The Ginkgo biloba extract EGb761 reduces stress sensitivity, ROS accumulation and expression of catalase and glutathione S-transferase 4 in Caenorhabditis elegans Fulltext Access 9 Pages 2007
Effects of chlorpromazine on plasma membrane permeability and fluidity in the rat brain: A dynamic positron autoradiography and fluorescence polarization study Fulltext Access 9 Pages 2007
Transient hypolocomotion in rats repeatedly exposed to phencyclidine: An appraisal of motor function and motivation Fulltext Access 9 Pages 2007
Effectiveness and safety of olanzapine in the treatment of schizophrenia among Asian patients switching from conventional antipsychotics Fulltext Access 9 Pages 2007
The importance of cytochrome P450 2B6 in the human metabolism of environmental chemicals Fulltext Access 9 Pages 2007
l-Arginine transporters in cardiovascular disease: A novel therapeutic target Fulltext Access 9 Pages 2007
Cytochrome P450-catalyzed pathways in human brain: Metabolism meets pharmacology or old drugs with new mechanism of action? Fulltext Access 9 Pages 2007
Role of reactive oxygen species and spinal cord apoptotic genes in the development of neuropathic pain Fulltext Access 9 Pages 2007
Rewarding effects of 3,4-methylenedioxymethamphetamine (“Ecstasy”) in dominant and subordinate OF-1 mice in the place preference conditioning paradigm Fulltext Access 9 Pages 2007
Pharmacokinetics of tramadol enantiomers and their respective phase I metabolites in relation to CYP2D6 phenotype Fulltext Access 9 Pages 2007
Inhibition of extracellular signal-regulated kinase (ERK1/2) activity reverses endotoxin-induced hypotension via decreased nitric oxide production in rats Fulltext Access 9 Pages 2007
Cytoprotective effect of preparations from various parts of Punica granatum L. fruits in oxidatively injured mammalian cells in comparison with their antioxidant capacity in cell free systems Fulltext Access 9 Pages 2007
Berberine suppresses inflammatory agents-induced interleukin-1β and tumor necrosis factor-α productions via the inhibition of IκB degradation in human lung cells Fulltext Access 9 Pages 2007
The potential insulin sensitizing and glucose lowering effects of a novel indole derivative in vitro and in vivo Fulltext Access 9 Pages 2007
Preference for palatable food is reduced by the gamma-hydroxybutyrate analogue GET73, in rats Fulltext Access 9 Pages 2007
Reduction of fat deposition by combined inhibition of monoamine oxidases and semicarbazide-sensitive amine oxidases in obese Zucker rats Fulltext Access 9 Pages 2007
Microarray analysis of vanillin-regulated gene expression profile in human hepatocarcinoma cells Fulltext Access 9 Pages 2007
Adiponectin circulating levels: A new emerging biomarker of cardiovascular risk Fulltext Access 9 Pages 2007
The potentiation of curcumin on insulin-like growth factor-1 action in MCF-7 human breast carcinoma cells Fulltext Access 9 Pages 2007
Polygonum cuspidatum, compared with baicalin and berberine, inhibits inducible nitric oxide synthase and cyclooxygenase-2 gene expressions in RAW 264.7 macrophages Fulltext Access 9 Pages 2007
Pharmacology under the microscope: the use of fluorescence correlation spectroscopy to determine the properties of ligand-receptor complexes Fulltext Access 9 Pages 2007
Direct modulation of Ca2+-activated K+ current by H-89 in rabbit coronary arterial smooth muscle cells Fulltext Access 9 Pages 2007
Evidence supporting changes in Nogo-B levels as a marker of neointimal expansion but not adaptive arterial remodeling Fulltext Access 9 Pages 2007
Involvement of endothelial cell-derived CGRP in heat stress-induced protection of endothelial function Fulltext Access 9 Pages 2007
Endothelial injury in the initiation and progression of vascular disorders Fulltext Access 9 Pages 2007
Pharmacological preconditioning by levosimendan is mediated by inducible nitric oxide synthase and mitochondrial KATP channel activation in the in vivo anesthetized rabbit heart model Fulltext Access 9 Pages 2007
Epothilone D, a microtubule-stabilizing compound, inhibits neointimal hyperplasia after rat carotid artery injury by cell cycle arrest via regulation of G1-checkpoint proteins Fulltext Access 9 Pages 2007
Changes in stretch-induced tone induced by intracellular acidosis in rabbit basilar artery: Effects on BKCa channel activity Fulltext Access 9 Pages 2007
A modified fluorescent microsphere-based approach for determining resting and hyperemic blood flows in individual murine skeletal muscles Fulltext Access 9 Pages 2007
Oxidized low density lipoprotein receptor-1 mediates oxidized low density lipoprotein-induced apoptosis in human umbilical vein endothelial cells: Role of reactive oxygen species Fulltext Access 9 Pages 2007
Large scale analysis of genes contributing to the herbal preparation dependent hippocampal plasticity in postischemic rehabilitation Fulltext Access 9 Pages 2007
Possible involvement of enhanced arginase activity due to up-regulated arginases and decreased hydroxyarginine in accelerating intimal hyperplasia with hyperglycemia Fulltext Access 9 Pages 2007
Alterations of intracellular calcium concentration and nitric oxide generation in pulmonary artery endothelium after subarachnoid hemorrhage of the rabbit Fulltext Access 9 Pages 2007
Antiproliferative activity of NQ304, a synthetic 1,4-naphthoquinone, is mediated via the suppressions of the PI3K/Akt and ERK1/2 signaling pathways in PDGF-BB-stimulated vascular smooth muscle cells Fulltext Access 9 Pages 2007
Trafficking of δ-opioid receptors and other G-protein-coupled receptors: implications for pain and analgesia Fulltext Access 9 Pages 2007
Exploring the pharmacological properties of insect nicotinic acetylcholine receptors Fulltext Access 9 Pages 2007
Functional biology of the α2δ subunits of voltage-gated calcium channels Fulltext Access 9 Pages 2007
Impaired pre-attentive auditory processing in opioid dependence with and without benzodiazepine co-dependence revealed by combined magnetoencephalography and electroencephalography Fulltext Access 9 Pages 2007
Proline-rich polypeptides in Alzheimer's disease and neurodegenerative disorders — Therapeutic potential or a mirage? Fulltext Access 9 Pages 2007
Monoaminergic agents modulate antidepressant-like effect caused by diphenyl diselenide in rats Fulltext Access 9 Pages 2007
Alterations of muscarinic and GABA receptor binding in the posterior cingulate cortex in schizophrenia Fulltext Access 9 Pages 2007
The value added by measuring myocardial contractility ‘in vivo’ in safety pharmacological profiling of drug candidates Fulltext Access 9 Pages 2007
Promoter hypermethylation of p16INK4A, p14ARF, CyclinD2 and Slit2 in serum and tumor DNA from breast cancer patients Fulltext Access 9 Pages 2007
Arachidonic acid promotes glutamate-induced cell death associated with necrosis by 12- lipoxygenase activation in glioma cells Fulltext Access 9 Pages 2007
Analogs of SR-141716A (Rimonabant) alter d-amphetamine-evoked [3H] dopamine overflow from preloaded striatal slices and amphetamine-induced hyperactivity Fulltext Access 9 Pages 2007
Effects of leucine and phenylalanine supplementation during intermittent periods of food restriction and refeeding in adult rats Fulltext Access 9 Pages 2007
Nifurtimox nitroreductase activity in different cellular fractions from male rat pancreas. Biochemical and ultrastructural alterations Fulltext Access 9 Pages 2007
Reproductive experience modifies dopaminergic function, serum levels of prolactin, and macrophage activity in female rats Fulltext Access 9 Pages 2007
Search of the human proteome for endomorphin-1 and endomorphin-2 precursor proteins Fulltext Access 9 Pages 2007
Stable expression of adenylyl cyclase 2 leads to the functional rescue of human 5-HT6 receptor in a CHODUKX cell line Fulltext Access 9 Pages 2007
Non-invasive optical biosensor for assaying endogenous G protein-coupled receptors in adherent cells Fulltext Access 9 Pages 2007
Analysis of the nonclinical telemetered ECG: Impact of logging rate and RR bin width in the dog and cynomolgus monkey Fulltext Access 9 Pages 2007
A panic experimental model: Validation of a complex operant behavioral method in undernourished rats, with desipramine to provide a template effect profile Fulltext Access 9 Pages 2007
Pharmacokinetic comparisons of tail-bleeding with cannula- or retro-orbital bleeding techniques in rats using six marketed drugs Fulltext Access 9 Pages 2007
Long-term d-galactose injection combined with ovariectomy serves as a new rodent model for Alzheimer's disease Fulltext Access 9 Pages 2007
Towards automation of a valuable preclinical cardiac safety pharmacology assay: Evaluation of the effects of cardiac ion channel blockers on cardiac repolarisation in vitro Fulltext Access 9 Pages 2007
A cardiovascular monitoring system used in conscious cynomolgus monkeys for regulatory safety pharmacology: Part 2: Pharmacological validation Fulltext Access 9 Pages 2007
Comparison of rat and dog models of vasodilatation and lipolysis for the calculation of a therapeutic index for GPR109A agonists Fulltext Access 9 Pages 2007
A bladder-cooling reflex in the anaesthetised guinea-pig: A model of the positive clinical ice-water test Fulltext Access 9 Pages 2007
Altered ion transport and responsiveness to methacholine and hyperosmolarity in air interface-cultured guinea-pig tracheal epithelium Fulltext Access 9 Pages 2007
Comparison of the influence of NSAIDs with different COX-selectivity on histamine release from mast cells isolated from naïve and sensitized rats Fulltext Access 9 Pages 2007
Modulation of immune response in mice immunised with an inactivated Salmonella vaccine and gavaged with Andrographis paniculata extract or andrographolide Fulltext Access 9 Pages 2007
Anti-inflammatory effects of β-lapachone in lipopolysaccharide-stimulated BV2 microglia Fulltext Access 9 Pages 2007
Equol inhibits nitric oxide production and inducible nitric oxide synthase gene expression through down-regulating the activation of Akt Fulltext Access 9 Pages 2007
Ovalbumin modified by gamma irradiation alters its immunological functions and allergic responses Fulltext Access 9 Pages 2007
Protective effect of CpG-DNA against mastitis induced by Staphylococcus aureus infection in a rat model Fulltext Access 9 Pages 2007
Role of nitric oxide/cyclic GMP/K+ channel pathways in the antinociceptive effect caused by 2,3-bis(mesitylseleno)propenol Fulltext Access 9 Pages 2007
Augmented behavioral response and enhanced synaptosomal calcium transport induced by repeated cocaine administration are decreased by calcium channel blockers Fulltext Access 9 Pages 2007
Testosterone deficiency impairs glucose oxidation through defective insulin and its receptor gene expression in target tissues of adult male rats Fulltext Access 9 Pages 2007
Mechanism of ethanol enhancement of apoptosis and caspase activation in serum-deprived PC12 cells Fulltext Access 9 Pages 2007
The regulatory effect of endogenous hydrogen sulfide on pulmonary vascular structure and gasotransmitters in rats with high pulmonary blood flow Fulltext Access 9 Pages 2007
Icaritin and its glycosides enhance osteoblastic, but suppress osteoclastic, differentiation and activity in vitro Fulltext Access 9 Pages 2007
Isoform-specific downregulation of peroxiredoxin in human failing myocardium Fulltext Access 9 Pages 2007
Kinin B1 receptor participates in the control of cardiac function in mice Fulltext Access 9 Pages 2007
Protease-activated receptor 4-mediated Ca2+ signaling in mouse lung alveolar epithelial cells Fulltext Access 9 Pages 2007
Potential involvement of the cyclooxygenase-2 pathway in hepatocellular carcinoma-associated angiogenesis Fulltext Access 9 Pages 2007
Carboxylesterase in the liver and small intestine of experimental animals and human Fulltext Access 9 Pages 2007
Nucleotide metabolizing ecto-enzymes in Walker 256 tumor cells: Molecular identification, kinetic characterization and biochemical properties Fulltext Access 9 Pages 2007
The influence of stress and methionine-enkephalin on macrophage functions in two inbred rat strains Fulltext Access 9 Pages 2007
Experimental AA amyloidosis in mice is inhibited by treatment with triptolide, a purified traditional Chinese medicine Fulltext Access 9 Pages 2007
Prostaglandin E2 and I2 facilitate noxious heat-induced spike discharge but not iCGRP release from rat cutaneous nociceptors Fulltext Access 9 Pages 2007
Evidence that glutaric acid reduces glutamate uptake by cerebral cortex of infant rats Fulltext Access 9 Pages 2007
Cardiomyocyte apoptosis in the right auricle of patients with ostium secundum atrial septal defect diseases Fulltext Access 9 Pages 2007
Altered expression profiles of clock genes hPer1 and hPer2 in peripheral blood mononuclear cells of cancer patients undergoing surgery Fulltext Access 9 Pages 2007
Effects of resveratrol on nerve functions, oxidative stress and DNA fragmentation in experimental diabetic neuropathy Fulltext Access 9 Pages 2007
ACTX-8, a cytotoxic l-amino acid oxidase isolated from Agkistrodon acutus snake venom, induces apoptosis in Hela cervical cancer cells Fulltext Access 9 Pages 2007
Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms Fulltext Access 9 Pages 2007
Hypertension aggravates glomerular dysfunction with oxidative stress in a rat model of diabetic nephropathy Fulltext Access 9 Pages 2007
Inhibition by epigallocatechin gallate of CoCl2-induced apoptosis in rat PC12 cells Fulltext Access 9 Pages 2007
Antioxidant responses and lipid peroxidation following intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in rats: increased susceptibility of olfactory bulb Fulltext Access 9 Pages 2007