کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10218369 | 1687148 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prognostic factors and treatment effect of standard-volume plasma exchange for acute and acute-on-chronic liver failure: A single-center retrospective study
ترجمه فارسی عنوان
عوامل پیش آگهی و اثر درمان معاوضه پلاسما با حجم استاندارد برای نارسایی حاد و مزمن کبدی: یک مطالعه گذشته نگر تک مرکزی
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
هماتولوژی
چکیده انگلیسی
Patients with acute liver failure (ALF) and acute-on-chronic liver failure (ACLF) have a high risk of mortality. Few studies have reported prognostic factors for patients receiving plasma exchange (PE) for liver support. We conducted a retrospective analysis using data of 55 patients with severe ACLF (nâ¯=â¯45) and ALF (nâ¯=â¯10) who received standard-volume PE (1-1.5 plasma volume) in the ICU. Hepatitis B virus infection accounts for the majority of ACLF (87%) and ALF (50%) patients. PE significantly improved the levels of total bilirubin, prothrombin time and liver enzymes (P<0.05). Thirteen ACLF patients (29%) and one ALF patient (10%) underwent liver transplantation. Two ALF patients (20%) recovered spontaneously without transplantation. The overall in-hospital survival rates for ACLF and ALF patients were 24% and 30%, and the transplant-free survival rates were 0% and 20%, respectively. For the 14 transplanted patients, the one-year survival rate was 86%. Multivariate analysis showed that pre-PE hemoglobin (Pâ¯=â¯0.008), post-PE hemoglobin (Pâ¯=â¯0.039), and post-PE CLIF-C ACLF scores (Pâ¯=â¯0.061) were independent predictors of survival in ACLF. The post-PE CLIF-C ACLF scores â¥59 were a discriminator predicting the in-hospital mortality (area under the curveâ¯=â¯0.719, Pâ¯=â¯0.030). Cumulative survival rates differed significantly between patients with CLIF-C ACLF scores ⤠58 and those with CLIF-C ACLF scores ⥠59 after PE (P< 0.05). The findings suggest that PE is mainly a bridge for liver transplantation and spontaneous recovery is exceptional even in patients treated with PE. A higher improvement in the post-PE CLIF-C ACLF score is associated with a superior in-hospital survival rate.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transfusion and Apheresis Science - Volume 57, Issue 4, August 2018, Pages 537-543
Journal: Transfusion and Apheresis Science - Volume 57, Issue 4, August 2018, Pages 537-543
نویسندگان
Ya-Lien Cheng, Chih-Hsiang Chang, Wei-Ting Chen, Ming-Hung Tsai, Wei-Chen Lee, Kun-Hua Tu, Ya-Chung Tian, Yung-Chang Chen, Cheng-Chieh Hung, Ji-Tseng Fang, Chih-Wei Yang, Ming-Yang Chang,