[+]-Huperzine A treatment protects against N-methyl-d-aspartate-induced seizure/status epilepticus in rats Fulltext Access 9 Pages 2008
α,β-Dehydrophenylalanine choline esters, a new class of reversible inhibitors of human acetylcholinesterase and butyrylcholinesterase Fulltext Access 9 Pages 2008
Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s Fulltext Access 9 Pages 2008
Roles of ERK and p38 mitogen-activated protein kinases in phorbol ester-induced NF-κB activation and COX-2 expression in human breast epithelial cells Fulltext Access 9 Pages 2008
Effects of cyclopenta[c]phenanthrene and its derivatives on zona radiata protein, ERα, and CYP1A mRNA expression in liver of rainbow trout (Oncorhynchus mykiss Walbaum) Fulltext Access 9 Pages 2008
Effects of resveratrol and its derivatives on lipopolysaccharide-induced microglial activation and their structure–activity relationships Fulltext Access 9 Pages 2008
Comparison of hypolipidemic activity of synthetic gallic acid–linoleic acid ester with mixture of gallic acid and linoleic acid, gallic acid, and linoleic acid on high-fat diet induced obesity in C57BL/6 Cr Slc mice Fulltext Access 9 Pages 2008
Melatonin exerts a more potent effect than S-adenosyl-l-methionine against iron metabolism disturbances, oxidative stress and tissue injury induced by obstructive jaundice in rats Fulltext Access 9 Pages 2008
Inhibition of benzopyrene diol epoxide-induced apoptosis by cadmium(II) is AP-1-independent: Role of extracelluler signal related kinase Fulltext Access 9 Pages 2008
Sanguinarine causes DNA damage and p53-independent cell death in human colon cancer cell lines Fulltext Access 9 Pages 2008
Molecular cloning and expression analysis of cDNA ends of chicken neuropathy target esterase Fulltext Access 9 Pages 2008
Tetramethylphenylenediamine-induced hepatocyte cytotoxicity caused by lysosomal labilisation and redox cycling with oxygen activation Fulltext Access 9 Pages 2008
Farnesol ameliorates massive inflammation, oxidative stress and lung injury induced by intratracheal instillation of cigarette smoke extract in rats: An initial step in lung chemoprevention Fulltext Access 9 Pages 2008
The neuroprotective effect of ladostigil against hydrogen peroxide-mediated cytotoxicity Fulltext Access 9 Pages 2008
Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds Fulltext Access 9 Pages 2008
Drugging the Plasmodium kinome: the benefits of academia–industry synergy Fulltext Access 9 Pages 2008
Potentiation and priming of platelet activation: a potential target for antiplatelet therapy Fulltext Access 9 Pages 2008
Inhibition of c-Jun N-terminal kinase sensitizes tumor cells to flavonoid-induced apoptosis through down-regulation of JunD Fulltext Access 9 Pages 2008
Copper accumulation and lipid oxidation precede inflammation and myelin lesions in N,N-diethyldithiocarbamate peripheral myelinopathy Fulltext Access 9 Pages 2008
Molecular mechanism of reduction in pregnenolone synthesis by cigarette smoke Fulltext Access 9 Pages 2008
Comparison of polycyclic aromatic hydrocarbon levels in placental tissues of Indian women with full- and preterm deliveries Fulltext Access 9 Pages 2008
Antimutagenic, antigenotoxic and antioxidant activities of Acacia salicina extracts (ASE) and modulation of cell gene expression by H2O2 and ASE treatment Fulltext Access 9 Pages 2008
Cytoskeletal alterations in interphase cells of the green alga Spirogyra decimina in response to heavy metals exposure: II. The effect of aluminium, nickel and copper Fulltext Access 9 Pages 2008
Use of the rat postimplantation embryo culture to assess the embryotoxic potency within a chemical category and to identify toxic metabolites Fulltext Access 9 Pages 2008
Toxic effects of DDT and methyl mercury on the hepatocytes from Hoplias malabaricus Fulltext Access 9 Pages 2008
Ability of rabbit antiserum against crotapotin to neutralize the neurotoxic, myotoxic and phospholipase A2 activities of crotoxin from Crotalus durissus cascavella snake venom Fulltext Access 9 Pages 2008
Anti-cancer activity of highly purified sulfur in immortalized and malignant human oral keratinocytes Fulltext Access 9 Pages 2008
Effects of mixing metal ions on oxidative DNA damage mediated by a Fenton-type reduction Fulltext Access 9 Pages 2008
Estrogen and environmental estrogenic chemicals exert developmental effects on rat hypothalamic neurons and glias Fulltext Access 9 Pages 2008
Induction of oxidative stress in human Chang liver cells by octachlorostyrene, the persistent and bioaccumulative toxicant Fulltext Access 9 Pages 2008
Apoptogenic activity of two benzophenanthridine alkaloids from Chelidonium majus L. does not correlate with their DNA damaging effects Fulltext Access 9 Pages 2008
Utility of polyclonal antibodies targeted toward unique tryptic peptides in the proteomic analysis of cytochrome P450 isozymes Fulltext Access 9 Pages 2008
Ketamine inhibits tumor necrosis factor-α and interleukin-6 gene expressions in lipopolysaccharide-stimulated macrophages through suppression of toll-like receptor 4-mediated c-Jun N-terminal kinase phosphorylation and activator protein-1 activation Fulltext Access 9 Pages 2008
Mercury in breast milk - A health hazard for infants in gold mining areas? Fulltext Access 9 Pages 2008
Principal component analysis and discrimination of variables associated with pre- and post-natal exposure to mercury Fulltext Access 9 Pages 2008
Drinking water nitrate and prevalence of methemoglobinemia among infants and children aged 1–7 years in Moroccan areas Fulltext Access 9 Pages 2008
Assessment of environmental worry in health-related settings: Re-evaluation and modification of an environmental worry scale Fulltext Access 9 Pages 2008
Residential proximity to waste sites and industrial facilities and chromosomal anomalies in offspring Fulltext Access 9 Pages 2008
Nasturtium officinale reduces oxidative stress and enhances antioxidant capacity in hypercholesterolaemic rats Fulltext Access 9 Pages 2008
Erratum to “Prediction of non-genotoxic carcinogenesis in rats using changes in gene expression following acute dosing” Fulltext Access 9 Pages 2008
Efficacy of Siddha formulation Kalpaamruthaa in ameliorating joint destruction in rheumatoid arthritis in rats Fulltext Access 9 Pages 2008
The anti-fatty liver effects of garlic oil on acute ethanol-exposed mice Fulltext Access 9 Pages 2008
The 3,4-oxide is responsible for the DNA binding of benzo[ghi]perylene, a polycyclic aromatic hydrocarbon without a “classic” bay-region Fulltext Access 9 Pages 2008
Effect of ursolic acid, a triterpenoid antioxidant, on ultraviolet-B radiation-induced cytotoxicity, lipid peroxidation and DNA damage in human lymphocytes Fulltext Access 9 Pages 2008
Attenuating the toxicity of cisplatin by using selenosulfate with reduced risk of selenium toxicity as compared with selenite Fulltext Access 9 Pages 2008
2,5-hexanedione (HD) treatment alters calmodulin, Ca2+/calmodulin-dependent protein kinase II, and protein kinase C in rats' nerve tissues Fulltext Access 9 Pages 2008
An enhanced postnatal autoimmune profile in 24 week-old C57BL/6 mice developmentally exposed to TCDD Fulltext Access 9 Pages 2008
Use of epidemiologic data in Integrated Risk Information System (IRIS) assessments Fulltext Access 9 Pages 2008
Towards standards for data exchange and integration and their impact on a public database such as CEBS (Chemical Effects in Biological Systems) Fulltext Access 9 Pages 2008
Resources for global risk assessment: The International Toxicity Estimates for Risk (ITER) and Risk Information Exchange (RiskIE) databases Fulltext Access 9 Pages 2008
Human health risk assessment database, “the NHSRC toxicity value database”: Supporting the risk assessment process at US EPA's National Homeland Security Research Center Fulltext Access 9 Pages 2008
A single administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin that produces reduced food and water intake induces long-lasting expression of corticotropin-releasing factor, arginine vasopressin, and proopiomelanocortin in rat brain Fulltext Access 9 Pages 2008
Interaction of osteopontin with neutrophil α4β1 and α9β1 integrins in a rodent model of alcoholic liver disease Fulltext Access 9 Pages 2008
Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel Fulltext Access 9 Pages 2008
Methylation and demethylation of intermediates selenide and methylselenol in the metabolism of selenium Fulltext Access 9 Pages 2008
Ofloxacin induces apoptosis in microencapsulated juvenile rabbit chondrocytes by caspase-8-dependent mitochondrial pathway Fulltext Access 9 Pages 2008
3,3′,5-Triiodo-l-thyronine-like activity in effluents from domestic sewage treatment plants detected by in vitro and in vivo bioassays Fulltext Access 9 Pages 2008
Subchronic inhalation of zinc sulfate induces cardiac changes in healthy rats Fulltext Access 9 Pages 2008
Recurrent exposure to nicotine differentiates human bronchial epithelial cells via epidermal growth factor receptor activation Fulltext Access 9 Pages 2008
Rapid activation of ERK1/2 and AKT in human breast cancer cells by cadmium Fulltext Access 9 Pages 2008
The NADPH oxidase inhibitor apocynin induces nitric oxide synthesis via oxidative stress Fulltext Access 9 Pages 2008
Rats fed soy protein isolate (SPI) have impaired hepatic CYP1A1 induction by polycyclic aromatic hydrocarbons as a result of interference with aryl hydrocarbon receptor signaling Fulltext Access 9 Pages 2008
Specific cerebral heat shock proteins and histamine receptor cross-talking mechanisms promote distinct lead-dependent neurotoxic responses in teleosts Fulltext Access 9 Pages 2008
Mutual enhancement of central neurotoxicity induced by ketamine followed by methamphetamine Fulltext Access 9 Pages 2008
Neuronal effects of 4-t-Butylcatechol: A model for catechol-containing antioxidants Fulltext Access 9 Pages 2008
Involvement of mitogen-activated protein kinases and NFκB in LPS-induced CD40 expression on human monocytic cells Fulltext Access 9 Pages 2008
Genetic variability of aryl hydrocarbon receptor (AhR)-mediated regulation of the human UDP glucuronosyltransferase (UGT) 1A4 gene Fulltext Access 9 Pages 2008
NF-κB inhibition is involved in tobacco smoke-induced apoptosis in the lungs of rats Fulltext Access 9 Pages 2008
Inhibition of aryl hydrocarbon receptor transactivation and DNA adduct formation by CYP1 isoform-selective metabolic deactivation of benzo[a]pyrene Fulltext Access 9 Pages 2008
Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2+/− mice: Two-stage oxidative injury Fulltext Access 9 Pages 2008
Both direct and indirect effects account for the pro-inflammatory activity of enteropathogenic mycotoxins on the human intestinal epithelium: Stimulation of interleukin-8 secretion, potentiation of interleukin-1β effect and increase in the transepithelial Fulltext Access 9 Pages 2008
Cytotoxic, genotoxic and cell-cycle disruptive effects of thio-dimethylarsinate in cultured human cells and the role of glutathione Fulltext Access 9 Pages 2008
Delta-9-tetrahydrocannabinol accumulation, metabolism and cell-type-specific adverse effects in aggregating brain cell cultures Fulltext Access 9 Pages 2008
From topical antidote against skin irritants to a novel counter-irritating and anti-inflammatory peptide Fulltext Access 9 Pages 2008
Involvement of SREBPs in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced disruption of lipid metabolism in male guinea pig Fulltext Access 9 Pages 2008
Disulfiram promotes the conversion of carcinogenic cadmium to a proteasome inhibitor with pro-apoptotic activity in human cancer cells Fulltext Access 9 Pages 2008
Teratogen-induced distortions in the classical NF-κB activation pathway: Correlation with the ability of embryos to survive teratogenic stress Fulltext Access 9 Pages 2008
A cell-based in vitro alternative to identify skin sensitizers by gene expression Fulltext Access 9 Pages 2008
Hypo-responsiveness of interleukin-8 production in human embryonic epithelial intestine 407 cells independent of NF-κB pathway: New lessons from endotoxin and ribotoxic deoxynivalenol Fulltext Access 9 Pages 2008
Cytogenetic status and oxidative DNA-damage induced by atorvastatin in human peripheral blood lymphocytes: Standard and Fpg-modified comet assay Fulltext Access 9 Pages 2008
Delphinidin inhibits cell proliferation and invasion via modulation of Met receptor phosphorylation Fulltext Access 9 Pages 2008
Expression profiling of interindividual variability following xenobiotic exposures in primary human hepatocyte cultures Fulltext Access 9 Pages 2008
Mitochondria as an important target in heavy metal toxicity in rat hepatoma AS-30D cells Fulltext Access 9 Pages 2008
PPARα regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes Fulltext Access 9 Pages 2008
An underlying role for hepatobiliary dysfunction in cyclosporine A nephrotoxicity Fulltext Access 9 Pages 2008
Sprague-Dawley rats display metabolism-mediated sex differences in the acute toxicity of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) Fulltext Access 9 Pages 2008
Increased oxidative stress and antioxidant expression in mouse keratinocytes following exposure to paraquat Fulltext Access 9 Pages 2008
Arsenite reduces insulin secretion in rat pancreatic β-cells by decreasing the calcium-dependent calpain-10 proteolysis of SNAP-25 Fulltext Access 9 Pages 2008
Clarifying CB2 receptor-dependent and independent effects of THC on human lung epithelial cells Fulltext Access 9 Pages 2008
Developmentally-regulated sodium channel subunits are differentially sensitive to α-cyano containing pyrethroids Fulltext Access 9 Pages 2008
Development of human cell models for assessing the carcinogenic potential of chemicals Fulltext Access 9 Pages 2008
Mechanisms and implications of air pollution particle associations with chemokines Fulltext Access 9 Pages 2008
Propiverine-induced accumulation of nuclear and cytosolic protein in F344 rat kidneys: Isolation and identification of the accumulating protein Fulltext Access 9 Pages 2008