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Pharmacology Research Articles

The partial α7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus
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Surface expression of metabotropic glutamate receptor variants mGluR1a and mGluR1b in transfected HEK293 cells
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Folic acid administration produces an antidepressant-like effect in mice: Evidence for the involvement of the serotonergic and noradrenergic systems
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The aspirin metabolite salicylate enhances neuronal excitation in rat hippocampal CA1 area through reducing GABAergic inhibition
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Synergism between fluoxetine and the mGlu2/3 receptor agonist, LY379268, in an in vitro model for antidepressant drug-induced neurogenesis
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Decreased anticonvulsant efficacy of allopregnanolone during ethanol withdrawal in female Withdrawal Seizure-Prone vs. Withdrawal Seizure-Resistant mice
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Withdrawal from chronic administration of cocaine decreases delta opioid receptor signaling and increases anxiety- and depression-like behaviors in the rat
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Substrate-mediated regulation of γ-aminobutyric acid transporter 1 in rat brain
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Bidirectional activity-dependent plasticity of membrane potential and the influence on spiking in rat hippocampal dentate granule cells
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Increased protein SUMOylation following focal cerebral ischemia
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(±)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: A comparison of single vs once per week treatment for 5 weeks
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Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown
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Chronic haloperidol and clozapine produce different patterns of effects on phosphodiesterase-1B, -4B, and -10A expression in rat striatum
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The inhibition of release by mGlu7 receptors is independent of the Ca2+ channel type but associated to GABAB and adenosine A1 receptors
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Theoretical Dissolution Model of Poly-Disperse Drug Particles in Biorelevant Media
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Improved Intestinal Membrane Permeability of Hexose-Quinoline Derivatives via the Hexose Transporter, SGLT1
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Evaluation of the Pharmacokinetics of All-Trans-Retinoic Acid (ATRA) in Wistar Rats After Intravenous Administration of ATRA Loaded into Tributyrin Submicron Emulsion and its Cellular Activity on Caco-2 and HepG2 Cell Lines
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The Effect of Cyclodextrins on Chemical and Physical Stability of Glucagon and Characterization of Glucagon/γ-CD Inclusion Complexes
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Chemical Degradation of Peptides and Proteins in PLGA: A Review of Reactions and Mechanisms
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Validation of a Rapid Equilibrium Dialysis Approach for the Measurement of Plasma Protein Binding
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Your Prodrug Releases Formaldehyde: Should You Be Concerned? No!
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Heterogeneity in Skin Treated with Low-Frequency Ultrasound
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Logic models of pathway biology
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Assessing drug-likeness – what are we missing?
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Drug discovery in the extracellular matrix
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cAMP promotes neurite outgrowth and extension through protein kinase A but independently of Erk activation in cultured rat motoneurons
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Noradrenergic stimulation of BDNF synthesis in astrocytes: Mediation via α1- and β1/β2-adrenergic receptors
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Low tryptophan diet increases stress-sensitivity, but does not affect habituation in rats
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Functional expression of release-regulating glycine transporters GLYT1 on GABAergic neurons and GLYT2 on astrocytes in mouse spinal cord
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CB1 receptor stimulation in specific brain areas differently modulate anxiety-related behaviour
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Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors
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Pharmacological evidence for the involvement of diacylglycerol lipase in depolarization-induced endocanabinoid release
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Inhibition of opioid release in the rat spinal cord by α2C adrenergic receptors
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Docosahexaenoic and eicosapentaenoic acids increase neuronal death in response to HuPrP82-146 and Aβ1-42
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Enhancement of long-term potentiation by brain-derived neurotrophic factor requires adenosine A2A receptor activation by endogenous adenosine
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Neurokinin B/NK3 receptors exert feedback inhibition on l-DOPA actions in the 6-OHDA lesion rat model of Parkinson's disease
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Blockade of 5-HT1B receptors facilitates contextual aversive learning in mice by disinhibition of cholinergic and glutamatergic neurotransmission
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Implication of neuropeptide-Y Y2 receptors in the effects of immune stress on emotional, locomotor and social behavior of mice
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Prefrontal cortex–nucleus accumbens interaction: In vivo modulation by dopamine and glutamate in the prefrontal cortex
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Memantine protects against amphetamine derivatives-induced neurotoxic damage in rodents
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Affective and somatic aspects of spontaneous and precipitated nicotine withdrawal in C57BL/6J and BALB/cByJ mice
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Plasticity and repair in the post-ischemic brain
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Magnetic resonance imaging in cerebral ischemia: Focus on neonates
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The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in rats
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Brown adipose tissue sympathetic nerve activity is potentiated by activation of 5-hydroxytryptamine (5-HT)1A/5-HT7 receptors in the rat spinal cord
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Serotonergic approaches in the development of novel antipsychotics
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Pharmacological MRI in animal models: A useful tool for 5-HT research?
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5-HT4 receptors: History, molecular pharmacology and brain functions
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Depression of spinal network activity by thiopental: Shift from phasic to tonic GABAA receptor-mediated inhibition
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Chloride-dependent acute excitotoxicity in adult rat retinal ganglion cells
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Endocannabinoid-mediated enhancement of fear-conditioned analgesia in rats: Opioid receptor dependency and molecular correlates
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Chronic pain reconsidered
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A prospective identification of neuropathic pain in specific chronic polyneuropathy syndromes and response to pharmacological therapy
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Middle short gyrus of the insula implicated in pain processing
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An fMRI study measuring analgesia enhanced by religion as a belief system
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The mu opioid receptor A118G gene polymorphism moderates effects of trait anger-out on acute pain sensitivity
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Activity-dependent potentiation of calcium signals in spinal sensory networks in inflammatory pain states
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Antinociceptive effect of resveratrol in carrageenan-evoked hyperalgesia in rats: Prolonged effect related to COX-2 expression impairment
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Naturally occurring variations in maternal care modulate the effects of repeated neonatal pain on behavioral sensitivity to thermal pain in the adult offspring
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Allodynia and hyperalgesia in diabetic rats are mediated by GABA and depletion of spinal potassium-chloride co-transporters
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The dynamic mechanisms of placebo induced analgesia: Evidence of sustained and transient regional involvement
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The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB1, TRPV1 and PPARγ receptors and neurotrophic factors
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Diffusion tensor fiber tracking in patients with central post-stroke pain; correlation with efficacy of repetitive transcranial magnetic stimulation
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Effects of mood on pain responses and pain tolerance: An experimental study in chronic back pain patients
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Sleep pattern in an experimental model of osteoarthritis
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The persistence of a long-term negative affective state following the induction of either acute or chronic pain
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Nociception et douleur chronique orale et cervicofaciale
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Les syndromes douloureux régionaux complexes (SDRC) de type I et II
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The influence of clozapine treatment and other antipsychotics on the 18 kDa translocator protein, formerly named the peripheral-type benzodiazepine receptor, and steroid production
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Bright light exposure during acute tryptophan depletion prevents a lowering of mood in mildly seasonal women
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The immediate early gene Arc is associated with behavioral resilience to stress exposure in an animal model of posttraumatic stress disorder
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The role of D1–D2 receptor hetero-dimerization in the mechanism of action of clozapine
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Regulation of rat cortical 5-hydroxytryptamine2A receptor-mediated electrophysiological responses by repeated daily treatment with electroconvulsive shock or imipramine
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Behavioral effects of dietary cholesterol in rats tested in experimental models of mild stress and cognition tasks
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Time dependent alterations on tyrosine hydroxylase, opioid and cannabinoid CB1 receptor gene expressions after acute ethanol administration in the rat brain
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Deletion of Melanin-Concentrating Hormone Receptor-1 gene accentuates d-amphetamine-induced psychomotor activation but neither the subsequent development of sensitization nor the expression of conditioned activity in mice
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Locomotor stimulation produced by 3,4-methylenedioxymethamphetamine (MDMA) is correlated with dialysate levels of serotonin and dopamine in rat brain
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Actions of 3,4-methylenedioxymethamphetamine (MDMA) on cerebral dopaminergic, serotonergic and cholinergic neurons
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Consequences of changes in BDNF levels on serotonin neurotransmission, 5-HT transporter expression and function: Studies in adult mice hippocampus
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Listening to neuropeptides by microdialysis: Echoes and new sounds?
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Cocaine cue versus cocaine dosing in humans: Evidence for distinct neurophysiological response profiles
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Antipsychotic property of a muscarinic receptor agonist in animal models for schizophrenia
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Calcium-dependent mechanisms of the reinstatement of nicotine-conditioned place preference by drug priming in rats
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A test of the catecholamines hypothesis for an acute exercise–cognition interaction
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Effects on spontaneous and cocaine-induced behavior of pharmacological inhibition of noradrenergic and serotonergic systems
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Additional evidence for anxiolytic- and antidepressant-like activities of saredutant (SR48968), an antagonist at the neurokinin-2 receptor in various rodent-models
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Noradrenergic antagonism enhances the conditioned aversive effects of cocaine
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Evidence for the involvement of glutamatergic and GABAergic systems and protein kinase A pathway in the antinociceptive effect caused by p-methoxy-diphenyl diselenide in mice
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Nitric oxide involvement in the antidepressant-like effects of acute lithium administration in the mouse forced swimming test
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Infant rats exhibit aversive learning mediated by ethanol's orosensory effects but are positively reinforced by ethanol's post-ingestive effects
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Gaboxadol — a different hypnotic profile with no tolerance to sleep EEG and sedative effects after repeated daily dosing
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The role of GABAA receptors in the development of alcoholism
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Alpha2-containing GABAA receptors are involved in mediating stimulant effects of cocaine
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Differentiating the discriminative stimulus effects of gamma-hydroxybutyrate and ethanol in a three-choice drug discrimination procedure in rats
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Baclofen, raclopride, and naltrexone differentially reduce solid fat emulsion intake under limited access conditions
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Effects of acute and repeated administration of caffeine on temporal discounting in rats
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Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeys
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Idazoxan blocks the nicotine-induced reversal of the memory impairment caused by the NMDA glutamate receptor antagonist dizocilpine
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Quantitative testing of pain perception in subjects with PTSD - Implications for the mechanism of the coexistence between PTSD and chronic pain
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Trends in use of opioids for non-cancer pain conditions 2000-2005 in Commercial and Medicaid insurance plans: The TROUP study
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