کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10010944 | 1587680 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mechanisms of action of topical therapies and the rationale for combination therapy
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کلمات کلیدی
Retinoid X receptorNF-ATRXRRARTCIIκBαNF-κBGM-CSFAP-1IFN-γinterleukin - اینترلوکینAtopic dermatitis - درماتیت آتوپیکNuclear Factor of Activated T Cells - عامل هسته ای سلول های T فعال شدهgranulocyte-macrophage colony-stimulating factor - عامل گرانولوسیت-ماکروفاژ colony-stimulating factorNuclear factor-kappa B - فاکتور هسته ای-کاپا Btopical calcineurin inhibitor - مهارکننده کالسیروئین موضعیactivator protein-1 - پروتئین فعال کننده-1Interferon gamma - گاما اینترفرونRetinoic acid receptor - گیرنده اسید رتینوئیک
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The advent of new topical agents such as topical calcineurin inhibitors, as well as the reformulations of older agents in new vehicles, has broadened the treatment approaches to psoriasis and atopic dermatitis. The clinician must now consider additional novel physiologic pathways and mechanisms of action as well as expanding options for combination therapy. Combination therapy is especially beneficial when the selected agents possess differing mechanisms of action that provide additive or synergistic efficacy, reducing the required doses of the individual agents compared with monotherapy and potentially limiting side effects. Therapeutic approaches also can be rotated or used in various sequences for maintenance therapy. In psoriasis, a number of trials have demonstrated the effectiveness of combination therapy. Although combination therapy has not been extensively studied in atopic dermatitis, many practitioners combine topical corticosteroids and topical calcineurin inhibitors in their clinical practice because the two drug classes have different and possibly complementary mechanisms of action. For both diseases, the decision as to what agents are combined must also be tempered by patient type, disease presentation or severity, and patient preferences.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Dermatology - Volume 53, Issue 1, Supplement, July 2005, Pages S17-S25
Journal: Journal of the American Academy of Dermatology - Volume 53, Issue 1, Supplement, July 2005, Pages S17-S25
نویسندگان
David A. MD,