Effect of P‐Glycoprotein Expression Levels on the Concentration‐Dependent Permeability of Drugs to the Cell Membrane Fulltext Access 13 Pages 2008
Rectal immunization generates protective immunity in the female genital tract against herpes simplex virus type 2 infection: Relative importance of myeloid differentiation factor 88 Fulltext Access 13 Pages 2008
Protein kinase inhibitors of the quinazoline class exert anti-cytomegaloviral activity in vitro and in vivo Fulltext Access 13 Pages 2008
Progress in identifying virulence determinants of the 1918 H1N1 and the Southeast Asian H5N1 influenza A viruses Fulltext Access 13 Pages 2008
Peptide-conjugated morpholino oligomers inhibit porcine reproductive and respiratory syndrome virus replication Fulltext Access 13 Pages 2008
Effects of repeated callbacks on response rate and nonresponse bias: Results from a 17-state pharmacy survey Fulltext Access 13 Pages 2008
A modified model of pharmacists' job stress: The role of organizational, extra-role, and individual factors on work-related outcomes Fulltext Access 13 Pages 2008
Pilot study of a hierarchical Bayes method for utility estimation in a choice-based conjoint analysis of prescription benefit plans including medication therapy management services Fulltext Access 13 Pages 2008
Long-term alterations in vulnerability to addiction to drugs of abuse and in brain gene expression after early life ethanol exposure Fulltext Access 13 Pages 2008
Role of calpain and caspase in β-amyloid-induced cell death in rat primary septal cultured neurons Fulltext Access 13 Pages 2008
Glutamate-mediated spinal reflex potentiation involves ERK 1/2 phosphorylation in anesthetized rats Fulltext Access 13 Pages 2008
Chronic administration of heroin to mice produces up-regulation of brain apoptosis-related proteins and impairs spatial learning and memory Fulltext Access 13 Pages 2008
New opportunities for field research on the pathogenesis and treatment of Lassa fever Fulltext Access 13 Pages 2008
Rational Estimation of the Optimum Amount of Non‐Fibrous Disintegrant Applying Percolation Theory for Binary fast Disintegrating Formulation Fulltext Access 13 Pages 2008
A mechanistic Study on the Chemical and Enzymatic Degradation of PEG‐Oligo(ε‐caprolactone) Micelles Fulltext Access 13 Pages 2008
Silicone Elastomer Uptake Method for Determination of Free 1‐Alkyl‐2‐Pyrrolidone Concentration in Micelle and Hydroxypropyl‐β‐Cyclodextrin Systems Used in Skin Transport Studies Fulltext Access 13 Pages 2008
Release Kinetics of Benzoic Acid and its Sodium Salt From a Series of Poly(N‐Isopropylacrylamide) Matrices with Various Percentage Crosslinking Fulltext Access 13 Pages 2008
Correlation between Chemical Reactivity and the Hammett Acidity Function in Amorphous Solids Using Inversion of Sucrose as a Model Reaction Fulltext Access 13 Pages 2008
Effect of propylene glycol on ibuprofen absorption into human skin in vivo Fulltext Access 13 Pages 2008
Porcine Vagina Ex Vivo as a Model for Studying Permeability and Pathogenesis in Mucosa Fulltext Access 13 Pages 2008
PLGA Nanoparticles for Oral Delivery of Hydrophobic Drugs: Influence of Organic Solvent on Nanoparticle Formation and Release Behavior In Vitro and In Vivo Using Estradiol as a Model Drug Fulltext Access 13 Pages 2008
Contribution of Variable Domains to the Stability of Humanized IgG1 Monoclonal Antibodies Fulltext Access 13 Pages 2008
Phosphatidylserine Containing Liposomes Reduce Immunogenicity of Recombinant Human Factor VIII (rFVIII) in a Murine Model of Hemophilia A* Fulltext Access 13 Pages 2008
The Development of Thermally Assisted Particle Manipulation and Thermal Nanointeraction Studies as a Means of Investigating Drugâpolymer Interactions Fulltext Access 13 Pages 2008
Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain Fulltext Access 13 Pages 2008
Healing properties of malabaricone B and malabaricone C, against indomethacin-induced gastric ulceration and mechanism of action Fulltext Access 13 Pages 2008
Benidipine, an anti-hypertensive drug, inhibits reactive oxygen species production in polymorphonuclear leukocytes and oxidative stress in salt-loaded stroke-prone spontaneously hypertensive rats Fulltext Access 13 Pages 2008
Influence of soluble guanylate cyclase inhibition on inflammation and motility disturbances in DSS-induced colitis Fulltext Access 13 Pages 2008
Pertussis toxin induces parallel loss of neuropeptide Y Y1 receptor dimers and Gi α subunit function in CHO cells Fulltext Access 13 Pages 2008
Selective transrepression versus transactivation mechanisms by glucocorticoid receptor modulators in stress and immune systems Fulltext Access 13 Pages 2008
Agonist-evoked calcium entry in vascular smooth muscle cells requires IP3 receptor-mediated activation of TRPC1 Fulltext Access 13 Pages 2008
Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice Fulltext Access 13 Pages 2008
Fluoxetine Pretreatment Effects Pharmacokinetics of 3,4âMethylenedioxymethamphetamine (MDMA, ECSTASY) in Rat Fulltext Access 13 Pages 2008
Effects of chronic citalopram treatment on 5-HT1A and 5-HT2A receptors in group- and isolation-housed mice Fulltext Access 13 Pages 2008
Coordinated regulation of esterification and lipolysis by palmitate, H2O2 and the anti-diabetic sulfonylurea drug, glimepiride, in rat adipocytes Fulltext Access 13 Pages 2008
Long-term persistence with statin therapy: A nationwide register study in Finland Fulltext Access 13 Pages 2008
Cost-effectiveness of intensive atorvastatin treatment in high-risk patients compared with usual care in a postgeneric statin market: Economic analysis of the aggressive lipid-lowering initiation abates new cardiac events (ALLIANCE) study Fulltext Access 13 Pages 2008
Management of mixed dyslipidemia in patients with or at risk for cardiovascular disease: A role for combination fibrate therapy Fulltext Access 13 Pages 2008
Effects of Carvedilol on Left Ventricular Function and Oxidative Stress in Infants and Children with Idiopathic Dilated Cardiomyopathy: A 12-Month, Two-Center, Open-Label Study Fulltext Access 13 Pages 2008
Pharmacokinetics of single-dose and multiple-dose memantine in healthy chinese volunteers using an analytic method of liquid chromatography-tandem mass spectrometry Fulltext Access 13 Pages 2008
Emergency hospital admissions after income-based deductibles and prescription copayments in older users of inhaled medications Fulltext Access 13 Pages 2008
Involvement of basic amino acid residues in transmembrane regions 6 and 7 in agonist and antagonist recognition of the human platelet P2Y12-receptor Fulltext Access 13 Pages 2008
Mass spectrometric assay and physiological–pharmacological activity of androgenic neurosteroids Fulltext Access 13 Pages 2008
Moisture Sorption and Permeability Characteristics of Polymer Films: Implications for Their Use as Barrier Coatings for Solid Dosage Forms Containing Hydrolyzable Drug Substances Fulltext Access 13 Pages 2008
Structure-Permeability Relationship Analysis of the Permeation Barrier Properties of the Stratum Corneum and Viable Epidermis/Dermis of Rat Skin Fulltext Access 13 Pages 2008
Effect of Thermodynamic Activities of the Unionized and Ionized Species on Drug Flux across Buccal Mucosa Fulltext Access 13 Pages 2008
Chronic treatment with a dopamine uptake blocker changes dopamine and acetylcholine but not glutamate and GABA concentrations in prefrontal cortex, striatum and nucleus accumbens of the awake rat Fulltext Access 13 Pages 2008
Deorphanisation of G protein-coupled receptors: A tool to provide new insights in nervous system pathophysiology and new targets for psycho-active drugs Fulltext Access 13 Pages 2008
Seizures in the developing brain: Cellular and molecular mechanisms of neuronal damage, neurogenesis and cellular reorganization Fulltext Access 13 Pages 2008
9-Methyl-β-carboline up-regulates the appearance of differentiated dopaminergic neurones in primary mesencephalic culture Fulltext Access 13 Pages 2008
The neurosteroid system: Implication in the pathophysiology of hepatic encephalopathy Fulltext Access 13 Pages 2008
Role of Mechanical Stress in Crystallization and Relaxation Behavior of Amorphous Indomethacin Fulltext Access 13 Pages 2008
The flavonoid baicalin counteracts ischemic and oxidative insults to retinal cells and lipid peroxidation to brain membranes Fulltext Access 13 Pages 2008
Ubiquitination-mediated internalization and degradation of the astroglial glutamate transporter, GLT-1 Fulltext Access 13 Pages 2008
Modern multiple sclerosis treatment – what is approved, what is on the horizon Fulltext Access 13 Pages 2008
Microfluidics for drug discovery and development: From target selection to product lifecycle management Fulltext Access 13 Pages 2008
New challenges for pharmaceutical formulations and drug delivery systems characterization using isothermal titration calorimetry Fulltext Access 13 Pages 2008
Microdialysis of GABA and glutamate: Analysis, interpretation and comparison with microsensors Fulltext Access 13 Pages 2008
Human olfactory detection of homologous n-alcohols measured via concentration-response functions Fulltext Access 13 Pages 2008
Effects of mammalian CYP3A inducers on CYP3A-related enzyme activities in grass carp (Ctenopharyngodon idellus): Possible implications for the establishment of a fish CYP3A induction model Fulltext Access 13 Pages 2008
Hepatic biotransformation responses in Atlantic salmon exposed to retinoic acids and 3,3′,4,4′-tetrachlorobiphenyl (PCB congener 77) Fulltext Access 13 Pages 2008
Spontaneous Crystallinity Loss of Drugs in the Disordered Regions of Poly(Ethylene Oxide) in the Presence of Water Fulltext Access 13 Pages 2008
Effects of E. Coli lipopolysaccharide on the pharmacokinetics of ipriflavone and its metabolites, M1 and M5, after intravenous and oral administration of ipriflavone to rats: Decreased metabolism of ipriflavone due to decreased expression of hepatic CYP1A Fulltext Access 13 Pages 2008
Ordering and disordering of molecular solids upon mechanical milling: The case of fananserine Fulltext Access 13 Pages 2008
Peptide-mediated lipofection is governed by lipoplex physical properties and the density of surface-displayed amines Fulltext Access 13 Pages 2008
pH-Dependent Interactions of Indinavir and Lipids in Nanoparticles and Their Ability to Entrap a Solute Fulltext Access 13 Pages 2008
Evaluation of Hydrophilic Permeant Transport Parameters in the Localized and Non-Localized Transport Regions of Skin Treated Simultaneously With Low-Frequency Ultrasound and Sodium Lauryl Sulfate Fulltext Access 13 Pages 2008
Transungual Iontophoretic Transport of Polar Neutral and Positively Charged Model Permeants: Effects of Electrophoresis and Electroosmosis Fulltext Access 13 Pages 2008
Interactions of pluronic block copolymers on Pâgp efflux activity: Experience with HIVâ1 protease inhibitors Fulltext Access 13 Pages 2008
Changes in metformin pharmacokinetics after intravenous and oral administration to rats with shortâterm and longâterm diabetes induced by streptozotocin Fulltext Access 13 Pages 2008
Site-specific drug delivery to the middle-to-lower region of the small intestine reduces food-drug interactions that are responsible for low drug absorption in the fed state Fulltext Access 13 Pages 2008
Functionality of magnesium stearate derived from bovine and vegetable sources: Dry granulated tablets Fulltext Access 13 Pages 2008
Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Aciclovir Fulltext Access 13 Pages 2008
3-Hydroxy-3-methylglutaryl coenzyme A reductase in rainbow trout: Effects of fasting and statin drugs on activities and mRNA transcripts Fulltext Access 13 Pages 2008
Role of Agglomeration in the Dispersion of Salmeterol Xinafoate from Mixtures for Inhalation with Differing Drug to Fine Lactose Ratios Fulltext Access 13 Pages 2008
Potential Use of Polyamidoamine Dendrimer/α-Cyclodextrin Conjugate (Generation 3, G3) as a Novel Carrier for Short Hairpin RNA-Expressing Plasmid DNA Fulltext Access 13 Pages 2008
Characterization of the “hygroscopic” properties of active pharmaceutical ingredients Fulltext Access 13 Pages 2008
A Comparison of the Effect of Chitosan and Chitosan-Coated Vesicles on Monolayer Integrity and Permeability Across Caco-2 and 16HBE14o-Cells Fulltext Access 13 Pages 2008
An Investigation into the Mechanisms of Drug Release From Taste-Masking Fatty Acid Microspheres Fulltext Access 13 Pages 2008
Physicochemical Characterisation of a Novel Thermogelling Formulation for Percutaneous Penetration of 5-Aminolevulinic Acid Fulltext Access 13 Pages 2008
Stabilization of Low Glass Transition Temperature Indomethacin Formulations: Impact of Polymer-Type and Its Concentration Fulltext Access 13 Pages 2008
Inhibition of Aggregation of Aluminum Hydroxide Adjuvant During Freezing and Drying Fulltext Access 13 Pages 2008
Pharmacokinetic/Pharmacodynamic Modeling of Corticosterone Suppression and Lymphocytopenia by Methylprednisolone in Rats Fulltext Access 13 Pages 2008
N-in-1 Dosing Pharmacokinetics in Drug Discovery: Experience, Theoretical and Practical Considerations Fulltext Access 13 Pages 2008
Quality-by-Design (QbD): Effects of Testing Parameters and Formulation Variables on the Segregation Tendency of Pharmaceutical Powder Measured by the ASTM D 6940-04 Segregation Tester Fulltext Access 13 Pages 2008