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Pharmacology Research Articles

Hexachlorobenzene stimulates uroporphyria in low affinity AHR mice without increasing CYP1A2
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Rat epileptic seizures evoked by BmK αIV and its possible mechanisms involved in sodium channels
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Meliae cortex extract exhibits anti-allergic activity through the inhibition of Syk kinase in mast cells
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Hydrolysis of a series of parabens by skin microsomes and cytosol from human and minipigs and in whole skin in short-term culture
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Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity
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Inhibitory effect of phytoglycoprotein on tumor necrosis factor-α and interleukin-6 at initiation stage of colon cancer in 1,2-dimethylhydrazine-treated ICR mice
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Quantitative GFP fluorescence as an indicator of arsenite developmental toxicity in mosaic heat shock protein 70 transgenic zebrafish
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Calcium dependent and independent cytokine synthesis by air pollution particle-exposed human bronchial epithelial cells
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Various effects of antidepressant drugs on bone microarchitectecture, mechanical properties and bone remodeling
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Exposure in utero to 2,2′,3,3′,4,6′-hexachlorobiphenyl (PCB 132) impairs sperm function and alters testicular apoptosis-related gene expression in rat offspring
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Mercury species in lymphoid and non-lymphoid tissues after exposure to methyl mercury: Correlation with autoimmune parameters during and after treatment in susceptible mice
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Cigarette smoke toxicants as substrates and inhibitors for human cytosolic SULTs
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Concentration-dependent interactions of the organophosphates chlorpyrifos oxon and methyl paraoxon with human recombinant acetylcholinesterase
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Transplacental exposure to inorganic arsenic at a hepatocarcinogenic dose induces fetal gene expression changes in mice indicative of aberrant estrogen signaling and disrupted steroid metabolism
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DHA down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes by attenuating CAR translocation
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Differential role of CYP2E1-mediated metabolism in the lethal and vestibulotoxic effects of cis-crotononitrile in the mouse
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Activation of p38 mitogen-activated protein kinase by celecoxib oppositely regulates survivin and gamma-H2AX in human colorectal cancer cells
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The quercetin paradox
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Phytoestrogens levels determination in the cord blood from Malaysia rural and urban populations
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Modulation of neurological related allergic reaction in mice exposed to low-level toluene
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Bioaccessibility and excretion of arsenic in Niu Huang Jie Du Pian pills
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Insights into the carcinogenic mode of action of arsenic
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Arsenic-induced toxicity and the protective role of ascorbic acid in mouse testis
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Metabolic differences between two dimethylthioarsenicals in rats
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Arsenic methylation capability and hypertension risk in subjects living in arseniasis-hyperendemic areas in southwestern Taiwan
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Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): Novel gene therapeutic for metastatic melanoma
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Cyclophosphamide as a potent inhibitor of tumor thioredoxin reductase in vivo
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Trichostatin A, a critical factor in maintaining the functional differentiation of primary cultured rat hepatocytes
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1,25-Dihydroxyvitamin D3 regulates genes responsible for detoxification in intestine
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Percutaneous characterization of the insect repellent DEET and the sunscreen oxybenzone from topical skin application
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Mixtures in the real world: The importance of plant self-defense toxicants, mycotoxins, and the human diet
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The effect of centaurein on interferon-γ expression and Listeria infection in mice
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Modulation of aflatoxin toxicity and biomarkers by lycopene in F344 rats
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Thioacetamide-induced cirrhosis in selenium-adequate mice displays rapid and persistent abnormity of hepatic selenoenzymes which are mute to selenium supplementation
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Characterization of Bizzy Nut extracts in estrogen-responsive MCF-7 breast cancer cells
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Intracellular free calcium concentration and calcium transport in human erythrocytes of lead-exposed workers
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Prostate cancer chemoprevention: Current status and future prospects
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EGCG-targeted p57/KIP2 reduces tumorigenicity of oral carcinoma cells: Role of c-Jun N-terminal kinase
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Urinary arsenic profile affects the risk of urothelial carcinoma even at low arsenic exposure
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Novel Hedgehog pathway targets against basal cell carcinoma
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Polyamines and nonmelanoma skin cancer
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p53 and the pathogenesis of skin cancer
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Interleukin-12 and photocarcinogenesis
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Boric acid inhibits embryonic histone deacetylases: A suggested mechanism to explain boric acid-related teratogenicity
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The combination of donepezil and procyclidine protects against soman-induced seizures in rats
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The regulatory effect of SC-236 (4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-l]benzenesulfonamide) on stem cell factor induced migration of mast cells
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Toxicogenomic evaluation of microcystin-LR treated with ultrasonic irradiation
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Aluminum stimulates uptake of non-transferrin bound iron and transferrin bound iron in human glial cells
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1-Methyl-4-phenylpyridinium-induced alterations of glutathione status in immortalized rat dopaminergic neurons
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Cell death and impairment of glucose-stimulated insulin secretion induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the β-cell line INS-1E
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Colorectal distension-induced pseudoaffective changes as indices of nociception in the anesthetized female rat: Morphine and strain effects on visceral sensitivity
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Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon
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Fructose-induced hepatic gluconeogenesis: Effect of l-carnitine
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Non-steroidal anti-inflammatory agents, tolmetin and sulindac attenuate quinolinic acid (QA)-induced oxidative stress in primary hippocampal neurons and reduce QA-induced spatial reference memory deficits in male Wistar rats
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Transfection of cells attached to selected cell based biosensor surfaces
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A biochemical and toxicological study with diethyl 2-phenyl-2-tellurophenyl vinylphosphonate in a sub-chronic intraperitoneal treatment in mice
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Obesity influences the food consumption and cytokine pattern in ghrelin-treated endotoxemic rats
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Combination of dipeptidylpeptidase IV inhibitor and low dose thiazolidinedione: Preclinical efficacy and safety in db/db mice
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Activation of p38/MEF2C pathway by all-trans retinoic acid in cardiac myoblasts
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Reinforcing effect for corn oil stimulus was concentration dependent in an operant task in mice
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A novel method for fast determination of Ranitidine in its pharmaceutical formulations by fast continuous cyclic voltammetry
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Monophasic action potential in anaesthetized guinea pigs as a biomarker for prediction of liability for drug-induced delayed ventricular repolarization
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A novel approach for the determination of contractile and calcium responses of the basilar artery employing real-time confocal laser microscopy
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Differentiation of eosinophilic leukemia EoL-1 cells into eosinophils induced by histone deacetylase inhibitors
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Electrical alternans and hemodynamics in the anesthetized guinea pig can discriminate the cardiac safety of antidepressants
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Methodological validation of an existing telemetry system for QT evaluation in conscious guinea pigs
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Evaluation of the guinea pig monophasic action potential (MAP) assay in predicting drug-induced delay of ventricular repolarisation using 12 clinically documented drugs
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ILSI–HESI cardiovascular safety subcommittee dataset: An analysis of the statistical properties of QT interval and rate-corrected QT interval (QTc)
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Measurements with fluorescent probes in primary neural cultures; improved multiwell techniques
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Washout of heme-containing proteins dramatically improves tetrazolium-based infarct staining
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Mapping pharmaceuticals in tissues using MALDI imaging mass spectrometry
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Correlation of in vitro cytotoxicity with paracellular permeability in mortal rat intestinal cells
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An in vitro model to study chemoresistance in non-Hodgkin's lymphoma patients over-expressing mutant p53
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A comprehensive model of allergic rhinitis in guinea pigs
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Suppression by Curcuma comosa Roxb. of pro-inflammatory cytokine secretion in phorbol-12-myristate-13-acetate stimulated human mononuclear cells
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Possible involvement of organic anion and cation transporters in renal excretion of xanthine derivatives, 3-methylxanthine and enprofylline
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15d-PGJ2 stimulates HO-1 expression through p38 MAP kinase and Nrf-2 pathway in rat vascular smooth muscle cells
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Time course of cholinesterase inhibition in adult rats treated acutely with carbaryl, carbofuran, formetanate, methomyl, methiocarb, oxamyl or propoxur
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The effect of trichlorfon and methylazoxymethanol on the development of guinea pig cerebellum
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NMDA antagonists exert distinct effects in experimental organophosphate or carbamate poisoning in mice
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Modulation of parathion toxicity by glucose feeding: Is nitric oxide involved?
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Tissue distribution and urinary excretion of dimethylated arsenic and its metabolites in dimethylarsinic acid- or arsenate-treated rats
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Lung vitamin E transport processes are affected by both age and environmental oxidants in mice
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MAPK-ERK activation in kidney of male rats chronically fed ochratoxin A at a dose causing a significant incidence of renal carcinoma
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H-89 potentiates adipogenesis in 3T3-L1 cells by activating insulin signaling independently of protein kinase A
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Effects of magnolol (5,5′-diallyl-2,2′-dihydroxybiphenyl) on diabetic nephropathy in type 2 diabetic Goto–Kakizaki rats
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Up-regulation of skeletal muscle LIM protein 1 gene by 25-hydroxycholesterol may mediate morphological changes of rat aortic smooth muscle cells
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Estradiol-17β: Tracing its metabolic significance in female fatbody of fifth instar larvae of silkworm, Bombyx mori L (race: Nistari)
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The role of adenosine A2 receptors in the regulation of TNF-α production and PGE2 release in mouse peritoneal macrophages
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Isoproterenol-induced impairment of heart function and remodeling are attenuated by the nonpeptide angiotensin-(1-7) analogue AVE 0991
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Amelioration of dextran sulfate sodium-induced colitis in mice by oral administration of β-caryophyllene, a sesquiterpene
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Mechanisms by which acyclovir reduces the oxidative neurotoxicity and biosynthesis of quinolinic acid
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Expression, microsomal and mitochondrial activities of cytochrome P450 enzymes in brain regions from control and phenobarbital-treated rabbits
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Erythropoietin (EPO) — EPO-receptor signaling improves early endochondral ossification and mechanical strength in fracture healing
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7′-(3′,4′-dihydroxyphenyl)-N-[(4-methoxyphenyl)ethyl]propenamide (Z23), an effective compound from the Chinese herb medicine Fissistigma oldhamii (Hemsl.) Merr, suppresses T cell-mediated immunity in vitro and in vivo
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Salbutamol increases tristetraprolin expression in macrophages
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Chronic cardiac resynchronization therapy and reverse ventricular remodeling in a model of nonischemic cardiomyopathy
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Antihyperglycemic effect of a new thiazolidinedione analogue and its role in ameliorating oxidative stress in alloxan-induced diabetic rats
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Effect of 2-(6-cyano-1-hexyn-1-yl)adenosine on ocular blood flow in rabbits
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Hepatic granulomas induced by Schistosoma mansoni in mice deficient for connexin 43 present lower cell proliferation and higher collagen content
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