Poly(ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury

► Cisplatin is an important chemotherapeutic drug that causes nephrotoxicity/nephropathy ► The nephrotoxicity of cisplatin involves oxidative/nitrative stress-PARP pathway ► PARP-1 deletion/inhibition prevents cisplatin-induced kindey inflammation and injury ► PARP inhibition enhances the antitumor effect of cisplatin in human cancer(s)/cells ► PARP is a novel therapeutic target to prevent cisplatin's nephrotoxicity