Techniques used for the discovery of therapeutic compounds: The case of SARS Fulltext Access 7 Pages 2006
Effects of risperidone on locomotor activity and spatial memory in rats with hippocampal damage Fulltext Access 7 Pages 2006
An Investigation into the Interaction between Taste Masking Fatty Acid Microspheres and Alkaline Buffer using Thermal and Spectroscopic Analysis Fulltext Access 7 Pages 2006
Anisotropic Lattice Contraction in Pharmaceuticals: The Influence of Cryo-Crystallography on Calculated Powder Diffraction Patterns Fulltext Access 7 Pages 2006
An Investigation into the In Vivo Performance Variability of pH Responsive Polymers for Ileo-Colonic Drug Delivery Using Gamma Scintigraphy in Humans Fulltext Access 7 Pages 2006
Structural determination of the stable and meta-stable forms of atomoxetine HCl using single crystal and powder X-ray diffraction methods Fulltext Access 7 Pages 2006
Reduced tabletability of roller compacted granules as a result of granule size enlargement Fulltext Access 7 Pages 2006
New technologies in computer-aided drug design: Toward target identification and new chemical entity discovery Fulltext Access 7 Pages 2006
L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for α5-containing GABAA receptors Fulltext Access 7 Pages 2006
Targeting transcription factors in cancer: Challenges and evolving strategies Fulltext Access 7 Pages 2006
New concepts and approaches for drug discovery based on traditional Chinese medicine Fulltext Access 7 Pages 2006
Mouse models of asthma and rhinitis to study the role of dendritic cells in sensitization and development of inflammation Fulltext Access 7 Pages 2006
Cracking the black box – and putting it back together again: Animal models of spinal cord injury Fulltext Access 7 Pages 2006
SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2′methyl-4′-(5-methyl-1,2,3-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): A novel, potent and selective 5-HT1B receptor antagonist Fulltext Access 7 Pages 2006
Diazepam inhibits the induction and maintenance of LTP of C-fiber evoked field potentials in spinal dorsal horn of rats Fulltext Access 7 Pages 2006
Regulation of CART mRNA in the rat nucleus accumbens via D3 dopamine receptors Fulltext Access 7 Pages 2006
Transforming growth factor-α induces sex-specific neurochemical imbalance in the stress- and memory-associated brain structures Fulltext Access 7 Pages 2006
Prenatal nicotine exposure alters the nicotinic receptor subtypes that modulate excitation of parasympathetic cardiac neurons in the nucleus ambiguus from primarily α3β2 and/or α6βX to α3β4 Fulltext Access 7 Pages 2006
Endogenous opioids mediate the hypoalgesia induced by selective inhibitors of cyclo-oxygenase 2 in rat paws treated with carrageenan Fulltext Access 7 Pages 2006
Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway Fulltext Access 7 Pages 2006
Blockade of group II metabotropic glutamate receptors in the nucleus accumbens produces hyperlocomotion in rats previously exposed to amphetamine Fulltext Access 7 Pages 2006
Binge administration of 3,4-methylenedioxymethamphetamine (“ecstasy”) impairs the survival of neural precursors in adult rat dentate gyrus Fulltext Access 7 Pages 2006
ERβ mediates the estradiol increase of D2 receptors in rat striatum and nucleus accumbens Fulltext Access 7 Pages 2006
The effects of acute and long-term lithium treatments on trkB neurotrophin receptor activation in the mouse hippocampus and anterior cingulate cortex Fulltext Access 7 Pages 2006
CyclinB2 and BIRC5 genes as surrogate biomarkers for neurite outgrowth in SH-SY5Y subclonal cells Fulltext Access 7 Pages 2006
Reversal of methamphetamine-induced behavioral sensitization by repeated administration of a dopamine D1 receptor agonist Fulltext Access 7 Pages 2006
Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models Fulltext Access 7 Pages 2006
Acetyl-l-carnitine protects striatal neurons against in vitro ischemia: The role of endogenous acetylcholine Fulltext Access 7 Pages 2006
Long-lasting neuropathic pain induced by brachial plexus injury in mice: Role triggered by the pro-inflammatory cytokine, tumour necrosis factor α Fulltext Access 7 Pages 2006
Different roles of two nitric oxide activated pathways in spinal long-term potentiation of C-fiber-evoked field potentials Fulltext Access 7 Pages 2006
Effects of ketamine on acute somatic nociception in wild-type and N-methyl-d-aspartate (NMDA) receptor É1 subunit knockout mice Fulltext Access 7 Pages 2006
Investigation of the SSRI augmentation properties of 5-HT2 receptor antagonists using in vivo microdialysis Fulltext Access 7 Pages 2006
Fluvastatin stabilizes the blood–brain barrier in vitro by nitric oxide-dependent dephosphorylation of myosin light chains Fulltext Access 7 Pages 2006
Fluvoxamine, a selective serotonin reuptake inhibitor, exerts its antiallodynic effects on neuropathic pain in mice via 5-HT2A/2C receptors Fulltext Access 7 Pages 2006
Comparison of inhibitory action of candesartan and enalapril on brain ischemia through inhibition of oxidative stress Fulltext Access 7 Pages 2006
Isolation and pharmacological characterisation of hostoxin-1, a postsynaptic neurotoxin from the venom of the Stephen's banded snake (Hoplocephalus stephensi) Fulltext Access 7 Pages 2006
Cycloheximide impairs acquisition but not extinction of cocaine self-administration Fulltext Access 7 Pages 2006
Halocynthiaxanthin and fucoxanthinol isolated from Halocynthia roretzi induce apoptosis in human leukemia, breast and colon cancer cells Fulltext Access 7 Pages 2006
Exploiting the enhanced permeability and retention effect for tumor targeting Fulltext Access 7 Pages 2006
Regulating biopharmaceuticals under CDER versus CBER: an insider's perspective Fulltext Access 7 Pages 2006
Canonical transient receptor potential channels in disease: targets for novel drug therapy? Fulltext Access 7 Pages 2006
Potassium transmembrane fluxes in anoxic hepatocytes from goldfish (Carassius auratus L.) Fulltext Access 7 Pages 2006
Antioxidant enzymes in ringed seal tissues: Potential protection against dive-associated ischemia/reperfusion Fulltext Access 7 Pages 2006
Hexokinase and glucose-6-phosphatase activity in woodchuck model of hepatitis virus-induced hepatocellular carcinoma Fulltext Access 7 Pages 2006
Response of catalase activity to Ag+, Cd2+, Cr6+, Cu2+ and Zn2+ in five tissues of freshwater fish Oreochromis niloticus Fulltext Access 7 Pages 2006
A β-galactose-specific lectin isolated from the marine worm Chaetopterus variopedatus possesses anti-HIV-1 activity Fulltext Access 7 Pages 2006
Serum IgM levels against select marine bacteria in the Atlantic sharpnose shark (Rhizoprionodon terraenovae) from three estuaries Fulltext Access 7 Pages 2006
Lupeol ameliorates aflatoxin B1-induced peroxidative hepatic damage in rats Fulltext Access 7 Pages 2006
Vitellogenic effects of 17β-estradiol in male Chinese loach (Misgurnus anguillicaudatus) Fulltext Access 7 Pages 2006
Tolerance and biomarkers as useful tools for assessing environmental quality in the Oued Souss estuary (Bay of Agadir, Morocco) Fulltext Access 7 Pages 2006
Comparison of endothelial function in the carotid artery between normal and short-term hypercholesterolemic rabbits Fulltext Access 7 Pages 2006
Metal accumulation and enzyme activities in gills and digestive gland of pearl oyster (Pinctada fucata) exposed to copper Fulltext Access 7 Pages 2006
Antioxidant protection and plasma carotenoids of incubating great tits (Parus major L.) in relation to health state and breeding conditions Fulltext Access 7 Pages 2006
Role of calcium channels in cadmium-induced disruption of cortisol synthesis in rainbow trout (Oncorhynchus mykiss) Fulltext Access 7 Pages 2006
Phosphoinositide 3-kinase (PI3K) family of signalling enzymes and their role in asthma Fulltext Access 7 Pages 2006
Sirt1 as a key regulator orchestrating the response to caloric restriction Fulltext Access 7 Pages 2006
Effect of ethanolic extracts of Ananas comosus L. leaves on insulin sensitivity in rats and HepG2 Fulltext Access 7 Pages 2006
Contributions of T-type calcium channels to the pathophysiology of pain signaling Fulltext Access 7 Pages 2006
Propagation of hepatitis C virus infection: Elucidating targets for therapeutic intervention Fulltext Access 7 Pages 2006
New development in the mechanistic understanding of peptic ulcer diseases Fulltext Access 7 Pages 2006