کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10302246 | 542708 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Two subdomains of negative symptoms in psychotic disorders: Established and confirmed in two large cohorts
ترجمه فارسی عنوان
دو زیرمجموعه از علائم منفی در اختلالات روانپریشی: ایجاد و تایید در دو گروه بزرگ است
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کلمات کلیدی
تجزیه و تحلیل فاکتور، علائم منفی، اختلال روان پریشی، جنون جوانی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Negative symptoms of schizophrenia are normally grouped into a single category. However, the diversity of such symptoms suggests that they are actually made up of more than one dimension. The DSM-V proposes two negative symptom domains, namely expressive deficits and avolition/asociality. We investigated whether the negative symptoms do indeed have two dimensions. An exploratory factor analysis was carried out based on interviews with the PANSS (664 patients). We restricted our analysis to items that had been described as negative symptoms in previous factor analyses. The symptom structure was then tested for stability by performing a confirmatory factor analysis on PANSS interviews from a separate cohort (2172 patients). Exploratory factor analysis yielded a two-factor structure of negative symptoms. The first factor consisted of PANSS items Flat affect, Poor rapport, Lack of spontaneity, Mannerisms and posturing, Motor retardation, and Avolition. The second factor consisted of Emotional withdrawal, Passive/apathetic social withdrawal, and Active social avoidance. The first factor could be related to expressive deficits, reflecting a loss of initiative, and the second factor to social amotivation, related to community interaction. This factor structure supports the DSM-V classification and may be relevant for pathophysiology and treatment of schizophrenia and other psychotic disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychiatric Research - Volume 47, Issue 6, June 2013, Pages 718-725
Journal: Journal of Psychiatric Research - Volume 47, Issue 6, June 2013, Pages 718-725
نویسندگان
Edith Liemburg, Stynke Castelein, Roy Stewart, Mark van der Gaag, André Aleman, Henderikus Knegtering, Genetic Risk and Outcome of Psychosis (GROUP) Investigators Genetic Risk and Outcome of Psychosis (GROUP) Investigators,