کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10161986 | 1114310 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Imprinted Contact Lenses for Sustained Release of Polymyxin B and Related Antimicrobial Peptides
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کلمات کلیدی
Controlled release - انتشار کنترل شدهBiomaterials - بیومتریال، بیومواد Ophthalmic drug delivery - تحویل داروی OphthalmicMucosal delivery - تحویل مخاطیPeptide delivery - تحویل پپتیدPseudomonas aeruginosa - سودوموناس آئروژینوزاMolecular imprinting - قالب مولکولی Contact lens - لنزهای تماسی، عدسکHydrogels - هیدروژل ها
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The aim of this work was to develop drug-soft contact lens combination products suitable for controlled release of antimicrobial peptides on the ocular surface. Incorporation of functional monomers and the application of molecular imprinting techniques were explored to endow 2-hydroxyethyl methacrylate (HEMA) hydrogels with the ability to load and to sustain the release of polymyxin B and vancomycin. Various HEMA-drug-functional monomer-cross-linker molar ratios were evaluated to prepare polymyxin B imprinted and non-imprinted hydrogels. Acrylic acid-functionalized and imprinted hydrogels loaded greater amounts of polymyxin B and led to more sustained release profiles, in comparison with non-functionalized and non-imprinted networks. Polymyxin B-loaded hydrogels showed good biocompatibility in hen's egg test-chorioallantoic membrane tests. Functionalized hydrogels also loaded vancomycin and sustained its release, but the imprinting effect was only exhibited with polymyxin B, as demonstrated in rebinding tests. Microbiological assays carried out with Pseudomonas aeruginosa allowed identification of the most suitable hydrogel composition for efficient bacteria eradication; some hydrogels being able to stand several continued challenges against this important bacterial pathogen. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:3386-3394, 2015
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 10, October 2015, Pages 3386-3394
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 10, October 2015, Pages 3386-3394
نویسندگان
Negin Malakooti, Cameron Alexander, Carmen Alvarez-Lorenzo,