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Pharmacology Research Articles

Anti-oxidative effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. leaf in chronic bronchitis rats
Fulltext Access 9 Pages 2006
Involvement of AE3 isoform of Na+-independent Cl−/HCO3− exchanger in myocardial pHi recovery from intracellular alkalization
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Reactive nitrogen species derived activation of rat liver microsomal glutathione S-transferase
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Selective modulation of L-type calcium current by magnesium lithospermate B in guinea-pig ventricular myocytes
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Chronic morphine treatment induces oxidant and apoptotic damage in the mice liver
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Kaurane and pimarane-type diterpenes from the Viguiera species inhibit vascular smooth muscle contractility
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Induction of apoptosis by pterocarpans from Platymiscium floribundum in HL-60 human leukemia cells
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In rat hepatocytes, different adenosine receptor subtypes use different secondary messengers to increase the rate of ureagenesis
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Citrus polymethoxylated flavones improve lipid and glucose homeostasis and modulate adipocytokines in fructose-induced insulin resistant hamsters
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Increasing synaptic noradrenaline, serotonin and histamine enhances in vivo binding of phosphodiesterase-4 inhibitor (R)-[11C]rolipram in rat brain, lung and heart
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Adenohypophyseal and hypothalamic GABA B receptor subunits are downregulated by estradiol in adult female rats
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Simvastatin potentiates tumor necrosis factor α-mediated apoptosis of human vascular endothelial cells via the inhibition of the geranylgeranylation of RhoA
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p38 and ERK MAP kinase mediates iron chelator-induced apoptosis and -suppressed differentiation of immortalized and malignant human oral keratinocytes
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Differences in the nitric oxide metabolism in streptozotocin-treated rats and children suffering from Type 1 diabetes
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The astroglial-derived S100β protein stimulates the expression of nitric oxide synthase in rodent macrophages through p38 MAP kinase activation
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Effect of compressive force on the expression of MMPs, PAs, and their inhibitors in osteoblastic Saos-2 cells
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Exhaustion of the Frank–Starling mechanism in conscious dogs with heart failure induced by chronic coronary microembolization
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Serum ethanolamine and hepatocyte proliferation in perinatal and partially hepatectomized rats
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Antioxidant effect of tetrahydrocurcumin in streptozotocin–nicotinamide induced diabetic rats
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An antioxidant treatment potentially protects myocardial energy metabolism by regulating uncoupling protein 2 expression in a chronic β-adrenergic stimulation rat model
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Successive alterations of hippocampal gamma-aminobutyric acid B receptor subunits in a rat model of febrile seizure
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Upregulation of heme oxygenase-1 by Epigallocatechin-3-gallate via the phosphatidylinositol 3-kinase/Akt and ERK pathways
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Irreversible morphological changes in leg bone following chronic gravitational unloading of growing rats
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Effect of sinomenine on gene expression of the IL-1β-activated human synovial sarcoma
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Lycium barbarum polysaccharides: Protective effects against heat-induced damage of rat testes and H2O2-induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats
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Antioxidant and antiradical activities of l-carnitine
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Modulation of Na, K-ATPase activity by prostaglandin E1 and [d-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin
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Protective effect of labedipinedilol-A, a novel dihydropyridine-type calcium channel blocker, on myocardial apoptosis in ischemia–reperfusion injury
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Atrial natriuretic peptide-dependent modulation of hypoxia-induced pulmonary vascular remodeling
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Pre-clinical toxicology and pathology of 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), a novel anti-cancer agent in male Beagle dogs
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Raw and boiled garlic enhances plasma antioxidant activity and improves plasma lipid metabolism in cholesterol-fed rats
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Milk growth factor (MGF) induces transformation into ATDC5 cells, prechondrocytes, and cooperates with retinoic acid to transform the cells into new forms
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Contribution of glibenclamide-sensitive, ATP-dependent K+ channel activation to acetophenone analogues-mediated in vitro pulmonary artery relaxation of rat
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Antioxidant properties and PC12 cell protective effects of APS-1, a polysaccharide from Aloe vera var. chinensis
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The cannabinoid CB2 receptor selective agonist JWH133 reduces mast cell oedema in response to compound 48/80 in vivo but not the release of β-hexosaminidase from skin slices in vitro
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Tributyltin inhibits osteoblastic activity and disrupts calcium metabolism through an increase in plasma calcium and calcitonin levels in teleosts
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Interleukin-6 decreases senescence and increases telomerase activity in malignant human cholangiocytes
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Characteristics of acid extrusion from Chinese hamster ovary cells expressing different prostaglandin EP receptors
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Effects of tight blood pressure control on glomerular hypertrophy in a model of genetic hypertension and experimental diabetes mellitus
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Angiogenesis and inflammation in skeletal muscle in response to ascites tumor in mice
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Ouabain-induced hypertension enhances left ventricular contractility in rats
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Differences in sensitivity of cultured rat brain neuronal and glial cytochrome P450 2E1 to ethanol
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Inhibition of vascular smooth muscle cell proliferation in vitro by genetically engineered marrow stromal cells secreting calcitonin gene-related peptide
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Implication of glucocorticoid in anti-inflammatory effects of Ro5-4864 in mouse pleurisy induced by carrageenan
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Characterization of the transient receptor potential channels mediating lysophosphatidic acid-stimulated calcium mobilization in B lymphoblasts
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Insulin sensitizing and α-glucoamylase inhibitory action of sennosides, rheins and rhaponticin in Rhei Rhizoma
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Lipoteichoic acid induces prostaglandin E2 release and cyclooxygenase-2 synthesis in rat cortical neuronal cells: Involvement of PKCε and ERK activation
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Genistein abrogates pre-hemolytic and oxidative stress damage induced by 2,2′-Azobis (Amidinopropane)
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Differential regulation of anti-inflammatory proteins in human rheumatoid synoviocyte MH7A cell by celecoxib and ibuprofen
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Chronic ethanol consumption alters cardiovascular functions in conscious rats
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Pressure ulcer-induced oxidative organ injury is ameliorated by β-glucan treatment in rats
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Human NK cell IFN-γ production is regulated by endogenous TGF-β
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Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma
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Role of H1 receptors in histamine-mediated up-regulation of STAT4 phosphorylation
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Prevention of early renal injury by mycophenolate mofetil and its mechanism in experimental diabetes
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CpG oligodinucleotides induce strong humoral and cellular responses to swine streptococcic septicemia vaccine in piglets in vivo
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Functional characterization of human mast cells cultured from adult peripheral blood
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Progesterone regulates mouse dendritic cells differentiation and maturation
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The effects of some antibiotics on polymorphonuclear leukocyte functions of elderly patients in vitro before and after zinc supplementation
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Generation and characterization of a novel tetravalent anti-CD22 antibody with improved antitumor activity and pharmacokinetics
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Achyranthes aspera stimulates the immunity and enhances the antigen clearance in Catla catla
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Protection of lethal toxicity of endotoxin by Salvia miltiorrhiza BUNGE is via reduction in tumor necrosis factor alpha release and liver injury
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Piper longum inhibits VEGF and proinflammatory cytokines and tumor-induced angiogenesis in C57BL/6 mice
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FTY720 preferentially depletes naive T cells from peripheral and lymphoid organs
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Fludarabine induces pro-inflammatory activation of human monocytic cells through a MAPK/ERK pathway
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Roles of Ras and extracellular signal-regulated kinase-dependent IκBα degradation in oridonin-enhanced phagocytosis of apoptotic cells by human macrophage-like U937 cells
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Modulation of eosinophil generation and migration by Mangifera indica L. extract (Vimang®)
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Protective and anti-inflammatory effect of a traditional Chinese medicine, Xia-Bai-San, by modulating lung local cytokine in a murine model of acute lung injury
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Intracellular Ca2+ contributes to K+-induced increase in renal kallikrein secretion
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Prolactin modulates the functions of murine spleen CD11c-positive dendritic cells
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HIV-1 gp120 up-regulation of the mu opioid receptor in TPA-differentiated HL-60 cells
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Galanin in the trinitrobenzene sulfonic acid rat model of experimental colitis
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Fraxetin inhibits the induction of anti-Fas IgM, tumor necrosis factor-α and interleukin-1β-mediated apoptosis by Fas pathway inhibition in human osteoblastic cell line MG-63
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Anti-allergic properties of Cissampelos sympodialis and its isolated alkaloid warifteine
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Anergic lymphocytes generated by blocking CD28 and ICOS pathways in vitro prolong rat cardiac graft survival
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Distribution of mRNA and binding sites of adrenoceptors and muscarinic receptors in the rat heart
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Testosterone modulation of reproductive indices vs. morphine antinociception in male rats
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Inhibition of phosphodiesterase activity, airway inflammation and hyperresponsiveness by PDE4 inhibitor and glucocorticoid in a murine model of allergic asthma
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Transport and toxic mechanism for aluminum citrate in human neuroblastoma SH-SY5Y cells
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Anti-cancer effect and structural characterization of endo-polysaccharide from cultivated mycelia of Inonotus obliquus
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Role of nitric oxide and endothelium-derived hyperpolarizing factor (EDHF) in the regulation of blood pressure by leptin in lean and obese rats
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Herbal monoterpene alcohols inhibit propofol metabolism and prolong anesthesia time
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Advanced glycation end-products induce apoptosis involving the signaling pathways of oxidative stress in bovine retinal pericytes
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Reactive oxygen species damaged human serum albumin in patients with type 1 diabetes mellitus: Biochemical and immunological studies
Fulltext Access 9 Pages 2006
Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain
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Sequence of pituitary–adrenal cortical hormone responses to low-dose physostigmine administration in young adult women and men
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Catechin and epicatechin from Smilacis chinae rhizome protect cultured rat cortical neurons against amyloid β protein (25–35)-induced neurotoxicity through inhibition of cytosolic calcium elevation
Fulltext Access 9 Pages 2006
Cardiovascular oxidative stress is reduced by an ACE inhibitor in a rat model of streptozotocin-induced diabetes
Fulltext Access 9 Pages 2006
Inhibited cell death, NF-κB activity and increased IL-10 in TCR-triggered thymocytes of transgenic mice overexpressing the glucocorticoid-induced protein GILZ
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Endoplasmic reticulum stress response is involved in the pathogenesis of stress induced gastric lesions in rats
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Immunolocalization of vascular endothelial growth factor on intramuscular ectopic osteoinduction by bone morphogenetic protein-2
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Angiotensin II regulates phosphoinositide 3 kinase/Akt cascade via a negative crosstalk between AT1 and AT2 receptors in skin fibroblasts of human hypertrophic scars
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The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes
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Polymethoxylated flavones induce Ca2+-mediated apoptosis in breast cancer cells
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An in vivo model to assess factors that may stimulate the generation of an immune reaction to erythropoietin
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Effect of horse gram lectin (Dolichos biflorus agglutinin) on degranulation of mast cells and basophils of atopic subjects: Identification as an allergen
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Protective role of wogonin against lipopolysaccharide-induced angiogenesis via VEGFR-2, not VEGFR-1
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Histone deacetylase inhibitors induce antigen specific anergy in lymphocytes: A comparative study
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Immunomodulating effects of lichen-derived polysaccharides on monocyte-derived dendritic cells
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Oral immunogenicity of the plant proteinase bromelain
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