2,3,4,6-Penta-O-galloyl-Ã-D-glucose, a bioactive compound in Elaeocarpus sylvestris extract, inhibits varicella-zoster virus replication Fulltext Access 7 Pages 2017
Antiviral activity of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones against chikungunya virus targeting the viral capping nsP1 Fulltext Access 7 Pages 2017
Role of hepatitis B core protein in HBV transcription and recruitment of histone acetyltransferases to cccDNA minichromosome Fulltext Access 7 Pages 2017
A pilot study to expand treatment of chronic hepatitis C in resource-limited settings Fulltext Access 7 Pages 2017
An RNA polymerase II-driven Ebola virus minigenome system as an advanced tool for antiviral drug screening Fulltext Access 7 Pages 2017
Immunogenicity of an influenza virus-vectored vaccine carrying the hepatitis C virus protein epitopes in mice Fulltext Access 7 Pages 2017
The cholesterol transport inhibitor U18666A inhibits type I feline coronavirus infection Fulltext Access 7 Pages 2017
The TOronto ThromboProphylaxis Patient Safety Initiative (TOPPS): A cluster randomised trial Fulltext Access 7 Pages 2017
Phenolic constituents of Pulicaria undulata (L.) C.A. Mey. sub sp. undulata (Asteraceae): Antioxidant protective effects and chemosystematic significances Fulltext Access 7 Pages 2017
An ecofriendly green liquid chromatographic method for simultaneous determination of nicotinamide and clindamycin phosphate in pharmaceutical gel for acne treatment Fulltext Access 7 Pages 2017
Identification and in silico characterization of a novel peptide inhibitor of angiotensin converting enzyme from pigeon pea (Cajanus cajan) Fulltext Access 7 Pages 2017
Morphological and chemical analyses of Eriocauli Flos sold in Taiwan markets Fulltext Access 7 Pages 2017
Factors predisposing nursing home resident to inappropriate transfer to emergency department. The FINE study protocol Fulltext Access 7 Pages 2017
AExaCTT - Aerobic Exercise and Consecutive Task-specific Training for the upper limb after stroke: Protocol for a randomised controlled pilot study Fulltext Access 7 Pages 2017
A cross-cutting approach to enhancing clinical trial site success: The Department of Veterans Affairs' Network of Dedicated Enrollment Sites (NODES) model Fulltext Access 7 Pages 2017
The Vitamin D for Enhancing the Immune System in Cystic Fibrosis (DISC) trial: Rationale and design of a multi-center, double-blind, placebo-controlled trial of high dose bolus administration of vitamin D3 during acute pulmonary exacerbation of cystic fib Fulltext Access 7 Pages 2017
Raising standards in clinical research - The impact of the ECRIN data centre certification programme, 2011-2016 Fulltext Access 7 Pages 2017
Personalized medicine enrichment design for DHA supplementation clinical trial Fulltext Access 7 Pages 2017
External data required timely response by the Trial Steering-Data Monitoring Committee for the NALoxone InVEstigation (N-ALIVE) pilot trial Fulltext Access 7 Pages 2017
An open-label cluster randomised trial to evaluate the effectiveness of a counselling intervention on linkage to care among HIV-infected patients in Uganda: Study design Fulltext Access 7 Pages 2017
Sponsorship, conflict of interest, risk of bias, and reporting of participant's flow and baseline demographic information in studies applicable to the federal law to post the results in clinicaltrials.gov Fulltext Access 7 Pages 2017
The dual trigger study: Rationale and study design of a prospective double-blind randomized clinical trial comparing pregnancy rates after co-administration of low dose hCG at the time of GnRH agonist trigger or 35Â h later for the prevention of OHSS Fulltext Access 7 Pages 2017