کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10162058 1114315 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Engineering of Recombinant Spider Silk Proteins Allows Defined Uptake and Release of Substances
ترجمه فارسی عنوان
مهندسی پروتئین های ابریشم بازسازی شده عنکبوت به جذب و انتشار مواد معین کمک می کند
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی
Drug delivery carriers stabilize drugs and control their release, expanding the therapeutic window, and avoiding side effects of otherwise freely diffusing drugs in the human body. Materials used as carrier vehicles have to be biocompatible, biodegradable, nontoxic, and nonimmunogenic. Previously, particles made of the recombinant spider silk protein eADF4(C16) could be effectively loaded with positively and neutrally charged model substances. Here, a new positively charged variant thereof, named eADF4(κ16), has been engineered. Its particle formation is indistinguishable to that of polyanionic eADF4(C16), but in contrast polycationic eADF4(κ16) allows incorporation of negatively charged substances. Both high-molecular-weight substances, such as nucleic acids, and low-molecular-weight substances could be efficiently loaded onto eADF4(κ16) particles, and release of nucleic acids was shown to be well controlled. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 3, March 2015, Pages 988-994
نویسندگان
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