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Pharmacology Research Articles

Spontaneous neural tube defects in splotch mice supplemented with selected micronutrients
Fulltext Access 9 Pages 2006
Differential sensitivity of rat voltage-sensitive sodium channel isoforms to pyrazoline-type insecticides
Fulltext Access 9 Pages 2006
Enhancement of DMNQ-induced hepatocyte toxicity by cytochrome P450 inhibition
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The effects of combined exposure to the pyrethroids deltamethrin and S-bioallethrin on hippocampal inhibition and skeletal muscle hyperexcitability in rats
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Genetic damage caused by methyl–parathion in mouse spermatozoa is related to oxidative stress
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Potentiation of lead-induced cell death in PC12 cells by glutamate: Protection by N-acetylcysteine amide (NACA), a novel thiol antioxidant
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Methyl-β-cyclodextrin enhances the susceptibility of human breast cancer cells to carboplatin and 5-fluorouracil: Involvement of Akt, NF-κB and Bcl-2
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Characterizing the role of endothelin-1 in the progression of cardiac hypertrophy in aryl hydrocarbon receptor (AhR) null mice
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Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert-butyl hydroperoxide
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d-Methionine attenuated cisplatin-induced vestibulotoxicity through altering ATPase activities and oxidative stress in guinea pigs
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Metabolic transformation of methylseleninic acid through key selenium intermediate selenide
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The effect of the PKC inhibitor calphostin C and the PKC agonist phorbol 12-myristate 13-acetate on regulation of cytosolic Ca2+ in mammalian skeletal muscle cells
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The NADPH oxidase inhibitor apocynin (acetovanillone) induces oxidative stress
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Leflunomide or A77 1726 protect from acetaminophen-induced cell injury through inhibition of JNK-mediated mitochondrial permeability transition in immortalized human hepatocytes
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Effects of garlic oil and two of its major organosulfur compounds, diallyl disulfide and diallyl trisulfide, on intestinal damage in rats injected with endotoxin
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Putranjivain A from Euphorbia jolkini inhibits proliferation of human breast adenocarcinoma MCF-7 cells via blocking cell cycle progression and inducing apoptosis
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Effect of Ginkgo biloba extract on procarcinogen-bioactivating human CYP1 enzymes: Identification of isorhamnetin, kaempferol, and quercetin as potent inhibitors of CYP1B1
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Changes in the carbon dioxide expirogram in response to ozone exposure
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Ginkgolide A contributes to the potentiation of acetaminophen toxicity by Ginkgo biloba extract in primary cultures of rat hepatocytes
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Enhancement of rat bladder contraction by artificial sweeteners via increased extracellular Ca2+ influx
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Preconditioning with low concentration NO attenuates subsequent NO-induced apoptosis in vascular smooth muscle cells via HO-1-dependent mitochondrial death pathway
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DNA repair systems as targets of cadmium toxicity
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Thiodiglycol, the hydrolysis product of sulfur mustard: Analysis of in vitro biotransformation by mammalian alcohol dehydrogenases using nuclear magnetic resonance
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CYP1A2 and NAT2 phenotyping and 3-aminobiphenyl and 4-aminobiphenyl hemoglobin adduct levels in smokers and non-smokers
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Immunomodulatory effects of maternal atrazine exposure on male Balb/c mice
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Stimulation of toll-like receptor 2 with bleomycin results in cellular activation and secretion of pro-inflammatory cytokines and chemokines
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Bioaccumulation and locomotor effects of manganese sulfate in Sprague–Dawley rats following subchronic (90 days) inhalation exposure
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Distinct roles of NF-κB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity
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Epoxidation of the methamphetamine pyrolysis product, trans-phenylpropene, to trans-phenylpropylene oxide by CYP enzymes and stereoselective glutathione adduct formation
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Folic acid and pantothenic acid protection against valproic acid-induced neural tube defects in CD-1 mice
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Indole-3-carbinol, but not its major digestive product 3,3′-diindolylmethane, induces reversible hepatocyte hypertrophy and cytochromes P450
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Effect of toluene diisocyanate on homeostasis of intracellular-free calcium in human neuroblastoma SH-SY5Y Cells
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O6-methylguanine DNA-methyltransferase (MGMT) overexpression in melanoma cells induces resistance to nitrosoureas and temozolomide but sensitizes to mitomycin C
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Increased FasL expression correlates with apoptotic changes in granulocytes cultured with oxidized clozapine
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Arsenite pretreatment enhances the cytotoxicity of mitomycin C in human cancer cell lines via increased NAD(P)H quinone oxidoreductase 1 expression
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Estrogenic effects of marijuana smoke condensate and cannabinoid compounds
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Upregulation of endothelial heme oxygenase-1 expression through the activation of the JNK pathway by sublethal concentrations of acrolein
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Comparison of effects of estradiol (E2) with those of octylmethoxycinnamate (OMC) and 4-methylbenzylidene camphor (4MBC) - 2 filters of UV light - on several uterine, vaginal and bone parameters
Fulltext Access 9 Pages 2006
Hyperoxia increases hepatic arginase expression and ornithine production in mice
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Induction of hepatic cytochrome P450 isozymes, benzo(a)pyrene metabolism and DNA binding following exposure to polycyclic aromatic hydrocarbon residues generated during repeated fish fried oil in rats
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Toxins not neutralized by brown snake antivenom
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Understanding arsenic metabolism through a comparative study of arsenic levels in the urine, hair and fingernails of healthy volunteers from three unexposed ethnic groups in the United Kingdom
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Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line
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Enhancement of caffeic acid phenethyl ester on all-trans retinoic acid-induced differentiation in human leukemia HL-60 cells
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Lack of activity of cadmium in in vitro estrogenicity assays
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Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-κB
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The expression of Hedgehog genes (Ihh, Dhh) and Hedgehog target genes (Ptc1, Gli1, Coup-TfII) is affected by estrogenic stimuli in the uterus of immature female rats
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Differences in gene expression profiles in the liver between carcinogenic and non-carcinogenic isomers of compounds given to rats in a 28-day repeat-dose toxicity study
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Influence of cAMP on reporter bioassays for dioxin and dioxin-like compounds
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Establishment of a protocol for the gene expression analysis of laser microdissected rat kidney samples with affymetrix genechips
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New approaches to reduce the burden of RSV infection
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STAT1 phosphorylation and cleavage is regulated by the histamine (H4) receptor in human atopic and non-atopic lymphocytes
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Immunomodulatory properties of new conjugates of muramyl dipeptide and nor-muramyl dipeptide with retro-tuftsin (Arg-Pro-Lys-Thr-OMe)
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IL-1β regulation of BDNF expression in rat cultured hypothalamic neurons depends on the presence of glial cells
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Transporter mediated GABA release in the retina: Role of excitatory amino acids and dopamine
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Exocytotic release of dopamine in ventral tegmental area slices from C57BL/6 and dopamine transporter knockout mice
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Flow cytometry-based method to analyze the change in Tau phosphorylation in a hGSK-3β and hTau over-expressing EcR-293 cell line
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Brain 5-HT synthesis in the Flinders Sensitive Line rat model of depression: An autoradiographic study
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PKC-dependent stimulation of EAAT3 glutamate transporter does not require the integrity of actin cytoskeleton
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Characterization of the pro-inflammatory signaling induced by protein acetylation in microglia
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Release of glutamate by the embryonic spinal motoneurons of rat positively regulated by acetylcholine through the nicotinic and muscarinic receptors
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Prenatal exposure to the cannabinoid receptor agonist WIN 55,212-2 and carbon monoxide reduces extracellular glutamate levels in primary rat cerebral cortex cell cultures
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RNAi-based treatment of HIV/AIDS: Current status and perspectives
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In vivo effects of oligodeoxynucleotides containing synthetic immunostimulatory motifs in weaned piglets
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Dendritic cells in Asthma: A target for novel therapeutics?
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Countering core and co-morbid symptoms of affective disorders: Complementary multi-target strategies
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Modern analytical technologies for the detection of drug abuse and doping
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Glycomics – a new target for pharmaceuticals
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Determination of inflammatory biomarkers by immunoaffinity capillary electrophoresis
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Prediction of failure load using micro-finite element analysis models: Toward in vivo strength assessment
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Microarrays meet the Voltaire challenge: Drug discovery on a chip?
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Proteomics in antitumor research
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In silico target fishing: Predicting biological targets from chemical structure
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Chemical diversity and biological activity
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Integration of virtual and physical screening
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Rat models of asthma and chronic obstructive lung disease
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Investigation of the proinflammatory potential of biodegradable nanoparticle drug delivery systems in the lung
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Further studies on aberrant gene expression associated with arsenic-induced malignant transformation in rat liver TRL1215 cells
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Highlights on the appropriate use of fluoroquinolones in respiratory tract infections
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The biology of vascular endothelial growth factor-B (VEGF-B)
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ADAM33: a newly identified protease involved in airway remodelling
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Bronchodilator reversibility testing in an adult general population; the importance of smoking and anthropometrical variables on the response to a β2-agonist
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Prodrug of proline analogue reduces hypoxic pulmonary hypertension in rats
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Bimosiamose, an inhaled small-molecule pan-selectin antagonist, attenuates late asthmatic reactions following allergen challenge in mild asthmatics: A randomized, double-blind, placebo-controlled clinical cross-over-trial
Fulltext Access 9 Pages 2006
Efficacy and safety of budesonide/formoterol compared with salbutamol in the treatment of acute asthma
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A review of guidelines for antibacterial use in acute exacerbations of chronic bronchitis
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The use of bronchodilators in the treatment of airway obstruction in elderly patients
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Comparable efficacy of ciclesonide once daily versus fluticasone propionate twice daily in asthma
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Hit and lead identification: Integrated technology-based approaches
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Does work on obsessive-compulsive spectrum disorders contribute to understanding the heterogeneity of obsessive-compulsive disorder?
Fulltext Access 9 Pages 2006
Altered coordination of the neuroendocrine response during psychosocial stress in subjects with high trait anxiety
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Novelty P3 and P3b in first-episode schizophrenia and chronic schizophrenia
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Amphetamine and pentylenetetrazole given post-trial 1 enhance one-trial tolerance to the anxiolytic effect of diazepam in the elevated plus-maze in mice
Fulltext Access 9 Pages 2006
Immunohistochemical localisation of the NK1 receptor in the human amygdala: Preliminary investigation in schizophrenia
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Dopamine D2 receptor-mediated G protein activation assessed by agonist-stimulated [35S]guanosine 5′-O-(γ-thiotriphosphate) binding in rat striatal membranes
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Genetically predisposed offspring with schizotypal features: An ultra high-risk group for schizophrenia?
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Acute effects of tianeptine on circulating neurotransmitters and cardiovascular parameters
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Impact of interleukin-1 and interleukin-6 in murine primary schistosomiasis
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Modulation of neutrophil apoptosis by β-amyloid proteins
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Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats
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