Efficacy and safety of duloxetine for treatment of fibromyalgia in patients with or without major depressive disorder: Results from a 6-month, randomized, double-blind, placebo-controlled, fixed-dose trial Fulltext Access 13 Pages 2008
GABAB receptor-mediated presynaptic inhibition of glycinergic transmission onto substantia gelatinosa neurons in the rat spinal cord Fulltext Access 13 Pages 2008
Touch or pain? Spatio-temporal patterns of cortical fMRI activity following brief mechanical stimuli Fulltext Access 13 Pages 2008
Propentofylline attenuates allodynia, glial activation and modulates GABAergic tone after spinal cord injury in the rat Fulltext Access 13 Pages 2008
Cytokine profile in human skin in response to experimental inflammation, noxious stimulation, and administration of a COX-inhibitor: A microdialysis study Fulltext Access 13 Pages 2008
NK-1 receptors in the rostral ventromedial medulla contribute to hyperalgesia produced by intraplantar injection of capsaicin Fulltext Access 13 Pages 2008
EphrinB-EphB receptor signaling contributes to neuropathic pain by regulating neural excitability and spinal synaptic plasticity in rats Fulltext Access 13 Pages 2008
Offset analgesia: A temporal contrast mechanism for nociceptive information Fulltext Access 13 Pages 2008
Spinal brain-derived neurotrophic factor governs neuroplasticity and recovery from cold-hypersensitivity following dorsal rhizotomy Fulltext Access 13 Pages 2008
Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats Fulltext Access 13 Pages 2008
Fibromyalgia relapse evaluation and efficacy for durability of meaningful relief (FREEDOM): A 6-month, double-blind, placebo-controlled trial with pregabalin Fulltext Access 13 Pages 2008
A review on the impact of P-glycoprotein on the penetration of drugs into the brain. Focus on psychotropic drugs Fulltext Access 13 Pages 2008
TNF signaling contributes to the development of nociceptive sensitization in a tibia fracture model of complex regional pain syndrome type I Fulltext Access 13 Pages 2008
Alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist for the treatment of opioid-induced bowel dysfunction: Results from a randomized, double-blind, placebo-controlled, dose-finding study in subjects taking opioids for chronic non-cance Fulltext Access 13 Pages 2008
A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral–CA1 synapses in hippocampus Fulltext Access 13 Pages 2008
The novel compound (±)-1-[10-((E)-3-Phenyl-allyl)-3,10-diaza-bicyclo[4.3.1]dec-3-yl]-propan-1-one (NS7051) attenuates nociceptive transmission in animal models of experimental pain; a pharmacological comparison with the combined μ-opioid receptor agonist Fulltext Access 13 Pages 2008
The L293 residue in transmembrane domain 2 of the 5-HT3A receptor is a molecular determinant of allosteric modulation by 5-hydroxyindole Fulltext Access 13 Pages 2008
CB1 receptor blockade reduces the anxiogenic-like response and ameliorates the neurochemical imbalances associated with alcohol withdrawal in rats Fulltext Access 13 Pages 2008
Blockade of central vasopressin receptors reduces the cardiovascular response to acute stress in freely moving rats Fulltext Access 13 Pages 2008
Identification of the sites of 2-arachidonoylglycerol synthesis and action imply retrograde endocannabinoid signaling at both GABAergic and glutamatergic synapses in the ventral tegmental area Fulltext Access 13 Pages 2008
Nociceptive sensations evoked from 'spots' in the skin by mild cooling and heating Fulltext Access 13 Pages 2008
A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1 Fulltext Access 13 Pages 2008
Neuroprotection by Imipramine against lipopolysaccharide-induced apoptosis in hippocampus-derived neural stem cells mediated by activation of BDNF and the MAPK pathway Fulltext Access 13 Pages 2008
Attenuated disruption of prepulse inhibition by dopaminergic stimulation after maternal deprivation and adolescent corticosterone treatment in rats Fulltext Access 13 Pages 2008
The role of heterosynaptic facilitation in long-term potentiation (LTP) of human pain sensation Fulltext Access 13 Pages 2008
A new rat model for thrombus-induced ischemic pain (TIIP); development of bilateral mechanical allodynia Fulltext Access 13 Pages 2008
Early loss of peptidergic intraepidermal nerve fibers in an STZ-induced mouse model of insensate diabetic neuropathy Fulltext Access 13 Pages 2008
An Interfaculty Pain Curriculum: Lessons learned from six years experience Fulltext Access 13 Pages 2008
A longitudinal study of the efficacy of a comprehensive pain rehabilitation program with opioid withdrawal: Comparison of treatment outcomes based on opioid use status at admission Fulltext Access 13 Pages 2008
TRP channels and ASICs mediate mechanical hyperalgesia in models of inflammatory muscle pain and delayed onset muscle soreness Fulltext Access 13 Pages 2008
A randomized trial of behavioral physical therapy interventions for acute and sub-acute low back pain (NCT00373867) Fulltext Access 13 Pages 2008
Ralfinamide administered orally before hindpaw neurectomy or postoperatively provided long-lasting suppression of spontaneous neuropathic pain-related behavior in the rat Fulltext Access 13 Pages 2008
Thermal nociception and TRPV1 function are attenuated in mice lacking the nucleotide receptor P2Y2 Fulltext Access 13 Pages 2008
Pharmacological approach to the treatment of long and short QT syndromes Fulltext Access 14 Pages 2008
cDNA microarray analysis of the differentially expressed genes involved in murine pre-osteoclast RAW264.7 cells proliferation stimulated by dexamethasone Fulltext Access 14 Pages 2008
Centchroman induces G0/G1 arrest and Caspase-dependent Apoptosis involving Mitochondrial Membrane Depolarization in MCF-7 and MDA MB-231 Human Breast Cancer Cells Fulltext Access 14 Pages 2008
Impact of study design on proarrhythmia prediction in the SCREENIT rabbit isolated heart model Fulltext Access 14 Pages 2008
Brief post-stressor treatment with pregabalin in an animal model for PTSD: Short-term anxiolytic effects without long-term anxiogenic effect Fulltext Access 14 Pages 2008
Opioid receptor agonists enhance the phosphorylation state of Fas-associated death domain (FADD) protein in the rat brain: Functional interactions with casein kinase Iα, Gαi proteins, and ERK1/2 signaling Fulltext Access 14 Pages 2008
Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity Fulltext Access 14 Pages 2008
In Vivo comparative study of lipid/DNA complexes with different In Vitro serum stability: Effects on biodistribution and tumor accumulation Fulltext Access 14 Pages 2008
Metabolism and Disposition of Resveratrol in the Isolated Perfused Rat Liver: Role of Mrp2 in the Biliary Excretion of Glucuronides Fulltext Access 14 Pages 2008
Dosimetry considerations in the enhanced sensitivity of male Wistar rats to chronic ethylene glycol-induced nephrotoxicity Fulltext Access 14 Pages 2008
Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons Fulltext Access 14 Pages 2008
Glutamatergic dysfunction in schizophrenia: From basic neuroscience to clinical psychopharmacology Fulltext Access 14 Pages 2008
Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells Fulltext Access 14 Pages 2008
Subchronic effects of valproic acid on gene expression profiles for lipid metabolism in mouse liver Fulltext Access 14 Pages 2008
Intense pseudotransport of a cationic drug mediated by vacuolar ATPase: Procainamide-induced autophagic cell vacuolization Fulltext Access 14 Pages 2008
Clofibrate and gemfibrozil induce an embryonic malabsorption syndrome in zebrafish Fulltext Access 14 Pages 2008
In vitro expression of hard metal dust (WC–Co) — responsive genes in human peripheral blood mononucleated cells Fulltext Access 14 Pages 2008
Secretory phospholipase A2 mediates progression of acute liver injury in the absence of sufficient cyclooxygenase-2 Fulltext Access 14 Pages 2008
Stress and immunity: An integrated view of relationships between the brain and the immune system Fulltext Access 14 Pages 2008
Gene expression profiles in the cerebellum and hippocampus following exposure to a neurotoxicant, Aroclor 1254: Developmental effects Fulltext Access 14 Pages 2008
Rat behavior after chronic variable stress and partial lesioning of 5-HT-ergic neurotransmission: Effects of citalopram Fulltext Access 14 Pages 2008
The potential and the pitfalls of β-adrenoceptor agonists for the management of skeletal muscle wasting Fulltext Access 14 Pages 2008
Examination of Barriers and Barrier Alteration in Transscleral Iontophoresis Fulltext Access 14 Pages 2008
New perspectives from microdialysis studies in freely-moving, spontaneously hypertensive rats on the pharmacology of drugs for the treatment of ADHD Fulltext Access 14 Pages 2008
Role of glutathione peroxidase in the ontogeny of hippocampal oxidative stress and kainate seizure sensitivity in the genetically epilepsy-prone rats Fulltext Access 14 Pages 2008
The attenuating effect of memantine on staurosporine-, salsolinol- and doxorubicin-induced apoptosis in human neuroblastoma SH-SY5Y cells Fulltext Access 14 Pages 2008
Internalization and degradation of the glutamate transporter GLT-1 in response to phorbol ester Fulltext Access 14 Pages 2008
Neurotrophic estrogens: essential profile and endpoints for drug discovery Fulltext Access 14 Pages 2008
Atomizing into a Chilled Extraction Solvent Eliminates Liquid Gas from a Spray-Freeze Drying Microencapsulation Process Fulltext Access 14 Pages 2008
MPZP: A novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist Fulltext Access 14 Pages 2008
The effect of corticotropin-releasing factor on prepulse inhibition is independent of serotonin in Brown Norway and Wistar-Kyoto rats Fulltext Access 14 Pages 2008
MDMA (N-methyl-3,4-methylenedioxyamphetamine) and its stereoisomers: Similarities and differences in behavioral effects in an automated activity apparatus in mice Fulltext Access 14 Pages 2008
Efficacy of percutaneous electrical nerve stimulation and therapeutic exercise for older adults with chronic low back pain: A randomized controlled trial Fulltext Access 14 Pages 2008
Intrathecal neuropeptide Y reduces behavioral and molecular markers of inflammatory or neuropathic pain Fulltext Access 14 Pages 2008
Psychometric properties of the Beck Depression Inventory-Second Edition (BDI-II) in individuals with chronic pain Fulltext Access 14 Pages 2008
Effect of anti-NGF antibodies in a rat tibia fracture model of complex regional pain syndrome type I Fulltext Access 14 Pages 2008
Formulating Poly(Lactide-Co-Glycolide) Particles for Plasmid DNA Delivery Fulltext Access 14 Pages 2008
A Laser Imaging and Neutron Reflection Investigation Into the Monolayer Behaviour of Fatty Acids Used for Taste Masking Microspheres Fulltext Access 14 Pages 2008
Noncovalent PEGylation: Different Effects of Dansyl-, l-Tryptophan-, Phenylbutylamino-, Benzyl- and Cholesteryl-PEGs on the Aggregation of Salmon Calcitonin and Lysozyme Fulltext Access 14 Pages 2008
Effect Of Structural Relaxation On The Preparation And Drug Release Behavior Of Poly(lactic-co-glycolic)acid Microparticle Drug Delivery Systems Fulltext Access 14 Pages 2008
Conformation and Side Chains Environments of Recombinant Human Interleukin-1 Receptor Antagonist (rh-IL-1ra) Probed by Raman, Raman Optical Activity, and UV-Resonance Raman Spectroscopy Fulltext Access 14 Pages 2008
Extent and Mechanism of Solvation and Partitioning of Isomers of Substituted Benzoic Acids: A Thermodynamic Study in the Solid State and in Solution Fulltext Access 14 Pages 2008
Increased Paracellular Absorption by Bile Salts and P-Glycoprotein Stimulated Efflux of Otilonium Bromide in Caco-2 Cells Monolayers as a Model of Intestinal Barrier Fulltext Access 14 Pages 2008
Evaluation of human nasal RPMI 2650 cells grown at an air-liquid interface as a model for nasal drug transport studies Fulltext Access 14 Pages 2008
Alternative Drug Delivery Approaches for the Therapy of Inflammatory Bowel Disease Fulltext Access 14 Pages 2008
Biodegradable Films Developed by Electrospray Deposition for Sustained Drug Delivery Fulltext Access 14 Pages 2008
Comparison of Delivery Characteristics from a Combination Metered-Dose Inhaler Using the Andersen Cascade Impactor and the Next Generation Pharmaceutical Impactor Fulltext Access 14 Pages 2008
Influence of polymeric excipients on crystal hydrate formation kinetics in aqueous slurries Fulltext Access 14 Pages 2008
Variability in Caco-2 and MDCK Cell-Based Intestinal Permeability Assays Fulltext Access 14 Pages 2008