Pharmacokinetic and pharmacodynamic effects of midodrine on blood pressure, the autonomic nervous system, and plasma natriuretic peptides: a prospective, randomized, single-blind, two-period, crossover, placebo-controlled study Fulltext Access 10 Pages 2008
A case-control study of the association between polymorphisms of the endothelial nitric oxide synthase and glycoprotein IIIa genes and upper gastrointestinal bleeding in users of low-dose aspirin Fulltext Access 10 Pages 2008
Comparison of the effects of doxazosin and atenolol on target organ damage in adults with type 2 diabetes mellitus and hypertension in the CARDHIAC study: A 9-month, prospective, randomized, open-label, blinded-evaluation trial Fulltext Access 10 Pages 2008
Treatment persistence with adalimumab, etanercept, or infliximab in combination with methotrexate and the effects on health care costs in patients with rheumatoid arthritis Fulltext Access 10 Pages 2008
Pharmacokinetic and pharmacodynamic characteristics of aranidipine sustained-release, enteric-coated tablets in healthy chinese men: A phase I, randomized, open-label, single- and multiple-dose study Fulltext Access 10 Pages 2008
Acetylsalicylic acid + extended-release dipyridamole combination therapy for secondary stroke prevention Fulltext Access 10 Pages 2008
Benefits and risks of adjunctive inhaled corticosteroids in chronic obstructive pulmonary disease: A meta-analysis Fulltext Access 10 Pages 2008
Significance of a decline in bone mineral density while receiving oral bisphosphonate treatment Fulltext Access 10 Pages 2008
Effects of short-term and long-term danazol treatment on lipoproteins, coagulation, and progression of atherosclerosis: Two clinical trials in healthy volunteers and patients with hereditary angioedema Fulltext Access 10 Pages 2008
3,3′-Diindolylmethane reduces levels of HIF-1α and HIF-1 activity in hypoxic cultured human cancer cells Fulltext Access 10 Pages 2008
Metabolism of 17α-hydroxyprogesterone caproate by hepatic and placental microsomes of human and baboons Fulltext Access 10 Pages 2008
Inhibitory effect of fluoxetine on lymphoma growth through the modulation of antitumor T-cell response by serotonin-dependent and independent mechanisms Fulltext Access 10 Pages 2008
Direct hospital resource utilization and costs of treating patients with multiple myeloma in Southwest Sweden: A 5-year retrospective analysis Fulltext Access 10 Pages 2008
14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy Fulltext Access 10 Pages 2008
Implication of NAG-1 in synergistic induction of apoptosis by combined treatment of sodium salicylate and PI3K/MEK1/2 inhibitors in A549 human lung adenocarcinoma cells Fulltext Access 10 Pages 2008
Short-term regulation of the Cl−/HCO3− exchanger in immortalized SHR proximal tubular epithelial cells Fulltext Access 10 Pages 2008
Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme Fulltext Access 10 Pages 2008
A cyclopentanediol analogue selectively suppresses the conserved innate immunity pathways, Drosophila IMD and TNF-α pathways Fulltext Access 10 Pages 2008
Sarcoplasmic reticulum Ca2+ release channel ryanodine receptor (RyR2) plays a crucial role in aconitine-induced arrhythmias Fulltext Access 10 Pages 2008
Inhibitory effect of acetyl-11-keto-β-boswellic acid on androgen receptor by interference of Sp1 binding activity in prostate cancer cells Fulltext Access 10 Pages 2008
Observations of nonadherence to recombinant human growth hormone therapy in clinical practice Fulltext Access 10 Pages 2008
Increased glycogen stores due to γ-AMPK overexpression protects against ischemia and reperfusion damage Fulltext Access 10 Pages 2008
Acetylation of prostaglandin H2 synthases by aspirin is inhibited by redox cycling of the peroxidase Fulltext Access 10 Pages 2008
Mechanisms of cell death induced by 2-chloroadenosine in leukemic B-cells Fulltext Access 10 Pages 2008
WRC-213, an l-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: Identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers Fulltext Access 10 Pages 2008
4â²-Methoxy-2-styrylchromone a novel microtubule-stabilizing antimitotic agent Fulltext Access 10 Pages 2008
Molecular pharmacology and therapeutic potential of neuronal Kv7-modulating drugs Fulltext Access 10 Pages 2008
The alchemy of immune privilege explored from a neuroimmunological perspective Fulltext Access 10 Pages 2008
Recent progress in the development of selected hepatitis C virus NS3·4A protease and NS5B polymerase inhibitors Fulltext Access 10 Pages 2008
Angiotensin II receptor blockers in the treatment of the cardiovascular disease continuum Fulltext Access 10 Pages 2008
Cost-effectiveness analysis of emtricitabine/tenofovir versus lamivudine/zidovudine, in combination with efavirenz, in antiretroviral-naive, HIV-1-infected patients Fulltext Access 10 Pages 2008
Induction of G2/M arrest, endoreduplication, and apoptosis by actin depolymerization agent pextenotoxin-2 in human leukemia cells, involving activation of ERK and JNK Fulltext Access 10 Pages 2008
Budget impact model of adding erlotinib to a regimen of gemcitabine for the treatment of locally advanced, nonresectable or metastatic pancreatic cancer Fulltext Access 10 Pages 2008
Review of recent results of montelukast use as a monotherapy in children with mild asthma Fulltext Access 10 Pages 2008
A retrospective study of the use of fluticasone propionate/salmeterol combination as initial asthma controller therapy in a commercially insured population Fulltext Access 10 Pages 2008
Efficacy of cefditoren pivoxil and amoxicillin/clavulanate in the treatment of pediatric patients with acute bacterial rhinosinusitis in Thailand: A randomized, investigator-blinded, controlled trial Fulltext Access 10 Pages 2008
Short- versus long-course antibiotic therapy for acute pyelonephritis in adolescents and adults: A meta-analysis of randomized controlled trials Fulltext Access 10 Pages 2008
A 16-week, randomized, double-blind, placebo-controlled, crossover trial to quantify the combined effect of an angiotensin-converting enzyme inhibitor and a β-blocker on blood pressure reduction Fulltext Access 10 Pages 2008
Cost-effectiveness analysis of antifungal prophylaxis in patients undergoing hematopoietic stem cell transplantation Fulltext Access 10 Pages 2008
Effect of exenatide on 24-hour blood glucose profile compared with placebo in patients with type 2 diabetes: A randomized, double-blind, two-arm, parallel-group, placebo-controlled, 2-week study Fulltext Access 10 Pages 2008
A retrospective analysis of the prevalence and treatment of hypertension and dyslipidemia in Southwestern Ontario, Canada Fulltext Access 10 Pages 2008
Appropriateness of antibiotic prescribing in veterans with community-acquired pneumonia, sinusitis, or acute exacerbations of chronic bronchitis: A cross-sectional study Fulltext Access 10 Pages 2008
Different time schedules affect conditioned place preference after morphine and morphine-6-glucuronide administration Fulltext Access 10 Pages 2008
Topical transduction of superoxide dismutase mediated by HIV-1 Tat protein transduction domain ameliorates 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice Fulltext Access 10 Pages 2008
JM91, a newly synthesized indoledione derivative, inhibits rat aortic vascular smooth muscle cells proliferation and cell cycle progression through inhibition of ERK1/2 and Akt activations Fulltext Access 10 Pages 2008
TGF-β1 increases motility and αvβ3 integrin up-regulation via PI3K, Akt and NF-κB-dependent pathway in human chondrosarcoma cells Fulltext Access 10 Pages 2008
Modulation of gold(III) porphyrin 1a-induced apoptosis by mitogen-activated protein kinase signaling pathways Fulltext Access 10 Pages 2008
Quinolones as enhancers of camptothecin-induced cytotoxic and anti-topoisomerase I effects Fulltext Access 10 Pages 2008
Next generation topoisomerase I inhibitors: Rationale and biomarker strategies Fulltext Access 10 Pages 2008
Insulin therapy restores impaired function and expression of P-glycoprotein in blood–brain barrier of experimental diabetes Fulltext Access 10 Pages 2008
Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of Clostridium perfringens enterotoxin, by site-directed mutagenesis Fulltext Access 10 Pages 2008
(2R,3R)-2-(3′,4′-dihydroxybenzyl)-3-(3″,4″-dimethoxybenzyl)butyrolactone suppresses fMLP-induced superoxide production by inhibiting fMLP-receptor binding in human neutrophils Fulltext Access 10 Pages 2008
Compensatory effects of the human nucleoside transporters on the response to nucleoside-derived drugs in breast cancer MCF7 cells Fulltext Access 10 Pages 2008
RETRACTED: Antiviral and antiparasite properties of an l-amino acid oxidase from the Snake Bothrops jararaca: Cloning and identification of a complete cDNA sequence Fulltext Access 10 Pages 2008
Bupropion differentially impacts acquisition of methamphetamine self-administration and sucrose-maintained behavior Fulltext Access 10 Pages 2008
Structure–activity relationship of coumarin derivatives on xanthine oxidase-inhibiting and free radical-scavenging activities Fulltext Access 10 Pages 2008
Gonadal steroids mediate the opposite changes in cocaine-induced locomotion across adolescence in male and female rats Fulltext Access 10 Pages 2008
Central vs. peripheral administration of ethanol, acetaldehyde and acetate in rats: Effects on lever pressing and response initiation Fulltext Access 10 Pages 2008
Intracranial infusions of amphetamine into the medial preoptic area but not the nucleus accumbens affect paced mating behavior in female rats Fulltext Access 10 Pages 2008
Differences in the behavioral time course of effects of rate-increasing and rate-decreasing doses of cocaine in pigeons Fulltext Access 10 Pages 2008
Sex differences in NMDA antagonist enhancement of morphine antihyperalgesia in a capsaicin model of persistent pain: Comparisons to two models of acute pain Fulltext Access 10 Pages 2008
Sex and opioid maintenance dose influence response to naloxone in opioid-dependent humans: A retrospective analysis Fulltext Access 10 Pages 2008
Influence of hormonal status on behavioral responses to an acute ethanol challenge during ethanol withdrawal in male and female rats Fulltext Access 10 Pages 2008
Bupropion differentially alters the aversive, locomotor and rewarding properties of nicotine in CD-1 mice Fulltext Access 10 Pages 2008
Estrogen is necessary for 5α-pregnan-3α-ol-20-one (3α,5α-THP) infusion to the ventral tegmental area to facilitate social and sexual, but neither exploratory nor affective behavior of ovariectomized rats Fulltext Access 10 Pages 2008
Brain temperature responses to salient stimuli persist during dopamine receptor blockade despite a blockade of locomotor responses Fulltext Access 10 Pages 2008
Virus entry inhibition by chlorite-oxidized oxyamylose versus induction of antiviral interferon by poly(I:C) Fulltext Access 10 Pages 2008
The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan Fulltext Access 10 Pages 2008
Interference with actin dynamics is superior to disturbance of microtubule function in the inhibition of human ovarian cancer cell motility Fulltext Access 10 Pages 2008
ASP8497 is a novel selective and competitive dipeptidyl peptidase-IV inhibitor with antihyperglycemic activity Fulltext Access 10 Pages 2008
Fifty years of Biochemical Pharmacology: The discipline and the journal Fulltext Access 10 Pages 2008
Physalin B, a novel inhibitor of the ubiquitin-proteasome pathway, triggers NOXA-associated apoptosis Fulltext Access 10 Pages 2008
HDL-cholesterol: Is it really good?: Differences between apoA-I and HDL Fulltext Access 10 Pages 2008
Application and interpretation of hPXR screening data: Validation of reporter signal requirements for prediction of clinically relevant CYP3A4 inducers Fulltext Access 10 Pages 2008
Celecoxib potently inhibits TNFα-induced nuclear translocation and activation of NF-κB Fulltext Access 10 Pages 2008
A new chemical tool (C0036E08) supports the role of adenosine A2B receptors in mediating human mast cell activation Fulltext Access 10 Pages 2008
Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1 Fulltext Access 10 Pages 2008
Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets Fulltext Access 10 Pages 2008
Autonomic activation associated with ethanol self-administration in adult female P rats Fulltext Access 10 Pages 2008
Characterization of mouse flavin-containing monooxygenase transcript levels in lung and liver, and activity of expressed isoforms Fulltext Access 10 Pages 2008
Critical role of hydrogen peroxide in the differential susceptibility of Th1 and Th2 cells to tributyltin-induced apoptosis Fulltext Access 10 Pages 2008
An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3α-HSD, type 5 17β-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent m Fulltext Access 10 Pages 2008
Characterization of a new peptide agonist of the protease-activated receptor-1 Fulltext Access 10 Pages 2008
Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress Fulltext Access 10 Pages 2008
Inhibition of glioblastoma growth and angiogenesis by gambogic acid: An in vitro and in vivo study Fulltext Access 10 Pages 2008
Synergic antiproliferative and antiangiogenic effects of EGFR and mTor inhibitors on pancreatic cancer cells Fulltext Access 10 Pages 2008
The role of 15-deoxy-Δ12,14-prostaglandin J2, an endogenous ligand of peroxisome proliferator-activated receptor γ, in tumor angiogenesis Fulltext Access 10 Pages 2008
Novel roles for ceramides, calpains and caspases in kidney proximal tubule cell apoptosis: Lessons from in vitro cadmium toxicity studies Fulltext Access 10 Pages 2008