Maintaining good hearing: Calorie restriction, Sirt3, and glutathione

► Age-related hearing loss (AHL) is a common feature of aging. ► Calorie restriction (CR) is known to delay the onset of AHL. ► We review the roles of mitochondrial Sirt3 and glutathione in maintaining normal hearing under CR. ► Potentially relevant mechanisms for the CR-mediated prevention of AHL are discussed.