Viewpoint: Crosstalks between neurofibrillary tangles and amyloid plaque formation

► In this review, we discuss the recent discoveries that link amyloid plaque and NFT formation in AD pathogenesis. ► Presented cellular Aβ trafficking. ► Five proposed crosstalk pathways between pathogenic amyloid plaque and NFT formation are summarized ► Four proposed pathways of Aβ-mediated upregulation of tau kinases are shown.