کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10148619 | 1646615 | 2018 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Time- and sex-dependent efficacy of magnesium sulfate to prevent behavioral impairments and cerebral damage in a mouse model of cerebral palsy
ترجمه فارسی عنوان
اثربخشی وابسته به زمان و جنس سولفات منیزیم برای جلوگیری از اختلالات رفتاری و آسیب مغزی در یک مدل موس فلج مغزی
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
MBPNPRMgSO4NORNMDARFFTTTCinflammation - التهاب( توروم) Triphenyltetrazolium chloride - ترفتhenyltetrazolium chlorideSex - جنسیت، رابطه ی جنسیMemory - حافظهSensorimotor behavior - رفتار سنسورpostnatal day 5 - روز پس از تولد 5Cognition - شناختNovel object recognition - شناسایی شیء رمانcerebral palsy - فلج مغزیmagnesium sulfate - منیزیم سولفاتgestational week - هفته بارداریhypoxia-ischemia - هیپوکسی-ایسکمیavian myeloblastosis virus reverse transcriptase - ویروس معروف ویرولواستاز ویروس معدهMyelin basic protein - پروتئین پایه میلینPerinatal - پریناتالN-methyl-d-aspartate receptor - گیرنده N-methyl-d-aspartate
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
چکیده انگلیسی
Cerebral lesions acquired in the perinatal period can induce cerebral palsy (CP), a multifactorial pathology leading to lifelong motor and cognitive deficits. Several risk factors, including perinatal hypoxia-ischemia (HI), can contribute to the emergence of CP in preterm infants. Currently, there is no international consensus on treatment strategies to reduce the risk of developing CP. A meta-analysis showed that magnesium sulfate (MgSO4) administration to mothers at risk of preterm delivery reduces the risk of developing CP (Crowther et al., 2017). However, only a few studies have investigated the long-term effects of MgSO4 and it is not known whether sex would influence MgSO4 efficacy. In addition, the search for potential deleterious effects is essential to enable broad use of MgSO4 in maternity wards. We used a mouse model of perinatal HI to study MgSO4 effects until adolescence, focusing on cognitive and motor functions, and on some apoptosis and inflammation markers. Perinatal HI at postnatal day 5 (P(5)) induced (1) sensorimotor deficits in pups; (2) increase in caspase-3 activity 24â¯h after injury; (3) production of proinflammatory cytokines from 6â¯h to 5â¯days after injury; (4) behavioral and histological alterations in adolescent mice with considerable interindividual variability. MgSO4 prevented sensorimotor alterations in pups, with the same efficacy in males and females. MgSO4 displayed anti-apoptotic and anti-inflammatory effects without deleterious side effects. Perinatal HI led to motor coordination impairments in female adolescent mice and cognitive deficits in both sexes. MgSO4 tended to prevent these motor and cognitive deficits only in females, while it prevented global brain tissue damage in both sexes. Moreover, interindividual and intersexual differences appeared regarding the lesion size and neuroprotection by MgSO4 in a region-specific manner. These differences, the partial prevention of disorders, as well as the mismatch between histological and behavioral observations mimic clinical observations. This underlines that this perinatal HI model is suitable to further analyze the mechanisms of sex-dependent perinatal lesion susceptibility and MgSO4 efficacy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 120, December 2018, Pages 151-164
Journal: Neurobiology of Disease - Volume 120, December 2018, Pages 151-164
نویسندگان
Ismaël Daher, Bérénice Le Dieu-Lugon, Maryline Lecointre, Nicolas Dupré, Caroline Voisin, Philippe Leroux, Nathalie Dourmap, Bruno J. Gonzalez, Stéphane Marret, Isabelle Leroux-Nicollet, Carine Cleren,