A novel GLP-1/GIP dual agonist is more effective than liraglutide in reducing inflammation and enhancing GDNF release in the MPTP mouse model of Parkinson's disease Fulltext Access 9 Pages 2017
Characterization of 6-methoxyflavanone as a novel anxiolytic agent: A behavioral and pharmacokinetic approach Fulltext Access 9 Pages 2017
The superoxide dismutase mimetic tempol blunts diabetes-induced upregulation of NADPH oxidase and endoplasmic reticulum stress in a rat model of diabetic nephropathy Fulltext Access 9 Pages 2017
A new benzenediamine derivative modulates Toll-like receptors-induced myeloid dendritic cells activation and ameliorates lupus-like syndrome in MRLlpr/lpr mice Fulltext Access 9 Pages 2017
Inhibition of agonist-induced smooth muscle contraction by picotamide in the male human lower urinary tract outflow region Fulltext Access 9 Pages 2017
Effects of the fibroblast activation protein inhibitor, PT100, in a murine model of pulmonary fibrosis Fulltext Access 9 Pages 2017
Targeting human telomerase RNA component using antisense oligonucleotide induces rapid cell death and increases ATO-induced apoptosis in APL cells Fulltext Access 9 Pages 2017
RP5063, a novel, multimodal, serotonin receptor modulator, prevents Sugen 5416-hypoxia-induced pulmonary arterial hypertension in rats Fulltext Access 9 Pages 2017
Efficacy of carbosilane dendrimers with an antiretroviral combination against HIV-1 in the presence of semen-derived enhancer of viral infection Fulltext Access 9 Pages 2017
Fucoxanthin inhibits profibrotic protein expression in vitro and attenuates bleomycin-induced lung fibrosis in vivo Fulltext Access 9 Pages 2017
Activation of CB2 receptor system restores cognitive capacity and hippocampal Sox2 expression in a transgenic mouse model of Alzheimer's disease Fulltext Access 9 Pages 2017
L-theanine prevent quinolinic acid induced motor deficit and striatal neurotoxicity: Reduction in oxido-nitrosative stress and restoration of striatal neurotransmitters level Fulltext Access 9 Pages 2017
Current pharmacological developments in 2,3,4â²,5-tetrahydroxystilbene 2-O-β-D-glucoside (TSG) Fulltext Access 9 Pages 2017
n-Propyl gallate suppresses lipopolysaccharide-induced inducible nitric oxide synthase activation through protein kinase Cδ-mediated up-regulation of heme oxygenase-1 in RAW264.7 macrophages Fulltext Access 9 Pages 2017
Neu-P11, a novel MT1/MT2 agonist, reverses diabetes by suppressing the hypothalamic-pituitary-adrenal axis in rats Fulltext Access 9 Pages 2017
Fumigaclavine C exhibits anti-inflammatory effects by suppressing high mobility group box protein 1 relocation and release Fulltext Access 9 Pages 2017
Ovatodiolide suppresses allergic airway inflammation and hyperresponsiveness in a murine model of asthma Fulltext Access 9 Pages 2017
SN003, a CRF1 receptor antagonist, attenuates depressive-like behavior and detrusor overactivity symptoms induced by 13-cis-retinoic acid in rats Fulltext Access 9 Pages 2017
Aristeromycin and DZNeP cause growth inhibition of prostate cancer via induction of mir-26a Fulltext Access 9 Pages 2017
Synergistic inhibition of Aβ production by combinations of γ-secretase modulators Fulltext Access 9 Pages 2017
Imiquimod-induced psoriasis-like inflammation in differentiated Human keratinocytes: Its evaluation using curcumin Fulltext Access 9 Pages 2017
Trimucrin, an Arg-Gly-Asp containing disintegrin, attenuates myocardial ischemia-reperfusion injury in murine by inhibiting platelet function Fulltext Access 9 Pages 2017
Effect of sirolimus on arteriosclerosis induced by advanced glycation end products via inhibition of the ILK/mTOR pathway in kidney transplantation recipients Fulltext Access 9 Pages 2017
Pinocembrin, a novel histidine decarboxylase inhibitor with anti-allergic potential in in vitro Fulltext Access 9 Pages 2017
Enhancement of S1P-induced contractile response in detrusor smooth muscle of rats having cystitis Fulltext Access 9 Pages 2017
Hypaconitine inhibits TGF-β1-induced epithelial-mesenchymal transition and suppresses adhesion, migration, and invasion of lung cancer A549 cells Fulltext Access 9 Pages 2017
MicroRNAs in intestinal barrier function, inflammatory bowel disease and related cancers - their effects and therapeutic potentials Fulltext Access 9 Pages 2017
Ultrasound-guided Stellate Ganglion Block Improves Gastrointestinal Function After Thoracolumbar Spinal Surgery Fulltext Access 9 Pages 2017
Cost-effectiveness of Paclitaxel + Ramucirumab Combination Therapy for Advanced Gastric Cancer Progressing After First-line Chemotherapy in Japan Fulltext Access 9 Pages 2017
Effects of boiling duration in processing of White Paeony Root on its overall quality evaluated by ultra-high performance liquid chromatography quadrupole/time-of-flight mass spectrometry based metabolomics analysis and high performance liquid chromatogra Fulltext Access 9 Pages 2017
Distribution patterns of the contents of five biologically activate ingredients in the root of Scutellaria baicalensis Fulltext Access 9 Pages 2017
Flavonoids isolated from Sinopodophylli Fructus and their bioactivities against human breast cancer cells Fulltext Access 9 Pages 2017
A feasible, economical, and accurate analytical method for simultaneous determination of six alkaloid markers in Aconiti Lateralis Radix Praeparata from different manufacturing sources and processing ways Fulltext Access 9 Pages 2017
Optimization of critical medium components for enhancing antibacterial thiopeptide nocathiacin I production with significantly improved quality Fulltext Access 9 Pages 2017
Characterization and quantitation of aristolochic acid analogs in different parts of Aristolochiae Fructus, using UHPLC-Q/TOF-MS and UHPLC-QqQ-MS Fulltext Access 9 Pages 2017
Mechanism for ginkgolic acid (15 : 1)-induced MDCK cell necrosis: Mitochondria and lysosomes damages and cell cycle arrest Fulltext Access 9 Pages 2017
Apigenin's anticancer properties and molecular mechanisms of action: Recent advances and future prospectives Fulltext Access 9 Pages 2017
Heparin-derived oligosaccharide inhibits vascular intimal hyperplasia in balloon-injured carotid artery Fulltext Access 9 Pages 2017
Zoledronic acid, an FPPS inhibitor, ameliorates liver steatosis through inhibiting hepatic de novo lipogenesis Fulltext Access 9 Pages 2017
Liver metabolomics study reveals protective function of Phyllanthus urinaria against CCl4-induced liver injury Fulltext Access 9 Pages 2017
Vascular protective effects of aqueous extracts of Tribulus terrestris on hypertensive endothelial injury Fulltext Access 9 Pages 2017
Effects of ethanol extract of Bombax ceiba leaves and its main constituent mangiferin on diabetic nephropathy in mice Fulltext Access 9 Pages 2017
Characterization of molecular signature of the roots of Paeonia lactiflora during growth Fulltext Access 9 Pages 2017
Anti-proliferation activity of terpenoids isolated from Euphorbia kansui in human cancer cells and their structure-activity relationship Fulltext Access 9 Pages 2017
Garcinia xanthochymus extract protects PC12 cells from H2O2-induced apoptosis through modulation of PI3K/AKT and NRF2/HO-1 pathways Fulltext Access 9 Pages 2017
Polyphenols isolated from Acacia mearnsii bark with anti-inflammatory and carbolytic enzyme inhibitory activities Fulltext Access 9 Pages 2017
The effects of novel chitosan-targeted gemcitabine nanomedicine mediating cisplatin on epithelial mesenchymal transition, invasion and metastasis of pancreatic cancer cells Fulltext Access 9 Pages 2017
Simultaneous targeting of CD14 and factor XIa by a fusion protein consisting of an anti-CD14 antibody and the modified second domain of bikunin improves survival in rabbit sepsis models Fulltext Access 9 Pages 2017
Modulation by NADPH oxidase of the chronic cardiovascular and autonomic interaction between cyclosporine and NSAIDs in female rats Fulltext Access 9 Pages 2017
L-F001, a novel multifunctional ROCK inhibitor, suppresses neuroinflammation in vitro and in vivo: Involvement of NF-κB inhibition and Nrf2 pathway activation Fulltext Access 9 Pages 2017
Characterization of a thienylcarboxamide derivative that inhibits the transactivation functions of cytomegalovirus IE2 and varicella zoster virus IE62 Fulltext Access 9 Pages 2017
Rational design and efficacy of a multi-epitope recombinant protein vaccine against foot-and-mouth disease virus serotype A in pigs Fulltext Access 9 Pages 2017
Umifenovir effectively inhibits IL-10 dependent persistent Coxsackie B4 virus infection Fulltext Access 9 Pages 2017
shRNAs targeting either the glycoprotein or polymerase genes inhibit Viral haemorrhagic septicaemia virus replication in zebrafish ZF4 cells Fulltext Access 9 Pages 2017
DNA vaccination regimes against Schmallenberg virus infection in IFNARâ/â mice suggest two targets for immunization Fulltext Access 9 Pages 2017
Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor Fulltext Access 9 Pages 2017
Antiviral activity of favipiravir (T-705) against mammalian and avian bornaviruses Fulltext Access 9 Pages 2017
The role of epidermal growth factor receptor (EGFR) signaling in SARS coronavirus-induced pulmonary fibrosis Fulltext Access 9 Pages 2017
Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity Fulltext Access 9 Pages 2017
A recombinant H7N9 influenza vaccine with the H7 hemagglutinin transmembrane domain replaced by the H3 domain induces increased cross-reactive antibodies and improved interclade protection in mice Fulltext Access 9 Pages 2017
Regulation of enterovirus 2A protease-associated viral IRES activities by the cell's ERK signaling cascade: Implicating ERK as an efficiently antiviral target Fulltext Access 9 Pages 2017
Structure-activity relationship studies on a Trp dendrimer with dual activities against HIV and enterovirus A71. Modifications on the amino acid Fulltext Access 9 Pages 2017
A neonatal mouse model of coxsackievirus A10 infection for anti-viral evaluation Fulltext Access 9 Pages 2017
Emetine inhibits replication of RNA and DNA viruses without generating drug-resistant virus variants Fulltext Access 9 Pages 2017
Efficacy and cytotoxicity in cell culture of novel α-hydroxytropolone inhibitors of hepatitis B virus ribonuclease H Fulltext Access 9 Pages 2017
Identification of KX2-391 as an inhibitor of HBV transcription by a recombinant HBV-based screening assay Fulltext Access 9 Pages 2017
Evaluation of antiviral effect of type I, II, and III interferons on direct-acting antiviral-resistant hepatitis C virus Fulltext Access 9 Pages 2017
Combination therapy with brincidofovir and valganciclovir against species C adenovirus infection in the immunosuppressed Syrian hamster model allows for substantial reduction of dose for both compounds Fulltext Access 9 Pages 2017
A SCID mouse-human lung xenograft model of varicella-zoster virus infection Fulltext Access 9 Pages 2017
Efficacy of a high potency O1 Manisa monovalent vaccine against heterologous challenge with foot-and-mouth disease virus of O/SEA/Mya-98 lineage in sheep Fulltext Access 9 Pages 2017
Viral minority variants in the core promoter and precore region identified by deep sequencing are associated with response to peginterferon and adefovir in HBeAg negative chronic hepatitis B patients Fulltext Access 9 Pages 2017
Targeted inhibition of hantavirus replication and intracranial pathogenesis by a chimeric protein-delivered siRNA Fulltext Access 9 Pages 2017
Ranolazine and Microvascular Angina by PET in the Emergency Department: Results From a Pilot Randomized Controlled Trial Fulltext Access 9 Pages 2017
Danshensu accelerates angiogenesis after myocardial infarction in rats and promotes the functions of endothelial progenitor cells through SDF-1α/CXCR4 axis Fulltext Access 9 Pages 2017
Investigating the involvement of glycogen synthase kinase-3β and gap junction signaling in TRPV1 and remote hind preconditioning-induced cardioprotection Fulltext Access 9 Pages 2017
Inhibition of the mevalonate pathway by simvastatin interferes with mast cell degranulation by disrupting the interaction between Rab27a and double C2 alpha proteins Fulltext Access 9 Pages 2017
Esculetin exerts antitumor effect on human gastric cancer cells through IGF-1/PI3K/Akt signaling pathway Fulltext Access 9 Pages 2017
Prevention of cholesterol gallstone disease by schaftoside in lithogenic diet-induced C57BL/6 mouse model Fulltext Access 9 Pages 2017
CO-independent modification of K+ channels by tricarbonyldichlororuthenium(II) dimer (CORM-2) Fulltext Access 9 Pages 2017
Human brown adipose tissue - function and therapeutic potential in metabolic disease Fulltext Access 9 Pages 2017
In Vitro Anaerobic Pharmacokinetic/Pharmacodynamic Model to Simulate the Bactericidal Activity of Levornidazole Against Bacteroides fragilis Fulltext Access 9 Pages 2017
The Pharmacokinetics of the CYP3A Substrate Midazolam After Steady-state Dosing of Delafloxacin Fulltext Access 9 Pages 2017
Real-world Clinical Outcomes Among Patients With Type 2 Diabetes Receiving Canagliflozin at a Specialty Diabetes Clinic: Subgroup Analysis by Baseline HbA1c and Age Fulltext Access 9 Pages 2017
Health Status of Patients with Moderate to Severe COPD after Treatment with Nebulized Arformoterol Tartrate or Placebo for 1 Year Fulltext Access 9 Pages 2017
Identification of 2â²-deoxy-2â²-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus Fulltext Access 9 Pages 2017
Management of Venetoclax-Posaconazole Interaction in Acute Myeloid Leukemia Patients: Evaluation of Dose Adjustments Fulltext Access 9 Pages 2017
Efficacy and Safety of Delayed-release Dimethyl Fumarate for Relapsing-remitting Multiple Sclerosis in Prior Interferon Users: An Integrated Analysis of DEFINE and CONFIRM Fulltext Access 9 Pages 2017
Bioequivalence Study of a New Fixed-dose Combination Tablet Containing S-Amlodipine Nicotinate and Olmesartan Medoxomil in Healthy Korean Male Subjects Fulltext Access 9 Pages 2017
Dicranostiga leptopodu (Maxim.) Fedde extracts attenuated CCl4-induced acute liver damage in mice through increasing anti-oxidative enzyme activity to improve mitochondrial function Fulltext Access 9 Pages 2017
Oleuropein protects L-02 cells against H2O2-induced oxidative stress by increasing SOD1, GPx1 and CAT expression Fulltext Access 9 Pages 2017
Clinically isolated enterovirus A71 subgenogroup C4 strain with lethal pathogenicity in 14-day-old mice and the application as an EV-A71 mouse infection model Fulltext Access 9 Pages 2017
Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface Fulltext Access 9 Pages 2017
Celastrol inhibits dengue virus replication via up-regulating type I interferon and downstream interferon-stimulated responses Fulltext Access 9 Pages 2017
Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model Fulltext Access 9 Pages 2017
Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy Fulltext Access 9 Pages 2017
Protein kinases C as potential host targets for the inhibition of chikungunya virus replication Fulltext Access 9 Pages 2017