Subchronic inhalation of mixtures of cigarette smoke constituents in Xpaâ/âp53+/â knock-out mice: A comparison of intermittent with semi-continuous exposure to acetaldehyde, formaldehyde, and acrolein Fulltext Access 10 Pages 2008
COX-2 expression and inflammatory effects by diesel exhaust particles in vitro and in vivo Fulltext Access 10 Pages 2008
Estrogenic activity of environmental polycyclic aromatic hydrocarbons in uterus of immature Wistar rats Fulltext Access 10 Pages 2008
Cytotoxicity of oxidised lipids in cultured colonal human intestinal cancer cells (caco-2 cells) Fulltext Access 10 Pages 2008
Influence of deoxynivalenol on NF-κB activation and IL-8 secretion in human intestinal Caco-2 cells Fulltext Access 10 Pages 2008
Mitochondrial protein thiol modifications in acetaminophen hepatotoxicity: Effect on HMG-CoA synthase Fulltext Access 10 Pages 2008
Time dependencies in perfluorooctylacids disposition in rat and monkeys: A kinetic analysis Fulltext Access 10 Pages 2008
Classification structure–activity relationship (CSAR) studies for prediction of genotoxicity of thiophene derivatives Fulltext Access 10 Pages 2008
On the incorporation of chemical-specific information in risk assessment Fulltext Access 10 Pages 2008
The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells Fulltext Access 10 Pages 2008
Pharmacokinetics of aminomethylpropanol in rats following oral and a novel dermal study design Fulltext Access 10 Pages 2008
Effects of flavonoid mixtures on the transport of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through Caco-2 monolayers: An in vitro and kinetic modeling approach to predict the combined effects on transporter inhibition Fulltext Access 10 Pages 2008
Neurotoxicological mechanism of methylmercury induced by low-dose and long-term exposure in mice: Oxidative stress and down-regulated Na+/K+-ATPase involved Fulltext Access 10 Pages 2008
Safety evaluation of chicken breast extract containing carnosine and anserine Fulltext Access 10 Pages 2008
Dioscorea villosa (wild yam) induces chronic kidney injury via pro-fibrotic pathways Fulltext Access 10 Pages 2008
Ginsenoside Rd prevents and rescues rat intestinal epithelial cells from irradiation-induced apoptosis Fulltext Access 10 Pages 2008
Safety assessment of dietary diacylglycerol oil: A two-generation reproductive toxicity study in rats Fulltext Access 10 Pages 2008
Human percutaneous absorption of a direct hair dye comparing in vitro and in vivo results: Implications for safety assessment and animal testing Fulltext Access 10 Pages 2008
Protective effects of total saponins from stem and leaf of Panax ginseng against cyclophosphamide-induced genotoxicity and apoptosis in mouse bone marrow cells and peripheral lymphocyte cells Fulltext Access 10 Pages 2008
An investigation of the effects of methylmercury in rats fed different dietary fats and proteins: Testicular steroidogenic enzymes and serum testosterone levels Fulltext Access 10 Pages 2008
Antioxidant activities of Toona Sinensis leaves extracts using different antioxidant models Fulltext Access 10 Pages 2008
Detoxification of patulin and ochratoxin A, two abundant mycotoxins, by lactic acid bacteria Fulltext Access 10 Pages 2008
(−)Epigallocatechin gallate hampers collagen destruction and collagenase activation in ultraviolet-B-irradiated human dermal fibroblasts: Involvement of mitogen-activated protein kinase Fulltext Access 10 Pages 2008
Extracts of dietary plants are efficient modulators of nuclear factor kappa B Fulltext Access 10 Pages 2008
Microcystin-RR induced apoptosis in tobacco BY-2 suspension cells is mediated by reactive oxygen species and mitochondrial permeability transition pore status Fulltext Access 10 Pages 2008
Cytotoxic activity of 3,3′,4,4′,5,5′-hexahydroxystilbene against breast cancer cells is mediated by induction of p53 and downregulation of mitochondrial superoxide dismutase Fulltext Access 10 Pages 2008
Leiden reconstructed human epidermal model as a tool for the evaluation of the skin corrosion and irritation potential according to the ECVAM guidelines Fulltext Access 10 Pages 2008
A high-throughput screening method based on stably transformed human cells was used to determine the immunotoxic effects of fluoranthene and other PAHs Fulltext Access 10 Pages 2008
Aromatic antiepileptic drugs and mitochondrial toxicity: Effects on mitochondria isolated from rat liver Fulltext Access 10 Pages 2008
The mycotoxin Zearalenone induces apoptosis in human hepatocytes (HepG2) via p53-dependent mitochondrial signaling pathway Fulltext Access 10 Pages 2008
Use of Z310 cells as an in vitro blood–cerebrospinal fluid barrier model: Tight junction proteins and transport properties Fulltext Access 10 Pages 2008
Synergistic toxicity induced by prolonged glutathione depletion and inhibition of nuclear factor-kappaB signaling in liver cells Fulltext Access 10 Pages 2008
Combined treatment of P-gp-positive L1210/VCR cells by verapamil and all-trans retinoic acid induces down-regulation of P-glycoprotein expression and transport activity Fulltext Access 10 Pages 2008
Manganese-induced potentiation of in vitro proinflammatory cytokine production by activated microglial cells is associated with persistent activation of p38 MAPK Fulltext Access 10 Pages 2008
Role of p38 MAPK in the selective release of IL-8 induced by chemical allergen in naïve THP-1 cells Fulltext Access 10 Pages 2008
Glycoprotein of Zanthoxylum piperitum DC has a hepatoprotective effect via anti-oxidative character in vivo and in vitro Fulltext Access 10 Pages 2008
Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver Fulltext Access 10 Pages 2008
Effect of chlorhexidine digluconate on different cell types: A molecular and ultrastructural investigation Fulltext Access 10 Pages 2008
Chelerythrine and dihydrochelerythrine induce G1 phase arrest and bimodal cell death in human leukemia HL-60 cells Fulltext Access 10 Pages 2008
Tetrabromobisphenol A (TBBPA), induces cell death in TM4 Sertoli cells by modulating Ca2+ transport proteins and causing dysregulation of Ca2+ homeostasis Fulltext Access 10 Pages 2008
Antiproliferative activity of pristimerin isolated from Maytenus ilicifolia (Celastraceae) in human HL-60 cells Fulltext Access 10 Pages 2008
Protein alkylation, transcriptional responses and cytochrome c release during acrolein toxicity in A549 cells: Influence of nucleophilic culture media constituents Fulltext Access 10 Pages 2008
Tributyltin (TBT) inhibition of oligomycin-sensitive Mg-ATPase activity in mussel mitochondria Fulltext Access 10 Pages 2008
Biotransformation of genistein and bisphenol A in cell lines used for screening endocrine disruptors Fulltext Access 10 Pages 2008
Significant decreasing trend in human dietary exposure to PCDD/PCDFs and PCBs in Catalonia, Spain Fulltext Access 10 Pages 2008
Effects of in utero and lactational exposure to endosulfan in prefrontal cortex of male rats Fulltext Access 10 Pages 2008
Cobalt chloride attenuates hypobaric hypoxia induced vascular leakage in rat brain: Molecular mechanisms of action of cobalt chloride Fulltext Access 10 Pages 2008
Pyrrolidine dithiocarbamate-zinc(II) and -copper(II) complexes induce apoptosis in tumor cells by inhibiting the proteasomal activity Fulltext Access 10 Pages 2008
Role of vitamin C transporters and biliverdin reductase in the dual pro-oxidant and anti-oxidant effect of biliary compounds on the placental-fetal unit in cholestasis during pregnancy Fulltext Access 10 Pages 2008
Particles from wood smoke and traffic induce differential pro-inflammatory response patterns in co-cultures Fulltext Access 10 Pages 2008
Integrated metabolomic analysis of the nano-sized copper particle-induced hepatotoxicity and nephrotoxicity in rats: A rapid invivo screening method for nanotoxicity Fulltext Access 10 Pages 2008
Opposing roles for caspase and calpain death proteases in l-glutamate-induced oxidative neurotoxicity Fulltext Access 10 Pages 2008
Fluorescence in situ hybridization techniques (FISH) to detect changes in CYP19a gene expression of Japanese medaka (Oryzias latipes) Fulltext Access 10 Pages 2008
Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroidogenesis and pituitary hormone synthesis in developing Wistar rats Fulltext Access 10 Pages 2008
Mechanism of erythrocyte death in human population exposed to arsenic through drinking water Fulltext Access 10 Pages 2008
Developmental toxicity and alteration of gene expression in zebrafish embryos exposed to PFOS Fulltext Access 10 Pages 2008
High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity Fulltext Access 10 Pages 2008
Critical role of cyclooxygenase-2 activation in pathogenesis of hydronephrosis caused by lactational exposure of mice to dioxin Fulltext Access 10 Pages 2008
Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity Fulltext Access 10 Pages 2008
Sensitivity to sodium arsenite in human melanoma cells depends upon susceptibility to arsenite-induced mitotic arrest Fulltext Access 10 Pages 2008
Developmental exposure to trichloroethylene promotes CD4+ T cell differentiation and hyperactivity in association with oxidative stress and neurobehavioral deficits in MRL+/+ mice Fulltext Access 10 Pages 2008
Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner Fulltext Access 10 Pages 2008
Characterization of cadmium uptake and cytotoxicity in human osteoblast-like MG-63 cells Fulltext Access 10 Pages 2008
The impact of different nanoparticle surface chemistry and size on uptake and toxicity in a murine macrophage cell line Fulltext Access 10 Pages 2008
Reciprocal regulation of extracellular signal regulated kinase 1/2 and mitogen activated protein kinase phosphatase-3 Fulltext Access 10 Pages 2008
How can biologically-based modeling of arsenic kinetics and dynamics inform the risk assessment process? - A workshop review Fulltext Access 10 Pages 2008
Role of rat sodium/phosphate cotransporters in the cell membrane transport of arsenate Fulltext Access 10 Pages 2008
Novel function of glutathione transferase in rat liver mitochondrial membrane: Role for cytochrome c release from mitochondria Fulltext Access 10 Pages 2008
Low concentration of arsenite exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activity Fulltext Access 10 Pages 2008
Chemical mixtures: Evaluation of risk for child-specific exposures in a multi-stressor environment Fulltext Access 10 Pages 2008
Effect of ergot alkaloids associated with fescue toxicosis on hepatic cytochrome P450 and antioxidant proteins Fulltext Access 10 Pages 2008
Protective mechanisms of Aralia continentalis extract against tert-butyl hydroperoxide-induced hepatotoxicity: In vivo and in vitro studies Fulltext Access 10 Pages 2008
Subchronic feeding study of high oleic acid soybeans (Event DP-3Ø5423-1) in Sprague–Dawley rats Fulltext Access 10 Pages 2008
Dihydrolipoic acid inhibits tetrachlorohydroquinone-induced tumor promotion through prevention of oxidative damage Fulltext Access 10 Pages 2008
Acute, subchronic and genotoxicity studies conducted with Oligonol, an oligomerized polyphenol formulated from lychee and green tea extracts Fulltext Access 10 Pages 2008
Zizyphus jujuba and Origanum majorana extracts protect against hydroquinone-induced clastogenicity Fulltext Access 10 Pages 2008
Prioritizing veterinary pharmaceuticals for aquatic environment in Korea Fulltext Access 10 Pages 2008
Orai1–STIM1 formed store-operated Ca2+ channels (SOCs) as the molecular components needed for Pb2+ entry in living cells Fulltext Access 10 Pages 2008
Regulation of caveolin-1 expression, nitric oxide production and tissue injury by tumor necrosis factor-α following ozone inhalation Fulltext Access 10 Pages 2008
Direct mitochondrial dysfunction precedes reactive oxygen species production in amiodarone-induced toxicity in human peripheral lung epithelial HPL1A cells Fulltext Access 10 Pages 2008
Intervention of d-glucose ameliorates the toxicity of streptozotocin in accessory sex organs of rat Fulltext Access 10 Pages 2008
Low-dose dioxins alter gene expression related to cholesterol biosynthesis, lipogenesis, and glucose metabolism through the aryl hydrocarbon receptor-mediated pathway in mouse liver Fulltext Access 10 Pages 2008
Curcumin protects against cytotoxic and inflammatory effects of quartz particles but causes oxidative DNA damage in a rat lung epithelial cell line Fulltext Access 10 Pages 2008
Tissue dosimetry, metabolism and excretion of pentavalent and trivalent dimethylated arsenic in mice after oral administration Fulltext Access 10 Pages 2008
Lipid homeostasis and oxidative stress in the liver of male rats exposed to perfluorododecanoic acid Fulltext Access 10 Pages 2008
Phototoxicity and cytotoxicity of fullerol in human lens epithelial cells Fulltext Access 10 Pages 2008
Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase Fulltext Access 10 Pages 2008
Characterization of early events involved in human dendritic cell maturation induced by sensitizers: Cross talk between MAPK signalling pathways Fulltext Access 10 Pages 2008
Naturally-occurring estradiol-17β-fatty acid esters, but not estradiol-17β, preferentially induce mammary tumorigenesis in female rats: Implications for an important role in human breast cancer Fulltext Access 10 Pages 2008
Modulation of pulmonary inflammatory responses and antimicrobial defenses in mice exposed to diesel exhaust Fulltext Access 10 Pages 2008
Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity Fulltext Access 10 Pages 2008
Gene expression profiling in rat liver treated with compounds inducing phospholipidosis Fulltext Access 10 Pages 2008