کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1071540 | 949408 | 2007 | 5 صفحه PDF | دانلود رایگان |
ObjectiveIn-treatment and post-treatment outcomes were compared for three detoxification procedures (lofexidine + naloxone, lofexidine + placebo naloxone, and methadone).Sample and designThe sample was 137 opiate dependent in-patients. Detoxification treatments were 6-day lofexidine + naloxone (n = 45), lofexidine + placebo naloxone (n = 46), or 10-day methadone reduction (n = 46). A cohort study design was used with double-blind random allocation to lofexidine + naloxone versus lofexidine + placebo. Patients who did not consent to, or who were excluded from randomisation received methadone.ResultsOutcome differences between treatment groups at follow-up were generally associated with length of stay post-detoxification rather than detoxification procedure. Among patients who were not opiate abstinent throughout follow-up (n = 85), those who received lofexidine + naloxone detoxification reported a longer interval to first heroin use, with an interaction between detoxification medication and subsequent retention in treatment also identified.ConclusionsDetoxification medication may influence medium-term opiate use outcomes via its effect upon retention in treatment.
Journal: Drug and Alcohol Dependence - Volume 88, Issue 1, 17 April 2007, Pages 91–95