The Fading Electricity Theory of Ageing: The missing biophysical principle?

► An increasing number of experimental data do not support the ROS theory of ageing. ► A new paradigm that integrates the different ageing theories may be needed. ► This paradigm likely is physical rather than chemical in nature. ► Our paradigm: the fading of self-generated electricity is the key issue in ageing. ► This paradigm is compatible with evolutionary theory.