An aqueous extract of the popular Chinese nutraceutical Kwei Ling Ko (Tortoise shell-Rhizome Jelly) activates the PPARγ pathway and down-regulates the NFκB activity Fulltext Access 12 Pages 2005
Comparison of the efficacy of ciclesonide 160 μg QDand budesonide 200 μg BID in adults with persistent asthma: A phase III, randomized, double-dummy, open-label study Fulltext Access 12 Pages 2005
Cisplatin increases brain 2-arachidonoylglycerol (2-AG) and concomitantly reduces intestinal 2-AG and anandamide levels in the least shrew Fulltext Access 12 Pages 2005
The efficacy and safety of inhaled fluticasone propionate/salmeterol and ipratropium/albuterol for the treatment of chronic obstructive pulmonary disease: An eight-week, multicenter, randomized, double-blind, double-dummy, parallel-group study Fulltext Access 12 Pages 2005
Propentofylline attenuates tau hyperphosphorylation in Alzheimer's Swedish mutant model Tg2576 Fulltext Access 12 Pages 2005
Clinic blood pressure responses to two amlodipine salt formulations, adipate and besylate, in adult Korean patients with mild to moderate hypertension: A multicenter, randomized, double-blind, parallel-group, 8-week comparison Fulltext Access 12 Pages 2005
Phasic cardiovascular responses to mevinphos are mediated through differential activation of cGMP/PKG cascade and peroxynitrite via nitric oxide generated in the rat rostral ventrolateral medulla by NOS I and II isoforms Fulltext Access 12 Pages 2005
Endocannabinoid release from midbrain dopamine neurons: a potential substrate for cannabinoid receptor antagonist treatment of addiction Fulltext Access 12 Pages 2005
Neuronal Kir3.1/Kir3.2a channels coupled to serotonin 1A and muscarinic m2 receptors are differentially modulated by the 'short' RGS3 isoform Fulltext Access 12 Pages 2005
Differential expression of P2X receptors on neurons from different parasympathetic ganglia Fulltext Access 12 Pages 2005
Efficacy and safety of biphasic insulin aspart 30 combined with pioglitazone in type 2 diabetes poorly controlled on glibenclamide (glyburide) monotherapy or combination therapy: An 18-week, randomized, open-label study Fulltext Access 12 Pages 2005
Safety and effectiveness of topiramate for the management of painful diabetic peripheral neuropathy in an open-label extension study Fulltext Access 12 Pages 2005
Role of α7-nicotinic acetylcholine receptors in tetanic stimulation-induced γ oscillations in rat hippocampal slices Fulltext Access 12 Pages 2005
Incidence of infection during efalizumab therapy for psoriasis: Analysis of the clinical trial experience Fulltext Access 12 Pages 2005
Reversal of caffeine-induced anxiety by neurosteroid 3-alpha-hydroxy-5-alpha-pregnane-20-one in rats Fulltext Access 12 Pages 2005
Effect of acute and chronic psychostimulant drugs on redox status, AP-1 activation and pro-enkephalin mRNA in the human astrocyte-like U373 MG cells Fulltext Access 12 Pages 2005
Antimuscarinic agents: Implications and concerns in themanagement of overactive bladder in the elderly Fulltext Access 12 Pages 2005
Effectiveness and tolerability of the buprenorphinetransdermal system in patients with moderate to severe chronic pain: A multicenter, open-label, uncontrolled, prospective, observational clinical study Fulltext Access 12 Pages 2005
Nizatidine for the treatment of pediatric gastroesophageal reflux symptoms: An open-label, multiple-dose, randomized, multicenter clinical trial in 210 children Fulltext Access 12 Pages 2005
Quantifying the use of the statin antilipemic drugs: Comparisons and contrasts between Nova Scotia, Canada, and Queensland, Australia Fulltext Access 12 Pages 2005
Analgesic efficacy and tolerability of oxycodone 5 mg/ibuprofen400 mg compared with those of oxycodone 5 mg/acetaminophen 325 mg and hydrocodone 7.5 mg/acetaminophen 500 mg in patients with moderate to severe postoperative pain: A randomized, double-blind Fulltext Access 12 Pages 2005
Ncm-d-aspartate: A novel caged d-aspartate suitable for activation of glutamate transporters and N-methyl-d-aspartate (NMDA) receptors in brain tissue Fulltext Access 12 Pages 2005
Patterns of care, outcomes, and direct health plan costs of antiepileptic therapy: a pharmacoeconomic analysis of the available carbamazepine formulations Fulltext Access 12 Pages 2005
The substituted aspartate analogue l-β-threo-benzyl-aspartate preferentially inhibits the neuronal excitatory amino acid transporter EAAT3 Fulltext Access 12 Pages 2005
Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain Fulltext Access 12 Pages 2005
Group II mGluR-induced long term depression in the dentate gyrus in vivo is NMDA receptor-independent and does not require protein synthesis Fulltext Access 12 Pages 2005
FlexPen®: Addressing issues of confidence andconvenience in insulin delivery Fulltext Access 12 Pages 2005
Prevalence and correlates of potentially inappropriate prescribing among ambulatory older patients in the year 2001: Comparison of three explicit criteria Fulltext Access 12 Pages 2005
Group II and III mGluRs-mediated presynaptic inhibition of EPSCs recorded from hippocampal interneurons of CA1 stratum lacunosum moleculare Fulltext Access 12 Pages 2005
Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats Fulltext Access 12 Pages 2005
Effects of switching from olanzapine to risperidone on the prevalence of the metabolic syndrome in overweight or obese patients with schizophrenia or schizoaffective disorder: Analysis of a multicenter, rater-blinded, open-label study Fulltext Access 12 Pages 2005
Combination oxycodone 5 mg/ibuprofen 400 mg for thetreatment of pain after abdominal or pelvic surgery in women: A randomized, double-blind, placebo- and active-controlled parallel-group study Fulltext Access 13 Pages 2005
Triple therapy with glimepiride in patients with type 2diabetes mellitus inadequately controlled by metformin and a thiazolidinedione: Results of a 30-week, randomized, double-blind, placebo-controlled, parallel-group study Fulltext Access 13 Pages 2005
Equipotent doses of transdermal fentanyl and transdermal buprenorphine in patients with cancer and noncancer pain: Results of a retrospective cohort study Fulltext Access 13 Pages 2005
Evaluation of the cost-effectiveness of Sirolimus versus cyclosporin for immunosuppression after renal transplantation in the United Kingdom Fulltext Access 13 Pages 2005
Efficacy and safety profile of fenofibrate-coated microgranules 130 mg, with and without food, in patients with hypertriglyceridemia and the metabolic syndrome: An 8-week, randomized, double-blind, placebo-controlled study Fulltext Access 13 Pages 2005
CYP2K6 from zebrafish (Danio rerio): Cloning, mapping, developmental/tissue expression, and aflatoxin B1 activation by baculovirus expressed enzyme Fulltext Access 13 Pages 2005
Apoptosis and biochemical biomarkers of stress in spiders from industrially polluted areas exposed to high temperature and dimethoate Fulltext Access 13 Pages 2005
Pain-related emotions modulate experimental pain perception and autonomic responses Fulltext Access 13 Pages 2005
Sensory and motor effects of experimental muscle pain in patients with lateral epicondylalgia and controls with delayed onset muscle soreness Fulltext Access 13 Pages 2005
Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia Fulltext Access 13 Pages 2005
Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation Fulltext Access 13 Pages 2005
Peripheral inflammation selectively increases TRPV1 function in IB4-positive sensory neurons from adult mouse Fulltext Access 13 Pages 2005
A systematic review of trial methodology, using the placebo groups of randomized controlled trials in paediatric postoperative pain Fulltext Access 13 Pages 2005
Practical approaches to insulin therapy for type 2 diabetes mellitus with premixed insulin analogues Fulltext Access 13 Pages 2005
Microarray analysis of gene expression following the formalin test in the infant rat Fulltext Access 13 Pages 2005
α-Conotoxins as selective probes for nicotinic acetylcholine receptor subclasses Fulltext Access 13 Pages 2005
The role of luteinizing hormone-releasing hormone therapy in locally advanced prostate cancer and biochemical failure: considerations for optimal use Fulltext Access 13 Pages 2005
New class of linoleic acid metabolites biosynthesized by corn and rice lipoxygenases: Suppression of proinflammatory mediator expression via attenuation of MAPK- and Akt-, but not PPARγ-, dependent pathways in stimulated macrophages Fulltext Access 13 Pages 2005
Clinical applications of exhaled nitric oxide for the diagnosis and management of asthma: A consensus report Fulltext Access 13 Pages 2005
An open-label, noncomparative study of miglustat in type I Gaucher disease: Efficacy and tolerability over 24 months of treatment Fulltext Access 13 Pages 2005
Coupling of human nicotinic acetylcholine receptors α7 to calcium channels in GH3 cells Fulltext Access 13 Pages 2005
Establishment of robust functional assays for the characterization of neuropeptide Y (NPY) receptors: identification of 3-(5-benzoyl-thiazol-2-ylamino)-benzonitrile as selective NPY type 5 receptor antagonist Fulltext Access 13 Pages 2005
Long-term potentiation persists in an occult state following mGluR-dependent depotentiation Fulltext Access 13 Pages 2005
Peripheral, but not central effects of cannabidiol derivatives: Mediation by CB1 and unidentified receptors Fulltext Access 13 Pages 2005
β-Carbolines induce apoptosis in cultured cerebellar granule neurons via the mitochondrial pathway Fulltext Access 13 Pages 2005
Interaction of corticosterone and nicotine in regulation of prepulse inhibition in mice Fulltext Access 13 Pages 2005
Virus-encoded chemokine receptors - putative novel antiviral drug targets Fulltext Access 13 Pages 2005
Antiabsence effects of carbenoxolone in two genetic animal models of absence epilepsy (WAG/Rij rats and lh/lh mice) Fulltext Access 13 Pages 2005
Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing Fulltext Access 13 Pages 2005
Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus Fulltext Access 13 Pages 2005
The regulation of hippocampal LTP by the molecular switch, a form of metaplasticity, requires mGlu5 receptors Fulltext Access 13 Pages 2005
Effects of a novel glutamate transporter blocker, (2S, 3S)-3-{3-[4-(trifluoromethyl)benzoylamino]benzyloxy}aspartate (TFB-TBOA), on activities of hippocampal neurons Fulltext Access 13 Pages 2005
Transmembrane domains 1 and 3 of the glycine transporter GLYT1 contain structural determinants of N[3-(4â²-fluorophenyl)-3-(4â²-phenylphenoxy)-propyl]sarcosine specificity Fulltext Access 13 Pages 2005
Understanding the Polymorphic Behavior of Sibenadet Hydrochloride through Detailed Studies Integrating Structural and Dynamical Assessment Fulltext Access 13 Pages 2005
Sulfoalkyl Ether-Alkyl Ether Cyclodextrin Derivatives, their Synthesis, NMR Characterization, and Binding of 6α-Methylprednisolone Fulltext Access 13 Pages 2005
Comparison of statistical analysis and Bayesian networks in the evaluation of dissolution performance of BCS Class II model drugs Fulltext Access 13 Pages 2005
Reversible Self-Association Increases the Viscosity of a Concentrated Monoclonal Antibody in Aqueous Solution Fulltext Access 13 Pages 2005
Effect Of the Variation in the Ambient Moisture on the Compaction Behavior of Powder Undergoing Roller-Compaction And On The Characteristics Of Tablets Produced From The Post-Milled Granules Fulltext Access 13 Pages 2005
Influence of Ambient Moisture on the Compaction Behavior of Microcrystalline Cellulose Powder Undergoing Uni-Axial Compression and Roller-Compaction: A Comparative Study Using Near-Infrared Spectroscopy Fulltext Access 13 Pages 2005
Amphiphilic pyridinium salts block TNFα/NFκB signaling and constitutive hypersecretion of interleukin-8 (IL-8) from cystic fibrosis lung epithelial cells Fulltext Access 13 Pages 2005
Dicoumarol relieves serum withdrawal-induced G0/1 blockade in HL-60 cells through a superoxide-dependent mechanism Fulltext Access 13 Pages 2005
Quercetin, but not rutin and quercitrin, prevention of H2O2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages Fulltext Access 13 Pages 2005
Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: Involvement of p38 mitogen-activated protein kinase Fulltext Access 13 Pages 2005
Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells Fulltext Access 13 Pages 2005
Tangutorine induces p21 expression and abnormal mitosis in human colon cancer HT-29 cells Fulltext Access 13 Pages 2005
Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway Fulltext Access 13 Pages 2005
SCF-Engineered Powders for Delivery of Budesonide from Passive DPI Devices Fulltext Access 13 Pages 2005
HDAC inhibition prevents NF-κB activation by suppressing proteasome activity: Down-regulation of proteasome subunit expression stabilizes IκBα Fulltext Access 13 Pages 2005
Changes in spectrin organisation in leukaemic and lymphoid cells upon chemotherapy Fulltext Access 13 Pages 2005
Kinetics of tienilic acid bioactivation and functional generation of drug-protein adducts in intact rat hepatocytes Fulltext Access 13 Pages 2005
Bile acid-induced proliferation of a human colon cancer cell line is mediated by transactivation of epidermal growth factor receptors Fulltext Access 13 Pages 2005
Extracts and molecules from medicinal plants against herpes simplex viruses Fulltext Access 13 Pages 2005
Inhibition of CCR5-mediated infection by diverse R5 and R5X4 HIV and SIV isolates using novel small molecule inhibitors of CCR5: Effects of viral diversity, target cell and receptor density Fulltext Access 13 Pages 2005
Binding and functional properties of the novel somatostatin analogue KE 108 at native mouse somatostatin receptors Fulltext Access 13 Pages 2005
Neurosteroid paradoxical enhancement of paired-pulse inhibition through paired-pulse facilitation of inhibitory circuits in dentate granule cells Fulltext Access 13 Pages 2005
Dopamine inhibits cell growth and cell cycle by blocking ribonucleotide reductase Fulltext Access 13 Pages 2005