Circumvention and reactivation of the p53 oncogene checkpoint in mouse colon tumors Fulltext Access 11 Pages 2006
Decreased polyphenol transport across cultured intestinal cells by a salivary proline-rich protein Fulltext Access 11 Pages 2006
Cellular FLICE-like inhibitory protein (c-FLIP): A novel target for Taxol-induced apoptosis Fulltext Access 11 Pages 2006
The BH3-only protein, PUMA, is involved in oxaliplatin-induced apoptosis in colon cancer cells Fulltext Access 11 Pages 2006
Understanding the longevity of the β-lactam antibiotics and of antibiotic/β-lactamase inhibitor combinations Fulltext Access 11 Pages 2006
NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs Fulltext Access 11 Pages 2006
Evaluation of ligand selectivity using reporter cell lines stably expressing estrogen receptor alpha or beta Fulltext Access 11 Pages 2006
Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1α Fulltext Access 11 Pages 2006
Suppressive effects of antimycotics on tumor necrosis factor-α-induced CCL27, CCL2, and CCL5 production in human keratinocytes Fulltext Access 11 Pages 2006
Regulation of death and survival in astrocytes by ADP activating P2Y1 and P2Y12 receptors Fulltext Access 11 Pages 2006
AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3 Fulltext Access 11 Pages 2006
Clozapine bioactivation induces dose-dependent, drug-specific toxicity of human bone marrow stromal cells: A potential in vitro system for the study of agranulocytosis Fulltext Access 11 Pages 2006
Niacin induces PPARγ expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways Fulltext Access 11 Pages 2006
The 21-aminosteroid U74389G prevents the down-regulation and decrease in activity of CYP1A1, 1A2 and 3A6 induced by an inflammatory reaction Fulltext Access 11 Pages 2006
Differential toxicity of antimonial compounds and their effects on glutathione homeostasis in a human leukaemia monocyte cell line Fulltext Access 11 Pages 2006
Inhibition of interleukin-4 production in activated T cells via the downregulation of AP-1/NF-AT activation by N-lauroyl-d-erythro-sphingosine and N-lauroyl-d-erythro-C20-sphingosine Fulltext Access 11 Pages 2006
The challenge of drug discovery of a GPCR target: Analysis of preclinical pharmacology of histamine H3 antagonists/inverse agonists Fulltext Access 11 Pages 2006
Contractile mechanisms coupled to TRPA1 receptor activation in rat urinary bladder Fulltext Access 11 Pages 2006
Cytosolic heat shock proteins and heme oxygenase-1 are preferentially induced in response to specific and localized intramitochondrial damage by tetrafluoroethylcysteine Fulltext Access 11 Pages 2006
Antagonism of peroxisome proliferator-activated receptor γ prevents high-fat diet-induced obesity in vivo Fulltext Access 11 Pages 2006
Activation of coupled Ah receptor and Nrf2 gene batteries by dietary phytochemicals in relation to chemoprevention Fulltext Access 11 Pages 2006
Two open-label, randomized, crossover studies assessing the bioequivalence of ofloxacin administered as immediateand extended-release formulations in healthy subjects Fulltext Access 11 Pages 2006
A post hoc subgroup analysis of meropenem versus imipenem/cilastatin in a multicenter, double-blind, randomized study of complicated skin and skin-structure infections in patients with diabetes mellitus ** Fulltext Access 11 Pages 2006
Patterns of Dosage changes with transdermal buprenorphine and transdermal fentanyl for the treatment of noncancer and cancer pain: A retrospective data analysis in Germany Fulltext Access 11 Pages 2006
Clinically important drug-disease interactions and their prevalence in older adults * Fulltext Access 11 Pages 2006
Mild cognitive impairment: An opportunity to identify patients at high risk for progression to Alzheimer's disease Fulltext Access 11 Pages 2006
Different methods of presenting risk information and their influence on medication compliance intentions: results of three studies Fulltext Access 11 Pages 2006
Oral clindamycin 300 mg BID compared with oral amoxicillin/clavulanic acid 1 g BID in the outpatient treatment of acute recurrent pharyngotonsillitis caused by group a β-hemolytic streptococci: An international, multicenter, randomized, investigator-blind Fulltext Access 11 Pages 2006
Second-generation antidepressant discontinuation and depressive relapse in adult patients with bipolar depression: Results of a retrospective database analysis 4 Fulltext Access 11 Pages 2006
Comparison of the lipid-modifying efficacy and safety profiles of ezetimibe coadministered with simvastatin in older versus younger patients with primary hypercholesterolemia: A post Hoc analysis of subpopulations from three pooled clinical trials Fulltext Access 11 Pages 2006
Adherence to infectious diseases society of America guidelines for empiric therapy for patients with community-acquired pneumonia in a commercially insured cohort * Fulltext Access 11 Pages 2006
The newborn drug development initiative workshop: Summary proceedings from the neurology group on neonatal seizures * Fulltext Access 11 Pages 2006
Pharmacokinetic and pharmacodynamic characteristics of a new S-amlodipine formulation in healthy Korean male subjects: A randomized, open-label, two-period, comparative, crossover study Fulltext Access 11 Pages 2006
Cloning of a cDNA encoding a novel marmoset CYP2C enzyme, expression in yeast cells and characterization of its enzymatic functions Fulltext Access 11 Pages 2006
Determinants of antipyretic misuse in children up to 5 years of age: A cross-sectional study Fulltext Access 11 Pages 2006
Single-dose bioavailability of levetiracetam intravenous infusion relative to oral tablets and multiple-dose pharmacokinetics and tolerability of levetiracetam intravenous infusion compared with placebo in healthy subjects Fulltext Access 11 Pages 2006
Clinical Assessment of Pain, Tolerability, and Preference of an Autoinjection Pen Versus a Prefilled Syringe for Patient Self-Administration of the Fully Human, Monoclonal Antibody Adalimumab: The TOUCH Trial * Fulltext Access 11 Pages 2006
Leucovorin-induced resistance against FDH growth suppressor effects occurs through DHFR up-regulation Fulltext Access 11 Pages 2006
Biochemical and pharmacological properties of an allosteric modulator site of the human P-glycoprotein (ABCB1) Fulltext Access 11 Pages 2006
Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: Structural basis for differences in the ability to reactivate tabun conjugates Fulltext Access 11 Pages 2006
Differential anti-proliferative actions of peroxisome proliferator-activated receptor-γ agonists in MCF-7 breast cancer cells Fulltext Access 11 Pages 2006
Different roles of liver X receptor α and β in lipid metabolism: Effects of an α-selective and a dual agonist in mice deficient in each subtype Fulltext Access 11 Pages 2006
Strong modulation by RFamide neuropeptides of the ASIC1b/3 heteromer in competition with extracellular calcium Fulltext Access 11 Pages 2006
Role of noradrenergic and GABA-ergic inputs in pedunculopontine tegmentum for regulation of rapid eye movement sleep in rats Fulltext Access 11 Pages 2006
The H current blocker ZD7288 decreases epileptiform hyperexcitability in the rat neocortex by depressing synaptic transmission Fulltext Access 11 Pages 2006
Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice Fulltext Access 11 Pages 2006
Chronic methylphenidate modulates locomotor activity and sensory evoked responses in the VTA and NAc of freely behaving rats Fulltext Access 11 Pages 2006
Nicotine, but neither the α4β2 ligand RJR2403 nor an α7 nAChR subtype selective agonist, protects against a partial 6-hydroxydopamine lesion of the rat median forebrain bundle Fulltext Access 11 Pages 2006
A slow-onset, long-duration indanamine monoamine reuptake inhibitor as a potential maintenance pharmacotherapy for psychostimulant abuse: Effects in laboratory rat models relating to addiction Fulltext Access 11 Pages 2006
Effects of dorsal and ventral hippocampal NMDA stimulation on nucleus accumbens core and shell dopamine release Fulltext Access 11 Pages 2006
Trafficking of presynaptic AMPA receptors mediating neurotransmitter release: Neuronal selectivity and relationships with sensitivity to cyclothiazide Fulltext Access 11 Pages 2006
Use of an inverse agonist radioligand [3H]A-317920 reveals distinct pharmacological profiles of the rat histamine H3 receptor Fulltext Access 11 Pages 2006
Down-regulation of GFRα-1 expression by antisense oligodeoxynucleotide aggravates thermal hyperalgesia in a rat model of neuropathic pain Fulltext Access 11 Pages 2006
Airjet and FG-7142-induced Fos expression differs in rats selectively bred for high and low anxiety-related behavior Fulltext Access 11 Pages 2006
Reinforcing effects of nicotine microinjections into the ventral tegmental area of mice: Dependence on cholinergic nicotinic and dopaminergic D1 receptors Fulltext Access 11 Pages 2006
Tinospora cordifolia induces enzymes of carcinogen/drug metabolism and antioxidant system, and inhibits lipid peroxidation in mice Fulltext Access 11 Pages 2006
Dopaminergic control of food choice: Contrasting effects of SKF 38393 and quinpirole on high-palatability food preference in the rat Fulltext Access 11 Pages 2006
Expression of D2 receptor isoforms in cultured neurons reveals equipotent autoreceptor function Fulltext Access 11 Pages 2006
Dopamine D4 receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation Fulltext Access 11 Pages 2006
Protection against MDMA-induced dopaminergic neurotoxicity in mice by methyllycaconitine: Involvement of nicotinic receptors Fulltext Access 11 Pages 2006
The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system Fulltext Access 11 Pages 2006
Inhibition of the striatum-enriched phosphodiesterase PDE10A: A novel approach to the treatment of psychosis Fulltext Access 11 Pages 2006
NMDA depresses glutamatergic synaptic transmission in the striatum through the activation of adenosine A1 receptors: Evidence from knockout mice Fulltext Access 11 Pages 2006
The effect of dibutyryl cAMP on tetrodotoxin-sensitive and -resistant voltage-gated sodium currents in rat dorsal root ganglion neurons and the consequences for their sensitivity to lidocaine Fulltext Access 11 Pages 2006
In vitro galantamine-memantine co-application: Mechanism of beneficial action Fulltext Access 11 Pages 2006
Increasing prevalence of HIV-1 protease inhibitor-associated mutations correlates with long-term non-suppressive protease inhibitor treatment Fulltext Access 11 Pages 2006
Mitochondrial permeability transition induced by novel pyridothiopyranopyrimidine derivatives: Potential new antimitochondrial antitumour agents Fulltext Access 11 Pages 2006
Human equilibrative nucleoside transporter-1 (hENT1) is required for the transcriptomic response of the nucleoside-derived drug 5′-DFUR in breast cancer MCF7 cells Fulltext Access 11 Pages 2006
Protective effect of monosialoganglioside GM1 against chemically induced apoptosis through targeting of mitochondrial function and iron transport Fulltext Access 11 Pages 2006
Inhibition of NF-κB activation through targeting IκB kinase by celastrol, a quinone methide triterpenoid Fulltext Access 11 Pages 2006
Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice Fulltext Access 11 Pages 2006
Quercetin, a flavonoid, inhibits proliferation and increases osteogenic differentiation in human adipose stromal cells Fulltext Access 11 Pages 2006
Gene expression profiling in R-flurbiprofen-treated prostate cancer: R-Flurbiprofen regulates prostate stem cell antigen through activation of AKT kinase Fulltext Access 11 Pages 2006
Inhibition of phosphatidylinositol 3-kinase-mediated glucose metabolism coincides with resveratrol-induced cell cycle arrest in human diffuse large B-cell lymphomas Fulltext Access 11 Pages 2006
Fluorinated Cpd 5, a pure arylating K-vitamin derivative, inhibits human hepatoma cell growth by inhibiting Cdc25 and activating MAPK Fulltext Access 11 Pages 2006
Identification and analysis of fitness of resistance mutations against the HCV protease inhibitor SCH 503034 Fulltext Access 11 Pages 2006
Combination chemotherapy, a potential strategy for reducing the emergence of drug-resistant influenza A variants Fulltext Access 11 Pages 2006
Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin Fulltext Access 11 Pages 2006
Cholinergic receptor-independent dysfunction of mitochondrial respiratory chain enzymes, reduced mitochondrial transmembrane potential and ATP depletion underlie necrotic cell death induced by the organophosphate poison mevinphos Fulltext Access 11 Pages 2006
Inhibition of respiratory syncytial virus in cultured cells by nucleocapsid gene targeted deoxyribozyme (DNAzyme) Fulltext Access 11 Pages 2006
Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins Fulltext Access 11 Pages 2006
Application of the cycloSal-prodrug approach for improving the biological potential of phosphorylated biomolecules Fulltext Access 11 Pages 2006
Potent inhibition of HIV-1 gene expression and TAT-mediated apoptosis in human T cells by novel mono- and multitarget anti-TAT/Rev/Env ribozymes and a general purpose RNA-cleaving DNA-enzyme Fulltext Access 11 Pages 2006
Screening of novel nuclear receptor agonists by a convenient reporter gene assay system using green fluorescent protein derivatives Fulltext Access 11 Pages 2006
Mechanisms involved in the gastro-protective effect of STW 5 (Iberogast®) and its components against ulcers and rebound acidity Fulltext Access 11 Pages 2006
Pharmacological actions of Thespesia populnea relevant to Alzheimer's disease Fulltext Access 11 Pages 2006