کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1069815 1486141 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long-term outcomes from the National Drug Abuse Treatment Clinical Trials Network Prescription Opioid Addiction Treatment Study
ترجمه فارسی عنوان
نتایج درازمدت از مطالعه درمان وابستگی به مواد افیونی تجویز شبکه ملی آزمایشات بالینی درمان مواد مخدر
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


• Prescription opioid dependent patients were followed post-treatment for 42 months.
• Long-term outcomes demonstrated clear improvement from baseline.
• 61% were abstinent from illicit opioids, including 29% on agonist therapy.
• Agonist therapy was associated with a greater likelihood of Month-42 abstinence.
• 10% initiated heroin use, and 10% initiated injection heroin use post-treatment.

BackgroundDespite the growing prevalence of prescription opioid dependence, longitudinal studies have not examined long-term treatment response. The current study examined outcomes over 42 months in the Prescription Opioid Addiction Treatment Study (POATS).MethodsPOATS was a multi-site clinical trial lasting up to 9 months, examining different durations of buprenorphine-naloxone plus standard medical management for prescription opioid dependence, with participants randomized to receive or not receive additional opioid drug counseling. A subset of participants (N = 375 of 653) enrolled in a follow-up study. Telephone interviews were administered approximately 18, 30, and 42 months after main-trial enrollment. Comparison of baseline characteristics by follow-up participation suggested few differences.ResultsAt Month 42, much improvement was seen: 31.7% were abstinent from opioids and not on agonist therapy; 29.4% were receiving opioid agonist therapy, but met no symptom criteria for current opioid dependence; 7.5% were using illicit opioids while on agonist therapy; and the remaining 31.4% were using opioids without agonist therapy. Participants reporting a lifetime history of heroin use at baseline were more likely to meet DSM-IV criteria for opioid dependence at Month 42 (OR = 4.56, 95% CI = 1.29–16.04, p < .05). Engagement in agonist therapy was associated with a greater likelihood of illicit-opioid abstinence. Eight percent (n = 27/338) used heroin for the first time during follow-up; 10.1% reported first-time injection heroin use.ConclusionsLong-term outcomes for those dependent on prescription opioids demonstrated clear improvement from baseline. However, a subset exhibited a worsening course, by initiating heroin use and/or injection opioid use.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug and Alcohol Dependence - Volume 150, 1 May 2015, Pages 112–119
نویسندگان
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