Symptomatologia chorób alergicznych u dzieci - marsz alergiczny

The atopic disease results from a close interaction between environmental (allergens and adjuvants) and genetic factors (innate predisposition) at all the stages of development of a morbid process. Besides specific factors (allergens), non-specific environmental factors modify the onset, development and course of the atopic allergy. Symptoms on the part of different organs frequently coexist in one patient and/or exist in the family, therefore it needs to be assumed that it is one atopic disease with diverse organic manifestation. Epidemiological research and long-term clinical observation indicate the existence of a specific sequence of prevalence of atopic conditions in a given individual. The sequence is associated with occurrence and dynamics of change of specific IgEs against food and aeroallergens. This phenomenon has been called 'the allergic march' and it is clinically understood as the organic (systemic) change of a bodily reaction to harmful allergens, that progresses with age. This phenomenon manifests itself through the occurrence of food hypersensitivity being the first atopic disease in life - with primordial clinical manifestation on the part of alimentary tract and/or skin, and subsequently progressing with patient's age in the direction of asthma and allergic rhinitis.