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Pharmacology Research Articles

Involvement of central α1- and α2-adrenoceptors on cardiovascular responses to moxonidine
Fulltext Access 8 Pages 2007
11,13-dihydro-dehydroleucodine, a derivative of dehydroleucodine with an inactivated alkylating function conserves the anti-proliferative activity in G2 but does not cause cytotoxicity
Fulltext Access 8 Pages 2007
Gas6/Axl-PI3K/Akt pathway plays a central role in the effect of statins on inorganic phosphate-induced calcification of vascular smooth muscle cells
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Synergistic effect of PGD2 via prostanoid DP receptor on TNF-α-induced production of MCP-1 and IL-8 in human monocytic THP-1 cells
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Expression and antioxidant function of liver fatty acid binding protein in normal and bile-duct ligated rats
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Taxol normalizes the impaired agonist-induced β2-adrenoceptor internalization in splenocytes from GRK2+/− mice
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The neuronal 5-HT3 receptor network after 20 years of research — Evolving concepts in management of pain and inflammation
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Amelioration of collagen-induced arthritis in mice by a novel phosphodiesterase 7 and 4 dual inhibitor, YM-393059
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Inhibition of eosinophilia in vivo by a small molecule inhibitor of very late antigen (VLA)-4
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Effects of serotonin 5-HT1B receptor ligands on the cocaine- and food-maintained self-administration in rats
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Ability of carbazole salts, inhibitors of Alzheimer β-amyloid fibril formation, to cross cellular membranes
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PARP inhibition reduces acute colonic inflammation in rats
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Verrucotoxin inhibits KATP channels in cardiac myocytes through a muscarinic M3 receptor-PKC pathway
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Striatal serotonin depletion facilitates rat egocentric learning via dopamine modulation
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Increased sensitivity of adolescent spontaneously hypertensive rats, an animal model of attention deficit hyperactivity disorder, to the locomotor stimulation induced by the cannabinoid receptor agonist WIN 55,212-2
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A Tyr-W-MIF-1 analog containing d-Pro2 discriminates among antinociception in mice mediated by different classes of μ-opioid receptors
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Effect of matrine on HeLa cell adhesion and migration
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Raloxifene inhibits transient outward and ultra-rapid delayed rectifier potassium currents in human atrial myocytes
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RNA interference for HIF-1α inhibits foam cells formation in vitro
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Effect of PPARα activation of macrophages on the secretion of inflammatory cytokines in cultured adipocytes
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Antinociceptive and antiedematogenic activities of fenofibrate, an agonist of PPAR alpha, and pioglitazone, an agonist of PPAR gamma
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Modulation by heme and zinc protoporphyrin of colonic heme oxygenase-1 and experimental inflammatory bowel disease in the rat
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The effect of N-acetylcysteine and melatonin in adult spontaneously hypertensive rats with established hypertension
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Increased oxidative stress in the streptozotocin-induced diabetic apoE-deficient mouse: Changes in expression of NADPH oxidase subunits and eNOS
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Neuroprotective effect of MnTMPyP, a superoxide dismutase/catalase mimetic in global cerebral ischemia is mediated through reduction of oxidative stress and DNA fragmentation
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Analysis of proarrhythmic potential of antipsychotics risperidone and olanzapine in anesthetized dogs
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Use of scopoletin to inhibit the production of inflammatory cytokines through inhibition of the IκB/NF-κB signal cascade in the human mast cell line HMC-1
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5-HT1A receptors are involved in the anxiolytic effect of Δ9-tetrahydrocannabinol and AM 404, the anandamide transport inhibitor, in Sprague–Dawley rats
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Characterization of ethanol-induced dopamine elevation in the rat nucleus accumbens
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Dual effect of endothelin 1 on angiotensin II-potentiated purinergic neurotransmission in prostatic rat vas deferens
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Asymmetric dimethylarginine (ADMA) induces vascular endothelium impairment and aggravates post-ischemic ventricular dysfunction in rats
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3β-hydroxysteroids and pregnenolone sulfate inhibit recombinant rat GABAA receptor through different channel property
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NO-1886, a lipoprotein lipase activator, attenuates vascular smooth muscle contraction in rat aorta
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Adrenergic receptors in the nucleus accumbens shell differentially modulate dopamine and acetylcholine receptor-mediated turning behaviour
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Paradoxical hyperalgesia induced by μ-opioid receptor agonist endomorphin-2, but not endomorphin-1, microinjected into the centromedial amygdala of the rat
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The action of the novel gastrointestinal prokinetic prucalopride on the HERG K+ channel and the common T897 polymorph
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Extracellular glutamate and GABA in the ventral tegmental area of alcohol-preferring AA and alcohol-avoiding ANA rats treated repeatedly with morphine
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Prevention of aortic calcification by etidronate in the renal failure rat model
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Intrathecal co-administration of morphine and nimodipine produces higher antinociceptive effect by synergistic interaction as evident by injecting different doses of each drug in rats
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Brazilein protects the brain against focal cerebral ischemia reperfusion injury correlating to inflammatory response suppression
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Local peripheral antinociceptive effects of 14-O-methyloxymorphone derivatives in inflammatory and neuropathic pain in the rat
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Endocannabinoids block status epilepticus in cultured hippocampal neurons
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Anticlastogenic activity of morin against whole body gamma irradiation in Swiss albino mice
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Ribavirin uptake by cultured human choriocarcinoma (BeWo) cells and Xenopus laevis oocytes expressing recombinant plasma membrane human nucleoside transporters
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Effects of the treatment with glibenclamide, an ATP-sensitive potassium channel blocker, on intestinal ischemia and reperfusion injury
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Effects of TS-022, a newly developed prostanoid DP1 receptor agonist, on experimental pruritus, cutaneous barrier disruptions and atopic dermatitis in mice
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Aspirin restores normal baroreflex function in hypercholesterolemic rats by its antioxidative action
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Enalapril improves impairment of SERCA-derived relaxation and enhancement of tyrosine nitration in diabetic rat aorta
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Mechanisms underlying ATP-induced endothelium-dependent contractions in the SHR aorta
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The role of nitric oxide within the nucleus accumbens on the acquisition and expression of morphine-induced place preference in morphine sensitized rats
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The effects of cholinergic stimulation and of nucleoside transport inhibition on spikes and spike patches in the canine small intestine in vivo
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Cytoprotective properties of phenolic antidiarrheic ingredients in cultured astrocytes and neurons of rat brains
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β-adrenoceptor agonists downregulate adiponectin, but upregulate adiponectin receptor 2 and tumor necrosis factor-α expression in adipocytes
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Endothelial gap junctions are down-regulated by arsenic trioxide
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Indomethacin stimulates activity and expression of ecto-5′-nucleotidase/CD73 in glioma cell lines
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Lycopene, quercetin and tyrosol prevent macrophage activation induced by gliadin and IFN-γ
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Increases in vanilloid TRPV1 receptor protein and CGRP content during endotoxemia in rats
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Functional properties of a novel mutant of staphylokinase with platelet-targeted fibrinolysis and antiplatelet aggregation activities
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Acute effects of nicotine on restraint stress-induced anxiety-like behavior, c-Fos expression, and corticosterone release in mice
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Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist pharmacophores
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Modulation of function of multidrug resistance associated-proteins by Kaempferia parviflora extracts and their components
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Urine osmolality, cyclic AMP and aquaporin-2 in urine of patients under lithium treatment in response to water loading followed by vasopressin administration
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Platelet activation triggered by Chlamydia pneumoniae is antagonized by 12-lipoxygenase inhibitors but not cyclooxygenase inhibitors
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Comparison of the effects of bupropion on nicotinic receptor-evoked [3H]dopamine release from rat striatal synaptosomes and slices
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Curative-like analgesia in a neuropathic pain model: Parametric analysis of the dose and the duration of treatment with a high-efficacy 5-HT1A receptor agonist
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Inhibition of human equilibrative nucleoside transporters by dihydropyridine-type calcium channel antagonists
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Carvedilol ameliorates endothelial dysfunction in streptozotocin-induced diabetic rats
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Activity of “reversed” diamidines against Trypanosoma cruzi “in vitro”
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Identification of two herbal compounds with potential cholesterol-lowering activity
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Inter-individual variability in esterases in human liver
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Involvement of p38MAPK on the antinociceptive action of myricitrin in mice
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Relevance of extracellular and intracellular interactions of camptothecins as determinants of antitumor activity
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Constitutive activity and inverse agonism at the α1adrenoceptors
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Heterodimerization and surface localization of G protein coupled receptors
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A1 receptor deficiency causes increased insulin and glucagon secretion in mice
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Tianeptine increases brain-derived neurotrophic factor expression in the rat amygdala
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Two types of circulating endothelial progenitor cells in patients receiving long term therapy by HMG-CoA reductase inhibitors
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The calcitonin gene-related peptide (CGRP) receptor antagonist BIBN4096BS reduces neurogenic increases in dural blood flow
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Pharmacokinetics of eugenol and its effects on thermal hypersensitivity in rats
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Antinociceptive effect of intra-hippocampal CA1 and dentate gyrus injection of MK801 and AP5 in the formalin test in adult male rats
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Microtubule-stabilizing agent prevents protein accumulation-induced loss of synaptic markers
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Effect of magnolol on TGF-β1 and fibronectin expression in human retinal pigment epithelial cells under diabetic conditions
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Calcium-activated potassium channel and connexin expression in small mesenteric arteries from eNOS-deficient (eNOS−/−) and eNOS-expressing (eNOS+/+) mice
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Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain
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Clioquinol attenuates zinc-dependent β-cell death and the onset of insulitis and hyperglycemia associated with experimental type I diabetes in mice
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Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor κB
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Gypenoside XLIX, a naturally occurring PPAR-α activator, inhibits cytokine-induced vascular cell adhesion molecule-1 expression and activity in human endothelial cells
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Effects of co-administration of antidepressants and monoamine oxidase inhibitors on 5-HT-related behavior in rats
Fulltext Access 8 Pages 2007
The involvement of AMP-activated protein kinases in the anti-inflammatory effect of nicotine in vivo and in vitro
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Changes in neuromodulatory effect of adenosine A1 receptors on piriform cortex field potentials in amygdala kindled rats
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The α-methylene-γ-butyrolactone moiety in dehydrocostus lactone is responsible for cytoprotective heme oxygenase-1 expression through activation of the nuclear factor E2-related factor 2 in HepG2 cells
Fulltext Access 8 Pages 2007
Suppressive effect of a novel water-soluble artemisinin derivative SM905 on T cell activation and proliferation in vitro and in vivo
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The anti-pruritic efficacy of TS-022, a prostanoid DP1 receptor agonist, is dependent on the endogenous prostaglandin D2 level in the skin of NC/Nga mice
Fulltext Access 8 Pages 2007
Comparative antiarrhythmic efficacy of amiodarone and dronedarone during acute myocardial infarction in rats
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Effects of acute and chronic treatment with fluoxetine on stress-induced hyperthermia in telemetered rats and mice
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Risperidone attenuates MK-801-induced hyperlocomotion in mice via the blockade of serotonin 5-HT2A/2C receptors
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Heat injury-induced drop of the noxious heat threshold measured with an increasing-temperature water bath: A novel rat thermal hyperalgesia model
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Protective effects of salidroside on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells
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Pharmacodynamic characteristics and cardioprotective effects of new NHE1 inhibitors
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Effect of two novel CGRP-binding compounds in a closed cranial window rat model
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