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Pharmacology Research Articles

Role of nitric oxide and protein kinase C in the tachyphylaxis to vasopressin in rat aortic rings
Fulltext Access 13 Pages 2005
Calcium-independent CaMKII activity is involved in ginsenoside Rb1-mediated neuronal recovery after hypoxic damage
Fulltext Access 13 Pages 2005
Ginsenoside-Rd from Panax notoginseng enhances astrocyte differentiation from neural stem cells
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Effects of artemisinin-tagged holotransferrin on cancer cells
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Apigenin induced apoptosis through p53-dependent pathway in human cervical carcinoma cells
Fulltext Access 13 Pages 2005
Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase
Fulltext Access 13 Pages 2005
The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase
Fulltext Access 13 Pages 2005
Effect of endothelin antagonist (TAK-044) on cerebral ischemic volume, oxidative stress markers and neurobehavioral parameters in the middle cerebral artery occlusion model of stroke in rats
Fulltext Access 13 Pages 2005
Natural cannabinoids: Templates for drug discovery
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Apolipoprotein A-I-dependent cholesterol esterification in patients with rheumatoid arthritis
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β adrenergic receptor-mediated atrial specific up-regulation of RGS5
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Disturbances in epithelial ionic secretion in different experimental models of colitis
Fulltext Access 13 Pages 2005
The PKC delta inhibitor, rottlerin, induces apoptosis of haematopoietic cell lines through mitochondrial membrane depolarization and caspases' cascade
Fulltext Access 13 Pages 2005
Chylomicron remnants regulate early growth response factor-1 in vascular smooth muscle cells
Fulltext Access 13 Pages 2005
SKI306X, an oriental herbal mixture, suppresses gastric leukotriene B4 synthesis without causing mucosal injury and the diclofenac-induced gastric lesions
Fulltext Access 13 Pages 2005
Effects of insulin resistance on geranylgeranylacetone-induced expression of heat shock protein 72 and cardioprotection in high-fat diet rats
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Pharmacokinetic interaction with digoxin and glucocorticoids in rats detected by radio-immunoassay using a novel specific antiserum
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The potential role of sigma-1 receptors in lipid transport and lipid raft reconstitution in the brain: Implication for drug abuse
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Protective effect of Coptidis Rhizoma on S-nitroso-N-acetylpenicillamine (SNAP)-induced apoptosis and necrosis in pancreatic RINm5F cells
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Anti-thyroid hormonal activity of tetrabromobisphenol A, a flame retardant, and related compounds: Affinity to the mammalian thyroid hormone receptor, and effect on tadpole metamorphosis
Fulltext Access 13 Pages 2005
Scopoletin induces apoptosis in human promyeloleukemic cells, accompanied by activations of nuclear factor κB and caspase-3
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Neuromechanical effects of pyrethroids, allethrin, cyhalothrin and deltamethrin on the cholinergic processes in rat brain
Fulltext Access 13 Pages 2005
Echinochrome, a naturally occurring iron chelator and free radical scavenger in artificial and natural membrane systems
Fulltext Access 13 Pages 2005
Cholecystokinin and endogenous opioid peptides: Interactive influence on pain, cognition, and emotion
Fulltext Access 14 Pages 2005
Cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells through activation of the proapoptotic Bcl-2 family proteins and MAPK pathway
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The effects of nitric oxide in acute lung injury
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On the trail of a cognitive enhancer for the treatment of schizophrenia
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Identification of MYCBP as a β-catenin/LEF-1 target using DNA microarray analysis
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Production of superoxide radical in reductive metabolism of a synthetic food-coloring agent, indigocarmine, and related compounds
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Effects of testosterone on muscarinic acetylcholine receptors in the rat epididymis
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Emerging roles of apelin in biology and medicine
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Effects of ethanol on locomotor and anxiety-like behaviors and the acquisition of ethanol intake in Lewis and spontaneously hypertensive rats
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Cellular abnormalities linked to endoplasmic reticulum dysfunction in cerebrovascular disease-therapeutic potential
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Carnitine depletion in rat pups from mothers given mildronate: A model of carnitine deficiency in late fetal and neonatal life
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5-HT6 receptors: a novel target for cognitive enhancement
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Kinetic and functional properties of [3H]ZM241385, a high affinity antagonist for adenosine A2A receptors
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From clinical evidence to molecular mechanisms underlying neuroprotection afforded by estrogens
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Understanding local Mediterranean diets: A multidisciplinary pharmacological and ethnobotanical approach
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Down-regulation of the sodium channel Nav1.1 α-subunit following focal ischemic brain injury in rats: In situ hybridization and immunohistochemical analysis
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The effect of repeated acute mental stress on habituation and recovery responses in hemoconcentration and blood cells in healthy men
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Effects of phencyclidine on schedule-controlled responding following neurotoxic lesions of the striatum
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Electro-acupuncture potentiates the disulphide-reducing activities of thioredoxin system by increasing thioredoxin expression in ischemia-reperfused rat brains
Fulltext Access 14 Pages 2005
A novel polysaccharide of black soybean promotes myelopoiesis and reconstitutes bone marrow after 5-flurouracil- and irradiation-induced myelosuppression
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Effect of donepezil and lercanidipine on memory impairment induced by intracerebroventricular streptozotocin in rats
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Protective effect of melatonin on contractile activity and oxidative injury induced by ischemia and reperfusion of rat ileum
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Role of p38 in nitric oxide synthase and cyclooxygenase expression, and nitric oxide and PGE2 synthesis in human gingival fibroblasts stimulated with lipopolysaccharides
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Pharmacological preconditioning with sildenafil: Basic mechanisms and clinical implications
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The effects of phenytoin and its metabolite 5-(4-hydroxyphenyl)-5-phenylhydantoin on cellular glucose transport
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Neuroprotective effect of Azadirachta indica on cerebral post-ischemic reperfusion and hypoperfusion in rats
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Alterations in antioxidant enzyme activities in the eyes, aorta and kidneys of diabetic rats relevant to the onset of oxidative stress
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Endothelium-dependent and -independent vasorelaxation by a theophylline derivative MCPT: Roles of cyclic nucleotides, potassium channel opening and phosphodiesterase inhibition
Fulltext Access 14 Pages 2005
Treatment for psychological dependence on morphine: Usefulness of inhibiting NMDA receptor and its associated protein kinase in the nucleus accumbens
Fulltext Access 14 Pages 2005
Zidovudine plus sulfamethoxazole-trimethoprim adversely affects B lymphocyte maturation in bone marrow of normal mice
Fulltext Access 14 Pages 2005
Impaired function of hepatic natural killer cells from murine chronic HBsAg carriers
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Utilization of in vivo ultrafiltration in biomedical research and clinical applications
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Ethanol induces the production of cytokines via the Ca2+, MAP kinase, HIF-1α, and NF-κB pathway
Fulltext Access 14 Pages 2005
Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors
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Intestinal uptake of MPP+ is differently affected by red and white wine
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Inhibition of phosphatase activity enhances preconditioning and limits cell death in the ischemic/reperfused aged rat heart
Fulltext Access 14 Pages 2005
Long-term treatment with the Na+-glucose cotransporter inhibitor T-1095 causes sustained improvement in hyperglycemia and prevents diabetic neuropathy in Goto-Kakizaki Rats
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Anti-inflammatory and opioid-mediated effects of melatonin on experimental peritonitis in chickens
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Antinociceptive properties of acetylenic thiophene and furan derivatives: Evidence for the mechanism of action
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Arsenic induced blood and brain oxidative stress and its response to some thiol chelators in rats
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Gentamicin induces Jun-AP1 expression and JNK activation in renal glomeruli and cultured mesangial cells
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Total glucosides of paeony suppresses adjuvant arthritis in rats and intervenes cytokine-signaling between different types of synoviocytes
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Anti-oxidative stress effects of Herba leonuri on ischemic rat hearts
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Study for anti-angiogenic activities of polysaccharides isolated from Antrodia cinnamomea in endothelial cells
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Diazepam augments gender differences in cutaneous LD flux response to local cooling
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Metformin treatment restores the altered microvascular reactivity in neonatal streptozotocin-induced diabetic rats increasing NOS activity, but not NOS expression
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The study of anti-metabolic syndrome effect of puerarin in vitro
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The anti-apoptotic effects of nordihydroguaiaretic acid: Inhibition of cPLA2 activation during TNF-induced apoptosis arises from inhibition of calcium signaling
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Pro-oxidant action of diphenyl diselenide in the yeast Saccharomyces cerevisiae exposed to ROS-generating conditions
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Red Star Ruby (Sunrise) and blond qualities of Jaffa grapefruits and their influence on plasma lipid levels and plasma antioxidant activity in rats fed with cholesterol-containing and cholesterol-free diets
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Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-κB activation in RAW 264.7 cells
Fulltext Access 14 Pages 2005
Long-term administration of aqueous garlic extract (AGE) alleviates liver fibrosis and oxidative damage induced by biliary obstruction in rats
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Acute noise stress analgesia in relation to 5-HT2 and μ-opioid receptor changes in the frontal cortex of young mice
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Stimulation of acyl-CoA oxidase by α-linolenic acid-rich perilla oil lowers plasma triacylglycerol level in rats
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Influence of high-intensity exercise training and anabolic androgenic steroid treatment on rat tissue glycogen content
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Dysfunction of myocardial sarcoplasmic reticulum in rats with myocardial calcification
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Leptin enhances TNF-α production via p38 and JNK MAPK in LPS-stimulated Kupffer cells
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Anticonvulsant effects of phencynonate hydrochloride and other anticholinergic drugs in soman poisoning: Neurochemical mechanisms
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Melatonin ameliorates carbon tetrachloride-induced hepatic fibrogenesis in rats via inhibition of oxidative stress
Fulltext Access 14 Pages 2005
Antioxidant treatment normalizes nitric oxide production, renal sodium handling and blood pressure in experimental hyperleptinemia
Fulltext Access 14 Pages 2005
Bone medullary arterioles from ovariectomized rats have smaller baseline diameters but normal eNOS expression and NO-mediated dilation
Fulltext Access 14 Pages 2005
Menatetrenone rescues bone loss by improving osteoblast dysfunction in rats immobilized by sciatic neurectomy
Fulltext Access 14 Pages 2005
Ilex paraguariensis extracts are potent inhibitors of nitrosative stress: A comparative study with green tea and wines using a protein nitration model and mammalian cell cytotoxicity
Fulltext Access 14 Pages 2005
Isoliquiritigenin induces apoptosis and cell cycle arrest through p53-dependent pathway in Hep G2 cells
Fulltext Access 14 Pages 2005
Ganoderic acid X, a lanostanoid triterpene, inhibits topoisomerases and induces apoptosis of cancer cells
Fulltext Access 14 Pages 2005
The search for the palmitoylethanolamide receptor
Fulltext Access 14 Pages 2005
Nonclinical proarrhythmia models: Predicting Torsades de Pointes
Fulltext Access 14 Pages 2005
HEK293 cell line: A vehicle for the expression of recombinant proteins
Fulltext Access 14 Pages 2005
An ethnobotanical survey of medicinal plants commercialized in the markets of La Paz and El Alto, Bolivia
Fulltext Access 14 Pages 2005
The entheomycological origin of Egyptian crowns and the esoteric underpinnings of Egyptian religion
Fulltext Access 14 Pages 2005
Bioprospecting Rumphius's Ambonese Herbal: Volume I
Fulltext Access 14 Pages 2005
Antioxidant approach to disease management and the role of 'Rasayana' herbs of Ayurveda
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Rescue of in vivo FAS-induced apoptosis of hepatocytes by corticosteroids either associated with alcohol consumption by mice or provided exogenously
Fulltext Access 14 Pages 2005
The liquid culture filtrates of Paecilomyces tenuipes (Peck) Samson (=Isaria japonica Yasuda) and Paecilomyces cicadae (Miquel) Samson (=Isaria sinclairii (Berk.) Llond) regulate Th1 and Th2 cytokine response in murine Peyer's patch cells in vitro and ex
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Cells isolated from bone-marrow and lungs of allergic BALB/C mice and cultured in the presence of IL-5 are respectively resistant and susceptible to apoptosis induced by dexamethasone
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Development and validation of a novel IL-10 deficient cell transfer model for colitis
Fulltext Access 14 Pages 2005
Systemic treatment with n-6 polyunsaturated fatty acids attenuates EL4 thymoma growth and metastasis through enhancing specific and non-specific anti-tumor cytolytic activities and production of TH1 cytokines
Fulltext Access 14 Pages 2005
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