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Pharmacology Research Articles

Glucocorticoids for the treatment of post-traumatic stress disorder and phobias: A novel therapeutic approach
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The effects of atropine on changes in the sleep patterns induced by psychological stress in rats
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Pedicularioside A from Buddleia lindleyana inhibits cell death induced by 1-methyl-4-phenylpyridinium ions (MPP+) in primary cultures of rat mesencephalic neurons
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Nicorandil enhances the effect of endothelial nitric oxide under hypoxia–reoxygenation: Role of the KATPatp" were changed to "KATP". Please check.--> channel
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Melatonin inhibits prostaglandin E2- and sodium nitroprusside-induced ion secretion in rat distal colon
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Actinonin, a meprin inhibitor, protects ischemic acute kidney injury in male but not in female rats
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Dexamethasone reduces food intake, weight gain and the hypothalamic 5-HT concentration and increases plasma leptin in rats
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Protective effects of naringenin-7-O-glucoside on doxorubicin-induced apoptosis in H9C2 cells
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Flurazepam inhibits the P-glycoprotein transport function: An insight to revert multidrug-resistance phenotype
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Cannabinoid CB1 receptor activation modulates spontaneous contractile activity in mouse ileal longitudinal muscle
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Endothelial dependence of matrix metalloproteinase-mediated vascular hyporeactivity caused by lipopolysaccharide
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The Na+/Ca2+ exchanger inhibitor KB-R7943 activates large-conductance Ca2+-activated K+ channels in endothelial and vascular smooth muscle cells
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Mineralocorticoid receptors in brain, in health and disease: Possibilities for new pharmacotherapy
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PET imaging of dopamine transporter and drug craving during methadone maintenance treatment and after prolonged abstinence in heroin users
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Glucocorticoid antagonists in neuropsychotic disorders
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Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice
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Role of GABAB receptors in the endomorphin-1-, but not endomorphin-2-, induced dopamine efflux in the nucleus accumbens of freely moving rats
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Genipin exhibits neurotrophic effects through a common signaling pathway in nitric oxide synthase-expressing cells
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Olanzapine inhibits glycogen synthase kinase-3β: An investigation by docking simulation and experimental validation
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p38MAPK inhibition attenuates LPS-induced acute lung injury involvement of NF-κB pathway
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A dual role of 5-hydroxytryptamine receptor 3 in serotonin induced ion transport in rat distal colon
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Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice
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Continuous stimulation of dopaminergic receptors by rotigotine does not interfere with the sleep–wake cycle in the rat
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Electrophysiologic effects of systemic and locally infused epibatidine on locus coeruleus neurons
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Bronchodilatory effects of S-isopetasin, an antimuscarinic sesquiterpene of Petasites formosanus, on obstructive airway hyperresponsiveness
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The effects on hTERT gene expression is an additional mechanism of amino-bisphosphonates in prostatic cancer cells
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Anti-inflammatory effect of 1-methylnicotinamide in contact hypersensitivity to oxazolone in mice; involvement of prostacyclin
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Glucagon like peptide-2 induces intestinal restitution through VEGF release from subepithelial myofibroblasts
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The effect of urocortin II administration on the coronary circulation and cardiac function in the anaesthetized pig is nitric-oxide-dependent
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Involvement of central histaminergic systems in modafinil-induced but not methylphenidate-induced increases in locomotor activity in rats
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Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus
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Chronic morphine treatment decreases the Cav1.3 subunit of the L-type calcium channel
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Effect of GCP-02, a PPARalpha/gamma dual activator, on glucose and lipid metabolism in insulin-resistant mice
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Pharmacological profile of the new inotropic agent AT-11
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Adenoviral gene transfer of viral interleukin-10 protects cerebrovascular impairment induced by lysophosphatidylcholine
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Effects of 15-deoxy-Δ12, 14 prostaglandin J2 and ciglitazone on human cancer cell cycle progression and death: The role of PPARγ
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Suppressive effects of leflunomide on leptin-induced TIMP-1 production involves on hepatic stellate cell proliferation and apoptosis
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Mechanism of action of the disease-modifying anti-arthritic thiol agents d-penicillamine and sodium aurothiomalate: Restoration of cellular free thiols and sequestration of reactive aldehydes
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The mechanism of anti-platelet activity of davallialactone: Involvement of intracellular calcium ions, extracellular signal-regulated kinase 2 and p38 mitogen-activated protein kinase
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Upregulation of heme oxygenase-1 by brazilin via the phosphatidylinositol 3-kinase/Akt and ERK pathways and its protective effect against oxidative injury
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Cross talk of tumor necrosis factor-α and the renin–angiotensin system in tumor necrosis factor-α-induced plasminogen activator inhibitor-1 production from hepatocytes
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Therapeutic effect of epigallocatechin-3-gallate in a mouse model of colitis
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MEN16132, a kinin B2 receptor antagonist, prevents the endogenous bradykinin effects in guinea-pig airways
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Mitochondrial dysfunction in an animal model of hyperoxaluria: A prophylactic approach with fucoidan
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Repeat oral dosing of prasugrel, a novel P2Y12 receptor inhibitor, results in cumulative and potent antiplatelet and antithrombotic activity in several animal species
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Endogenous opioid peptides, endomorphin-1 and -2 and deltorphin I, stimulate angiogenesis in the CAM assay
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Inducible nitric oxide synthase depresses cardiac contractile function in Zucker diabetic fatty rats
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Endogenous cannabinoids contribute to remote ischemic preconditioning via cannabinoid CB2 receptors in the rat heart
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Effects of olanzapine on ethanol withdrawal syndrome in rats
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Pharmacological properties of a novel nociceptin/orphanin FQ receptor agonist, 2-(3,5-dimethylpiperazin-1-yl)-1-[1-(1-methylcyclooctyl)piperidin-4-yl]-1H-benzimidazole, with anxiolytic potential
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Cognitive-enhancing and antioxidant activities of iridoid glycosides from Scrophularia buergeriana in scopolamine-treated mice
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5,7-Dihydroxitryptamine toxicity to serotonergic neurons in serum free raphe cultures
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Genistein induces apoptosis in ovarian cancer cells via different molecular pathways depending on Breast Cancer Susceptibility gene-1 (BRCA1) status
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Protective role of curcumin against nicotine-induced genotoxicity on rat liver under restricted dietary protein
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Mechanisms of allergy and asthma
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Neurovascular pharmacology of migraine
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Protective effect of JBP485 on concanavalin A-induced hepatocyte toxicity in primary cultured rat hepatocytes
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Anti-inflammatory drugs ameliorate opposite enzymatic changes in ileal 5-hydroxytryptamine metabolism in the delayed phase after cisplatin administration to rats
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Comparison of pharmacodynamics between carvedilol and metoprolol in rats with isoproterenol-induced cardiac hypertrophy: Effects of carvedilol enantiomers
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D-161, a novel pyran-based triple monoamine transporter blocker: Behavioral pharmacological evidence for antidepressant-like action
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Blockade of sensory abnormalities and kinin B1 receptor expression by N-Acetyl-l-Cysteine and ramipril in a rat model of insulin resistance
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The effect of an iron (III) chelator, silybin, on the proliferation and cell cycle of Jurkat cells: A comparison with desferrioxamine
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DNA vaccination efficiently induces antibodies to Nogo-A and does not exacerbate experimental autoimmune encephalomyelitis
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Pharmacological characterization of cellular mechanisms of the renal vasodilatory effect of nicotine in rats
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Regulation of aquaporin 3 expression by magnesium ion
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Beneficial effects of vegetable oils (corn, olive and sunflower oils) and α-tocopherol on anti-inflammatory and gastrointestinal profiles of indomethacin in rats
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Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill
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Rat urinary bladder-derived relaxant factor: Studies on its nature and release by coaxial bioassay system
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Therapeutic potential of 20(S)-ginsenoside Rg3 against streptozotocin-induced diabetic renal damage in rats
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Role of Ca2+ mobilization in desensitization of β-adrenoceptors by platelet-derived growth factor in airway smooth muscle
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Calebin-A induces apoptosis and modulates MAPK family activity in drug resistant human gastric cancer cells
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Inhibitory effect of mycophenolic acid on the replication of infectious pancreatic necrosis virus and viral hemorrhagic septicemia virus
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Treatment of Venezuelan equine encephalitis virus infection with (−)-carbodine
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Antiviral activity of type I interferons and interleukins 29 and 28a (type III interferons) against Apeu virus
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Quick identification of effective small interfering RNAs that inhibit the replication of coxsackievirus A16
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Effect of phosphodiesterase type 4 inhibitor rolipram on cyclophosphamide-induced cystitis in rats
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The β-lactam antibiotic ceftriaxone inhibits physical dependence and abstinence-induced withdrawal from cocaine, amphetamine, methamphetamine, and clorazepate in planarians
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Anti-tumor effects of paeonol in a HepA-hepatoma bearing mouse model via induction of tumor cell apoptosis and stimulation of IL-2 and TNF-α production
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Different affinities of native α1B-adrenoceptors for ketanserin between intact tissue segments and membrane preparations
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Protective effect of baicalin against Lipopolysaccharide/d-galactosamine-induced liver injury in mice by up-regulation of Heme oxygenase-1
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Combined simvastatin–manidipine protect against ischemia–reperfusion injury in isolated hearts from normocholesterolemic rats
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Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer
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Responses of differentiated MC3T3-E1 osteoblast-like cells to reactive oxygen species
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Exogenous hydrogen sulfide postconditioning protects isolated rat hearts against ischemia-reperfusion injury
Fulltext Access 7 Pages 2008
Comparative pharmacological activity of optical isomers of phenibut
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Histaminergic system of the lateral septum in the modulation of anxiety-like behaviour in rats
Fulltext Access 7 Pages 2008
Clofibrate treatment up-regulates novel organic cation transporter (OCTN)-2 in tissues of pigs as a model of non-proliferating species
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Novel triple neurokinin receptor antagonist CS-003 strongly inhibits neurokinin related responses
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Conditionally replicating lentiviral-hybrid episomal vectors for suicide gene therapy
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Adiponectin plasma levels are increased by atorvastatin treatment in subjects at high cardiovascular risk
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Cardioprotective effect of fluvastatin on isoproterenol-induced myocardial infarction in rat
Fulltext Access 7 Pages 2008
Stress and re-stress increases conditioned taste aversion learning in rats: Possible frontal cortical and hippocampal muscarinic receptor involvement
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Effects of glutamate-related drugs on marble-burying behavior in mice: Implications for obsessive–compulsive disorder
Fulltext Access 7 Pages 2008
Depletion of serotonin decreases the effects of the kappa-opioid receptor agonist U-69593 on cocaine-stimulated activity
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Neurosteroids 3β, 20 (R/S)-pregnandiols decrease offset rate of the GABA-site activation at the recombinant GABAA receptor
Fulltext Access 7 Pages 2008
Characterization of intestinal absorption of mizoribine mediated by concentrative nucleoside transporters in rats
Fulltext Access 7 Pages 2008
Olanzapine-induced weight gain: Chronic infusion using osmotic minipumps does not result in stable plasma levels due to degradation of olanzapine in solution
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Putting the diet back into diet-induced obesity: Diet-induced hypothalamic gene expression
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Multimeric α-MSH has increased efficacy to activate the melanocortin MC4 receptor
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SA13353 (1-[2-(1-Adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea) inhibits TNF-α production through the activation of capsaicin-sensitive afferent neurons mediated via transient receptor potential vanilloid 1 in vivo
Fulltext Access 7 Pages 2008
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