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Pharmacology Research Articles

Suppressive effects of cannabidiol on antigen-specific antibody production and functional activity of splenocytes in ovalbumin-sensitized BALB/c mice
Fulltext Access 8 Pages 2007
Characterization and antitumor activity of pollen polysaccharide
Fulltext Access 8 Pages 2007
After interleukin-12p40, are interleukin-23 and interleukin-17 the next therapeutic targets for inflammatory bowel disease?
Fulltext Access 8 Pages 2007
Suppression of interleukin-2 gene expression by isoeugenol is mediated through down-regulation of NF-AT and NF-κB
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Differential effects of single dose FTY720 on CD62L+ B-cells in stable renal allograft recipients
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Anti-inflammatory effects of short chain fatty acids in IFN-γ-stimulated RAW 264.7 murine macrophage cells: Involvement of NF-κB and ERK signaling pathways
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Simvastatin inhibits NF-κB signaling in intestinal epithelial cells and ameliorates acute murine colitis
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Inhibitory effects of eicosapentaenoic acid on lipopolysaccharide-induced activation in BV2 microglia
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Optimisation of the sensitisation conditions for an ovalbumin challenge model of asthma
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Isolation and characterization of an anti-complementary polysaccharide D3-S1 from the roots of Bupleurum smithii
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Effect of pentoxifylline on differentiation and maturation of human monocyte-derived dendritic cells in vitro
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Chemically-modified polysaccharide extract derived from Leucaena leucocephala alters Raw 264.7 murine macrophage functions
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Effect of matrine on the expression of substance P receptor and inflammatory cytokines production in human skin keratinocytes and fibroblasts
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Ethnobotanical survey of plants used to treat asthma in Andhra Pradesh, India
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Bucillamine mechanism inhibiting IL-1β-induced VEGF production from fibroblast-like synoviocytes
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The serum amyloid A response to sterile silver nitrate in mice and its inhibition by dexamethasone and macrolide antibiotics
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Sinomenine attenuates 2, 4, 6-trinitrobenzene sulfonic acid-induced colitis in mice
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Double-stranded RNA increases kinin B1 receptor expression and function in human airway epithelial cells
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A proline-rich polypeptide complex (PRP) isolated from ovine colostrum. Modulation of H2O2 and cytokine induction in human leukocytes
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Effect of a thiol proteinase inhibitor, E-64-d, on susceptibility to infection with Staphylococcus aureus in Chediak–Higashi syndrome (beige) mice
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Inhibition of gene expression and production of iNOS and TNF-α in LPS-stimulated microglia by methanol extract of Phellodendri cortex
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Gab2 antisense oligonucleotide blocks rat basophilic leukemic cell functions
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Evaluation of anti-tumor effects of tumor cell lysate enriched by HSP-70 against fibrosarcoma tumor in BALB/c mice
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The effects of the BT/TAMUS 2032 cationic peptides on innate immunity and susceptibility of young chickens to extraintestinal Salmonella enterica serovar Enteritidis infection
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Anti-inflammatory effects of exogenous uridine in an animal model of lung inflammation
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Herbal medicine Gamgungtang down-regulates autoimmunity through induction of TH2 cytokine production by lymphocytes in experimental thyroiditis model
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Expression of drug metabolizing enzymes in hepatocyte-like cells derived from human embryonic stem cells
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Change of drug excretory pathway by CCl4-induced liver dysfunction in rat
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The reactivity of ortho-methoxy-substituted catechol radicals with sulfhydryl groups: Contribution for the comprehension of the mechanism of inhibition of NADPH oxidase by apocynin
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Epothilone-paclitaxel resistant leukemic cells CEM/dEpoB300 are sensitive to albendazole: Involvement of apoptotic pathways
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The effect of opiates on the activity of human placental aromatase/CYP19
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Mechanism of action of AZD0865, a K+-competitive inhibitor of gastric H+,K+-ATPase
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Protective effect of the Chinese prescription Kangen-karyu against high glucose-induced oxidative stress in LLC-PK1 cells
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Usefulness of traditionally defined herbal properties for distinguishing prescriptions of traditional Chinese medicine from non-prescription recipes
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Mitochondrial involvement in Atuna racemosa induced toxicity
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Evidence of anti-inflammatory effects of Passiflora edulis in an inflammation model
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Essential oil of Pterodon polygalaeflorus inhibits electromechanical coupling on rat isolated trachea
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Brazilian plants as possible adaptogens: An ethnopharmacological survey of books edited in Brazil
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Human placenta promotes IL-8 expression through activation of JNK/SAPK and transcription factors NF-κB and AP-1 in PMA-differentiated THP-1 cells
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Anti-inflammatory and antinociceptive activities of extract, fractions and populnoic acid from bark wood of Austroplenckia populnea
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Ethnopharmacological investigation of plants used to treat susto, a folk illness
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Antimicrobial activity of the methanolic extracts and compounds from Vismia laurentii De Wild (Guttiferae)
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Behavioral, neurochemical and neuroendocrine effects of the ethanolic extract from Curcuma longa L. in the mouse forced swimming test
Fulltext Access 8 Pages 2007
A phytotherapeutic extract of Equisetum myriochaetum is not genotoxic either in the in vivo wing somatic test of Drosophila or in the in vitro human micronucleus test
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Protective effects of Ligustrum lucidum fruit extract on acute butylated hydroxytoluene-induced oxidative stress in rats
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Immunological and allergenic responses induced by latex fractions of Calotropis procera (Ait.) R.Br.
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Plants of restricted use indicated by three cultures in Brazil (Caboclo-river dweller, Indian and Quilombola)
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Effects of KIOM-79 on hyperglycemia and diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats
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Prevention of hepatic oxidative injury by Xiao-Chen-Chi-Tang in mice
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Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice
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Amiodarone inhibits tocopherol-mediated human lipoprotein peroxidation
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Pharmacokinetics of a hepatic stellate cell-targeted doxorubicin construct in bile duct-ligated rats
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Selective action of the iminosugar isofagomine, a pharmacological chaperone for mutant forms of acid-β-glucosidase
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Efficacy of increasing the therapeutic index of irinotecan, plasma and tissue selenium concentrations is methylselenocysteine dose dependent
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The role of esterases in the metabolism of ciclesonide to desisobutyryl-ciclesonide in human tissue
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Clotrimazole inhibits and modulates heterologous association of the key glycolytic enzyme 6-phosphofructo-1-kinase
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Curcumin induces electrical activity in rat pancreatic β-cells by activating the volume-regulated anion channel
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Interaction and transport characteristics of mycophenolic acid and its glucuronide via human organic anion transporters hOAT1 and hOAT3
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Artemisinin effectiveness in erythrocytes is reduced by heme and heme-containing proteins
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Accumulation, platinum–DNA adduct formation and cytotoxicity of cisplatin, oxaliplatin and satraplatin in sensitive and resistant human osteosarcoma cell lines, characterized by p53 wild-type status
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Probing the substrate specificity of the ergothioneine transporter with methimazole, hercynine, and organic cations
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Modulation of hepatic microsomal triglyceride transfer protein (MTP) induced by S-nitroso-N-acetylcysteine in ob/ob mice
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The inhibitors of protein acylation, cerulenin and tunicamycin, increase voltage-dependent Ca2+ currents in the insulin-secreting INS 832/13 cell
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Redox regulation of human estrogen sulfotransferase (hSULT1E1)
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A novel drug interaction between the quinolone antibiotic ciprofloxacin and a chiral metabolite of pentoxifylline
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Obesity-induced increase of CYP2E1 activity and its effect on disposition kinetics of chlorzoxazone in Zucker rats
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Evidence for significant contribution of a newly identified monoamine transporter (PMAT) to serotonin uptake in the human brain
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Harnessing the hypoxia-inducible factor in cancer and ischemic disease
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Pharmacological inhibition of the MAPK/ERK pathway increases sensitivity to 2-chloro-2′-deoxyadenosine (CdA) in the B-cell leukemia cell line EHEB
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The autocrine TNFα signalling loop in keratinocytes requires atypical PKC species and NF-κB activation but is independent of cholesterol-enriched membrane microdomains
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Functional studies on the activity of efflux transporters in an ex vivo model with chicken splenocytes and evaluation of selected fluoroquinolones in this model
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Multiple brain pathways and receptors underlying tobacco addiction
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Structure-guided drug design: Conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes
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Role of endogenous nicotinic signaling in guiding neuronal development
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Relaxin receptors in hepatic stellate cells and cirrhotic liver
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(R)-ACX, a pancreatic β-cell selective sulfonylurea, does not aggravate myocardial ischemia-reperfusion damage
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Protective effect of lipoic acid on oxidative and peroxidative damage in cyclosporine A-induced renal toxicity
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Apoptosis of murine lupus T cells induced by the selective cyclooxygenase-2 inhibitor celecoxib: Molecular mechanisms and therapeutic potential
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In hemocytes from Mytilus galloprovincialis Lmk., treatment with corticotropin or growth factors conditions catecholamine release
Fulltext Access 8 Pages 2007
Characterization and anti-tumor activity of pollen polysaccharide
Fulltext Access 8 Pages 2007
The effects of the EW dipeptide optical and chemical isomers on the CFU-S population in intact and irradiated mice
Fulltext Access 8 Pages 2007
Paeonol suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-α-stimulated human umbilical vein endothelial cells by blocking p38, ERK and nuclear factor-κB signaling pathways
Fulltext Access 8 Pages 2007
Differential effects of ginsenosides on NO and TNF-α production by LPS-activated N9 microglia
Fulltext Access 8 Pages 2007
Chlamydia pneumoniae stimulates the proliferation of HUVEC through the induction of VEGF by THP-1
Fulltext Access 8 Pages 2007
Sulforaphane suppresses lipopolysaccharide-induced cyclooxygenase-2 (COX-2) expression through the modulation of multiple targets in COX-2 gene promoter
Fulltext Access 8 Pages 2007
Inhibitory effects of thyroxine on cytokine production by T cells in mice
Fulltext Access 8 Pages 2007
Topical application of silymarin reduces chemical-induced irritant contact dermatitis in BALB/c mice
Fulltext Access 8 Pages 2007
Evaluation of stem cell administration in a model of kidney ischemia-reperfusion injury
Fulltext Access 8 Pages 2007
Conformational state of human cardiac 5-HT4(g) receptors influences the functional effects of polyclonal anti-5-HT4 receptor antibodies
Fulltext Access 8 Pages 2007
Melatonin reduces formalin-induced nociception and tactile allodynia in diabetic rats
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Topical levamisole hydrochloride therapy attenuates experimental murine allergic rhinitis
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Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates
Fulltext Access 8 Pages 2007
Contractile effect of TRPA1 receptor agonists in the isolated mouse intestine
Fulltext Access 8 Pages 2007
The myocardial infarct size-limiting and antiarrhythmic effects of acyl-CoA:Cholesterol acyltransferase inhibitor VULM 1457 protect the hearts of diabetic–hypercholesterolaemic rats against ischaemia/reperfusion injury both in vitro and in vivo
Fulltext Access 8 Pages 2007
Leukotrienes and cyclooxygenase products mediate anaphylactic venoconstriction in ovalbumin sensitized rat livers
Fulltext Access 8 Pages 2007
Pharmacological evidence for the involvement of the opioid system in the antidepressant-like effect of adenosine in the mouse forced swimming test
Fulltext Access 8 Pages 2007
Modulation of the motor response to dopaminergic drugs in a parkinsonian model of combined dopaminergic and noradrenergic degeneration
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p38 and JNK MAPK, but not ERK1/2 MAPK, play important role in colchicine-induced cortical neurons apoptosis
Fulltext Access 8 Pages 2007
Voltage-gated Ca2+ influx and insulin secretion in human and mouse β-cells are impaired by the mitochondrial Na+/Ca2+ exchange inhibitor CGP-37157
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Alterations in cytoskeletal protein expression by mycophenolic acid in human mesangial cells requires Rac inactivation
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